Interleukin 2로 활성화한 단핵구 배양 상청액이 다형핵백혈구 중개성 세포독성에 미치는 영향

최요섭 전북대학교 대학원 1995 국내박사

예배로서의 기도 연구

최요섭 감리교신학대학교 2014 국내석사

크로스핏 트레이닝이 체력에 미치는 영향

최요섭 용인대학교 2018 국내석사

The purpose of this study was to analyze effects of 10 week crossfit training program on basic physical strength of the registered members of Crossfit H Gym. For the purpose of this study, participants’ physical 7 fitness factors, including body, weight lifting and gymnastic skills, physical fitness, cardio exercise and anaerobic exercise capacities of participants, and so on were measured. The research hypothesis was that there would be differences in seven physical strength factors (muscle strength, muscular endurance, agility, power, cardiovascular endurance, flexibility, and balance) which were measured 3 times during the period of 10 week crossfit training program. As for the method, both cardio and anaerobic exercise program were conducted for 20 participants (10 people in each group). Data were analyzed using SPSS-PC 22.0 for window statistical software. For the first job, descriptive statistics were conducted to analyze participants’ physical fitness. The analysis method used for this research was frequency analysis Two-way Repeated ANOVA regression statistics. The significance level of the hypothesis test was set to α = .05. The statistical results were as follows. First, as for the statistical difference test of muscle strength (left and right hand), there showed difference when it considered the covariance of group difference test by week difference tests and also week difference tests. Also, there was statistically significant difference between week differences tests, specifically showing that there was difference between 1st week and 5th week test, and 1st week and 10th week test. Second, as for the statistical difference test of muscle endurance (sit-up and push-up), there showed no difference when it considered the covariance of group difference tests by week difference tests, and also group difference tests. That is also true to the groups of push–up. However, there was statistically significant difference between week difference tests, specifically showing that there was statistically significant difference between 1st week and 5th week test, 1st week and 10th week test, and 5th week and 10th week test. Third, as for the statistical difference test of agility (side step), there showed no difference when it considered the covariance of group difference tests by week difference tests and also group difference tests. However, there was statistically significant difference between week tests, specifically showing that there was statistically significant difference between 1st week and 5th week test, 1st week and 10th week test, and 5th week and 10th week test. Fourth, as for the statistical difference test of the improvised power (standing long jump), there showed no difference when it considered the covariance of group difference tests by week difference tests and also group difference tests. However, there was statistically significant difference between week difference tests, specifically showing that there was statistically significant difference between 1st week and 5th week test, 1st week and 10th week test, and 5th week and 10th week test. Fifth, as for the statistical difference test of cardiopulmonary endurance (shuttle run), there showed no difference when it considered the covariance of group difference tests by week difference tests and also group difference tests. However, there was statistically significant difference between week difference tests, specifically showing that there was statistically significant difference between 1st week and 5th week test, 1st week and 10th week test, and 5th week and 