NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

조선대학교 의과대학 의학과 학사편입제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

There are many advantages and disadvantages under the limited bachelor's admission system. To diminish the demerits and to increase the merits of this system, the authors posed questions to the faculties and students of the Department of Medicine. Chosun University College of Medicine and other colleges in Korea. The questionnaire was made according to trends and feelings in this system. We received a lot of information and suggestions as to how to improve the system, in the following paper we discuss and report the prospective aspects of the bachelor's admission system.

조선대학교 의과대학 의학과 학사편입학제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

전립선 비대증 진단에 있어서 전립선 이행대 용적 지수의 유용성

임재성,노안식,김용웅,육승모 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Purpose : Prostate volume has been poorly correlated to various parameters used to assess benign prostatic hyperplasia (BPH), including symptom score, peak urine flow and detrusor pressure at peak urine flow. The purpose of this study was 2-fold: 1) to determine if transrectal ultrasound measurement of the transition zone of the prostate served as a better proxy for determining prostate size and correlated better with IPSS, peak urine flow and detrusor pressure and 2) if the parameter transition zone index (the ratio between transition zone volume and prostate volume) was useful in evaluating clinical prostatism. Materials and Methods: We prospectively evaluated 30 men with symptomatic BPH (mean age 65.4 years) according to symptom sore, peak urine flow, pressure/flow study, transrectal ultrasound volume of the entire prostate and the transition zone and calculation of the transition zone index. Results : There was a week correlation between prostate volume and symptom score, peak urine flow and detrusor pressure at peak urine flow: a stronger correlation between volume of transition zone and symptom score (r=0.679 p=0.03), and peak urine flow (r=-0.672 p=0.05) and a significant correlation (p=0.001) between transition zone index and symptom score (r=0.868), and peak urine flow(r=-0.870). Conclusion : Transition zone index is a parameter that correlates siginificantly with parameters of BPH and may serve as a useful proxy for evaluating worsening obstruction. Studies are underway to determine whether transtion zone index can be used prospectively to predict and correlate response with therapies designed to ablate prostatic tissue medically or surgically.

Strut-and-Tie Model을 利用한 鐵筋콘크리트 部材의 剪斷解析

林承旭,朴弘用 명지대학교 공학기술연구소 1992 공학기술연구소 논문집 Vol.7 No.-

Recently, Strut-and-Tie Model(STM) is proposed as a rational and consistent basis for analysis and design of any part of cracked reinforced and prestressed concrete structures which include so called disturbed or discontinuity regions, subject to bending, shear and torsion. In this paper, first, theoritical backgrounds of STM as well as modelling and analyzing methods are introduced. Then, the funtion of STM is confirmed by applying STM to some examples of other reseacher's experiments on reinforced concrete deep beams and comparing with test results and ACI Code provisions.

마우스 Myeloma Cell P3-X63-Ag8.653 및 T Cell Hybridome DO11.10에서의 Programmed Cell Death 유발 특성 비교

임석원,정용훈,최용,한승룡,조양자 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2

This study was aimed to prove that the death of HGPRT myeloma V653 by aminopterin treatment is due to PCD. This PCD was also compared with a relatively well-defined dexamethasone-induced PCD of T-cell hybridoma DO11.10. And these PCD systems were further characterized by inhibiting protein synthesis with cycloheximide, inhibiting mRNA synthesis with actinomycin-D, increasing intracellular calcium with calcium ionophore A23187. Induction of c-myc, an universal apoptosis gene, was also compared between these 2 systems. Viability of V653 cell was decreased by aminopterin-treatment in a dose-dependent manner. After treatment of aminopterin, this decrease of viability began in 6 hours and was accelerated in 12-18 hours. DNA fragmentation of V653 was detectable at 3 hours of incubation and peaked in 12-18 hours. Patterns of decrease in cell viability and increase in DNA fragmentation of dexamethasone-treated DO11.10 cells was similar to that of aminopterin-treated V653 cell, but the progress was much slower. The decrease in cell viability and increase in DNA fragmentation of aminopterin-treated V653 cells were inhibited by protein synthesis inhibitor cycloheximide, and RNA synthesis inhibitor actinomycin-D. In contrast the decrease in cell viability and increase in DNA fragmentation of dexamethasone-treated DO11.10 cell were accelerated by cycloheximide and actinomycin-D additions. Ca^2+ ionophore A23187 addition to aminopterin-treated V653 cells and dexamethasone-treated DO11.10 accelerated the decrease in cell viability and the increase in DNA fragmentation of both cells. In northern blot analysis, induction of c-myc gene was observed in aminopterin-treated V653 cell reached peak at 2hours and thern decreased drastically. Induction of c-myc gene in dexamethasone-treated DO11.10 cells was much slower and the fold of gene induction was much lower than that of aminopterin-treated V653 cell. Ultrastructural changes during the death process were observed by using electron microscope. Dilatation of rough endoplasmic reticulum(RER) and detachment of ribosomes were the earliest ultrastructural changes, which were observed in 30 minutes after death induction. The results of this study suggest that aminopterin-induced selective elimination of fusion partner V653 myeloma cell is due to PCD, and that this process requires de novo protein and RNA synthesis in which a Ca^2+ -mediated signal transduction pathway is involved.

