유기용제 폭로가 여성 근로자들의 월경에 미치는 영향

김대환,이채관,김휘동,강동묵,문덕환,김정호,손병철,이창희,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

유기용제는 산업장에서 널리 사용되고 있다. 특히 여성근로자들의 폭로기회가 증가하고 있으며 이로 인한 자연유산, 수태능력 감소, 월경이상 등이 보고되고 있다. 따라서 유기용제 폭로가 여성근로자들의 월경에 미치는 영향을 보기 위해 설문조사와 월경주기별 여성생식 호르몬(progesterone, estrogen) 분석을 하였다. 그 결과 폭로군에서 progeterone의 억제효과가 유기용제에 폭로되는 여성근로자들의 다양한 월경이상을 초래할 가능성이 있는 것으로 생각된다. ■ Objectives This study was conducted to evaluate the effects of menstrual function in female workers exposed to organic solvents. ■ Methods Rates of menstrual disorders were studied in 87 female workers with exposure to organic solvents(Cn/Hn-value 0.713) in a factory manufacturing shoes and compared with 83 general female workers who had no exposure to organic solvents, Detailed menstrual and reproductive histories were obtained by personal interview using structured questionnaire, and plasma concentrations of progesterone and estrogen were assayed by radioimmunoassay(RIA). ■ Results The rates for menstrual irregularity, menstrual duration, blood clot in menstrual flow and dysmenorrhea were not significantly different in both groups. Number of using menstrual pad was significantly higher and the plasma level of progesterone during 6-11th day of menstrual cycle was significantly lower in the exposed group compared with non-exposed group(P<0.05). ■ Conclusions It seemed to be suppression effect of organic solvents on the reproductive hormones(progesterone and estrogen) in female workers. But there was no evidence that menstrual disorder was likely to result from exposure to organic solvents, because other behavioral, psychological and work related factors may also affect menstrual function.

소규모사업장 용접근로자들의 소음·용접흄·망간 노출에 관한 연구

김동구,문덕환,이채관,박명희,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted for the purpose of investigating the level exposure of welders to noise, welding fume and Manganese(Mn) related to this process. Methods and Material : All subjects in this study were welders engaged in CO2 arc and coated arc welding process especially in small-scale enterprises classified by type of manufacture of ship building, repairing and of other fabricated metal products, which is located in Gimhae and Milyang of Kyeongsang province in south Korea. Air sampling of welding fume was measured, shipped and analyzed on the basis of national institute for occupational safety and health(NIOSH) method in U.S. and work environment measurement method established in south Korea. To measure Noise in the work environment, Noise dosimeter was used on the basis of work environment measurement method established in south Korea. Result : This study was performed during a period from January, 2000 to December, 2001 and Results were as follows: 1. Noise level measured in this work environment was higher than national criteria for permissible exposure limit on health examinations related to hearing loss. 2. The concentration of welding fume and Mn in manufacture of ship building and repairing was higher than those in manufacture of other fabricated metal products. 3. In conditions of existing in ventilation system installed and operated, the concentration of welding fume and Mn was slightly lower than those of not existing. 4. In conditions of existing in sufficient air supply from out door into the work place relied on natural exhaust system, the concentration of welding fume and Mn was slightly lower than those of in not sufficient. 5. In all subjects, a rate of wearing ear plug and respiratory mask for dust and fume was lower than that of not wearing. Conclusion : According to above results, this study suggests that more positive work environment managements such as the use of portable local ventilation system, the supply of highly qualified personal protective equipment, and consecutive education and training related to health protection should be need to acquire suitable health protection program for welders engaged in small-scale enterprises in Korea.

