진료비 상담의 효율적인 업무개선을 통한 고객만족도 향상

서지연,채은경,고영준외 39인 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2

문제: 최근 몇 년간, 환자 및 보호자들이 의료와 관련된 전문기관을 대상으로, 민원발생이 급, 상승되고 있음이 통계상 확인되고 있다. 목적: 최근 몇 년간, 환자 및 보호자들이 의료와 관련된 전문기관을 대상으로, 민원발생이 급, 상승되고 있음이 통계상 확인되고 있다. 의료기관: 서울에 소재한 2,200병상의 전문종합요양기관 소속 보험 심사 팀 질 향상 활동: 상담 Data base 구축을 위한 전산개발 및 핵심 문제 부분에 대한 직무프로세스 변경, 보완 및 수정 활동결과: 진료비 사례 환자 상담건수는 2003년 기준 75.4%의 증가율을 보였으며, 본원의 민원검수는 전년대비 9%의 감소효과가 확인되었다.

Reading Performance Improvement in PDF-417 2-dimensional Bar code

안라연,박지후,우홍체 대구대학교 2006 대구대학교 학술논문집 Vol.1 No.2

As life style becomes to be complicated, lots of supportive technologies were developed. The bar code technology is one of them. It was renovating approach to merchandise industry. However, data storage ability of one dimensional bar code is limited because of growing the number of merchandise.. Two-dimensional bar code was proposed to overcome one-dimension bar code. PDF-417 bar code most commonly used in standard two-dimension bar codes has good performance at data decoding and error correction area. An algorithm to improve reading performance with PDF-417 is suggested. The threshold value is computed, and bar and space are extracted according to threshold value. PDF-417 is used everyday and is printed in many different materials. The printed PDF-417 is especially influenced by various light sources. It is hard to recognize the bar and space separation under the circumstance of changing illumination. The fixed threshold value to distinguish the bar and space can not be applied. The proposed algorithm is developed to investigate the variable threshold. The variable threshold can be obtained by simple calculation.

항결핵 6개월 단기요법의 성과 고찰

서지원,정연채,김남재,홍석철,김주옥,김선영,노흥규 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

To evaluate the effect of 6-month short term antituberculosis chemotherapy with INH, Rifampin, Ethambutol, and Pyrazinamide(2HREZ/4HRE) in the patients with pulmonary and/or extrapulmonary tuberculosis, the authors prescribed 2HREZ/4HRE regimen in 79 tuberculosis patients for 6 months with measuring the sputum staining for AFB, chest X-ray findings, recurrence rates and possible side reactions of the treatment. The result were as follow; 1. Pulmonary Tuberculosis 1) Among the 56 pulmonary tuberculosis patients who had taken 2HREZ/4HRE regimen. 32 patients showed initial positivity in sputum AFB smear stain(57.2%). Negative conversion occurred usually within 2 months after initiation of chemotherapy and the mean period of negative conversion was 1.4 months. 2) Among the 56 pulmonary tuberculosis patients, chest X-ray finding changed in 41 patients (37.21%). From these 41 patients 39 patients showed continuous improvements in chest X-ray finding, though 3 patients showed initial aggravation in spite of continuous medication. The remainder 2 cases aggravated due to the failure of treatment. 3) Treatment failure occurred in 2 patients (3.57%) during the chemotherapy among 56 patients of pulmonary tuberculosis and they were infected with secondary drug-resistant strains of M. tuberculosis. 2. Extrapulmonary tuberculosis. Among 8 patients with tuberculous pleurisy and 15 patients with superficial tuberculous lymphadenitis, there were no evidence of treatment failure after completion of antituberculosis chemotherapy for 6 months with 2HREZ/4HRE regimen. 3. Follow-up study was performed from 6 months to 50 months after completion of antituberculosis chemotherapy and the relapse was not noted in both pulmonary and extrapulmonary tuberculosis patients group during this period. 4. Serum AST/ALT elevated in 9 patients(11.4%) during the treatment and this occurred usually within 3 months after the initiation of antituberculosis chemotherapy. However treatment interruption occurred in 2 patients (2.5%) due to the development of hepatitisone due to drug-induced hapatitis and the other due to type B viral hepatitis. In conclusion, we could find this 2HREZ/4HRE 6-months short-term antituberculosis regimen is effective and could be recommanded as a promising regimen for the treatment of tuberculosis.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

