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서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
( Ji Su Lee ),( Hyun-sun Park ),( Hyun-sun Yoon ),( Soyun Cho ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Actinic keratosis (AK) is a common sun-induced skin disorder of importance for the progression to invasive squamous cell carcinoma. However, there is still no good way to predict high risk AK. Objectives: To identify markers which reflect the biologic behavior of AK and to understand the pathogenesis of AK Methods: A total of 52 patients with AK and site-matched 17 normal controls were included. We evaluated solar elastosis and immunohistochemical features using the following antibodies: p53, vitamin D receptor (VDR), claudin-1, and Langerin. Results: Solar elastosis increased and Langerhans cell (LC) density decreased with aging in both patients and controls. Solar elastosis and p53 expression were higher and VDR expression was lower in patients than controls; however, they showed no statistical difference in relation to the pathologic grade of AK. Claudin-1 expression gradually decreased from normal control to severe AK and decreased in the areas with epidermal atypia. LC density in severe AK was significantly lower than in normal control and mild AK; no difference in LC density was seen among control, mild AK and moderate AK. Conclusion: Claudin-1 can be a useful marker of pathologic severity of AK. In contrast, p53 increases and VDR decreases in AK not in gradual manner but in the early steps of carcinogenesis. LC density is relatively maintained in AK until it reaches severe dysplasia.
Multiplex PCR Detection for 3 Events of Genetically Modified Maize, DAS-59122-7, TC6275, and MIR604
Ji-Hye Ahn,Jae-Hwan Kim,Su-Youn Kim,Woo-Young Lee,Sun-Hee Park,Hae-Yeong Kim 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.3
A multiplex polymerase chain reaction (PCR) method was developed to simultaneously detect 3 events of genetically modified (GM) maize. The event-specific primers were used to discriminate the following 3 events of GM maize (DAS-59122-7, TC6275, and MIR604) using multiplex PCR method. The zein gene was used as an endogenous maize reference gene in the multiplex PCR detection. The primer pair Zein-F/R producing a 99 bp amplicon was used to amplify the zein gene. The primer JI-Das-F1/R1 for DAS-59122-7, JI-TC6275-F3/R3 for TC6275, and JI-MIR F1/R1 for MIR604 yielded an amplicon of 130, 162, and 197 bp, respectively. The detection limit of multiplex PCR was 1% for DAS-59122-7, TC6275, and MIR604 for one reaction.
Hairless Mice를 이용한 광노화 모델에서 APB-01의 경구반복투여에 의한 피부주름개선 효과 시험
이지해(Ji-Hae Lee),이병석(Byung-Suk Lee),변범선(Bum-Sun Byun),김완기(Wan-Gi Kim),이상준(Sang-Jun Lee),심영철(Young-Chul Sim),김배환(Bae-Hwan Kim) 한국독성학회 2003 Toxicological Research Vol.19 No.4
Ultraviolet (UV) is thought to induce erythema, sun-burn, photo-toxicity, photo-allergy, photo-aging and sometimes skin tumor. To investigate the photo-protective effects of APB-01 (Amore-<br/> Pacific Beauty-01, the mixture of Jaummi-dan and Fujiflavone P10) on UV-induced skin damage, forty of SKH hairless female mice were orally administered with APB-01 or saline fifth a week, and irradiated with UV third a week for up to ten weeks. We examined the relationship between visible changes and skin damage in the dermis and epidermis. In the APB-01 treated group, a better skin<br/> and less wrinkles formation were observed when compared to the UV control group. This results demonstrated that oral administration of APB-01 seems to have photo-protective effects on UV-induced<br/> skin damage of hairless mice due to an inhibitory effect on collagen breakdown, and the model using hairless mice is very useful to investigate the efficacy of functional beauty foods.
GC-ECD를 이용한 유기염소계 및 Pyrethroid계 농약 동시 분석법
김우성,이선화,김재이,정지윤,이명자,박영채,이영자,정성욱,이봉헌,박흥재 한국환경과학회 2003 한국환경과학회지 Vol.12 No.4
Pesticides were extracted from samples with 70% acetone and methylene chloride in order, and then cleaned up via open-column chromatography apparatus packed with florisil, and finally analyzed simultaneously the organochlorine and pyrethroid pesticides using GC(ECD). An ultra-2 fused silica capillary column was used to separate and identify the products. The resolution between the last isomeric peak of cypermethrin(59.987min) and the first isomeric peak of flucythrinate(60.043min) was not satisfactory. The last isomeric peak of fenvalerate(62.344min) and the first isomeric peak of fluvalinate(62.397min) were overlapped. Recoveries of soybean sample for the most pesticides were 73.3% to 102.4%. Detection limits were between 0.004 and 0.063 ㎍/㎎ when this method was used.
