한국에서의 발작성야간혈색소뇨증에 대한 임상적 고찰

최희정,이순남 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.3

배 경 : 발작성야간혈색소뇨증은 적혈구가 보체계에 민감해져 혈관내 용혈을 일으키는 드문 후천성용혈성빈혈로, 평균 수명은 약 10년정도이나 더 장기간 생존한예들을 경험하여 이를 포함한 종합적인 임상고찰을위하여 본 연구를 하였다. 방 법 : 1979년 12월부터 1994년 12월까지 이화여자대학교의과대학 부속병원 내과에서 경험한 6례와 국내문헌에 보고된 29례를 포함한 35례를 대상으로 임상적특징 및 치료, 경과 등에 대해서 고찰하였다. 결 과 : 1) 연령분포는 16∼61세로 평균 30세였고, 남자 21례, 여자 14례로 남녀비는 1.5 : 1이었다. 임상증상발현후 확진까지의 기간은 3일에서 40년까지 매우다양하였고 진단까지 5년이상 소요된 경우가 22.9%였다. 임상증상은 기록이 있던 14례중 13례에서 빈혈증상, 수면후 갈색뇨 10례, 황달 5례, 복통 3례, 출혈4례가 있었다. PNH로 확진되기전까지의 타진단명은재생불량성빈혈이 14례, 용혈성빈혈 5례, 간질환 4례,철결핍성빈혈 3례, 특발성혈소판감소성자반증 1례,재생불량성빈혈이 경과중 PNH로 전환된 경유가 2례있었다. 2) 진단당시의 혈색소치는 전례에서 12g/dL미만을보였고 평균 7.3g/dL이었다. 백혈구감소는 5례, 정상8례, 증가는 1례였고, 평균 4,100/mm^3, 평균 혈소판수는 106,OO0/mm^3로 감소를 보였다. 망상구수는 평균4.3%로 증가를 보였고 골수소견상 세포증가 3례,감소 2례, 정상 4례였고 전례에서 적아구계 증식을보였다. Ham's test는 14례중 13례에서 양성이었고,sucrose hemolysis test는 시행한 10례 모두에서 양성이었다. 혈청 haptoglobin은 3례중 2례에서 감소를보였다. 3) 35례중 수혈은 26례에서 시행되었고 그중 세척적혈구가 13례에서 투여되었고 철분은 14례, 엽산10례, dextran 5례, busulfan 1례, 부신피질 호르몬제26례, 남성호르몬제 15례와 항응고제가 3례에서 투 여 되 었다. 4) 합병증은 7례에서 발생하였고 감염 3례, 뇌혈관경색 2례, 급성 신부전증 2례였다.5) 33례중 생존 19례,사망 4례,추적 안된 경우가10례였고 추적기간은 0.3~ 115개월이고 가장 장기간생존한 례는 41년 10개월이었다. 결 론 : PNH환자들의 임상 특징 및 장기 생존자들의 특성상, 검사소견에 PNH특성이 남아 있더라도 보존적치료와 합병증의 예방 및 치료에 힘쓰면 비교적 오래생존할 수 있어 계속적인 추적관찰과 치료가 필요하며이에 대한 연구가 필요하다. Background : Paroxysmal nocturnal homoglobinuria is an uncommon acquired hemolyticanemia and characterized by increased sensitivity of erythrocytes to the lytic action of comptement system, developing intravascular hemolysis. PNH is complicated by anemia, infectionand thrombosis. The more prolonged survival comparable to literature was noted and so, weperformed this study. Method : The previously reported twenty nine cases and six cases were collected at EwhaWontons University Hospital from Dec.1979 to Dec.1994 and were analyzed for clinical characteristics and progress. Result : 1) The age distribution was ranged from 16 to 61 years with mean of 30 years andmale to female ratio was 1.5 : 1. The duration from the onset of symptoms to diagnosis wasranged from 3 days to 40 years and above 5 years was 22.9%. The subjective symptoms attributable to anemia were in 13 cases, to dark urine after sleep in 10 cases, to jaundice in 5 cases,to abdominal pain in 3 cases, to hemorrhage in 4 cases. The various diagnoses made beforePNH were aplastic anemia in 14 cases, hernolytic anemia in 5 cases, liver disease in 4 cases,iron deficiency anemia in 3 cases, idiopathic thrombocytopenic purpura in 1 cases, reversedcases from aplastic anemia to PNH in 2 cases. 2) Laboratory data showed ; (1) anemia(Hg below 12g/dL) in 35 cases with mean of 7.3g/dL. (2) leukocytopenia(below 4,000/mm^3) in 5 cases, leukocytosis in 1 case with mean 4,100/mm^3except patient with chronic myelocytic leukemia. (3) thrombocytopenia(below 150,000/mm^3) in 10 cases with mean 106,000/mm^3. (4) reticulocytosis(over 2.0% ) in 20 cases with mean 4.3%. (5) Bone marrow examination revealed hypocellular in 2 cages, normocellular in 4 cases,hypercellular in 3 cases and erythroid hyperplasia in all cases. (6) positive Ham's test in 13 cases among 14 cases. (7) positive sucrose hemolysis test in 10 cases anions 10 cases. (8) decreased serum haptoglobin in 2 cases among 3 cases. 3) The treatment was consisted of blood transfusion in 26 cases among 35 cases, especiallywashed RBC in 13 cases, iron in 14 cases, folic acid in 10 cases, dextran in 5 cases, busulfanin 1 case, corticosteroid in 26 cases, androgen in 15 cases and anticoagulant in 3 cases. 4) The observed complications were infection in 3 cases, cerebral infarct in 2 cases andacute renal failure in 2 cases. 5) The nineteen patients were still alive, four patients dead, ten patients were lost duringfollow-up period. The duration of most prolonged survival case was 41 years 10 months. Theywere fo11owed from 0.3 to 115 months. Conclusion : In analyzing the characteristics of PNH patients and prolonged survivals, thedata reported suggest, although the laboratory abnormalities persisted in the prolonged survival,the prognosis will be good if conservative tretment and prevention of complication is tried.

