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문철 대한교통학회 2021 대한교통학회 학술대회지 Vol.85 No.-
자율주행 레벨3 수준의 차량은 자체 센서만을 이용하기 때문에 인지 범위가 옆 차선 및 전 후방으로 제한되는 부분 인지(partial observation)의 한계가 발생한다. 또한, 주변 타 차량들의 경로 계획을 고려하지 않고 단독의 판단 및 경로를 계획을 수립하는 독립 드라이빙(independent driving)의 한계로 인해 자율주행 차량의 안전하고 효율적인 운행을 보장할 수 없다. 본 연구에서는 자율주행 차량의 부분인지 및 독립 드라이빙의 한계로 발생할 수 있는 도로합류부, 교차로, 돌발교통상황 등에서, 인프라의 센싱 및 고도 상황인지 정보를 차량들에게 제공함으로써 자율주행 Lv.4/4+ 차량의 안전하고 유연한 운행을 지원하는 기술을 개발한다. 본 발표에서는 도로상황에 최적화된 인프라 센서 네트워크의 구축과 인프라 센서 수집정보의 저지연 처리를 위한 무선 네트워크 기술, 클라우드 LDM(Local Dynamic Map)과 연계하여 인프라 센서 네트워크에서 센싱된 데이터의 수집, 융복합, 분석 등을 통해 초저지연 도로상황 인지 수행과 이를 저지연 및 고신뢰 전송하는 기술, 그리고 이를 통합한 스마트 도로상황 인지 노변 플랫폼 개발 및 구축하고 검증하기 위한 연구 계획을 소개한다.
슬롯라인 결합을 이용한 능동 위상배열안테나에 관한 연구
문철,김선택,윤영중,박한규,Mun, Cheol,Kim, Seon-Taek,Yoon, Young-Joong,Park, Han-Kyu 한국통신학회 1997 韓國通信學會論文誌 Vol.22 No.5
In this paper, the 5-element active phased array antennas coupled through slotline between elements are designed and fabricated. A recent studies on the active phased array antennas using the transmission line coupling which can be designed to provide strong coupling and the appropriate coupling phase. But this sturucture has limitation of expanding in two dimensions for planar active phased array antennas and distortion of the radiation pattern caused by coupling network. Thus our work proposes the slotline coupling structure asthe broadband coupling network for the active phased array antenna. In experiment, 5-elements active phased array antenas have steering range from -30.deg. to 20.deg. off broadside as the free-running frequencies of end elements are controlled. The overall results show that the proposed slotline coupling structure is suited for the coupling network in the actie phased array antenna system. And the proposed coupling structire solves the expansion problem and eliminates the distortion of the radiation pattern caused by the spurious radiation of the transmission line coupling network. Thus thiscan be expanded to two dimensional coupling network for the planar active phased array antenna system.