10th week test. Sixth, as for the statistical difference test of flexibility (seated hip adductor stretching), there showed difference when it considered the covariance of group difference tests by week difference tests and also week difference tests. Also, there was statistically significant difference between week tests, specifically showing that there was statistically significant difference between 1st week and 5th week test, 1st week and 10th week test, and 5th week and 10th week test. Seventh, as for the statistical difference test of equilibrium (standing up on one leg), there showed no difference when it considered the covariance of group difference tests by week difference tests and also group difference tests. However, there was statistically significant difference between week tests, specifically showing that there was statistically significant difference between 1st week and 5th week test, 1st week and 10th week test, and 5th week and 10th week test. To conclude, it was found that the crossfit program participants gradually improved their strength, muscle endurance, agility, power, cardiopulmonary endurance, flexibility and equilibrium as times past over 10 weeks. Specifically, there showed no difference when it considered the covariance of group difference tests by week difference tests and also group difference tests. However, there was statistically significant difference between week tests. Thus, it was considered that the crossfit participants’s consistent exercises and constant technical exercises would guarantee the improvement of their physicla fitness. 이 연구의 목적은 크로스핏 H 체육관에 등록한 회원들을 대상으로 10주간의 크로스핏 트레이닝 프로그램이 체력에 미치는 영향을 분석하는 것이었다. 이러한 목적을 달성하기 위해 이 연구는 프로그램 참여자들의 신체, 역도ㆍ체조 기술, 경기력 향상을 위한 체력, 유산소성 운동능력과 무산소성 운동능력 등 7가지 체력요인에 관하여 측정을 하였다. 이 연구의 연구가설은 다음과 같다. 7가지 체력요인(근력, 근지구력, 민첩성, 순발력, 심폐지구력, 유연성, 평형성)의 측정결과는 10주간의 크로스핏 트레이닝 프로그램 실시 전ㆍ중ㆍ후에 따라 차이가 있을 것이다. 연구방법으로 10주간에 걸쳐 매 주 3회를 참여자의 체력을 측정하였다. 구체적으로 유산소 집단 10명과 무산소 집단 10명, 총 20명 대상으로 유산소성 운동 프로그램과 무산소성 운동 프로그램을 실시하였으며, 통계자료 처리를 위하여 SPSS-PC 22.0 for window 통계 프로그램을 사용하였다. 프로그램 참여자들의 체력을 분석하기 위해 우선 기술통계를 실시하였고, 두 집단의 반복측정 간의 차이를 알아보기 위하여 반복이원변량분석(two-way Repeated ANOVA)을 실시하였다. 가설검정의 유의수준은 α=.05로 설정 하였다. 통계분석 결과는 다음과 같이 나타났다. 첫째, 근력(악력 좌ㆍ우)에 대한 차이검증 결과에서는 악력(좌)는 집단과 주차, 그리고 주차 간에서는 통계적으로 유의한 차이가 있었으나, 두 집단 간 사이에는 차이가 없었다. 악력(우) 역시 집단과 주차와 집단 간에서 차이가 없었다. 그러나 좌ㆍ우 악력에서는 주차 간에 모두 유의한 차이가 있었으며, 사후검증 결과, 5주와 10주는 차이가 없으나 1주와 5주, 1주와 10주 사이에는 통계적으로 유의한 차이가 나타났다. 둘째, 근지구력(윗몸일으키기와 팔굽혀펴기)에 대한 차이 검증 결과에서는 윗몸 일으키기는 집단과 주차, 그리고 두 집단 간 사이에는 차이가 없었고, 팔굽혀펴기에서도 집단과 주차와 집단 간에 차이가 없었다. 그러나 주차 간에는 모두 통계적으로 유의한 차이가 나타났으며, 사후검증 결과, 1주와 5주, 1주와 10주, 그리고 5주와 10주 사이에 모두 통계적으로 유의한 차이가 나타났다. 셋째, 민첩성(사이드 스텝)에 대한 차이 검증 결과에서는 집단과 주차, 그리고 두 집단 간에서는 차이가 없었으나, 주차 간에서는 통계적으로 차이가 있었다. 사후검증 결과, 1주와 5주, 1주와 10주, 그리고 5주와 10주 사이에 통계적으로 모두 유의한 차이가 나타났다. 넷째, 순발력(제자리 멀리뛰기)에 대한 차이 검증 결과에서는 집단과 주차, 그리고 두 집단 간에서는 차이가 없었으나, 주차 간에서는 통계적으로 유의한 차이가 있었다. 사후검증 결과, 1주와 5주, 1주와 10주, 그리고 5주와 10주 사이에 통계적으로 모두 유의한 차이가 나타났다. 다섯째, 심폐지구력(셔틀런)에 대한 차이 검증 결과에서는 집단과 주차, 그리고 두 집단에서는 차이가 없었으나, 주차 간에서는 차이가 있었다. 사후검증 결과, 1주와 5주, 1주와 10주, 그리고 5주와 10주 사이에 통계적으로 모두 유의한 차이가 나타났다. 여섯째, 유연성(윗몸 앞으로 굽히기)에 대한 차이 검증 결과 에서는 집단과 주차, 그리고 주차 간에서는 통계적으로 유의한 차이가 나타났으나 두 집단 간에는 차이가 없었다. 주차 간 사후검증 결과, 1주와 5주, 1주와 10주, 그리고 5주와 10주 사이에 통계적으로 모두 유의한 차이가 나타났다. 일곱째, 평형성(외발 서기)에 대한 차이 검증결과에서는 집단과 주차, 그리고 두 집단 간에는 차이가 없었으나, 주차 간에는 통계적으로 차이가 있었다. 사후검증 결과, 5주와 10주는 차이가 없었으나, 1주와 5주, 1주와 10주에서는 통계적으로 유의한 차이가 나타났다. 결론적으로 크로스핏 참여자들의 10주간 기초체력 프로그램 적용 결과에서는 근력, 근지구력, 민첩성, 순발력, 심폐지구력, 유연성, 평형성에는 훈련 시간이 경과됨에 따라 점진적으로 향상되었다. 집단과 주차와 집단 간 사이에는 통계적으로 유의한 차이는 없었지만, 주차 간에서는 모든 요인에서 통계적으로 유의한 차이를 보였으며, 평균 측청치는 모든 집단에서 꾸준하게 향상되었다. 따라서, 크로스핏 트레이닝 프로그램은 참여자들의 지속적인 운동과 꾸준한 기술연습을 통한다면 프로그램 참여자들의 체력 향상에 많은 도움을 주는 것으로 판명되었다.