리빙리디칼중합법을 통한 다중벽 탄소나노튜브용 표면개질제의 합성 및 이를 이용한 염료감응태양전지 대전극 제조

최희정,홍성철 한국고분자학회 2008 한국고분자학회 학술대회 연구논문 초록집 Vol.33 No.1

농업부산물인 옥수수속대(Corncob)를 이용한 수용액의 Cd(II) 제거

최희정 한국수처리학회 2017 한국수처리학회지 Vol.25 No.6

The aim of this study was to investigate the Cd(II) removal using agricultural byproduct corncob adsorbent in the aqueous solution. Effect of various process parameters, viz., initial Cd(II) concentration, pH and adsorbent dose has been studied for the removal of Cd(II). Batch experiments were carried out at various pH (2-7), adsorbent dose (2.5-20 g), Cd(II) concentration (5-500 mg/L) for a contact time of 60 min. The FT-IR (Fourier transform infrared spectroscopy) spectra of the corncob indicated that the carbonyl and carboxylic groups were major binding sites with Cd(II) ions. Corncob removed successfully 99% of the Cd(II) ions in the aqueous solution at pH 6. The adsorption process was fast and isotherm data better fit to the Langmuir isotherm than the Freundlich isotherm models. In addition, thermodynamic parameters (△G, △H, and △S)were also calculated from data obtained from experiments performed to study the effect of temperatures. The negative values of change in Gibbs free nergy indicate the feasibility and spontaneous nature of the adsorptive treatment. Taking all the above results into consideration, corncob is an inexpensive and excellent adsorbent.