[PB-0071] GBS 분석을 통한 국내 무(Raphanus sativus L.) 품종의 유전적 유연관계 분석

Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

[PB-0073] 무(Raphanus sativus L.) 품종의 표현형적 특성과 heterozygosity 간의 상관관계 분석

Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Intravitreal Delivery of Mesenchymal Stem Cells Loaded onto Hydrogel Affects the Regulatory Expression of Endogenous NGF and BDNF in Ischemic Rat Retina

( Ji Yeon Lee ),( Ji Man Shin ),( Chung Eun Yeum ),( Gue Tae Chae ),( Myung Hoon Chun ),( Su Ja Oh ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.5

The utility of a biodegradable hyaluronic acid (HyA)-based hydrogel as a tissue scaffold for intravitreal carriage of mesenchymal stem cells (MSCs) into the retina was tested. A rat model of retinal ischemia-reperfusion (IR) injury was used. DiI-labeled MSCs from three passages were loaded onto hydrogel and injected into the vitreous body of experimental and control eyeballs 1 week after IR. The neutral hydrogel was also modified to a basic pH. A control carrier, 0.01 M phosphate-buffered saline (pH 7.2; PBS) was compared. Retinal tissues were prepared 1 week and 2 weeks after MSCs application. MSCs localization and effects were evaluated on immunostained retinal preparations with confocal microscopy. MSCs localization was apparent in the retinas loaded onto hydrogels, adhering tightly to the inner limiting membrane, whereas those in PBS floated in the vitreous body. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were expressed in the end feet of M?ller cells in the normal retina. NGF expression was slightly reduced 2 weeks IR, had expanded into the proximal processes 3 weeks IR, but it appeared reversely 1 week and 2 weeks after MSCs application, respectively. BDNF expression was higher in the ischemic and MSCs-treated ischemic retinas than in the normal and MSCs-treated control retinas, respectively. These findings demonstrate that HyA-based hydrogel is an efficient vehicle for intravitreal MSC transplantation into the retina, and that MSCs thus transplanted induce M?ller glial cells to produce growth factors concerned with the survival of retinal ganglion cells.

FOXA2 Overexpression Promotes Hepatic Differentiation of Adipose Tissue Derived Stem Cells

( Yeon Ji Chae ),( Dae Won Jun ),( Chang Hong Lee ),( Jae Yoon Jeong ),( Joo Hyun Sohn ),( Ki Seok Jang ),( Jai Sun Lee ),( Hyeon Tae Kang ),( Ho Hyun Nam ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: We used non-viral vector gene delivery system and three dimensional culture using scaffold to increase the efficacy of hepatocyte differentiation. Methods: The adipose derived stem cells (ADSCs) were isolated from human adipose tissue. Using microporator, Foxa2 was over-expressed in ADSCs and cultured in poly-lactic-co-glycolic acid (PLGA) scaffold. Later, for hepatic differentiation ADSCs were pre-cultured in IMDM with 20 ng/mL epidermal growth factor and 10 ng/mL fibroblast growth factor-basic (bFGF). After 2 days, the cells were cultured in Step-1 differentiation medium consisting of IMDM with 20 ng/mL hepatocyte growth factor (HGF), 10 ng/mL bFGF, and nicotinamide 0.61 g/L for 7 days. Finally, the cells were cultured in Step-2 differentiation medium consisting of IMDM with 20 ng/mL oncostatin M, 1 mol/L dexamethasone, and 50 mg/mL ITS+ premix for 7 days. For in vivo experiments, Foxa2 over-expressed ADSCs cultured in IMDM with 20 ng/mL EGF and 10 ng/mL bFGF and were loaded in scaffold for 1 day and later were implanted in nude mice dorsum for 2 weeks. After 2 weeks the scaffold was retrieved from mice. After differentiation, periodic acid-Schiff (PAS) staining, and qPCR gene evaluation were performed. Results: After hepatic differentiation, Foxa2 over-expressed ADSCs increased the gene expression of hepatocyte-specific gene markers (alpha- fetoprotein [AFP], Cytokeratin 18 [CK18], Albumin[ALB]) in 2D cultures. In 3D cultures, Foxa2 over-expressed ADSCs increased the gene expression of hepatocyte-specific gene markers (AFP, CK18). In 2D, 3D cultures, Foxa2 over-expression increased glycogen storage ability in hepatic differentiated cells. In vivo experiments showed that after 2 weeks scaffold implant, the mRNA expression for AFP and CK18 increased in foxa2 over-expressed group while ALB expression remained the same as in vector group. Moreover, PAS staining was more pronounced in Foxa2 group. Conclusions: Foxa2 promotes hepatic differentiation by increasing AFP, ALB and CK18 expressions in 2D, while increasing AFP, and CK18 expressions in 3D culture and in vivo system.

