정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

담도폐쇄증 환아의 치과치료 : 증례보고

김재곤,양연미,백병주,이승익 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

Intra-& extra-hepatic duct system의 경화를 야기하는 Biliary atresia는 출생시 1:10,000의 발생빈도를 보이며, 5년 이하의 생존율을 나타내는 예후가 좋지 않은 질환이다. 담도폐쇄증의 원인은 아직 명확하지 않으나, 유전적인 요소나 발육성 원인으로 믿고 있다. 임상적 특징으로 두드러진 황달, 간비증대, 가려움증, 지방변, 황색종, 성장지연, 문맥압항진증, 출혈, 골연하증, 복수 그리고 호흡기계 감염 등을 나타낸다. 구강내 소견으로 녹색을 띄는 변색치아, 유치의 확장된 치수강과 치근관, 치아맹출지연, 법랑질 형성부전, 그리고 심한 치아 우식 등이다. 담도폐쇄증은 조기진단과 수술에 의해 사망률이 감소되고, 성장과 발달이 정상으로 돌아오며 생존율도 향상되었으나 여전히 그 원인과 치료에 대한 연구가 계속되어야 할 것이다. 이에 저자는 전북대학교 치과병원에 내원한 2명의 담도폐쇄증환아에 대해 임상, 방사선학적 특징 및 적합한 처치에 대하여 보고하고자 한다. Congenital biliary atresia with pregressive sclerosis of the intra-and extra-hepatic duct system occurs in 1:10,000 live births, and has a poor prognosis with an expected survival of less than 5 years. Etiology of biliary atresia is unclear, however, it is believed a genetic or developmental cause. The clinical characteristics include pronounced jaundice, hepatosplenomegaly, pruritus, steatorrhea, xanthomas, growth retardation, portal hypetension, bleedings, ascites and respiratory infections. Oral manifestations have seldom been reported in patients with biliary atresia, but there may be enamel hypoplasia, delayed tooth eruption, and green teeth. Early diagnosis and surgical intervention have decreased morbidity, returned growth and development to normal and improved the prognosis for survival. Authors report the clinical and radiologic characteristics, proper managements about two cases with biliary atresia.

우리나라 무도의 현황과 과제에 관한 연구

이병익,김병천 대한무도학회 2000 대한무도학회지 Vol.2 No.1

The purpose of this study is to investigate the situation of the Korean martial arts based on their contemporary concepts and patterns and propose the tasks to be accomplished by dividing them into martial arts for elite and martial arts for all and analyzing them. The problems for Korean martial are as follows: First, Korean organizations of martial arts have not overcome the distorted history and the absence of concrete ideas. Korean martial arts were introduced from Japan during its control over Korea, and partially from China. However no organizations accept this historical background. The 'Koeanization' with denial of true history has produced the absurd reasoning on the history of martial arts. Most discussions on them have been dominated by narrow and blind obsession on tradition and scientification, resulting in commercialization. Second, unbalanced support and academic unreadiness are pointed out. Putting a priority on Martial arts as sports has resulted in emphasizing their athletic aspects lusing their original meaning. The government's unbalanced supports have prevented martial arts as sports for all from being developed. The government's policy only including such sports as judo, kendo, taekwondo, ssireum, and ushu for the licence of sports leaders is against the rule of fairness by neglecting the supervision at the national level. Third, inappropriate research methods on martial arts should be considered. Most researches on martial arts are composed of personal views and prejudice with few literature, which results in the lack of validity and reliability. The athletic-oriented curricula of undergraduate schools and the tradition -oriented research trends fail to present long-term perspectives and research methods, limiting the current status of martial arts on the past history and invalid research method. Recommendations for further study based on these problems are as follows. First, the concrete ideas and concepts on martial arts should be provided. Academic foundation with understanding the historic changes of oriental culture and the meaning of martial arts must be established. Second, integrated policy for promoting martial arts is indispensable. Establishment of centralized organizations administering their affiliates is strongly suggested. It will facilitate the popularization of martial arts, the integration of similar kinds of martial arts, and the systematization of knowledge. Third, policy for supporting the academization of martial arts are urgently needed. To realize this, support for seminars and academic associations should be done free from political considerations.

