Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

Coevaporation에 의한 cd₁-xZn_(x)S 박막 제작 및 특성에 관한 연구

李載亨,李虎烈,朴鏞冠,申成浩,申載爀,朴光子 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-

In this paper, structural optical and electrical properties of Cd_(1-x)Zn_(x)S thin films prepared by coevaporation method were studied. Also, effects of ZnS mole ratio(x) to CdS on properties of thin film Cd_(1-x)Zn_(x)S/CdTe solar cells were investigated. When the ZnS mole ratio was less than 0.85, the crystal structure of Cd_(1-x)Zn_(x)S films was hexagonal with the c axis aligned perpendicular to the substrate. For x>0.85, however, the Cd_(1-x)Zn_(x)S films were grown with cubic zincblende structire. As the ZnS mole ratio increased the lattice constant of Cd_(1-x)Zn_(x)S films rapidly increased with ZnS mole ratio. The open circuit voltage of Cd₁xZnxS/CdTe solar cells increased with x due to reducing of the electron affinity difference between Cd₁xZnxS and CdTe films. However, the increase of series resistance due to the high resistivity of Cd_(1-x)Zn_(x)S films results on reducing conversion efficiency.

確率有限要素法을 利用한 Frame 構造物의 信賴性解析

신재철,정원석,한성호,김선훈 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.1

In this paper reliability analysis using stochastic finite element method is formulated, and with its result reliability analysis is accomplished. A displacement and member force of frame structure is acquired in SFEMP(Stochastic Finite Element Method Program) using perturbation method, and then DMCSP(Direct Monte Carlo Simulation Program) is used to verify and compare previous results. With the previous two results, approximate reliability analyses of the MFOSM(Mean First Order Second Moment), AFOSM(Advanced First Order Second Moment), and MCS(Monte Carlo Simulation) including a relatively simple limit state function have accomplished and base of a safety estimate could be acquired. Finally, When the reliability analysis of a complicated structure using stochastic finite element method is accomplished, time is efficiently reduced, and the safety of a structure can be easily evaluated. Hence SFEMP may be considered an efficient tool for evaluating the structural safety and reliability of frame structure.

AES-128 Rijndael 암·복호 알고리듬의 하드웨어 구현

신성호,이재흥 한밭대학교 정보통신전문대학원 2004 정보통신전문대학원 논문집 Vol.2 No.1

본 논문에서는 미국 국립표준기술연구소(NIST)에서 채택한 차세대 암호 표준인 Rijndael 암호 알고리듬을 하드웨어로 구현한다. 효율적인 연산을 위해 라운드를 2개의 부분 라운드로 나누고 부분 라운드 간에 파이프라인을 사용하였으며, 1 라운드 연산시 평균적으로 5클록이 소요된다. AES-128 암호 알고리듬을 ALTERA PPGA를 사용하여 하드웨어로 구현 후 성능을 분석하였다. 구현된 AES-128 암호 알고리듬은 암·복호화시 최대 90 Mhz의 동작 주파수와 약 230 Mbps의 암·복호율을 얻을 수 있었다. In this paper, Rijindal cipher algorithm is implemented by a hardware. It is selected as the AES(Advanced Encryption Standard) by NIST. The processor has structure that round operation divided into 2 subrounds and subrounds are pipelined to calculate efficiently. It takes 5 clocks for one-round. The AES-128 cipher algorithm is implemented for hardware by ALTERA FPGA, and then, analyzed the performance. The AES-128 cipher algorithm has approximately 230 Mbps encryption·decryption rate for 90Mhz max clock frequency.

