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주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4
Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)
박말영,임은성,박지영,노지현,추은영,유재연 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2
문제: 환자가 수술장내에서 수술을 기다리면서 느끼는 불안감을 최소화할수있도록해야하지만수술실의 효율성 및 의료진 편의성 위주로 운영되고 있어 수술실 내 대기시간이 연장되고 있다. 목적: 수술장내 대기시간을 단축시키기 위해 수술환자의 이동경로에 따른 지연요인과 문제점을파악하고 개선하여 환자가 수술을기다리면서 느끼는 불안감을 최소화하고자 한다. 의료기관: 부산시에 소재한 481병상의 종합병원 수술실 질 향상 활동: 수술환자의 대기시간 지연요인과 문제점을 파악하고 개선을 통해 질 향상을 도모하였다. 개선효과: 대기시간 수행율에서 수술장 도착까지의 수행율이 개선전 95%에서 개선후98%로, 수술방입실까지의 수행율이 개선전 88%에서 개선후 94%로, 마취시작 까지의 수행율이 개선전 93%에서 개선후 96%로 수행율이높아졌다.
Ji-Hyeon Kim,Do-Yeon Kim,Hee-Jeong Yang,Yeon-Ju Kim,Su-Jin Park,Jong-Won Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.05
The purpose of this study was to analyze the effects of aerobic exercise and resistance exercise on body composition, complete blood count (CBC) and metabolic syndrome factors in postmenopausal women. Twenty healthy postmenopausal women composed of the step box exercise and resistance exercise group (n=10) or to a “no exercise” control group (n=10). The variables of body composition, CBC, and metabolic syndrome factors were measured in all the subjects before and after the 12-week study. Waist circumference, lean body mass and % body fat had significantly decreased, but no significantly differences in blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and CBC in the post combined exercise group. However, individual metabolic syndrome factors were decreased compared to before combined exercise training and after combined exercise training. Our findings indicate that regular and continuous aerobic exercise and resistance exercise improves body composition, visceral fat and CBC factors. Consequently, exercise intensity and duration will be effective for preventing the immune system caused by metabolic syndrome patients in postmenopausal women.
Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model
( Hyeon Ji Yeo ),( Eun Ji Yeo ),( Min Jea Shin ),( Yeon Joo Choi ),( Chi Hern Lee ),( Hyeok Yil Kwon ),( Dae Won Kim ),( Won Sik Eum ),( Soo Young Choi ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.7
A major feature of type 1 diabetes mellitus (T1DM) is hyperglycemia and dysfunction of pancreatic β-cells. In a previous study, we have shown that Tat-DJ-1 protein inhibits pancreatic RINm5F β-cell death caused by oxidative stress. In this study, we examined effects of Tat-DJ-1 protein on streptozotocin (STZ)-induced diabetic mice. Wild type (WT) Tat-DJ-1 protein transduced into pancreas where it markedly inhibited pancreatic β-cell destruction and regulated levels of serum parameters including insulin, alkaline phosphatase (ALP), and free fatty acid (FFA) secretion. In addition, transduced WT Tat-DJ-1 protein significantly inhibited the activation of NF-kB and MAPK (ERK and p38) expression as well as expression of COX-2 and iNOS in STZ exposed pancreas. In contrast, treatment with C106A mutant Tat-DJ-1 protein showed no protective effects. Collectively, our results indicate that WT Tat-DJ-1 protein can significantly ameliorate pancreatic tissues in STZ-induced diabetes in mice. [BMB Reports 2018; 51(7): 362-367]
( Ji Hyeon Yeon ),( Kyung Hwan Jung ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.9
In this study, we investigated the performance of an immobilized β-galactosidase inclusion bodies-containing Escherichia coli cell reactor, where the cells were immobilized in alginate beads, which were then used in repeated-batch operations for the hydrolysis of o-nitrophenyl-β-D-galactoside or lactose over the long-term. In particular, in the Tris buffer system, disintegration of the alginate beads was not observed during the operation, which was observed for the phosphate buffer system. The o-nitrophenyl-β-Dgalactoside hydrolysis was operated successfully up to about 80 h, and the runs were successfully repeated at least eight times. In addition, hydrolysis of lactose was successfully carried out up to 240 h. Using Western blotting analyses, it was verified that the β-galactosidase inclusion bodies were sustained in the alginate beads during the repeatedbatch operations. Consequently, we experimentally verified that β-galactosidase inclusion bodies-containing Escherichia coli cells could be used in a repeated-batch reactor as a biocatalyst for the hydrolysis of o-nitrophenyl-β-D-galactoside or lactose. It is probable that this approach can be applied to enzymatic synthesis reactions for other biotechnology applications, particularly reactions that require long-term and stable operation.
Bioethanol Production from the Hydrolysate of Rape Stem in a Surface- Aerated Fermentor
( Ji Hyeon Yeon ),( Sang Eun Lee ),( Woon Yong Choi ),( Won Seok Choi ),( Il Chul Kim ),( Hyeon Yong Lee ),( Kyung Hwan Jung ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.1
In this study, we investigated the feasibility of producing bioethanol from the hydrolysate of rape stem. Specifically, the most ideal yeast strain was screened, and the microaeration was performed by surface aeration on a liquid medium surface. Among the yeast strains examined, Pichia stipitis CBS 7126 displayed the best performance in bioethanol production during the surface-aerated fermentor culture. Pichia stipitis CBS 7126 produced maximally 9.56 g/l of bioethanol from the initial total reducing sugars (about 28 g/l). The bioethanol yield was 0.397 (by the DNS method). Furthermore, this controlled surface aeration method holds promise for use in the bioethanol production from the xylose-containing lignocellulosic hydrolysate of biomass.