企業의 C.I.P 導入背景에 관한 硏究 : 뉴골든어패럴 C.I.P 導入을 中心으로

이재익,김병옥 부천대학 1992 論文集 Vol.13 No.-

This study was carried out to estimate the introduction background of C.I.P in Korea. Specially, this paper deals with the introduction background of C.I.P based on Newgolden Apparel C.I. design system. The basic elements of a C.I.P structure are V.I, M.I & B.I(V.I:Visual Identity, M.I: Mind Identity, B.I:Behaviour Identity). Therefore in this study, a introduction background of V.I, M.I & B.I element for Newgolden Apparel C.I.P was investigated. This study will be a basis for the planning & design criteria of Newgolden Apparel C.I.P in order to identify corporate image in Korea. In this paper, the study items chosen were "Corporate Symbol", "Corporate Logo", "Corporate Color", "Promotion Character", "Corporate Signature" which are the basic design system of Newgolden Apparel C.I.P.

한국 경륜 사업의 실태와 발전 방안

이병익, 김종필 용인대학교 체육과학연구소 2000 體育科學硏究論叢 Vol.10 No.1

Korea in the future as one of sound leisure industry. The first, the policy of pro-cycling business shall be established by relieving the advantages of Pro-cycling in comparison with horse racing, motorboat racing and casino, because the pro-cycling is for public good, controls gambling spirit and is familiar with the citizens. The second, actual study on the demand and supply plan of velodrome shall be required to develop pro-cycling equally in all of districts. In addition, shall seek a Plan to increase off-track betting place due to the limit of velodrome. The third, the organization and manpower of pro-cycling business headquarters are insufficient, the capacity to create reinvestment funds is lack, and the facilities of velodrome are not suitable, which these situations disturb the fair operation and smooth distribution of pro-cycling business, thus the former Problems shall be improved constantly. The fourth, pro-cycling training institute shall be founded in order to solve the short of player and judge caused by the constant supply of velodrome, and to train excellent players through hlgh-quality training. The fifth, businessmen related with pro-cycling shall create 〈Players' Association〉 and 〈Mutual Aid Union〉 to offer retirement pension, handicapped Person pension, living expenses and medical fee for injury received during racing or training in the welfare aspect so that Pro-cycling players can believe firmly in the living of player.

매복 견치 및 저위교합 제 1대구치의 자가 이식에 의한 치험례

이승익,김재곤,권선자,백병주 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

In orthodontic treatment of certain cases of tooth loss, aplasia, or ectopia, autotransplantation is sometimes valid treatment alternative often provides and improved result, compared to conventional orthodontic treatment, an apprporiate donor tooth is available and the anatomic circumstances permit it. Clinically, successful transplants must show a radiolucent space between the roots and surroundings bone. There must be no evidence of ankylosis, no permanent root resorption, and no inflammation. Histologically, the criterion of success is a normal and functional periodontal ligament between the root surfaces of transplants and the bone, or gingival connective tissues. The successful autotransplantation of a impacted maxillary canine and infraoccluded mandibular 1st molar is reported. In case Ⅰ, impacted canine with incompletely developed root apex was maintained pulp vitality due to appropriate root development and short extraoral time, atraumatic surgical procedure. In case Ⅱ, infraoccluded molar was started endodontic treatment after 3 weeks. Because of closed apex, possibility of revasculization is rare. Both case Ⅰ, Ⅱ did not ankylosis and the periodontal and periapical tissues appears to be normal after 3 months. In autotransplantation cases it is important to transplant the tooth as quickly and as atraumatically as possible to dimish the chance of ankylosis and root resorption. In all cases of transplantation, patient selection minimal operating time, and good oral hygine will increase the chance for a successful prognosis.

