지형공간 특성자료를 이용한 하천유역의 강우-유출해석

안승섭,이증석,도준현 한국환경과학회 2003 한국환경과학회지 Vol.12 No.9

The subject basin of the research was the basin of Yeongcheon Dam located in the upper reaches of the Kumho River. The parameters of the model were derived from the results of abstracting topological properties out of rainfall-runoff observation data about heavy rains and Digital Elevation Modeling(DEM) materials. This research aimed at suggesting the applicability of the CELLMOD Model. a distribution-type model, in interpreting runoff based on the topological properties of a river basin, by carrying out runoff interpretation for heavy rains using the model. To examine the applicability of the model, the calculated peaking characteristics in the hydrograph was analyzed in comparison with observed values and interpretation results by the Clark Model. According to the result of analysis using the CELLMOD Model proposed in the present research for interpreting the rainfall-runoff process, the model reduced the physical uncertainty in the rainfall-runoff process, and consequently, generated improved results in forecasting river runoff. Therefore it was concluded that the algorithm is appropriate for interpreting rainfall-runoff in river basins. However, to enhance accuracy in interpreting rainfall-runoff. it is necessary to supplement heavy rain patterns in subject basins and to subdivide a basin into minor basins for analysis. In addition, it is necessary to apply the model to basins that have sufficient observation data, and to identify the correlation between model parameters and the basin characteristics(channel characteristics).

중추성 요붕증이 동반된 랑게르한스 세포 조직구증 1예

김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.

말기신부전 환자의 혈색소 순환 : 투석 방식에 따른 양상 비교 및 관련 인자들에 대한 고찰

최재혁,김준섭,원기범,박준형,탁우택,이정호 동국대학교 의학연구소 2009 東國醫學 Vol.15 No.2

혈색소 순환은 말기신부전 환자에서 인체 재조합 적혈구 조혈 인자를 투여하여 빈혈을 치료하는 동안 빈번히 관찰되며 이는 환자의 입원과 사망률과 관계가 있다고 알려져 있다. 이에 저자는 투석중인 말기 신부전 환자를 대상으로 혈색소 순환 양상과 이와 연관된 인자들을 알아보고자 하였다. 혈색소 순환의 관련 인자들을 알아보기 위하여 투석 치료를 받고 있는 환자 40명 (혈액투석 환자군: 20형, 복막투석 환자군: 20명)을 대상으로 투석 시작부터 1년 동안의 환자의 나이와 성별, 투석시작 1년간의 평균 Hb, 수혈 횟수, 총입원 횟수, 감염으로 인한 입원 횟수, 혈청 ferritin 농도, 혈청 transferrin saturation (TSAT), 철분제제 복용 유무, 일주일 동안 투여된 rHuEPO 양, rHuEPO의 변화량, 알부민, C-reactive protein (CRP) 및 입원 원인 등을 후향적으로 조사하였다. 전체 환자 40명 중 33명 (82.5%)에서 혈색소 순환이 관찰되었다. 혈액투석 환자군에 비해 복막투석 환자군에서 혈색소 순환 첫수가 유의하게 높았다 (p=0.037).혈색소 순환 발생군과 혈색소 순환 미발생군의 관련인자들을 비교하였을 경우 혈색소 순환 발생군에서 총 입원 첫수 (p=0.01), 감염으로 인한 입원 횟수 (p=0.036)가 유의하게 많았으며, 혈중 알부민 수치는 유의하게 낮았다 (p=0.003).그러나 두 군간의 나이, 성별, 수혈 횟수, 혈청 ferritin농도, 혈청 transferrin saturation (TSAT) 및 혈청 철분 농도는 유의한 차이가 없었다. 혈색소 순환의 빈도는 일주일 동안 투여된 r-HuEPO변화량과 양의 상관관계를 보였고 (p=0.003),혈중 알부민 수치와 음의 상관관계를 보였다 (p=0.013). 복막투석 환자군에서 혈액투석 환자군에 비해 혈색소 순환이 유의하게 높게 발생하였다. 일주일 동안 투여된 r-HuEPO 변화량, 입원 및 혈청 알부민 수치는 투석 시작부터 1년 동안의 혈색소 순환과 관련이 있었다. Hemoglobin cycling is frequently observed during treatment of anemia with recombinant human erythropoietin (r-HuEPO) in patients with end stage renal disease (ESRD) it is also reported to be associated with hospitalization and morbidity. We analyzed hemoglobin cycling and potential associated factors in patients on dialysis. Forty new dialysis patients (20 hemodialysis, HD and 20 peritoneal dialysis, PD) were recruited during their first year. Age, gender, mean hemoglobin level, frequency of transfusion, frequency of hospital admission, frequency of admission due to infection, serum ferritin, transferrine saturation, iron levels, rHuEPO dose per week, serum albumin, and c-reactive protein were retrospectively evaluated in order to examine the possible correlations with hemoglobin cycling. Thirty-three patients (82.5%) were identified in the hemoglobin cycling group. The PD group had a higher frequency of hemoglobin cycling than did the HD group (p=0.037). The hemoglobin cycling group showed a significantly higher frequency of hospital admission (P=0.001), admission due to infection (p=0.036) and a lower serum albumin level (p=0.003) than the other group, but there was no significant difference between the groups for age, gender, frequency of transfusion, serum ferritin, transferrine saturation, and iron levels. The frequency of hemoglobin cycling showed a positive correlation with the i-HuEPO dose variation per week (p=0.003) and a negative correlation with serum albumin level (p=0.013). The PD group had a higher frequency of hemoglobin cycling than the HD group, and the change of rHuEPO dose per week, hospitalization and serum albumin were associated with the hemoglobin cycling during the first year of dialysis.