간호대학생의 인간관계와 커뮤니케이션 교육의 효과

최희정 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.1

본 연구의 목적은 간호대학생의 인간관계와 커뮤니케이션 교육의 효과를 파악하기 위하여 수행되었다. 대상자는 G 시에 소재한 U 대학교 간호학과 1학년 재학생, 82명이었다. 자료수집은 2019년 9월 3일부터 12월 6일까지였고, SPSS / WIN 21.0 프로그램을 사용하여 기술통계, Shapiro–Wilk, Paired t-test를 하였다. 대상자의 인간관계와 커뮤니케이션 교육 전·후의 의사소통능력(t=-2.87, p=.005), 의사소통역량 자가진단(t=-3.80, p=<.001)은 통계적으로 유의한 차이가 있었으나, 대인 간 의사소통(t=-0.09, p=.931)과 대인관계(t=-0.83, p=.409)는 통계적으로 유의한 차이가 없었다. 의사소통능력과 기술은 간호대학생뿐만 아니라 실무 간호사에게도 중요한 간호영역이므로 지속적인 의사소통 교육이 필요하다. 따라서 간호대학생의 의사소통능력 향상을 위한 단계적 프로그램을 개발하여 저학년부터 고학년까지 연계되어 지속적이고 반복적인 교육을 적용하고 그 효과를 검증하는 후속연구가 필요하다.

1920년대 출판경영인 강하형의 『자조론』 아류 서적 번역과 출판『위인성공의 경로』, 『(20세기) 청년독본: 일명 수양편』을 중심으로

최희정 한국근현대사학회 2022 한국 근현대사 연구 Vol.101 No.-

This study examines the process of reproducing the value of ‘Self-help’ and its meaning through the Self-help book published in the form of the biography of great men and youth training book at Taehwa Seogwan in the early 1920s. The three results of this study are summarized as follows. First, The biography of great men published by Taehwa Seogwan is a translation of The biography of world great men published in Japan in 1914. The biography of world great men, published in Japan, consists of the story of a person who achieved professional success through the spirit of self-help. Second, in Japan, it was composed of an exhibition of world greats composed of Japanese and Westerners. However, in the process of being translated by Taehwa Seogwan, this book of great men in the world was published as a book of great men of the West, composed only of Westerners. Third, The influence of Orison Sweat Madden’s successism, which was popular in Japan after the 1900’s, was reflected in the biography of great men and the youth training book published at Taehwa Seogwan in the early 1920s. 이 연구는 1920년대 초 태화서관에서 출판한 『위인성공의 경로』,『(20세기) 청년독본: 일명 수양편』과 같은 위인전과 수양서 형태로 출간된 서적이 ‘자조론’의 가치를 파급시킨 『자조론』아류 서적이라는 사실을 밝히고, 이 같은자조론』 아류 서적이 일본에서 한국으로 유통되는 과정 및 그 의미를 살펴본것이다. 『위인성공의 경로』와『(20세기) 청년독본: 일명 수양편 은 출판경영인강하형이 기획한 1920년대 태화서관의 새로운 상업적 출판물로서 검토하였다. 분석 결과는 다음과 같다. 첫째『위인성공의 경로』는 1914년 일본에서 출간된『정신수양분투가입지훈』을 번역한 것이며, 이것은 ‘자조론’의 정신을 통해 직업적 성공을 이룬 인물의 이야기로 구성되었다. 둘째 『정신수양분투가입지훈』은 일본인과 서구인으로 구성된 세계위인전이자 수양서인데, 이를 번역한 『위인성공의 경로는 서구인으로만 구성된 서구위인전으로 출간되었다. 셋째 『위인성공의 경로』의 치부성공한 위인 이야기 및『(20세기) 청년독본: 일명 수양편』에서 말하는 수양 덕목은 1900년대 이후 일본에서 오리슨 스웨트 마든이 주장하던 직업적 성공과 결부된 가치로 ‘자조론’이 유통되고 있던 상황이 반영된 것이었다. 요컨대 이 연구는 상업적 이익을 목적으로 한 출판경영인이 기획‧출판한『자조론』 아류 서적에 대한 사례 연구로서 의미가 있다. 특히 이 같은 작업을통해 1920년대『자조론』 아류 서적에 대한 ‘청년’의 구독 수요를 우회적으로밝혔다는 점에서도 의미가 있다.