하디의 생애와 신학사상 : 협성신학교 교수 시절 <신학세계> 수록 논문을 중심으로

최요섭 감리교신학대학교 대학원 2012 국내석사

Genipin inhibits the inflammatory response of rat brain microglial cells

최요섭 경희대학교 대학원 2010 국내박사

Microglia are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such as that in Alzheimer’s and Parkinson’s diseases. Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of various disorders in traditional oriental medicine. Genipin has recently been reported to have diverse pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The specific aim of this study was to examine whether genipin represses brain microglial activation. Genipin was effective at inhibiting LPS-induced nitric oxide (NO) release from cultured rat brain microglial cells. Genipin reduced the LPS-stimulated production of tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), prostaglandin E2 (PGE2), and intracellular reactive oxygen species. In addition, genipin reduced NO release from microglia stimulated with interferon-γ(IFN-γ) and amyloid-β(Aβ). Both pretreatment and post-treatment of genipin to LPS-stimulated microglia were effective at decreasing NO release. These results suggest that genipin provide neuroprotection by reducing the production of various neurotoxic molecules from activated microglia. 소교세포(microglia)는 중추신경계에서 면역과 염증 반응에 중요한 작용을 하는 인자로, 병적 상태에서는 소교세포가 활성화되어 중추신경의 항상성을 복구시킨다. 그러나 만성적인 소교세포의 활성은 다양한 염증전구물질과 신경독성 인자를 방출하여 신경세포의 생존을 위협하게 된다. 따라서 소교세포의 만성적 활성을 억제하는 것은 알쯔하이머나 파킨슨병과 같은 퇴행성 신경질환에 대한 치료 작용으로 간주되고 있다. Genipin은 치자열매의 활성물질로 항균작용, 항암작용, 항염증작용에 대한 약리작용이 있는 것으로 보고되고 있다. 이 논문은 특히 genipin이 뇌소교세포 활성을 억제 할 수 있는지에 초점을 두었다. 실험 결과에 의하면 genipin은 배양된 쥐의 뇌소교세포에서 lipopolysaccharide (LPS)에 의해 유발된 nitric oxide (NO)를 억제하는데 효과적이었다. 또한 LPS에 의해 유발된 tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), prostaglandin E2 (PGE2), 그리고 세포내 활성산소를 감소시켰고, interferon-γ(IFN-γ), amyloid-β(Aβ)에 의해 자극된 소교세포로부터 방출된 NO를 감소시켰다. LPS에 자극된 소교세포에 genipin을 전처리 한 것과 후처리한 것 모두 NO방출을 감소시키는데 효과적이었다. 따라서 이 연구 결과 genipin은 활성화된 소교세포에서 방출된 다양한 신경독성 분자들의 생성을 감소시킴으로써 신경 보호 작용이 있음을 알 수 있었다.

장소 개념을 통해 본 국내 슬로시티 개발전략의 개선방향 연구

최요섭 경북대학교 대학원 2010 국내석사

This study was conducted with a critical mind of limits that place promotion policy, which is carried out to settle rural problems, being focused on place marketing rather than place making and studied Slow city, recently emerging as an alternative for rural development, in a standpoint of place making, not place promotion. Slow City has been noticed as the alternative rural development at present. There are total six cities authentic in ROK (Republic Of Korea). Shin An, Wan Do, Jang Heung, Dam Yang which are located in Jeollanam-do was authenticated on december, 2007 and Ha Dong which is located in Gyeongsangnam-do on february, 2009 and Ye San which is located in Chungnam on september, 2009. Few cities are preparing authentication from International Cittaslow Network. There have been various trials to develop the indicators for making place with various perspectives. However, it is hard to find yet the case and research developing place assets. In this context, this study was performed as follows which are also a fundamental study to develop the visualization indicators as of Place Assets that appear in Slow City. Approaching place capital, which is being a target of promotion, with a concept of place making to derive patterns as well as formation process of Slow city's place capital and place capitalization of place resource was reestablished through theoretical background and case studies of Slow cities. According to previous study, rural area's patterns of place capital and progress of visibility, which is essential for the formation of place capital, were derived based on place capitalization analysis of Slow city network authentication items.