고등학교 교사의 여가활동 참여에 따른 직무태도의 관계

이병익,김진표,김종필,노동연 龍仁大學校 體育科學硏究所 2001 體育科學硏究論叢 Vol.11 No.1

The purpose of this research is to analyze the relations between on high-school teacher's participation in leisure activities and job attitude, and its conclusion is like as follows. First, high-school teachers' job satisfaction difference based on environment variables showed statistically no significant difference on the level of 5% in terms of sex and age. And as for devotion to the organization, it showed statistically significant difference on the level of 5% in terms of age, but no significant difference in terms of sex. Secondly, with the regard to high-school teachers' types of leisure activities, it showed statistically no important difference on the level of 5% in terms of both job satisfaction and devotion to the organization. Thirdly, for high-school teachers' job satisfaction depending on their participation time for leisure activities, it saw statistically significant difference on the level of 5%, and as for devotion to the organization, it saw no significant difference. Fourthly, for high-school teachers' job satisfaction depending on the frequency of leisure activities, it showed statistically significant difference on the level of 5%, but as for devotion to the organization, it showed no significant difference. Fifthly, the correlation(γ) among the variables ranged from -.128 to .542. And with 1.7% of explainable, βof job satisfaction is like these: participation time for leisure activities(.108); types of leisure activities(.057); and frequency of leisure activities(.055). As for βof devotion to the organization, with 2.2% of explainable, is like these: participation time for leisure activities(.118); frequency of leisure activities(.091); and types of leisure activities(-.062).

Thermal cycling 과 시효처리가 Glass-Ionomer수복재의 인장강도에 미치는 영향

이승익,백병주,김재곤,이승영,김문현 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

본 연구에서는 구강환경과 유사한 액상의 조건하에서의 온도변화가 광중합형 글래스아이오노머계 수복재의 인장강도에 미치는 영향을 평가하기 위해 대조군으로 2종의 재래형 glass ionomer를 선택하고 실험군으로 2종의 광중합형의 resin-modified glass ionomer와 2종의 polyacid-modified resin composite을 선택한 다음 수중에서의 thermal cycling과 시효처리를 행하였으며, 다음과 같은 결론을 얻었다. 1. 글래스아이오노머 수복재의 인장강도를 측정한 결과, polyacid-modified resin composite, resin-modified glass ionomer 그리고 재래형 glass ionomer의 순으로 나타났다. 2. 인장강도는 30일간의 시효처리로 증가되는 경향을 보였다. 3. 재래형 glass ionomer 수복재의 인장강도는 thermal cycling 처리로 증가되는 경향을 보였으며, 37℃의 증류수 중에 1시간 침적한 군과 10,000회의 thermal cycling을 비교한 결과 유의한 차이로서 강도의 증가를 나타냈다(P<0.01). 4. thermal cycling 군의 인장강도는 DR군이 45.4MPa로 최대치를, FL군이 13.4MPa로 최소치를 나타냈으며, 각 군간의 통계적 유의성을 검증한 결과 polyacid-modified resin composite의 인장강도가 나머지 군과 유의한 차이를 보였다(p<0.05). 5. 특성강도는 DR군이 48.6MPa로 가장 높은 강도치를 보였으나, Weibull 계수는 CG군이 8.9로 가장 높은 값을 보여 시험재료 중에서 가장 작은 강도의 분산을 나타냈다. This study was performed to evaluate the effect of aging and thermal cycling on the tensile strength of six commercially available glass-ionomer materials: two chemically set glass-ionomer materials(Fuji Ⅱ, fuji Ⅸ), two resin-modified glass-ionomer materials(Fuji Ⅱ LC, Vitremer), and two polyacid-modified composite resins(Compoglass, Dyract). Rectangular tension test specimens were fabricated in a teflon mold giving 5mm in gauge length and 2mm in thickness. All samples were divided into 3 groups. Group 1 was immersed in a 37℃ distilled water for 1 hour. Group 2 was immersed in a 37℃ distilled water for 30 days. Group 3 was subjected to 10,000 thermal cycles between 5℃ and 55℃, and the immersion time in each bath was 15 seconds per cycle. Tensile testing was carried out at a cross-head speed of 0.5mm/min and fracture surfaces were examined with scanning electron microscope. The results obtained were summarized as follows; 1. The polyacid-modified composite resins were stronger than the resin-modified glass-ionomer materials, which were much stronger than the conventional glass-ionomer materials. 2. Tensile strengths were slightly increased after aging treatments for 30days. 3. Tensile strengths of conventional glass ionomers were significantly increased after thermal cycling treatment(p<0.01). 4. The highest tensile strength value of 45.4MPa was observed in the Dyract group and the lowest value of 13.3MPa was observed in the Fuji Ⅱ LC group after the thermal cycling test, and the strengths of polyacid-modified composite groups were significantly higher than those of other groups. 5. The highest characteristic strength value of 48.6MPa was obtained in the Dyract group, however the highest Weibull modulus value of 8.9MPa was obtained in the Compoglass group after thermal cycling test.

