서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

각종 난치성 혈액 질환에서의 비혈연간 골수이식

김동욱,한훈,김정아,김희제,민창기,엄현석,최정현,이종욱,한치화,홍영선,최일봉,신완식,민우성,김학기,김춘추,김원일,김동집 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

목적: 비혈연간 골수이식은 혈연내에 적절한 골수공여자가 없는 만성골수성백혈병, 고위험군의 급성별혁병, 면역억제치료에 실패한 재생불량성빈혈 및 각종 난치성 조혈모세포질환의 완치를 위한 표준적인 치료방법으로 정착되고 있다. 혈연간 표준적인 동종 이식에 비하여 비혈연간 이식시에는 생착부전, 이식편대숙주반응과 감염이 더 빈번하게 발생하며, 국내에서는 아직까지 체계적인 임상연구결과가 보고된 바 없었다. 이에 본 센터에서는 1995년 10월 이후로 약 20개월간 26예의 비혈연간 골수이식을 시행하였으며 3개월 이상의 추적관찰이 가능하여 이식초기 합병증의 관찰 및 분석이 가능하였던 20예의 환자를 대상으로 이식성적 및 문제점을 보고함으로써 새롭게 확대되고 있는 이 분야의 임상연구 및 진료의 활성화를 꾀하고자 한다. 방법: 각종 혈액 종양질환으로 비혈연간 이식을 시행한 총 26예의 환자중 3개월이상의 추적관찰이 가능하였던 20예를 대상으로 후향적으로 임상경과를 분석한 후 생존 분석을 시행하였고, 환자의 연령, 성별, 질병의 상태, 조식 적합 항원의 일치정도, 이식편대 숙주 반응의 유무와 생존기간과의 상관관계를 살펴보았다. 또한 표준위험군과 고위험군으로 나누어 생존율을 비교하였고 이식과 관계된 생착 부전, 이식편대숙주반응, 감염의 발생과 양상 그리고 그 합병증을 관찰하였다. 결과: 1. 환자와 공여자간에 HLA 불일치가 20예 중 4예에서 있었으며, 생착여부의 확인이 가능했던 17예 중 16예에서 생착이 확인되어 94.1%의 생착율을 보였다. 2. 급성이식편대숙주반응은 62.5%(10/16예)에서 발생하였으며 111도 이상의 급성의 이식편대숙주 반응은 25%(4/16예)에서 발생하였다. 만성이식편대숙주반응은 40%(2/5예)의 환자에서 발생하였으며 이들 모두 국소형으로 중증의 진행형 만성이식편대숙주반응이 관찰된 환자는 없었다. 3. 호흡기 합병증은 10예(50%)에서 발생하였으며 감염성 폐렴을 포함한 호흡기 합병증이 가장 흔한 일차적인 사망 원인이었다. 호흡기 합병증이 발생했던 10예중 6예가 감염에 의한 폐렴이 의심되었고 나머지 4예는 특발성 간질성 폐렴이었다. 4. 8.5개월의 중앙추적기간 중 35%의 생존율을 관찰할 수 있었고, 생존기간은0.5개월에서 15개월 (중앙치:4개월)이었다. 한편 고위험군은 25%(3/12예), 표준위험군은 50%(4/8)의 생존율을 관찰할 수 있었다. 5. 가장 흔한 사망 원인은 감염성 폐렴을 포함한 호흡기 합병증(6예)이었고, 이외의 사망 원인으로는 급성 이식편대숙주반응과 다장기부전이 각각 2예, 생착 부전, 간정맥 폐쇄, 그리고 재발이 각각 1예였다. Unrelated bone marrow transplantation(UBMT) has been increasingly recognized as the standard treatment for cure of chronic myelogenous leukemia, high risk acute leukemia, aplastic failed on immunotherapy, and the variety of refractory hematologic diseases in patients lacking a related donor. However, as compared to HLA identical sibing transplantation, UBMT carries higher incidence of graft failure, graft versus host disease(GVHD), and infection. In our center, 26 patients underwent UMBT between October 1995 and June 1997. The minimum follow-up of 3 months was possible in 20 patients, for whom early complications and clinical outcomes were assessed. The median age of the 20 patients was 24 years. 8 patients had standard risk disease and 12 patients had high risk disease. All patients received various preparative regimens including total body irradiation according to disease and disease status. 19 patients received CsA + short course MTX for GVHD prophylaxis. One patient received marrow that was depleted of T cells ex vivo using avidinbiotin column. The class I loci were typed by serological methods and HLA-A, HLA-B and HLA-DRB1. 3 additional pairs were one minor mismatched at the HLA-B locus. Another one patients was one major mismatched at the DRBI alleles. 17 patients were evaluable for engraftment. Successful enfraftment was confirmed in 16 patients(94.1%). Only one patient who was performed one major DRBI mismatched transplants experienced graft rejection. 16 patients were evaluable for acute GVHD. The overall incidence of acute GVHD developed in 4 patients(25%). Five patients were evaluable for the development of Ⅳ acute GVHD developed in 4 patients (25%). Five patients were evaluanle for the development of chronic GVHD. 2 patients(40%) developed limited chronic GVHD. Respiratory complications including pulmonary infection developed in 10 patients(50%) and these complications were the most common primary cause of death. Of these 10patients, 6 had pneumonia due to fungus(4 patients), pacterial (1 patient), and CMV infection (1 patient) and 4(20%) had idiopathic interstitial pneumonitis and/or adult respiratory distress syndrome. The duration of median follow- up was 8.5 months and 7 of 20 patients(35%) are alive at the time of this analysis with survival duration of 0.5 to 15 months(median survival duration: 4 months). The overall survival was 25% (3/12 patients) in high risk group and 50%(4/8 patients) in standard group. From these results, we can predict that the incidence and severity of GVHD in Korea are lesser than multiracial countries and the long-term survival of patients with standard risk disease can approach that of HLA matched sibling transplants. For the past two years, the performance of UBMT has been rapidly increasing and it will be possible to analyze much larger number of patients soon in Korea. In the future the problems of graft failure, GVHD, and infection due to long lasting immunocompromised status will need to be overcome by continued medical research. In addition, the volunteer donor pool will have to be expanded by the promotion of the national awareness of its need.

