고유명사의 의미론

신운섭 한국독어독문학교육학회 2002 獨語敎育 Vol.24 No.-

Cell Surface Hydrophobic Protein of Candida albicans

신운섭 관동대학교 2000 關東醫大學術誌 Vol.4 No.1

BERT Learns More than Word Frequency Information: A Case Study of Do-Be Constructions

신운섭,송상헌 한국언어학회 2022 언어 Vol.47 No.3

This study aims to understand BERT’s linguistic ability using naturally occurring data. In particular, the study collected marginal language data, such as what we do is create Frankenstein, which is referred to as a Do-Be construction (DBC) (Flickinger & Wasow, 2013). Using web corpora, the study first collected 17,737 instances of the DBC across text genres and English dialects. The corpus analysis supports the idea that DBC is a computationally challenging phenomenon for data-driven language systems due to its statistical sparsity and linguistic complexity. With manual annotations of DBCs, the study designed two computational prediction tasks: subject―verb agreement and synonym substitution tasks, based on the introspective judgment of linguists. The study found that BERT is hugely sensitive to linguistic acceptability of grammatical forms and felicitous words in the prediction tasks, even though the target phenomenon is rarely observed in corpus data. These results show that the neural language model, BERT, can learn abstract linguistic properties beyond surface frequency information.

배양 조건이 Candida albicans의 phospholipase 생성에 미치는 영향

신운섭,이경호,박주영,고춘명 대한의진균학회 1997 대한의진균학회지 Vol.2 No.2

Background : The dimorphic yeast, Candida albicans, is considered as a dangerous opportunistic pathogen in immunocompromised hosts. Several phospholipases of C. albicans are known to be secreted into the culture medium. Phospholipases have been proposed as a virulence factor in the pathoenesis of Candida infections. Objective : In order to investigate enzyme production, we examined culture condition of secreted phospholipase production from C. albicans. Methods : C. albicans ATTCC 10231 was cultivated in various media at 37℃ for 3 days. Phospholipase activity was measured by fatty acid soap precipitaiton in plate containing 0.04T lecithin, 0.1 M citrate buffer, pH 4.2 and 1.5% noble agar. Results : Phospholipase was highly induced when C. albicans was cultivated in broth medium(containing glucose 2%, albumin 0.2% and Fe^++ ion 0.01%) and Saboulaud's dextrose agar supplemented with 0.01% sodium deoxycholate. Conclusion : Highly induction of secreted phospholipase by albumin from C. albicans may be play an importans role in tissue invasion in the pathogenesis of C. albicans.

Candida albicans 의 단백질분해효소, 인지질분해효소 및 세포벽 단백분획으로 면역시킨 생쥐에서의 칸디다증 방어 효과

신운섭,최선주,박수정,박주영,김수기,이경호,양영철 대한의진균학회 2009 대한의진균학회지 Vol.14 No.1

Background: The opportunistic fungus Candida albicans is a major pathogen especially to immunocompromised patients. Objectives: We examined the protective effect of the active and passive immunizations to evaluate the applicability for the treatment of candidosis in Candida-infected mice model. Methods: Candida cell wall components were obtained by treatment of lyticase, proteinase K, and dithiothreitol. The proteinase was purified from the culture filtrates of C. albicans using a series of chromatographic steps consisting of DEAE-Sepharose FF, Sephacryl S-200 HR and size-exclusion high performance liquid chromatography. The phospholipase was purified from the culture supernatant of C. albicans with DEAE column chromatography, reverse phase column chromatography, revere phase HPLC and size-exclusion HPLC. Antibodies to cell wall protein components, proteinase and phospholipase were produced by immunization into mice of same strain. Results: The mean survival times of active and passive immunized mice groups were longer than those of non-immunized groups. Conclusion: These results showed that immunization with proteinase and its antibody were the most effective to prolong survival time in Candida-infected mice. Background: The opportunistic fungus Candida albicans is a major pathogen especially to immunocompromised patients. Objectives: We examined the protective effect of the active and passive immunizations to evaluate the applicability for the treatment of candidosis in Candida-infected mice model. Methods: Candida cell wall components were obtained by treatment of lyticase, proteinase K, and dithiothreitol. The proteinase was purified from the culture filtrates of C. albicans using a series of chromatographic steps consisting of DEAE-Sepharose FF, Sephacryl S-200 HR and size-exclusion high performance liquid chromatography. The phospholipase was purified from the culture supernatant of C. albicans with DEAE column chromatography, reverse phase column chromatography, revere phase HPLC and size-exclusion HPLC. Antibodies to cell wall protein components, proteinase and phospholipase were produced by immunization into mice of same strain. Results: The mean survival times of active and passive immunized mice groups were longer than those of non-immunized groups. Conclusion: These results showed that immunization with proteinase and its antibody were the most effective to prolong survival time in Candida-infected mice.