대학생들의 전공 만족도와 진로결정수준과의 상관분석

최요섭 목포대학교 대학원 2002 국내석사

본 연구는 대학생들의 전공 선택이 전공 만족에 대한 중요성과 현실성 여부를 비교함으로써 전공의 만족 정도가 진로결정수준에 상관관계가 있는지를 알아보고자 하는데 그 목적이 있다. 본 연구의 문제는 다음과 같다. 첫째, 대학생들이 학과 전공에 어느 정도 만족하고 있는가? 둘째, 대학생들이 졸업 후 진로결정수준이 어느 정도 인가? 셋째, 대학생들의 전공 만족도가 진로결정수준과 상관이 있는가? 표집대상은 4년제 국립대학 6개의 단과 대학을 선정한 다음, 선정대학에 재학 중인 1, 2, 3, 4학년 학생 중 300명에게 설문지를 배부하였다. 본 연구에서 사용된 조사도구는 「전공만족도 검사」를 위해서 검사지(송유진,1995)의 내용 중 교육과정과 관련된 검사문항을 기초로 하여 사용하였고, 「진로결정수준 검사」는 Osiopow등(1980)이 개발한 진로결정검사(Career Decision Scale; CDS)를 고향자(1992)가 우리 문화에 적절한 문장표현으로 번안한 것을 사용하였다. 본 연구에서 사용된 분석방법은 전체적으로 우선 빈도와 백분율을 산출하였고, 전공만족도와 진로결정수준에 있어서 집단 간 차이를 알아보기 위해 t검증과 변량분석을 사용하였다. 또한 전공만족도와 진로결정수준과의 상관을 알아보기 위해서는 Pearson의 적률로 상관계수를 산출하였다. 위의 분석을 위해서 SPSSWIN 10.0 Program Package를 사용하였다. 이상의 연구 방법과 절차를 통하여 학과 학생들의 전공에 대한 만족정도를 조사한 본 연구의 결과는 다음과 같다. 첫째, 전공 만족도에서 진로방향이 가장 만족하는 것으로 나타났고, 그 다음으로 교과과정 부분에서 만족하는 것으로 나타났으며, 학교 환경과 평가 부분에서는 조금 덜 만족하는 것으로 나타났다. 전공 만족 전체를 보면 대학생들의 전공 만족도가 보통 이하인 것으로 나타났다. 둘째, 진로와 전공 선택에 대한 확신 수준이 보통 이상인 것으로 나타났고, 그 다음으로 교육과 진로미결정에 대한 확신 수준은 보통 이하인 것으로 나타났다. 진로결정수준 전체를 보면 학생들의 진로결정수준이 보통 이상인 것으로 나타났다. 셋째, 대학생들의 전공 선택에 따른 만족도가 좆ㄹ업 후 진로결정에 영향을 주는 것으로 알게 되었다. 이미 진로가 결정된 학생들에게는 자신에 대한 이해를 바탕으로 그 진로결정이 올바른지 숙고하고 검토하도록 하며, 진로 미결정 학생들에게는 진로 결정을 위한 올바른 선택과 준비를 할 수 있도록 적절한 지도를 할 수 있는 자료가 될 것이라 본다.

구미국가산업단지 미니클러스터사업의 지역적 뿌리내림에 관한 연구 : 구미금형협동화단지 조성과 구미테크노밸리협동조합을 중심으로 : Gumi Mold Work Cooperation Complex and Gumi Techno Valley Cooperative