불멸화된 악성구상상피에 대한 Retinoic Acid의 세포활성 및 유전자 발현 연구
문철,민승기 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.1
cDNA microarray allows to monitor the expression of thousthand genes simultaneously and has been successfully to explore the gene expression of carcinoma and other diseases. To identify and monitor gene expression profile changes in oral tumorigenesis and exposure to medicine may shed light not only on the cause of these pathological changes, but also provide the opportunity to identify novel targets for disease detection and intervention. Retinoids and interferon are important regulators of human epithelial cell differentiation and have been used successfully in the clinical treatment of HPV-involved cervical cancer. However, there is only a limited information available concerning to the effect or role of retinoic acid in oral precancerous and cancer cells. We studied the effect of retinoic acid on normal human oral keratinocyte(NHOK), HPV-16 E6E7 immortalized human oral keratinocyte(IHOK), and two oral squamous cell line(HNSCC30, HNSCC31) according to the carcinogenesis stage. The RA effect was evaluated by MTT assay and microarray. Complementary DNA microarray including 400 genes was used to systematically characterize the variation in gene expression patterns of RA treated IHOK cells vs. control IHOK cells . The results were as follows: 1. RA has negative effect on growth for all NHOK, IHOK, HNSCC30 and HNSCC31 dependently on the concentration and cultivation time. 2. We identified 18 clones cDNA exhibiting more than 2 fold overexpression in RA treated IHOK probes relative to control probe, 21 cDNA s reveal more than 2 fold overexpression in control IHOK relating to the experimental cells. Pearson correlation coefficients for the set of selected spots from duplicated hybridization was 0.86. 3. Examination of gene expression that differs between RA treated IHOK and control IHOK cells apprear to be related to : cell cycle regulator, cell growth and apoptosis, cell adhesion, signal transduction and miscellanous. 4. Cell cycle regulator uprgulation is noted in MAD2, CDK9, Cdc20, Cdc2, CDK inhibitor 1A, and only HUS-1 is downregulated. 5. Cytochrome P450 and interleukin 1-alpha for cell growth and apoptosis factor was upregualted, and capase 8 & FADD apotosis regualtor gene was decreased expression, so we observed increased apoptosis mecahnism and resistance to apoptosis. 6. Cytokine upregulation in RA treated IHOK was noted in interIeukin 1 alpha, downregualtion was in interleukin 8, interleukin 10, interleukin 10 receptor, interleukin 3 receptor, interleukin 9 receptor, and interleukin 19 7. Signal transducers including JAK binding protein, STAT1, and Burkitt lymphoma receptor were upregulated with RA reated IHOK , suggesting the RA regulates the JAK/STAT signal-transduction pathway. In conclusion, we have demonstrated the high-throughput utility of cDNA array hybridization in parallel to the gene expression analysis to identify genes that are expressed differentially in RA treated with HPV16 immortalized keratinocytes. The differentially expressed genes identified here should be informative in oral epithelial cell carcinogenesis.
위암에서 림프절 미세전이의 면역조직화학적 방법에 의한 측정 및 생존율과의 상관관계
문철,박경규,이문수,허경열,장용석,김재준,이민혁,진소영,이동화,Moon Chul,Park Kyung-Kyu,Lee Moon Soo,Hur Kyung Yul,Jang Yong Seog,Kim Jae Joon,Lee Min Hyuk,Jin So-Young,Lee Dong Wha 대한위암학회 2002 대한위암학회지 Vol.2 No.1
Purpose: The purpose of this study is to identify immunohistochemical evidence of lymph-node micrometastasis in histologic node-negative gastric cancer patients and to evaluate the prognostic significance of lymph-node micrometastasis.Materials and Methods: A retrospective study of 50 gastric cancer patients who underwent curative resections from October 1990 to November 1994 was performed. Two consecutive sections were prepared: one for ordinary hematoxylin and eosin staining, and the other for immunohistochemical staining with Pan cytokeratin antibody (Novocastra, UK). In the univariate analysis, the survival rate was calculated using the Life Table Method, and the multivariate analysis was determined using a Cox Proportional HazardsModel. The statistical analyses of the relationships between the clinicopathologic factors and micrometastases were performed by using a Chi-square test. Results: Of 2522 harvested lymph nodes, 81 ($4.1\%$) nodes and 19 ($38\%$) of 50 patients were identified as having lymphnode micrometastases by using immunohistochemical staining for cytokeratin. The incidence of lymph-node micrometastases was significantly higher in diffuse type carcinomas ($54\%$, P=0.024) and in patients with serosal invasion ($52.2\%$, P=0.05). For patients with lymph-node micrometastases (n=19), the 5-year survival rate was significantly decreased ($73.7\%$, P=0.015). The Lauren's classirication (P=0.021) and the depth of invasion (P=0.035) were shown by multivariate analysis to have a significant relationship with the presence of micrometastases. Multivariate analysis revealed that lymph-node micrometastasis was independently correlated with survival in histologic node-negative gastic cancer patients. Conclusion: The presence of cytokeratin detected lymphnode micrometastases correlates with the worse prognosis for patients with histologic node-negative gastric cancer.