열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

TFELD 절연층을 위해 ITO glass위에 증착된 (Ba_(0.5),Sr_(0.5))TiO₃박막의 특성

김정환,배승춘,권성렬,정훈,박진우,김기완 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

We have studied that dielectric and electrical properties of (Ba_(0.5),Sr_(0.5))TiO_(3) thin films deposited on Indium Tin Oxide-coated glass substrate by using rf-magnetron sputtering method in this paper. Substrates were heated at room, 300℃ , 400℃, and 500℃. Working pressure was changed 5mTorr, 10mTorr, 20mTorr, 30mTorr respectively substrates temperature, and Ar:O_(2), ratio was fixed 9:1. SEM analysis was conducted to investigate thickness of BST thin films. Dielectric constant, current-voltage(I-V), and transmittance were measured. We observed difference of that thickness, dielectric constant, current-voltage(I-V), and transmittance due to variable substrates temperature and working pressure. We also obtained best conditions at 400℃, 30mTorr. Dielectric constant was 209.1 at 1kHz, leakage current density was below 7.35X10^(-7)A/cm^(2) at 100V, and transmittance was over 91%.

해수교환방파제의 항내 해수순환 효과에 관한 실험적 연구

김성득,이성대,민석진,홍창배 한라대학교 2007 論文集 Vol.10 No.-

Establishing breakwater in ports have greatly improved the calmness in ports. However, the seawater exchange between landward and seaward areas in ports has greatly decreased. In ports near urban areas, the inflow of sewage or industrial wastewater and the accumulation of sludge are causing a variety of environmental problem. To realize a seawater exchange breakwater that will improve the calmness in ports and the seawater exchange, the tunneled caisson breakwater with intake holes was debeloped to allow fresh seawater into the port using wave energy. The seawater exchange breakwater composed of tunneled breakwater and submerged mound is under planned in Hupo fishing port on the East Sea. In this paper, the characteristics of seawater exchange and the inflow rate of this breakwater introduced based on the results of 3-dimensional hydraulic model tests.

조형된 연골막판을 사용한 이개재건에 대한 실험적 연구

김성수,배용찬,정성훈,김석권 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.4

Although carved cartilage grafts from rib are commonly used for ear reconstruction, it is difficult to mimic a normal pinna and these reconstructions are so firm and unnatural. Therefore, we had a basic experimental study for a new technique of ear reconstruction. We tried to creat a cartilage framework by moulding the perichondrial flap experimentally. The perichondrial flap with the vascular pedicle of the central vessels was elevated in rabbit ear and placed between the leaves of a silastic mould. This preparation was placed in a pocket under adjacent scalp and sic and eight weeks later the preparations was harvested and assessed gross and histological findings. The moulded perichondrial flap was well developed and a thin cartilage layer was recognized within the convolutions created by the mould. Grossly, it was not so firm but relatively soft and there was little difference between at six and eight weeks. Histologically, viable new chondrocytes and active cartilage formation were demonstrated in the perichondrium at both six and eight weeks. The moulded cartilage which was harvested after 6 weeks was irregular in thickness and it's chondrocytes were not completely developed. However, the cartilage which was harvested after eight weeks was relatively regular in thickness and it's cells, especially centrally located, were fully developed. Clinically, ear reconstructive may be completed by implantation of this moulded cartilage as traditional reconstructive method. Otherwise, this moulded cartilage can be harvested with its vascular pedicle and the pedicle can be anastomosed with superficial temporal artery. And then a split thickness skin graft on the perichondrium enveloping the moulded cartilage or covering with skin flap which was expanded with tissue expander may complete the ear reconstruction in single stage operation. If further investigations for materials of the mould, optimal period for maximum cartilage synthesis and durability of moulded cartilage are studied, this moulded perichondrial flap technique provides the potential advantage of ear reconstructions.