경련성 환아 부모들의 인식에 대한 연구

이경화(Kyoung Hwa Lee),서은숙(Eun Sook Suh),김영창(Yong Chang Kim),김창휘(Chang Hwi Kim),이동환(Dong Whan Lee) 대한소아신경학회 1996 대한소아신경학회지 Vol.3 No.2

Convulsive disorder is the most part of the pediatric neurologic disease. As far as the treatment of convulsive disorder concerned, we must consider familys' understanding, and the close cooperation between the epileptic child, parents, and doctors. We compared to Kim's report in 1985, to study the change of parents of epileptic children thinking. A prospective study was undertaken the analysis of 100 epileptic children parents visited to the pediatric dept, of Soonchunhyang university hospital from May to July, 1995. Psychological assessment, questionnaires which contains 17 items were given them, and these items were compared to Kims report in 1985 The results were as follows: 1) Parents of epileptic children answered convulsive disorder has influenced to children growth and development( 60.8% in 1985, 65.0% in 1995 ). 2) For asking the causes of children disease, 40.5% of them in 1985 and 50.0% of them in 1995 answered to uncertain, but only 7.8% of them in 1985 and 7.0% of them in 1995 answered to relation with familial inheritance. 3) The feelings at time of the diagnosis were gloomy or uncomfortable: 52.3% in 1985, 38.0% in 1995 and shameful 28.1% in 1985, 9.0% 1995. parents had belived in the epilepsy was treatable disease: 41.0% in 1995. 4) According to the this survey, patients explained reasons why their children take the medication increased from 23.5% in 1985 to 65.0% in 1995. 5) Only family, knew that their children had the convulsive disorder about 50.3% in 1995 and 22.0% in 1995. Family, patients and other people except family knew that their children had the convulsive disorder about 6.5% in 1985 and 43.0% in 1995. 6) The parents opinion and expectation toward the medical doctors were that they wanted to get full explanation for the disease 81.0% in 1985 and 35.1% in 1995, and others were explantation about toxicity and side effects of the medication and advises for the childrens life and activities.