XML 문서의 효율적인 구조 검색을 위한 동적 색인 모델

신승호,손충범,유재수 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.2

XML문서는 정보 표현의 기본 단위인 엘리먼트로 구성되어져 있다. 이러한 정보 표현의 기본 단위인 엘리먼트가 XML문서 내에서 구조 변정 이 발생 할 경우 보다 빠른 검색을 위해 기존의 색인 구조 정보의 변경 없이 효율적으로 처리 되어져야 한다. 이를 위해 본 논문에서는 XML 문서의 구조 변정 시 기존의 색인 구조에 효을적으로 수용될 수 있는 동적 색인 모뗄을 제안한다. 본 논문에서 제안 하는 동적 색인 모뗄을 위한 구조정보는 기존의 EID(Element Id), ETID(Element TrPe Id), SORD(Sibling ORDer) SSORD(Same Sibling ORDer), Ccount 구조정보 추출 방법에 SSORD를 대신한 STSOL(Same TyPe Sibling ORDer List). Scount (STSOL내의 SORD 개수). 그리고 COL(Child ORDer List)을 추가함으로써 구성된다. 이러한 구조정보를 이용해 효율적인 검색을 지원하기 위한 동적 색인 구성 알고리즘을 기술하고 제한하는 색인 기법이 기존의 동적 색인을 지원하는 기법 보다 내용 색인, 구조 색인, 애트리뷰트 색인 측면에서 우수함을 성능 평가를 통해 보인다. XML documents consist of elements that are basic units of information. When the structure of XML documents is changed dynamically, we need to update structure information efficiently without changing the information of an index structure for fast retrieval In this Paper, we propose a dynamic index modelling scheme that update index struoture in real time as the structure of XML documents is changed by insertion and deletion of elements. In recent, for indexing XML documents. we have proposed a structural information representation method such as element ID(EID), element type ID(ETID), sibling order(SORD). same sibling order(SSORD) and child count(Ccount). Besides them, our proposed dynamic index modelling method in this paper extracts additional structural information, such as same type sibling order list(STSOL) that substitutes for SSORD. Scount that is the number of SORDS in STSOL. and child order Bist(COL). We design a dynamic indexing technique with our structural information. We show through various experiments that our method outperforms existing enes in processing various types of queries such as content based queries, structural queries and hybrid queries.

전자빔으로 전처리한 제지폐수의 처리특성

신경숙,박재규,강호 忠南大學校 環境問題硏究所 1998 環境硏究 Vol.16 No.-

Treatability test for paper-mill wastewater pretreated with electron beam irradiation was investigated using the activated sludge simulation. The dose of electron beam irradiation exposed to paper-mill wastewater was relatively low(1kGy). The results showed that the BOD/CODCr of irradiated paper-mill wastewater increased up to 0.45 from 0.36 of unirradiated one. This was due to the conversion of nonbiodegradable organics to biodegradable ones by electron beam exposure. For the activated sludge systems operated at the various HRTs, BOD removal efficiency and COD removal efficiency of both reactors were similar. As a tool of sludge bulking measurement, sludge volume index(SVI) of activated sludge system operated with irradiated paper-mill wastewater was found to be lower (about 210∼ 241㎖/g)than that with unirradiated paper-mill wastewater(about 249∼298㎖/g). Biokinetic constants derived from Ekenfelder's modified model appeared 8.72/day for the irradiated paper-mill wastewater and 4.95/day for the unirradiated paper-mill wastewater, respectively. From the above results, it concluded that the pretreatment of paper mill wastewater with electron beam irradiation could improve the biodegradability as well as sludge activity even with the relatively low dose of electron beam irradiation.

대기업의 팀역량과 팀원 특성과의 관계

신재호,이찬 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.3

이 연구의 목적은 우리나라 대기업의 팀역량(팀지식, 팀스킬, 팀태도)과 팀원틀의 특성요인(능력요인, 성격요인) 평균 수준을 측정하고, 팀역량과 팀원 특성과의 관계를 구명하는 데 있었다. 모집단은 우리나라 300대 기업에 종사하고 있는 팀원이었으며, 표본 집단은 대한상공회의소 기업정보 (http://www.kochambiz.net)의 매출순위 300대 기업을 기준으로 업종별 비율을 고려하여 선정된 35개 기업 710명의 팀원이었다. 구체적인 연구결과는 다음과 같았다. 첫째, 우리나라 300대 기업의 팀역량 수준은 이론적 평균보다 높았으며, 팀원들은 대체로 외향성과 성실성의 성격을 가지고 있었다. 둘째, 팀원들의 능력요인이 성격요인보다 팀역량과 높은 상관관계를 보였으며, 팀역량을 통계적으로 유의미하게 설명하는 팀원 능력요인은 대인관계, 업무능력 등이었다. 셋째, 팀원들의 성격요인은 팀역량에 통계적으로 유의미한 설명력을 가지고 있지 않았다. 이와 같은 결론을 토대로 ① 팀원들의 경쟁력 향상과 기업성과 제고를 위한 교육훈련 및 인적자원 활용 전략 수립, ② 팀역량의 다양한 차원과 요소들을 포괄할 수 있는 팀역량 척도에 대한 지속적인 수정·보완 연구, ③ 팀역량 하위요인 수준의 시간 흐름에 따른 변화, 방향, 영향요인 등을 고찰하는 종단적 연구 수행, ④ 기업규모, 팀유형 등에 따라 연구대상을 다양화하여 팀역량과 팀원특성요인 간 관계 구명, ⑤ 팀원들의 특성과 팀역량 사이에서 이를 매개하거나 조절해줄 수 있는 변인을 구명하는 연구 등을 후속연구로 제안하였다. The Purpose of this study is to determine the relation between team competency and team members' characteristics(ability and personality) by measuring the average level of team competency and team members' characteristics working for top 300 companies in Korea. The population for the study was team members of top 300 companies, which were on top of the list of top 1000 companies categorized into the sales by the Korea Chamber of Commerce and Industry(http://www.kochambiz.net). Using the proportional stratified sampling technique, 710 team members of 35 companies were sampled for this study. The Major findings of this study were as follows: First, the team competency level of top 300 companies in Korea reached higher than the theoretical average and the personality of top-300-company team members was mainly extroverted and conscientious. Second, especially team members' ability variables were more related than personality variables and the statistics of the study showed that team competency could be measured mainly by interpersonal relationship and business capability in order. Third, all of the team members' personality variables didn't significantly explain team competency. Based on the results of this study, some recommendations for future research were made as follows: First, further researches are needed to develop the strategy for training & education, and practical application to human resources in the company. Second, the team competency scale which can comprehend various dimensions and elements should be developed continuously. Third, the longitudinal study about team competency should be conducted to measure the change, direction and influences in sub-variables. Forth, the relationship between team competency and team members' characteristics in other cases on various scale of enterprises or types of teams should be investigated. Fifth, the intermediary or controlling variables between team competency and team members' characteristics should be identified.