국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성

송진수,최평균,송경호,조재현,김성한,방지환,이창섭,박경화,박경운,신수,최희정,김의석,김동민,이미숙,박완범,김남중,오명돈,김의종,김홍빈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 최근 전세계적으로 지역사회획득 메티실린내성 황색포도알균(community-associated methicillin-resistant Staphylococcus aureus, CA-MRSA)의 보고가 증가하고 있다. 하지만, 우리나라에서는 CA-MRSA 감염증에 대한 증례보고만 있을 뿐 아직까지 체계적인 연구결과가 없는 실정이다. 저자들은 국내에서 CA-MRSA의 빈도, 감염증의 임상적 양상, 분리된 균주의 항균제내성 양상을 조사하였다. 재료 및 방법 : 2005년 1월부터 2005년 6월까지 7개 병원에서 MRSA가 분리된 환자의 명단을 파악한 후 의무기록지와 건강보험심사평가원의 자료를 검토하였다. 외래나 응급실에서 혹은 입원 후 72시간 이내에 균주가 분리되고 MRSA 획득과 관련된 위험인자가 없는 경우 CA-MRSA로 정의하였으며, 분리된 균주의 임상적 의미에 따라 원인병원체(pathogen), 집락화(colonizer), 미결정(undetermined)으로 분류하였다. Penicillin과 oxacillin을 제외하고 3개 이상의 다른 계열 항균제에 내성이면 다제내성으로 정의하였다. 결과 : 연구기간동안 총 3,251주의 황색포도알균이 분리되었으며, 이 중 MRSA는 1,900주(58.4%)였다. MRSA 가운데 CA-MRSA는 114주(6.0%) 였으며, 이들이 분리된 부위는 귀(62주), 비뇨기계(14주), 피부 및 연부조직(11주), 호흡기계(10주), 혈액(3주) 등이었다. CA-MRSA 균주 가운데 집락균은 22주, 원인병원체는 22주였으며, 나머지 균주에 대해서는 그 임상적 의미를 결정할 수 없었다. 항균제 감수성 검사를 시행한 73균주 중 47주(64.4%)는 다제내성이었다. CA-MRSA 감염증 22예 중 피부 및 연부조직 감염(9예)과 중이염/외이도염(9예)이 가장 흔하였다. 침습적 감염증(invasive infection)은 4명(원발성 균혈증 3예, 감염성 관절염 1예)에서 확인되었지만, CA-MRSA 감염증으로 사망한 환자는 없었다. 결론 : 병원내 감염증에서는 MRSA가 심각한 문제이지만, 아직까지 지역사회 감염증에서 CA-MRSA는 흔하지 않았다. Background : Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. In Korea, little is known about the epidemiology and clinical features of community-associated MRSA (CA-MRSA). Material and Methods : Clinical microbiology laboratory databases of 7 hospitals were reviewed to identify the patients from whom MRSA was isolated during the period of January to July 2005. Only one isolate per patient was enrolled. In order to identify the risk factors of MRSA acquisition, the medical records and the Health Insurance Review Agency databases were reviewed. CA-MRSA was defined as MRSA isolated from patient without established risk factors. We analyzed patient demographics, underlying medical conditions, characteristics of infection, and antimicrobial susceptibility profiles. Results : Of total 3,251 S. aureus isolates, 1900 (58.4%) were MRSAs. Of the MRSA isolates, 114 (6.0%) were CA-MRSA. Of 114 CA-MRSA isolates, 22 (19.3%) were colonizers, 22 (19.3%) were pathogens, and the clinical significance of remaining 70 (61.4%) could not be determined. Median age of the 22 patients with CA-MRSA disease was 47 years. Nine patients had skin and soft tissue infections, 9 ear infections, 3 bacteremia, 1 septic arthritis. Seven patients had underlying medical disease. None died of the CA-MRSA infections. Of the 73 isolates of CA-MRSA, 47 (64.4%) were resistant to more than 3 classes of antibiotics besides β-lactams. Conclusion : Although MRSA is highly prevalent among hospital-associated S. aureus infection, CA-MRSA infections are not common.

영월지역어의 연구와 특징

金東彦 강남대학교 1998 (강남대학교)논문집 Vol.32 No.1

화상처리에 의한 춉트 스트랜드 섬유배향의 분포측정

김혁,윤성운,한길영,심재기,이동기 조선대학교 생산기술연구소 1995 生産技術硏究 Vol.17 No.2

In order to examine the accuracy of intensity method, the fiber orientation distribution of chopped strand reinforced polymeric composites is measured using image processing. Theoretical and experimental results of fiber orientation function are compared with each other for the composites having different fiber content and fiber orientations. An intensity method is used for the experimental investigation and the measured fiber orientation function is compared to the calculated one. The results show that, firstly, the feature of fiber orientation can be represented and identified by the fiber orientation function J measured and theoretical fiber orientation functions, J_(M) and J, respectively and related as J_(M)=0.73J. Secondly, as far as the measuring of fiber orientation is concerned, the intensity method is, in general, found to be quite effective due to its feature of using the intensity difference in the measuring ranges. Finally, the accuracy of the method increases when the fiber with less clash is considered.