WSN을 통한 드론 자동 착륙 기법

신운섭,나승재,김기형 한국정보통신설비학회 2016 한국정보통신설비학회 학술대회 Vol.2016 No.09

Demand of drones that can perform the monitoring task of contaminated or difficult-to-access area without human pilot is a motivation for research high accuracy location tracking algorithm and autonomous landing algorithm. This paper describes the development of the noise reduction-type WSN-based system that can measure the accurate position of the drone. The noise reduction type WSN-based system by applying DGPS mechanism, can reduce the error of the WSN-based location tracking techniques due to noise. Such the system is needed for high-accuracy autonomous landing operations.

시공(時共) 명칭어와 결합되는 형용사 뒷가지의 의미 분석

신운섭 상명대학교 어문학연구소 1997 語文學硏究 Vol.5 No.-

방선균 WCM-9가 생산하는 Polyene 항진균성 항생물질(AF1)의 생물학적 성상

신운섭,정선호,이동희,이경호,김수기,박주영,고춘명 대한의진균학회 1996 대한의진균학회지 Vol.1 No.1

Background: Pathogenic fungi infect humans, especially immunocompromised patients, with superficial or deeply invasive pattern. In the past 20 years, fungal infections have been increased dramatically resulted by increment of organ transplantation, cancer, AIDS patients, or use of broad-spectrum antibacterial agents. Fungal infections are now important causes of morbidity and mortality of hospitalized patients. but there is no effective antifungal antibiotics as well as antibacterial antibiotics Objective: Effective new antifungal antibiotics are needed for the treatment of mycosis. So in an effort to develop effective antifungal antibiotics, we screened over 600 isolates of Streptomyces spp. from soil. Methods: Antifungal producing strain was selected using disk diffusion method, An antifungal substance (AF1) was purified with ethyl acetate extraction, silica gel column chromatography and reverse phase HPLC. MICs of AF1 were detected by agar dilition method. Results: The compound showed UV maxima of 307, 321, 340, 359 nm indicating methylpentaene. Minimum inhibitory concentrations of the AF1 were 3.7 ㎍/ml against mold, and 3.7 - 7.4 ㎍/ml against Candida species. AF1 was also active against Cryptococcus neoformans, with MIC of 0.9 ㎍/ml. The concentration of AF1 for K^+ ion release from human red blood cell and hemolysis were 5 ㎍/ml. Conclusion: The antibiotic purified from culture broth of Streptomyces sp. WCM-9 was a polyene antifungal antibiotic which have broad spectrum antifungal activity.

동사 기저어과 결합도는 형용사 뒷가지의 의미 분석

신운섭 상명대학교 어문학연구소 1996 語文學硏究 Vol.4 No.-

모바일 노드의 방향 결정을 위한 핑거프린팅 맵 구축 기법

신운섭,최정용,김기형 한국정보통신설비학회 2018 한국정보통신설비학회 학술대회 Vol.2018 No.08

In order to recognize the location of a person or object in indoor environment, many researches have been conducted to solve the problem by applying various signal information and position recognition techniques. The location awareness approach, which has been widely discussed since the introduction of the smartphone, has been widely applied to the general public without any additional equipment, such as Wi-Fi, BLE, acceleration, angular velocity, geomagnetism, altitude And the position is measured by using this method. In this paper, we propose a fingerprinting map construction method for determining the direction of a mobile node.