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이은정 ( Eun Jung Lee ),이정옥 ( Jeong Ock Lee ),배광학 ( Kwang Hak Bae ),진보형 ( Bo Hyoung Jin ),백대일 ( Dai Il Paik ) 대한예방치과·구강보건학회 2011 大韓口腔保健學會誌 Vol.35 No.4
연구목적. 우리나라 국민의 우식발생을 억제시킬 목적으로 녹차폴리페놀의 우식예방효과를 구강내우식원세균수 변화와 구강내완충능 변화를 통해 간접적으로 관찰하여, 녹차의 우식예방효과를 측정하고자 한다. 연구방법. 우식발생가능성이 높은 연령대의 집단을 대상으로 녹차가 아동의 치아우식 발생에 미치는 영향을 조사하기 위하여서울시에 소재하는 초등학교 4학년 254명을 연구대상으로 하여 실험군(n=131)에게 아침 등교 후와 점심식사 후 매일 2회 신선한 녹차를 12개월 동안 마시도록 하였고 대조군(n=97)은 녹차를 마시지 않도록 하였다. 세계보건기구의 기준에 따라 연구시작시점과 6, 12개월 후의 우식경험영구치아를 조사 하였으며, 연구대상자의 자극성타액을 수집하여 구강 내 S. mutans수와 Lactobacillus 수 및 타액완충능의 변화를 비교 검토하였다. 연구결과. 우식경험영구치아수는 녹차비음용군보다 녹차음용군에서 둔화되었고(p=0.8065) S. mutans는 녹차음용군에서 녹차비음용군보다 감소하였다(p=0.0031). Lactobacillus는 녹차음용군과 녹차비음용군 간에 유의적으로 감소하였으며(p=0.0006), 타액완충능은 녹차음용군에서 녹차비음용군보다 증가하였다(p<0.0001). 결론. 녹차 음용에 의해 구강 내 S. mutans수의 증가가 억제되고 타액 완충능이 증가 되는 양상을 보이므로, 우식발생 가능성이 높은 집단에서의 녹차음용법은 구강건강을 증진시키는 모델로 활용될 수 있을 것으로 검토되었다.
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새로운 5-치환 Uracil 유도체의 합성 및 생물활성
이원희(Won Hui Yi),박정섭(Jung Sup Park),원정희(Jeong Hee Won),이정옥(Chong Ock Lee),유응걸(Eung K. Ryu) 대한약학회 1991 약학회지 Vol.35 No.6
Six novel 5-substituted-1-[2-(3-methoxy-2-hydroxyphenyl)-l-methoxyethyl]uracils 2a-f were prepared by condensation of 2,4-bis(trimethylsilyloxy)-5-substituted uracils with 2,7-dimethoxy-2,3-dihydrobenzofuran (9) in the presence of Lewis acid. The 2,3-dihydrobenzofuran derivative 9 was obtained by intramolecular acetalization of 2-acetoxy-3-methoxyphenyl acetaldehyde (8) which was synthesized by oxidative cleavage of 1-allyl-2-acetoxy-3-methoxybenzene (7) using osmium tetroxide followed by NaIO4. Compounds 2a-f were evaluated for in vitro antiviral activity against HSV-1, HSV-2 and HRV. None of these compounds showed activity with ID50) values up to 100 mcg/ml except for 5-chlorouracil derivative 2d which exhibited antiviral activity against HSV-1 with ED50) 30 mcg/ml. In the antitumor activity against L1210 and P388 leukemia cell lines, 2d showed activity with ID50 values of 14 mcg/ml and 11.6 mcg/ml, and 2c with ID50 values of 22.9 mcg/ml and 8.8 mcg/ml, respectively.