본태성 고혈압에서 염산에포니디핀 (NZ-105, 핀테20정�)의 유효성 및 안전성 : 제3상 다기관 임상시험 The phaseⅢ multicenter open trial

배종화,손일석,강흥선,조정휘,강재헌,김성원,이선영,양윤준,김영식,선우성 대한간질학회 2003 대한간질학회지 Vol.9 No.1

ILQ 제어를 이용한 열간압연 폭 제어시스템 개발에 관한 연구

김성배,황이철 동의대학교 산업기술개발연구소 2001 産業技術硏究誌 Vol.15 No.-

This paper studies on the design of a ILQ(Inverse Linear Quadratic optimal control) looper control system for hot strip mills. The looper which is placed between each stand plays an important role in controlling strip width by regulating strip tension variation generated from the velocity difference of main work rolls. The mathematical model for looper is firstly obtained by Taylor's linearization of nonlinear differential equations, where it is given as a linear and time invariant state-space equation. Secondly, a looper servo controller is designed by ILQ control algorithm, which is an inverse problem of LQ(Linear Quadratic optimal control) control. By tunning control gain arbitration parameters and time constants, it is shown that the ILQ looper servo controller has the performance that makes well to follow desired trajectories of both strip tension and looper angle.

매립지 침출수내의 Ca^2+, Fe^2+,3+, 휴믹물질 동반제거에 관한 연구

김지태,고명욱,배성렬 漢陽大學校 工學技術硏究所 2002 工學技術論文集 Vol.11 No.-

탄산칼슘(CaCO_3) 결정화 석출과 수산화철(Fe(OH)_3)의 결정화 석출을 위해 반회분식 장치를 이용하였으며, 반응온도는 25±2℃로 유지하였고 교반속도는 40∼80rpm으로 교반하였다. 매립 침출수내에 함유되어져 있는 Ca^2+와 Fe^2+, Fe^3+를 응집 침전물로 결정화한 후, 활성탄에 흡착시켰다. 휴믹물질을 금속 이온 물질과 배위 결합시켜 함께 제거할 수 있었다. 침출수 처리의 적정pH 범위는 9∼10이었고, 약 90%이상의 Ca^2+, 휴믹물질이 동반제거됨을 알 수 있다. 그러나 Fenton 산화처리 이후에 활성탄 흡착에 의한 Fe^2+,3+, 휴믹물질의 동반제거에 있어서 충분한 처리방법이 되지 못함을 관찰할 수 있다. Batch reactor was used in this study for treating CaCO_3 and Fe(OH)_3, temperature was maintained at 25±2℃ and stirring speed was 40∼80rpm. Ionic metals such as Ca^2+, Fe^2+ and Fe^3+ in leachate were precipitated and adsorbed by activated carbon. Subsequently ionic metals and humic substances that combined with Ca^2+, Fe^2+ and Fe^3+ are removed. The removal efficiency of humic substances was varied with pH value. At the pH 9∼10 range in the treated leachate, Ca^2+, humic substances was removed over 90%. but removal of Fe^2+,3+, humic substances didn't show that the efficient treatment was absorbed by activated carbon after Fenton treat.

CO₂고정을 위한 화학독립영양미생물 Aeromonas sp. strain JS-1의 분리 및 특성

배상옥,곽경오,이용운,김성준,정선용 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-

The increase of CO2 in the atmosphere by fossil-fuel combustion has been recognized as a major cause of global warming. Thus many studies on CO2 removal from the combustion gas have been performed, and recently the techniques for biological CO2 fixation by photoautotrophs have also been developed, In this study, extensive screening was conducted to obtain micoorganism with high capability in fixing CO2, and its characteristics was investigated. As a result, a chemoautotrophs identified as a Aeromonas sp. strain JS-1 was isolated from the fresh water. The isolated strain used the molecular hydrogen and CO2 as an energy and a carbon source, respectively. Growth characteristics, which will be used in the development of a continuous culture system related in CO2 fixation, were examined in batch cultivation under conditions of various CO2 and NaCl concentrations, temperature, and pH. The results of the examination showed that the isolated strain had a good growth to high CO2 concentration(40%), indicating applicable in removing CO2 discharged from industries.

염수의 담수화를 위한 막분리 장치 설계제작 및 성능

배성렬,김영채,이종일 한양대학교 에너지·환경기술연구소 1997 에너지·環境技術論文集 Vol.3 No.-

폐수의 처리와 해수의 담수화에 사용되는 막분리장치의 효율을 증가시키기 위하여 새롭게 설계, 제작하였다. 유체의 흐름을 개선하여 염수를 사용한 실증 실험으로 상업용 제품과 비교하여 10%의 향상된 분리성능을 갖은 장치를 개발하였다.