만화 과제를 이용한 정신분열병 환자의 사회인지 능력의 측정

오정은,나명현,하태현,신용욱,노규식,홍순범,이경진,신민섭,이영호,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : This study is to investigate the hypothesis that schizophrenic patients have difficulty in inferring mental state of others. Methods : Twenty schizophrenic patients and twenty normal subjects were administered to the Cartoon Task required inferring the character's intention in a given context. Results : The schizophrenic patients showed a statistically significant impairment in the Cartoon Task. Both groups chose the card depicting a frequent everyday action significantly more rather than the similar card to the last picture in each story for wrong answers. Conclusion : These preliminary results suggest that schizophrenia is associated with a specific deficit of the cognitive ability referred to as social cognition, and this deficit can be detected not only in the acute phase as found in previous research studies, but also in remission. Also when subjects fail to appreciate what is going on in the minds of other people, they seem to rely on a socially familiar experience.

Reusable Electrical Activity of the Heart Monitoring Patch for Mobile/Ubiquitous Healthcare

Lee, Jeong-Whan,Lee, Kang-Hwi,Lee, Young-Jae,Hong, Lee-Yon,Kim, Dong-Jun,Kim, Kyeong-Seop,Lee, Bongsoo,Lee, Myoungho Springer-Verlag 2009 JOURNAL OF MEDICAL SYSTEMS Vol.33 No.1

Quality of information on the Internet for Korean patients with inflammatory bowel disease

( Jun Sik Yoon ),( Sang Jik Lee ),( Eun Soo Kim ),( Sung Kook Kim ),( Min Kyu Jung ),( Hyun Seok Lee ),( Yong Hwan Kwon ),( Su Youn Nam ),( Seong Woo Jeon ),( Sun Jin ),( Joon Seop Lee ),( Seong Jae Y 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.6

Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the information on IBD obtained from Korean websites. Methods: Using the terms “Crohn’s disease” or “ulcerative colitis,” websites were selected from those obtained with the three most renowned search engines in Korea; 60 websites from the results of each engine were chosen. The websites were classified into institutional, commercial, charitable, supportive, or alternative medicine types according to the characteristics of each site. The websites were evaluated regarding content quality using the validated DISCERN instrument and the Journal of the American Medical Association benchmarks. Results: The median score of all the websites according to the DISCERN instrument was 32 (interquartile range, 25 to 47) out of 80, indicating an insufficient overall quality of information. The alternative medicine sites scored the lowest, whereas the institutional sites scored the highest (p < 0.05). The quality of information was significantly different among the search engines (p = 0.028). The rank of appearance in the Google search result did not correlate with the quality level of the information. Conclusions: The quality of information on the Internet regarding IBD varied according to the website type and search engine. Accreditation and quality assurance systems should be implemented for websites to ensure that the public and patients obtain accurate information on IBD.

Discovery of Novel Functional Variants and Extensive Evaluation of<i>CYP2D6</i>Genetic Polymorphisms in Koreans

Lee, Su-Jun,Lee, Sang Seop,Jung, Hyun-Ju,Kim, Ho-Sook,Park, Soo-Jin,Yeo, Chang-Woo,Shin, Jae-Gook American Society for PharmacologyExperimental Ther 2009 Drug metabolism and disposition: the biological fa Vol.37 No.7

<P>Our objectives were to identify CYP2D6 genetic polymorphisms in a Korean population, to compare the allele frequencies with those of other ethnic groups, and to evaluate variant-induced functional variations in dextromethorphan (DM) metabolism in vitro and in vivo. Thirty-eight single nucleotide polymorphisms of CYP2D6 were identified by direct DNA sequencing in 51 Koreans. An extended set of 707 subjects were screened for the identified variants. A group of 202 healthy subjects was subjected to phenotypic analysis on DM metabolism. CYP2D6*10 was found to be the most frequent allele (45.6%), followed by CYP2D6*1 (32.3%), *2 (9.9%), *5 (5.6%), *41 (2.2%), *49 (1.4%), and some other rare alleles (<1%). The newly identified E418K and S183Stop were assigned as CYP2D6*52 and CYP2D6*60, respectively, by the Human P450 (CYP) Allele Nomenclature Committee. Individuals having the CYP2D6*10/*49 genotype (n = 5) exhibited a significant decrease in CYP2D6 metabolic activity compared with those with the CYP2D6*1/*1 genotype (n = 31) (P < 0.019). Variations in CYP2D6 protein levels in liver tissues (n = 49) were observed with CYP2D6 genotypes, and correlation between the CYP2D6 protein content and the activity was significant (r(2) = 0.7). Given the importance of CYP2D6 in drug metabolism, subjects with the CYP2D6*10/*49 genotype may benefit from genotype analysis to achieve optimal drug therapy.</P>

Platinum-decorated reduced graphene oxide/polyaniline:poly(4-styrenesulfonate) hybrid paste for flexible dipole tag-antenna applications.

Lee, Jun Seop,Kim, Minkyu,Lee, Choonghyeon,Cho, Sunghun,Oh, Jungkyun,Jang, Jyongsik RSC Pub 2015 Nanoscale Vol.7 No.8

<P>With recent developments in technology, tremendous effort has been devoted to producing materials for flexible device systems. As a promising approach, solution-processed conducting polymers (CPs) have been extensively studied owing to their facile synthesis, high electrical conductivity, and various morphologies with diverse substrates. Here, we report the demonstration of platinum decorated reduced graphene oxide intercalated polyanililne:poly(4-styrenesulfonate) (Pt_rGO/PANI:PSS) hybrid paste for flexible electric devices. First, platinum decorated reduced graphene oxide (Pt_rGO) was fabricated through the chemical reduction of platinum cations and subsequent heat reduction of GO sheets. Then, the Pt_rGO was mixed with PANI:PSS solution dispersed in diethylene glycol (DEG) using sonication to form a hybrid PANI-based paste (Pt_rGO/PANI:PSS). The Pt_rGO/PANI:PSS was printed as a micropattern and exhibited high electrical conductivity (245.3 S cm(-1)) with flexible stability. Moreover, it was used in a dipole tag antenna application, where it displayed 0.15 GHz bandwidth and high transmitted power efficiency (99.6%).</P>