비대칭 사장교의 정적 및 시공 단계 해석

신재철,남기수,정인수,한성호 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

The cable-stayed bridges are composed of cables, towers and girders. when the cable-stayed bridges are loaded, the whole structure display very complex behavior due to excessive cable deflection. Eventhough the material in the members of a cable-stayed bridge structure behaviors in a linear elastic manner. the overall load-displacement relationship for the structure will be nonlinear. The nonlinear behavior is a result of: due to the sag caused by their own dead weight and the nonlinear axial and bending force-deformation relationships for the bend members. In the construction stage analysis, some technical approaches and structure safety are needed to stimulate numerically the complicated changes of structural system during construction. In this study static and construction stage analysis is performed and compared. Static and construction stage analysis on unsymmetric Cable-stayed bridge is performed and linear and nonlinear analysis is performed to evaluate the structure characteristics. After Static analysis of final construction stage was performed, construction stage analysis was performed.

鋼橋梁 下部플랜지 맞대기 鎔接이음부의 鎔入不足에 따른 疲勞擧動에 관한 硏究

신재철,한성호,정인수 충남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.14 No.2

A major defective welding pattern in the steel bridges is identified as the lack of welding area due to the insufficient welding penetration. In this study is fatigue behavior and fatigue life of steel bridge under flange of weld insufficient of butt weld joint. Fatigue behavior and fatigue life test is minor's law and fracture analysis and nowaday, finite element method is used to many times. By considering the welding defect in the above, structural analysis is conducted to evaluate butt weld joint influence due to welding defect on the safety of steel bridges. The results indicate that, due to the insufficient welding penetration, the stress obtained in the analysis is over the allowable fatigue stress level, and its influence on safety of the bridges is significant

대형 화재로 인한 사상자의 손상 유형과 합병증 : 동인천 라이브호프 화재를 중심으로

신중호,김재광,염석란,신종환,민순식,임용수,양혁준,이근,황성연 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: High risks of fire alway exist for buildings in urban areas, especially those in downtown. Crowds, as well as more complex and larger structures, may cause more victims in the event of fire; therefore, emergency medical service plans must be established for such disastrous events. Methods: On the evening of October 30,1999, a fire broke out in downtown, Dong-Incheon Live-Hof restaurant; 56 people were killed and 76 were injured. Most of them were teenagers. We retrospectively reviewed the medical records of the victims, Results: 1) Among the 56 dead, 54 died from smoke inhalation, one from extensive burns, and one from sepsis during treatment. 2) Among the 76 injured, 70 patients suffered from smoke inhalation, 53 from burns, and 9 from several types of trauma (sprains, contusions, lacerations, abrasions, fractures, etc.). 3) Later complications were laryngeal edema, pulmonary edema, scar contracture, and hypoxic brain damage, and so forth. 4) Post traumatic stress syndrome was unexpectedly more prevalent in mildly to moderately injured survivors and witnesses than in seriously injured survivors. Conclusion: Many complications exist after a fire. Some may be resolved in time, but others may result in permanent sequelae. Early rescue, early triage, and early management during transport by emergency medical service (EMS) personnel can result in fewer complications and a lower mortality rate. Therefore, we propose the establishment of plans to be followed during various major disasters.