효소형 분석에 의한 국내 등줄쥐(Apodemus agrarius coreae)와 흰넓적다리붉은쥐(Apodemus peninsulae peninsulae)의 특성 조사

김희선,강문일,변정옥,한동운 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.4

경기, 강원, 충청, 경상 그리고 전라지역 에서 225마리의 들쥐를 포획하였더니 Apodemus agrarius coreae가 200마리로 전국적인 분포를 보였고, Apodemus peninsulae peninsulae는 25마리로 강원, 경상 및 전라지역에서만 포획되었다. 전기영동법을 이용하여 이들 두 종에 대한 간장 조직에서 조사하였던 G6PDH, ADA, PEP-A, PEP-B, AAT, SOD, LDH, MDH, PNP, GAPDH 등 10종 모두가 검출되었다. 등줄쥐에서는 전기영동분석 결과 32종의 표현형이, 흰넓적다리붉은쥐에서 8가지가 검출되었다. 두 종의 locus의 평균 유전학적인 다양성은 0.130으로 나타났고, 유전학적인 차이는 0.100~0.600으로 상대적인 차이를 보였으며, 등줄쥐는 0.150~0.398사이에 네 개의 집단으로 구분되었던 반면 흰넓적다리붉은쥐는 0.100~0.275의 차이로 확인되었다. 경기지역의 안성, 여주 그리고 전라지역의 완주에서 포획된 등줄쥐를 제외하고는 지역에 따라서 6~11개의 조직내 효소 표현형이 중복되어 있었다. 흰넓적다리붉은쥐 역시 한 가지 이상의 표현형이 있었고 이들은 지역적인 차이를 보였으며, 등줄쥐와 조직내 효소형과 중복되어 있었다. Two hundred of Apodemus agarius coreae and twenty five of Apodemus peninsulae peninsulae were caught from Kyonggi, Kangwon, Chungchong, Jeolla and Kyongssang provinces across the country. Isoenzyme patterns were analyzed by gel electrophoresis with liver homogenates of A. a. coreae and A. p. peninsulae. Using 10 enzyme systems, 32 electrophoretic types (ETs) were identified from two species of Apodemus including 8 ETs from A. p. peninsulae with genetic diversity per locus between 0.00 and 0.54 (mean 0.13). Genetic distances among ETs of A. a. coreae and A. p. peninsulae was between 0.100 and 0.600. Thirty two ETs of both species of Apodemus were classified to four major groups with genetic distance from 0.150 to 0.398. Eight ETs of A. p. peninsulae were grouped into four subgroups with genetic distance from 0.100 to 0.275. All ETs of A. p. peninsulae were belong to those of A. a. coreae with enzymatic variation. There was only one ET in A. a. coreae from Ansong an Yoju counties in Kyonggi and Wanju county in Jeolla province. However, all samples collected from the rest were identified to have 6 to 11 ETs on local enzymatic variance. Enzymatic overlap between both species was confirmed with at least one ET depending on the sites of collection.

적외선 열화상 카메라를 이용한 머시닝 센터 주축 열변위에 관한 열해석

김재열,윤성운,임노빈,유신,마상동,양동조,송인석 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

Diagnosis or measurements using Infrared thermo-image hasn't been available. A quick diagnosis and thermal analysis can be possible when that kind of system is introduced to the investigation of each part. In this study, Infrared Camera, Thermo-vision 900 was used in order to investigate. Infrared Camera usually detects only Infrared wave from the light in order to illustrate the temperature distribution. Infrared diagnosis system can be applied to various field. Also, it is more effective to analyze temperature distribution on the machining center main-axis process.