최요섭 경북대학교 정책정보대학원 2014 국내석사

The purpose of this study is to present policy alternatives for the continuous advancement of cluster projects, through the analysis of the implementation of cluster projects in Korea and of the process and outcome of the regional embeddedness of mini-cluster projects. The results of the study are summarized as follows: First, the cluster projects in Korea clearly enhanced participating enterprises' economic performance in terms of production, exports, and employment, because the government (i.e., the Korea Industrial Complex Corporation) played the role of network broker and contributed to the establishment of efficient systems in short periods of time by inducing the activation of the national and regional economies based on the foregoing economic performance. In particular, the derivation of the enterprises' difficult tasks based on industry-academy-research networks and solutions to problems via the government's support greatly contributed to the formation of social superstructures. These superstructures spread cooperation based on trust among industries, academies, and research institutes, thereby creating Korean-style cluster models. Second, the industry-academy-research network of the Gumi National Industrial Complex cluster project operates largely in two groups: mini-clusters, which are industry-academy-research consultative groups by business type based on information sharing; and working groups, which are smaller task-oriented learning groups. Mini-cluster operation began in 2005 with 10 electronic industry industry-academy-research consultative groups (a mini-cluster); currently, five industry-academy-research consultative groups are in operation. Working groups are characterized by free formation and extinction by task. Third, the possibility of developing sustainable clusters can be identified at the Gumi National Industrial Complex, because spontaneous communities have been organized through mini-cluster activities and working group operation for several years, and these communities jointly participate in other institutions' policy tasks. Cluster projects contributed not only to the reinforcement of enterprises' competitiveness by supporting difficult tasks based on industry-academy-research network activities but also to the activation of spontaneous communities through the construction of superstructures for mutual trust in the region and for institutional support. Fourth, the electronic component mold mini-cluster at the Gumi complex helped mold-related enterprises, which are one of root industries in the region, settle in the region through cooperation projects and networking activities. In addition, an independent project—the establishment and operation of the Gumi Techno Valley Cooperative—can be also considered as an important model for the activation and substantiality of clusters. The following policy suggestions are made based on the results of this study: First, policies regarding cluster projects should be continuously implemented, and the identity cluster projects should be established. The fact that cluster projects in Korea are inducing diverse ripple effects through the enhancement of enterprise competitiveness and spontaneous organization despite the short time period, is the result of great help from financial support based on government policies and specialized project management by the dedicated institution (Korea Industrial Complex Corporation). Therefore, for cluster projects to take root, continuous policy support and management by the dedicated institution are essential. Second, the cluster projects need the continuous support of systematic management through a public dedicated institution. According to the results of this study, the role of dedicated managers of mini-clusters was very important in the successful construction of cluster project bases and spontaneous organizations. Therefore, to diffuse the outcomes of the cluster projects and support cluster project embeddedness, the management and support of the projects by a dedicated public institution and close support by dedicated managers should be maintained. This study is meaningful in that it recognizes the necessity of voluntary cooperation through diverse network activities in mini-cluster projects. These activities are continuing and can provide benchmarking models for the spontaneous evolution not only of mini-cluster projects in other regions but also of government-led projects, through the development of models for “regional embeddedness”—namely, spontaneous evolution through cooperation.

中風 患者 偏麻痺에 同伴된 上肢浮腫에 대한 뜸治療의 有效性 檢討

최요섭 경희대학교 대학원 2003 국내석사

폐결핵 환자에서 Rifampicin이 이차 항체 생성에 미치는 영향

최요섭 全北大學校 大學院 1991 국내석사

Rifampicin is currently recognized as one of the most effective agents for tubereulosis therapy. In addition to its antibactarial properties, rifampicin appears to have immunosuppressive activity. The effect of rifampicin on the secondary antibody response, has been debated. This study was performed to clarify the affect of rifampicin on the secondary antibody response in pulmonary tuberculosis. Changes of tetanus specific IgG were evaluated using ELISA on the sera from patients with pulmonary tuberculosis after DT vaccination, The results were as follows; 1)Before vaccination, the values of tetanus specific IgG were lower in the pulmonary tuberculosis patients particularly in the patients treated with both isoniazid(INH)rifampicin and than those in controls(P<0.05). 2)After vaccination, the values of tetanus specific IgG were increased from 0.435±0.072 and 0.271±0.043 to 1.135±0.128 and 0.655±0.123 in controls and pulmonary tuberculosis patients respectively. Concerning pulmonary tuberculosis patients, the values of tetanus specific IgG were increased froe 0.271±0.043 to 0.655+0.123 in patients treated with INH alone and from 0.218±0,040 to 0.388*0.106 in patient treated with both INH and rifampicin. These results suggest that the suppressive effect of secondary antibody response in the pulmonary tuberculosis patients may be due to the pulmonary tuberculosis itself and the immunosuppressive activity of rifampicin.