생쥐 鼻中隔 各種 粘膜上皮 및 粘膜下腺의 分布樣狀과 그 表面積에 관한 硏究

金東煥,金武剛,申台均,金弘善,柳時潤,李永浩 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

In order to set the distribution pattern and surface area of the mucosal epithelium and submucosal gland in the mice nasal septum. 3-month-old healthy 6 mice weighing 25gm approximately have been contributed for this research. For the mapping of the each nasal epithelium and submucosal gland in the submicroscopic level, the routine paraffin block of the mice nasal septum were cut as the 10㎛ thick at 110㎛ intervals. Consecutive 2 slides were stained with H-E and PAS and reconstructed in form of maps representing the structure in a sagittal plane. The results obtained from this research were summarized as follows. 1. The unilateral nasal surface epithelial area of the mice nasal cavity was 31.23㎟ 2. The areas of the stratified squamous epithelium, respiratory epithelium and olfactory epithelium which compose the unilateral nasal epithelium were 4.47㎟(14.3%), 12.7㎟(40.8%), and 14.02㎟(44.9%), respectively. 3. Submucosal glands in the mice nasal septum were divided into the PAS-positive, PAS-negative and Bowman's glands by the PAS staining. 4. The surface area of the PAS-positive glands in the nasal unilateral septum was 5.23㎟ which is located in the central area of the respiratory portion. 5. The surface area of the PAS-negative glands in the nasal unilateral septum was 5.05㎟ which is located above and below the PAS-positive gland. 6. The surface area of the Bowman's glands was 12.1 ㎟ which was located in the olfactory region. 7. In the vestibular region., 3 ducts of PAS-negative glands of the respiratory region are found, and below the nasal septum there is the infraseptal gland(PAS-negative).

확률ㆍ통계영역을 중심으로 한 고교 수학 Ⅰ 교과서의 비교

김철환,박동준 釜慶大學校 1999 釜慶大學校 論文集 Vol.4 No.1

This paper considers the contents of current mathematics I textbooks in high schools. The contents of the textbooks are reviewed with related to education objects. In particular, probability and atatistics chapters re examined based on the definition and explanation for curriculum proposed by The Education Ministry. The textbooks analyzed are the current five mathematics I textbooks of high schools under the sixth educational procedures. The chapters of textbooks are specifically analyzed with respect to array, order, organization, development, terminalogy, symbol, historical mathematician, assignment of problems and chapter summary focused on probability and statistics chapters.

TRIO for PIANO VIOLIN and CELLO

김동환 중앙대학교 중앙음악연구소 1990 중앙음악연구 Vol.1 No.-

청소년에서 폭력에의 노출과 관련된 정신의학적 증상

김동기,이호분,민성길,송동호,육기환,전여숙 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

서울 시내 중학생 1345명을 대상으로 폭력에 노출되는 정도와 이와 연관된 정신의학적 증상을 알아보고자 하였다. 이를 위해 자기보고식 설문지를 사용하였는데. 설문지의 내용은 사회인구학적 자료와 집. 학교, 동네에서 폭력을 당하거나 목격했는지를 묻는 문항과 폭력에 의한 정신의학적 증상의 정도를 묻는 TSC(trauma symptom checklist)로 구성되었으며, 그 결과는 다음과 같다. 1) 전체 학생 중 45%가 폭력에 노출된 경험이 있었으며. 남자가 여자보다 많았다 (p<0.025). 집에서 구타 당한 경험은 여학생이 22.8%로 남학생보다 유의하게 높았다 (p<0.001). 학교. 동네에서 구타당한 경험은 남학생이 각각 22.1%. 10.1%로서 여학생보다 유의하게 높았다. 2) TSC를 요인 분석한 결과 불안-우울, PTSD, 해리, 분노 증상으로 나뉘었다. TSC는 폭력 경험 변인들과 상관 관계를 나타냈다. 다중 회귀분석을 실시한 결과 TSC와 연관된 폭력 노출 변인은 일생 동안의 폭력 노출(R²=0.18). 최근의 성폭력 경험(R²=7.12). 최근 집에서의 폭력 경험(R²=0.08), 최근 학교에서의 폭력 경험(R²=0.08), 최근 집에서의 폭력 목격(R²=0.07). 모든 종류의 폭력 노출(R²=0.29)로 나타났다. 3) TSC와 유의하게 연관된 사회인구학적 변인은 여성, 물질 남용의 가족력이 있는 경우, 술이나 담배 약물 남용을 하는 청소년인 것으로 나타났다. 따라서 청소년 폭력에의 희생자에 대한 정신의학적 개입에는 이러한 위험인자에 대한 고려가 필요하리라고 본다. In this research, we examined the frequency of exposure to violence in the home, school and neighborhood among middle school students as well as its related psychiatric symptoms. A total of 1,345 students from 5 middle schools in Seoul participated in this study : 670 were male,675 were female. We administered self-reported questionaires including discriptions of exposure to violence and a trauma symptom checklist(TSC)(Singer 1995). 1) The total frequency of exposure to any type of violence was 45% in our sample. The frequency of girls' being hit in home was 22.8%, which was significantly higher than it was for boys(p<0.001). The frequency of boys' exposure to violence in school and in the neighbor-hood was 22.1% and 10.1% respectively, which was higher than it was for girls(p <0.005). 2) In factor analysis of TSC, 4 factors were identified. TSC including depression-anxity, PTSD, dissociation and anger was correlated with violence exposure variables. Multiple regression analysis revealed that TSC is related with violence victimization in life(R2=0.18), sexual assault(R2= 0.12), recent victimization in the home(R2= 0.08), recent witness to violencein the home(R2=0.07), recent victimization in school(R2=0.08) and all violence exposures(R2=0.29). 3) Among the demographic variables, sex, parental alcohol problem and student alcohol-smoking-drug problems influenced the TSC(p <0.005). TSC could be result of witness to violence as well as violence victimization. And the risk factors for violence-related psychiatric symptoms were mainly seen in females, who have parents with alcohol problems or who themselves have alcohol-smoking-substance problems. So intervention programs for violence victims should be focused on the these high risk group.