축우 부루셀라병의 ELISA 진단법에 관한 연구

임윤규,이두식,박전홍,양기천,김승호,김공식,현관종,김우택,이영순 濟州大學校 農科大學 動物科學硏究所 1993 動物科學論叢 Vol.8 No.1

Enzyme-linked Immuno sorbent Assay (ELISA) for the serological diagnosis oi Bruceiia abortus was developed and compared with plate aggluhnation test Cell wall antigen was extracted from Brucella abortus 1119-3 by sonicabon and with a sodium deoxychlate solution Optimum protein concentra tion of coating antigen 0.4㎍/100㎕ protein on each microtiter plate well. Horse radish peroxidase(HRP) labled protein-G was used as a tracer of reacted antibodies ELISA confirmed the agreeable results of 40 rases out of 43 cases by plate aggulutination test ELISA diagnosed positive cases (10 out of 12) and negatiw cases (1 out of 12) with dubious sera by plate agglutination test From this results EL ISA could be used for the early diagnostic tools of Brucellosis in cattle.

시효처리와 마모체가 치과용 콤포짓트 레진의 마모에 주는 영향

김승헌,임범순,문현정,이용근,김철위 大韓齒科器材學會 2001 대한치과재료학회지 Vol.28 No.4

Over the last decade, the use of posterior resin composites has grown considerably. Wear resistance of restorative materials is important for clinical longevity, esthetics, and resistance to dental plaque. The purpose of this study was to evaluate the effect of artificial saliva and 75% ethanol solution on the wear resistance of composite resins by measuring the amounts of wear, and compare the effect of antagonistic materials on the wear resistance of composite resins. Four universal composite resins (Z100, Aelitefil, Spectrum, and Unifill F) and two condensable composite resins (Surefil and Synergy Compact) were measured. Cylinder type specimens were light-cured for 40 sec on the wear surface, and 20 sec on each side surface. The surface for wear testing was polished by 600 grit SiC paper. Three different antagonistic materials (600 grit SiC paper, amalgam, and procelain) were used as an antagonist for 2-body wear test. After speciments were aged in 37℃, artificial saliva and 75% ethanol solution for specific periods (1 day, 1 month and 2 month), 2-body wear testing was performed by the FRP-2000 friction tester with applying 500 g load (80 kPa) to the specimen. The wear test was performed for 10 min and 30㎖ distilled water was used as lubricant. Amount of wear was measured by microscopic measuring device of Micro Hardness Tester in 0.1㎛ scale. There was significant difference in wear resistance of composite resins (p<0.05). Composite resins with filler content below 59 vol.% showed higher wear resistance that composite resins those with filler content above 62 vol.%. In composite resins from 1 day to 1 months (p<0.05). On the contray, the wear amounts of groups which filler fraction were above 62 vol.% did not show any significant differences with increasing aging period (p>0.05). In 1 day aged groups, the wear amounts of the groups aged in 75% ethanol solution were more than those of the groups aged for 1 month (p=0.045) and Spectrum group aged for 2 month (p=0.006). Amounts of wear were significantly decreased with changing antagonist from 600 grit SiC paper to amalgam or porcelain (p<0.05).

만성폐쇄성 폐질환 환자에서 적혈구 항산화효소의 변화

국기용,이만재,조희충,임영국,박일,김원식,이승일,이병래 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disordesrs. Enhandng the intracellular content of antioxidant enzymes can provide means of limiting biological damage caused by oxygen free radicals. Many investigations have examined the potential of various oxyradical scavengers to modulate oxyradical injury. The oxygen free radicals play a role in the pathogenesis of chronic obstructive pulmonary disease. To investigate the pulmonary oxyradical injury and the protective role of antioxidant enzymes, author measured the amount of thiobarbituric acid reactants, the activiteies of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase) and the sulfhydryl groups in serum and red blood cells from the chronic obstructive pulmonary disease groups and the normal controls. The thiobarbituric acid reactant in chronic obstructive pulmonary disease groups was increased than the controls in both serum and red blood cells, and the superoxide dismutase activity in red blood cells was no statistically difference in both groups. But, the glutathione peroxidase and catalase activities were lowered in chronic obstructive pulmonary disease groups than the controls. The sulfhydryl groups in serum and red blood cells were no statistically difference in both groups. These results suggest that the increased thiobarbituric acid reactant in chronic obstructive pulmonary disease groups mean oxygen radical toxicity, and the decreased glutathione peroxidase and catalase activities may play a role in cellular injury.