김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.
최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1
This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.
이지선,이채호 圓光大學校 基礎自然科學硏究所 1996 基礎科學硏究誌 Vol.14 No.2
산촉매하에서 N―(2―arylethyl)sulfamiide 또는 N―alkyl―N'―(2―arylethyl)sulfanide와 1,1,3,3―tetraethoxypropene의 반응으로 2―(2―aryethyl)sulfamide―2H―1,2,6―thiadiazine 1,1―dioxide와 N―(3―acro―leino)―N―alkyl―N'―phenethylsulfanide를 얻었다. N―(2―aryethyl)sulfamides and N―alkyl―N'―(2―arylethyl)sulfamides were treated with with 1,1,3,3―tetraethoxypropene to yield 2―(2―aryethyl)sulfamide―2H―1,2,6―thiadiazine 1,1―dioxide and N―(3―acro―leino)―N―alkyl―N'―phenethylsulfanides
장애학생이 통합된 중학교 과학수업 실태 및 과학교사와 특수교사 간 협력요구
이지선,박승희 이화여자대학교 교육과학연구소 2009 교육과학연구 Vol.40 No.3
본 연구의 목적은 장애학생이 통합된 중학교 과학교과 통합수업의 실태 및 과학교사와 특수교사 간 협력요구와 두 집단 간 협력요구 차이를 알아보는 것이다. 전국 중학교 140개교의 과학교사 136명과 특수교사 140명의 질문지 응답 자료가 분석되었다. 과학교사들은 장애학생의 기초학업수준에 대해서 잘 모르는 경우가 30.1% 정도가 되었고, 별도의 과학수업목표를 세우지는 않았으며 특수교사에게 주로 교수 및 학습방법에 대한 조언을 구하였다. 과학교사는 일반수업 내용을 그대로 가르쳤으며, 수정할 경우 더 쉽고 간단하게 가르쳤다. 장애학생은 부분적으로 수업에 참여하며, 과학교사는 잘 도와주는 친구 모둠에 장애학생을 배치하여 1명의 학생도우미를 정해주었다. 장애학생의 수업평가는 일반학생들과 같은 내용과 같은 방법으로 과학교사에 의해 행해졌다. 과학교사는 학급학생 수가 많아서 장애학생을 배려하는 것에서 어려움을 지적하였으며, 장애학생이 수업 내용을 이해하지 못한다 하더라도 일반학생과 사회적 관계가 증진되기를 기대하였다. 과학교사와 특수교사 간 협력요구 정도는 높은 편이었다. 장애학생의 문제행동에 대한 중재방법과 행동특성에 대한 정보 제공이 공통적으로 가장 필요한 협력요구로 나타났다. 장애학생의 과학수업 학습수준과 행동특성에 대한 정보제공은 특수교사의 협력요구가 과학교사의 협력요구 보다 유의하게 높았다. 우리나라 중등 통합교육 전반과 교과 통합수업의 질 제고와 관련해 본 연구의 의의 및 제한점과 후속 연구를 위한 제언이 제공되었다. The purpose of this study was to analyze the current status of inclusive science classes for students with disabilities and collaboration needs among science and special class teachers in middle schools nationwide. The respondents were 136 science teachers and 140 special teachers from 140 inclusive middle schools. The data were analyzed by descriptive statistics and by performing t-tests to show group differences between two groups of teachers. The current status of inclusive science classes can be described as stagnating in the phases of physical and social inclusion. Curricular inclusion in inclusive science classes has not been achieved. There was a relatively high number of collaboration needs among teachers for 12 different collaboration items. In both groups, the highest collaboration needs were “how to mediate problem behaviors of students with disabilities” and “having information on the characteristics of behaviors.” For the two items of “having information about the academic levels of students with disabilities in science class” and “having information on the characteristics of behaviors,” statistically significant differences were found between the two groups. Discussions and implications on the current status of the inclusive science classes and collaboration needs were presented to improve the quality of inclusive lessons in many curricular areas and overall inclusive education practices in secondary schools.