Modified Reactive Hemophagocytic Syndrome Diagnostic Score as a Prognostic Factor in Lung Transplantation Patients

( Ji Yeon Choi ),( Moo Suk Park ),( Song Lee Kim ),( Sang Hoon Lee ),( Eun Young Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Jin Gu Lee ),( Hyo Chae P 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Lung transplantation (LTX) has been established as a current therapy for patients with end-stage lung disease. Despite year of experience with LTX, the rate of mortality still remains high. Calcineurin inhibitors sometimes have induced reactive hemophagocytic syndrome and influenced on mortality. Objective of this study was to search prognostic factors using modified reactive hemophagocytic syndrome diagnostic score (mrHScore) associated with mortality after LTX. Methods We conducted a retrospective analysis of 100 patients who underwent LTX at Severance Hospital from October 2012 to July 2018. We classified into two groups by high (n=52, mrHScore ≥78.5) and low mrHScore (n=48, mrHScore <78.5). The optimal cut-off value of mrHScore for the prediction of postoperative overall survival was set at 78.5 using receiver operating characteristics analysis. Five biologics (i.e., triglyceride, ferritin, serum glutamic oxaloacetic transaminase, fibrinogen and cytopenia) were used in calculating mrHScore. We analyzed the basal characteristics and mortality rates in low and high mrHScore groups as prognostic factors of LTX outcomes. Results The primary lung disease was idiopathic pulmonary fibrosis (n=51, 51%), interstitial lung disease (n=14, 14%), and bronchiectasis (n=5, 5%). High mrHScore group showed significantly cytopenia, hyperferritinemia, hypertriglyceremia, high LDH levels and high C-reactive protein levels compare to those of low mrHScore group. On Kaplan-Meier analysis, mortality rate was significantly increased in high mrHScore group than in low mrHScore group (hazard ratio: 2.074, p=0.015). Multivariate regression analysis showed that high mrHScore was significantly associated with postoperative mortality, even after adjusting for other confounding factors. Conclusion Our Results show that high mrHScore provides clues for adverse outcome during follow up period in LTX patients. The mrHScore can be used to estimate prognosis of post LTX patients, and provide useful information for predicting postoperative mortality.

Feasibility and Stability of Liver Biopsy before Treatment for Preclinical Nonalcoholic Fatty Liver Studies

Chae, Yeon Ji,Jun, Dae Won,Saeed, Waqar Khalid,Kang, Hyeon Tae,Oh, Ju Hee,Lee, Seung Min,Jang, Kiseok KOREAN ACADEMY OF MEDICAL SCIENCE 2019 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.34 No.2

<P><B>Background</B></P><P>The heterogeneity of histological findings in preclinical diet-induced nonalcoholic fatty liver disease (NAFLD) animal models is highly challenging. Here, we aimed to evaluate the feasibility and stability of repeated liver biopsy in NAFLD animal models.</P><P><B>Methods</B></P><P>Heterogeneity of diet-induced NAFLD was evaluated at different time points in 52 high-fat diet (HFD), 35 methionine choline-deficiency diet (MCD), and 166 western diet (WD) induced NAFLD mice. Serial liver biopsies (left lateral, right medial, and left medial lobes) were performed monthly for up to 3 months. Mortality rates and changes in food intake, body weight, and liver enzymes were assessed.</P><P><B>Results</B></P><P>At 12 weeks, of the HFD animals, 14% and 30% did not develop steatosis and lobular inflammation, respectively; of the MCD animals, 7% did not develop lobular inflammation; and of the WD animals, 14% and 51% did not develop steatosis and lobular inflammation, respectively. The mortality rate of repeated liver biopsy was 1.62% (2/123 mice died). Repeated liver biopsy can be used to trace disease progression. Although body weight, food intake, and liver enzymes slightly changed after biopsy, all recovered within a week. Repeated liver biopsy did not affect the degrees of inflammation and steatosis of the other liver lobes.</P><P><B>Conclusion</B></P><P>The diet-induced NAFLD models were quite heterogeneous. Our results suggest that the repeated liver biopsy before treatment was applicable and stable in this NAFLD animal study.</P>