Multidimensional Polypyrrole/Iron Oxyhydroxide Hybrid Nanoparticles for Chemical Nerve Gas Agent Sensing Application

Lee, Jun Seop,Shin, Dong Hoon,Jun, Jaemoon,Jang, Jyongsik American Chemical Society 2013 ACS NANO Vol.7 No.11

<P>Multidimensional FeOOH nanoneedle-decorated hybrid polypyrrole nanoparticles (PFFs) were fabricated using dual-nozzle electrospray and heat stirring process. To decorate metal oxide nanoneedles on the polypyrrole (PPy) surface, metal oxide particle-decorated PPys (E_PPy) were fabricated as starting materials. The E_PPy particles were prepared by dual-nozzle electrospray because ferric ions (Fe<SUP>3+</SUP>) dispersed on the surface reacted with hydroxide (OH<SUP>–</SUP>) ions in the collector solution without aggregation of each particles. Multidimensional hybrid PFFs with maximized surface area were then formed by heat stirring reaction in the aqueous metal precursor contained solutions. The decoration morphology of the metal oxide nanoneedles could be controlled by precursor concentration in the aqueous solution. These multidimensional hybrid PPFs were applied to nerve gas agent (DMMP) chemical sensor at room temperature with excellent sensitivity. The minimum detectable level (MDL) of PFFs was as low as 0.1 ppb, which is higher than that for a chemical sensor based on hybrid materials. This is because the metal oxide nanoneedles increase surface area and affinity to DMMP vapor.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-11/nn404353w/production/images/medium/nn-2013-04353w_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn404353w'>ACS Electronic Supporting Info</A></P>

Identification and functional assessment of BCRP polymorphisms in a Korean population.

Lee, Sang Seop,Jeong, Hye-Eun,Yi, Joo-Mi,Jung, Hyun-Ju,Jang, Jae-Eun,Kim, Eun-Young,Lee, Su-Jun,Shin, Jae-Gook American Society for Pharmacology and Experimental 2007 Drug metabolism and disposition: the biological fa Vol.35 No.4

<P>The breast cancer resistance protein (BCRP) is a member of the ATP-binding cassette transporters. The aim of the present study was to identify genetic variants of BCRP in Koreans and to assess the functional consequences of BCRP polymorphisms. Twenty single nucleotide polymorphisms (SNP), including four nonsynonymous SNP, were identified by DNA sequencing of the BCRP gene in 92 Korean subjects. BCRP V12M, Q141K, P269S, and Q126Stop were detected at frequencies of 23, 28, 0.2, and 1.9%, respectively. These four coding variants were also screened in Chinese and Vietnamese subjects; the allelic frequencies among the three populations were compared; and predictions were made as to the potential frequency of each variant. In vitro functional analyses of the P269S protein and the promoter SNP -19031C>T (mutated in the hypoxia-inducible factor-1alpha binding site) were performed and compared with those of the wild type. P269S exhibited a 35 to 40% decrease in vesicular uptake of [(3)H]estrone-3-sulfate and [(3)H]methotrexate compared with the wild type. The promoter SNP -19031C>T did not affect BCRP promoter activity in either the presence or absence of chemical-induced hypoxic stress. Our results suggest that the P269S variant could be a functionally altered variant. Genotyping of this variant in clinical studies is needed to address its phenotypic role. Genetic polymorphisms of BCRP were found to be very common in Koreans, as well as in other ethnic groups. Comparative analyses among three Asian populations revealed different frequencies for the four functional BCRP variants.</P>