최근 10년간 발생한 신손상 분석

최동은, 김원태, 김용준, 윤석중, 이상철, 김원재 충북대학교 의과대학 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.1

연구목적: 신손상은 보통 복부외상 환자의 10% 정도에서 발생하며 비뇨기계에서 발생하는 손상 중 가장 높은 빈도를 차지하고 있다. 신손상 치료의 궁극적인 목표가 환자의 생명을 구하는 것이고, 가능 하면 신조직을 최대한 보존하면서도 합병증은 최소화하여야 하므로 정확하게 평가된 진단을 내려, 혈류 역학적으로 안정된 경우 보존적 요법을 시행하는 빈도는 증가하고 있다. 본 연구에서는 10년간의 신손 상을 분석하여 손상의 원인, 정도, 치료 방법 등을 알아보고자 하였다. 대상및방법: 2000년 2월부터 2010년 6월까지 본원 응급실에 방문하여 신손상으로 진단된 59명의 환 자들을 후향적으로 분석하였다. 결과: 환자의 성별은 남자가 39례 (66.1%)였고, 여자가 20례 (33.9%)였다. 신손상의 원인은 교통 사고가 37례 (62.7%)였고, 낙상이 7례 (11.9%), 외상이 12례 (20.3%), 자상이 1례 (1.7%), 원 인미상이 2례 (3.4% )였다. 손상의 정도는 I 등급이 11례 (18.6%), II 등급이 10례 (16.9%), III 등급이 20례 (33.9%), IV 등급이 10례 (16.9%), V 등급이 8례 (13.6%)였다. 신손상 환자의 치료 는 대증치료가 46례 (77.9%)였고, 신절제술이 5례 (8.5%), 신혈관색전술이 5례 (8,5%), 그외 다른 치료들이 3례 (5.1%)였다. 결론: 신손상의 원인은 교통사고와 외상 등이 가장 많은 비중을 차지했으며, 3 등급의 손상이 가장 많 았고, 치료는 대증요법이 주를 이루었지만, 점차 신혈관색전술이 늘어나고 있다. 앞으로 지역단위로의 추가적인 연구가 필요할 것으로 생각된다.

반복작업에 의해 발생한 척골관 증후군 1례

김정원,박인선,이영준,김유창,김필자,강동묵,이채언 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : To report cubital tunnel syndrome due to repetitive motions. Methods : A worker complaining muscle weakness and atrophy of the right hand intrinsic muscles admitted to a hospital. We evaluated him with blood tests, neurophysio-logic studies (NCV & EMG), plain X-ray and US at the both elbows. We investigated his occupational history, and videotaped his work motions based on the work cycle at his previous work site. Finally, an ergonomics expert analyzed the motions using rapid upper limb assessment (RULA). Results : NCV & EMG studies reveals slow conduction velocity on both ulnar nerve across the elbow, more severely in the right side. US shows us compatible finding with diffuse neuritis of both ulnar nerves at both elbows. RULA score is 7. Conclusion : We confirmed that the worker's symptoms were related to his previous jobs demanding repetitive motions using the elbow joints. It is necessary that we should prepare appropriate measures to evaluate, prevent, rehabilitate, and help injured workers to return to work.

중합효소연쇄반응 기법을 이용한 돼지 증식성 장염 진단 기법의 확립

김대영,권언혜,송민동,양시용 建國大學校 自然科學硏究所 2002 建國自然科學硏究誌 Vol.13 No.1

This study was carried out to establish a efficient diagnosis method of pocine proliferative enteropathy (PPE) contributing major economic loss by inducing weight loss, poor growth and/or sudden death through out the growth period(6~22 wk). Therefore, in this study we established the PCR (polymerase chain reaction) which was a fast, specific and sensitive method for identification of Lawsonia intracellularis (L. intracellularis). We designed and synthesized primer on the 16S rDNA and p78 gene encoding L. intracellularis. Specificity of the method was confirmed by comparison of the PCR results using other enteric bacteria and the study has shown that PCR method was sensitive to detect lng of genomic DNA as a template. Also, the PCR method was applicable to the naturally affected pigs with PPE. Based on the results from this study, the PCR method could be used as a fast and specific dignistic tool for PPE.