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학부모의 학교계속구강건강관리사업에 관한 지식수준과 지지정도
이정옥,문혁수,김종배,백대일 대한구강보건학회 2002 大韓口腔保健學會誌 Vol.26 No.4
The purpose of this study was to clarify and eliminate the obstacles in developing the incremental dental care programs, The author had reported the results of investigating and analysing the knowledge and attitude on school-based incremental dental care programs of 955 students' parents in middle size of urban community. A Questionnaire was used to interview 955 students' parents in Sunchon. The data were analysed by age and gender, The results obtained and conclusions discussed were as follows ; 1. Most of students' parents have a little knowledge on school-based incremental dental care programs. 2. They got the informations about school-based incremental dental care programs mostly through their children and mass media, not through dentists. 3. After listening to the explanation about school-based incremental dental care programs, an absolute majority of them accepted that their children received school-based incremental dental care. 4. The majority of them agreed that school-based incremental dental care programs should be supported by social security. 5. The main obstacle in developing school-based incremental dental care programs was the poor knowledge of parents and dentists about them. 6. The more education about oral health care system is needed in dental college education for general dentist. 7. As a part of social and school education, it should be developed immediately the school-based oral health education about school-based incremental dental care.
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Ganoderma lucidum IY 009로 부터 분리된 항암성 다당류의 약리 및 독성
이권행,이정옥,이준우,정훈,한만덕,정준호,오두환 한국산업미생물학회 1994 한국미생물·생명공학회지 Vol.22 No.2
G. lucidum IY 009의 균사체의 조다당 분획, AS는 sarcoma 180 cell에 직접적인 toxicity를 나타내지 않았으나, ICR mouse의 항체 생성과 marcrophage의 탐식능 및 분리된 macrophage로부터 superoxide ion 생성을 촉진시켰으며, AS분획의 항암활성은 macrophage 기능의 특이한 저해제인 trypan blue에 의해 저해 받았다. 또한 AS분획은 human serum중의 complement C3를 활성화시켰으며, AS분획의 항암활성은 보체계 활성화에 관여하는 2가 양이온의 chelator인 EDTA에 의해 저해 받았다. Mouse leukemia P388 및 L1210이 이식된 inbreed mouse, BDF1에서 Krestin은 항암활성을 전혀 나타내지 못하였으나, AS분획은 수명연장 및 고형암 증식억제 효과를 나타내었다. AS분획을 ICR mouse에 경구투여한 경우, 별 다른 독성을 보이지 않았으며, LD_50은 2,230 ㎎/㎏ 이상으로 나타났다. The highest antitumor activity was observed in water soluble AS fraction of the Canoderma lucidum IY 009. AS fraction did not show any cytotoxicity on sarcoma 180 cell but stimulated antibody production, opsonization of macrophage in ICR mouse and superoxide ion production from isolated macrophage. AS fraction activated complement C3 in human serum, and their antitumor activity was inhibited by EDTA, a chelator of cation related complementary activation. AS fraction exerted on prolong of life span and inhibition of tumor growth in the leukemia P388 or L1210 transplanted inbreed mouse, BDF1 but Krestin did not. AS fraction did not show any serious and lethal effects through oral administration on ICR mouse, and LD_50 of those was above 2,230 ㎎/㎏.
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김병각,최응칠,정경수,김유진,이정옥,우정원 한국균학회 1983 韓國菌學會誌 Vol.11 No.1
A macromolecular fraction prepared from the aqueous extract of the carpophores of Clitocybe infundibuliformis an edible mushroom, which were collected at the Gwang-neung area, Gyeong-Gi Province in 1981, was investigated for antitumor activity against sarcoma 180 in mice. The inhibition ratio of this fraction against the tumor was 55% at the dose of 20 ㎎/㎏/day. This lraction was found to contain a polysaccharide and a protein. The hydrolysate of the polysaccharide yielded four monosaccharides: xylose (68.5%), glucose (14.6%), galactose (6.8%), and mannose (10.1%).
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박용환,김병각,최응칠,정경수,김유진,이정옥,김양섭,우정원 한국균학회 1983 韓國菌學會誌 Vol.11 No.1
To characterize the antineoplastic constituents of Laccaria laccata, an edible mushroom, the shake-cultured mycelia of L. Zaccata ISA-1008 were extracted with distilled water. Purification of the extract was carried out by acetone prccipitation, and by ion exchange chromatography using DEAE-Sephadex A-50, CM-Sephadex C-25 resins, and by gel filtration chromatography on Sephadex G-200. Each fraction obtained during the purification procedure was examined for antineoplastic activity against sarcoma 180 in ICR mice. The fraction. that was not adsorbed on DEAE Sephadex A-50 showed a marked activity.
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