酸化鐵의 CO/CO_2가스 還元速度에 미치는 不純物의 影響

金東義,裵錫煥 경북대학교 1985 論文集 Vol.40 No.-

The quantitative reaction of pure hematite and CO/CO_2 (80/20) gas mixture was studied at 900℃. Impurities such as CaO, SiO_2, and Al_2O_3 were added respectively to observe their effect on reduction of hematite. The micro-structure of reduced phases was observed by optical microscope and S. E. M. to investigate the depth of each phase. The results revealed that the change of reduction rate of pure hematite and added impurities increased rapidly to 30% and 39-50% respectively in the initial stage and then the reduction rate decreased, because the formation of dense iron layers by sintering and recrystalization surrounded partial reduced wu¨stite reflics, and this hindered the reducing gas diffusion. The reduction rate which impurities were added always is increased than that of pure hematite, was the maximum at 1.2wt.% regardless of its kinds of impurities. Each promoters is increased the reaction rate by the role of active center when the reduction is proceeding. The increased of reduction rate was proportional to ionic radius (r) and ionic charge (ε) of added impurities.

발달장애아동의 기능적 생활중심 교육과정 편성과 운영방안 탐색

김영환,정동영 국립특수교육원 1994 특수교육연구 Vol.1 No.-

The purpose of this present is to study the organization and management to adjust functional life centered curriculum to children with developmental disbility. Functional life centered curriculum is based on the philosophy of normalization that disabled children grow to be human having a full citizenship. The purpose of this curriculum is to have disabled children acquire of their full citizenship by teaching children knowledges, skills and attitudes in living situation which needed for present and furture lives of them. Therefore, the contents of this curriculum are the functional skills to have children interest of concern, to be effective in the real lives, and to improve their adaptive abilities toward change for their future. The skills selected in the curriculum are composed of several category should be organied to have continuity, sequency and intergration. In other words, the teaching principal of children with disability children is divided into the principal of development, principal of behavior and principal of functional life. Functional life centered curriculum is aimed the principal of founctional life and must be managed and reciprocally used the teaching principal of development and principal of behavior in according to text contents or subject of learning activity and ability or charicteritics of application object child. In addition, knowledge and founction in childrens' life is not used in pieces but used in reciprocally intergrated. So, this curriculum should be managed not to teach a piece of experience or knowledge but consist of intergrated learning unit. Especially, in case of children with developmental disability, learning activities should be provided intergrated type rather than seperated into each domain or subject because learned contents are able to be transitted and increased acquisition probability. Therefore, A finctional life centered curriculum should compose children's experience centered unit in terms of event, seasons, tasks and topics on the basis of their lives. So, if you agree with children with developmental disability to participate in society as a man with full citizenship human, we have to acknowledge them as children having a unique educational needs, organize and manage the founctional life centered curriculum that come up to their needs.

맥반석의 용출시험 및 중금속 흡착특성

김종부,신명국,성낙환,최문정,김경주,이동석 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

This experiment was done to investigate the leaching and adsorption properties of heavy metals on porphyry. The comparison with respect to the leachability of heavy metals from porphyry between the Korea Standard Leaching Test (KSLT) and the Toxicity Characteristic Leaching Procedure (TCLP) was carried out. The fractional composition of leachate and the total concentration of heavy metal of porphyry were studied through Sequential Extraction Procedure (SEP) and EPA Method 3050. Adsorption experiment of porphyry has pointed out that the optimum dosage of porphyry for 50ppm Pb was over 10g/L, the effective particle size for absorption was below 200 mesh and the optimum pH was about 7. From the Freundlich' adsorption equation, l/n was 1.0722, and k was 0.0041. After adsorption, the fractional composition of Pb was changed. The exchangeable, carbonate, reducible fractions were increased, and the organic fraction was not changed, and the residual fraction was decreased.