鐵原地區 自然草地에 대한 群落構造 生産性 再生力 및 土壤肥料學的 硏究

尹益錫,張楠基,金炳泰 건국대학교 1969 學術誌 Vol.10 No.1

The investigation was made on the relationship among vegetation, net productivity, regrowth and soils of Moonheri-Wasoori, Soodowon-Sungilkyo and Mt. Kumhak grasslands in Chulwon area. The following conclusions have been made as the results of study. 1.The vascular flora of the grassland in Moonheri-Wasoori was composed of 102 species, the most of which were Medicago denticulata, Miscanthus sinensis, Arundinella hirta, Festuca ovina and Cassia nomame. 2.The flora of Soodowon-Sungilkyo grassland was composed of 74 species, the most of which were Arundinella hirta, Miscanthus sinensis, Carex nanella, Festuca ovina and Cassia nomame. 3.It of Mt. Kumhak grassland was composed of 78 species, the most of which were Arundinella hirta, Carex nanella, Festuca ovina, Miscanthus sinensis and Aster scaber. 4.These five species contributed greatly to the standing crop of live material which was in excess of 60% of it. 5.The peak standing crop of each 413.7, 307.6 and 348.7 g/m2 in Moonheri-Wasoori, Soodowon-Sungilkyo and Mt. Kumhak grasslands wers reached in August under flooded conditions as a result of the growth of dominant species, Medicago denticulata and Arundinella hirta. 6.The net prodution of organic matter was slight in some intervals but occurred throughout the growing season. 7.After cutting of grasses, the regrowth of new leaves mainly depended on growing stage and edaphic factor. 8.Characteristics of the natural grassland soils, especially, concerning water, total nitrogen, available phosphorus and exchangeable calcium were clarified and might be depend upon the quantity of plant production. 9.Nitrogen, phosphorus and calcium concentration of leaves of Medicago denticulata, Arundinella hirta and Miscanthus sinensis were higher than of stems. 10.Even if there were differences in the amounts of nutrients amend Medicago denticulata, Arundinella hirta and Miscanthus sinensis for single species and stands, they were covered by variations within spesies in the present survey.

에어로빅 지도자의 직무만족에 관한 연구

이병익,정훈,김진표,이동희 龍仁大學校 人文社會科學硏究所 2002 인문사회논총 Vol.- No.8

This Study attempts to figure out job satisfaction level of aerobic instructors by gender, age and education background. It was carried out on the hypothesis that "there may be difference in the degree of job satisfaction among aerobic instructors by gender, age and education." For this study, a total of 145 instructors (26 males and 119 females), working in Seoul as of 2001, were surveyed In the survey, "Job Diagnostic Survey" that Cho Young-chang translated and revised (1988) was utilized as a questionnaire. Afterwards, Frequency Analysis, t-Test and One-person Variable Analysis methods were adopted to analyze survey results. Based on the aforementioned study procedures and data analyses, the study concluded as follows: First, gender is not a determinant factor of job satisfaction as both gender groups, male and female instructors surveyed, showed high level of job satisfaction. There is not noticeable difference in overall and detailed job satisfaction between the two gender groups. However, in the question of self-achievement evaluation, female groups showed much higher marks. Secondly, age affects job satisfaction level. The instructors in their 30s are found to be more gratified with their job than those in their 20s. In particular, the two age groups demonstrated significant variance in the question of self-achievement evaluation. Thirdly, job contentment level of aerobic instructors varies by educational background. Instructors with highschool education displayed higher level of satisfaction than those with university and graduate school education. However, for question of work environment, compensation, and facilities, those with higher educational background are more content than those with highschool education.