Sex Differentiation and Early Gonadogenesis in Sebastes inermis Cuvier

최희정,오승용,명정구,김종만,허준욱,박민욱,박인석 한국해양과학기술원 2008 Ocean and Polar Research Vol.30 No.4

Early gonadal development and sexual differentiation of dark-banded rockfish (Sebastes inermis Cuvier) were followed from parturition to 400 days post parturition (dpp). During this period, average total length (TL) increased from 0.57 to 13.18 cm. Primordial germ cells (PGCs) were first detected at 0.68 cm TL (10 dpp). When fish reached 1.52 cm TL (50 dpp), initial stages of ovarian differentiation were identified by the presence of PGCs containing condensed chromatin and their transformation into meiotic oocytes. At 10.23 cm TL (300 dpp), the ovaries gradually developed into oocytes in the primary yolk stages. Ovary growth was rapid after sex differentiation, but testis tissue continued to multiply without growing until fish reached 6.97 cm TL (200 dpp), after which the production of spermatocytes, spermatogonia, and cyst cells was apparent. Histological analysis of gonadal structure suggested a gonochoristic sexual development pathway. Our analysis of the sex ratio at 400 dpp showed a significantly higher proportion of males. Early gonadal development and sexual differentiation of dark-banded rockfish (Sebastes inermis Cuvier) were followed from parturition to 400 days post parturition (dpp). During this period, average total length (TL) increased from 0.57 to 13.18 cm. Primordial germ cells (PGCs) were first detected at 0.68 cm TL (10 dpp). When fish reached 1.52 cm TL (50 dpp), initial stages of ovarian differentiation were identified by the presence of PGCs containing condensed chromatin and their transformation into meiotic oocytes. At 10.23 cm TL (300 dpp), the ovaries gradually developed into oocytes in the primary yolk stages. Ovary growth was rapid after sex differentiation, but testis tissue continued to multiply without growing until fish reached 6.97 cm TL (200 dpp), after which the production of spermatocytes, spermatogonia, and cyst cells was apparent. Histological analysis of gonadal structure suggested a gonochoristic sexual development pathway. Our analysis of the sex ratio at 400 dpp showed a significantly higher proportion of males.

Preparation of surface modifiers for multi-walled carbon nanotubes through nitroxide mediated polymerization technique and their application in counter electrodes for dye-sensitized solar cells

최희정,이기원,김경곤,박남규,홍성철 한국고분자학회 2008 한국고분자학회 학술대회 연구논문 초록집 Vol.33 No.2

연안 레질리언스 강화를 위한 미국의 노력

최희정 한국해양수산개발원 2009 해양국토21 Vol.2 No.-

Relationship between the Clinical Characteristics and Intervention Scores of Infants with Apparent Life-threatening Events

최희정,김여향 대한의학회 2015 Journal of Korean medical science Vol.30 No.6

We investigated the clinical presentations, diagnostic and therapeutic modalities, and prognosis from follow-up of infants with apparent life-threatening events (ALTE). In addition, the relationship between the clinical characteristics of patients and significant intervention scores was analyzed. We enrolled patients younger than 12 months who were diagnosed with ALTE from January 2005 to December 2012. There were 29 ALTE infants with a peak incidence of age younger than 1 month (48.3%). The most common symptoms for ALTE diagnosis were apnea (69.0%) and color change (58.6%). Eleven patients appeared normal upon arrival at hospital but 2 patients required cardiopulmonary resuscitation during the initial ALTE. The most common ALTE cause was respiratory disease, including respiratory infection and upper airway anomalies (44.8%). There were 20 cases of repeat ALTE and 2 cases of death during hospitalization. Four patients (15.4%) experienced recurrence of ALTE after discharge and 4 patients (15.4%) showed developmental abnormalities during the follow-up period. The patients with ALTE during sleep had lower significant intervention scores (P = 0.015) compared to patients with ALTE during wakefulness and patients with previous respiratory symptoms had higher significant intervention scores (P = 0.013) than those without previous respiratory symptoms. Although not statistically significant, there was a weak positive correlation between the patient’s total ALTE criteria and total significant intervention score (Fig. 2, r = 0.330, P = 0.080). We recommend that all ALTE infants undergo inpatient observation and evaluations with at least 24 hr of cardiorespiratory monitoring, and should follow up at least within a month after discharge.

[자식이 쓰는 부모님 자서전] 옆집 외할머니

최희정 샘터사 2010 월간 샘터 Vol.488 No.-