양전자방출단층촬영을 이용한 초점주의와 작동기억의 뇌 활성화 양상 비교

김재진,조상수,김명선,손정우,이재성,이동수,이명철,권준수 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: 단순 초점주의 과제와 보다 고도의 집중을 요하는 작동기억 과제를 수행하는 동안의 뇌 활성화 양상을 비교하여, 두 인지기능 과정을 매개하는 정상적 신경회로의 특성과 차이를 알아보는 것을 목적으로 하였다. 방법: 정상인 14명을 대상으로 시각처리 대조 과제, 단순 초점주의 과제, 작동기억 과제 등 세 가지 인지과제를 주고, 과제 수행 동안 [□O]H₂O를 추적자로 한 양전자방출단층활영을 실시한 후 감산분석을 통해 초점주의와 작동기억의 신경회로 지도를 작성하여 비교분석하였다. 결과: 초점주의 동안 활성화되는 부위는 좌측으로 편측화되고 산발적으로 분포하는 양상이었고, 특히 전대상이랑과 운동영역을 포함한 전두엽, 일차 및 이차 시각피질 등의 활성화가 특징적이었다. 작동기억 동안의 뇌 활성화 역시 산발적 분포와 좌측 편측화 양상이 관찰되었으나, 시각피질보다는 전두엽의 활성화가 우세하였고, 특히 우측 전대상이랑의 현저한 활성화가 특징적이었다. 결론: 초점주의와 작동기억은 개념적으로 공통점과 차이점을 내포하고 있는 것처럼 매개 신경회로에서도 공통 혹은 특이한 영역을 각각 가지며, 전대상이랑의 역할이 두 기능에 공통적으로 중요하고, 이차 시각피질과 전전두피질이 두 기능 각각에 더 중요하게 작용하는 것 같다. Objectives:This study was undertaken to identify neural substrates for simple focused attention and more highly-focused working memory i normal people and investigate their characteristics and differences. Method: Fourteen normal subjects were studied with [□O]H₂O positron emission tomography during a visual processing baseline task, simple focused attention task and working memory task. Results were analyzed with the subtraction analysis to map the neural correlates of focused attention and working memory. Results: Activated areas during focused attention tended to be lateralized to the left and scattered over various regions including the anterior cingulate, motor area, and primary and secondary visual cortices. While the areas activated during working memory also show the left lateralization and scattered distribution, activation prevailed more in the frontal lobe than in the visual cortex, and was particularly remarkable in the right anterior cingulate. Conclusions: Focused attention and working memory do not have only conceptually commonalities and differences but also have common and specific areas in their neural substrates. The anterior cingulate may commonly play an important role in both cognitive functions, whereas secondary visual cortex and prefrontal cortex seem to be predominantly implicated in each function, respectively.

과실이 크고 품질이 우수한 조생종 배 ‘금촌조생’ 육성

조광식(Kwang-Sik Cho1),손동수(Dong-Soo Son),강삼석(Sam-Seok Kang),김명수(Myung-Su Kim),홍경희(Kyung-Hui Hong),윤석규(Seok-Kyu Yun),조강희(Gang-Hui Cho),조현모(Hyeon-Mo Cho) 한국원예학회HST 2004 원예과학기술지 Vol.22 No.1

發達性言語障碍兒의 單一光子防出電算化斷層撮影 所見에 관한 연구

曺洙哲,李明哲,朴鎭生 대한소아ㆍ청소년정신의학회 1992 소아청소년정신의학 Vol.3 No.1

과량의 Vitamin A가 Rat 태자에 미치는 영향

조순곤,김수일,곽명순,김원식 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

For the study on the effects of vitamin A on the rat fetuses, 500mg/kg of retinol palmitate was administered orally once at the day 8.5 of gestation. In this study, the Sprague-Dawley rats were used as an experimental animal, which was divided into control and retinol palmitate treated groups. The animals were sacrificed under ether anesthesia at the day 12.5, 13.5, 14.5, 15.5 and 16.5 of gestation, laparotomized and hysterectomized. After counting the pregnant sacs, opened the sacs and removed the fetuses under stereoscopic observations, - fetal status, congenital malformations and other external anomalies etc.. The weight of live fetuses was measured and analysed it statistically, and compared the growth curves between 2 groups. The results were as follows ; 1. The survival rate of fetuses in the retinol palmitate treated group was lower significantly than that of control group except the day 12.5 of gestation. The rate was lowered daily from the day 12.5 to the day 16.5 of gestation. 2. The mean body weight of fetuses was lowered in the retinol palmitate treated group significantly from the day 12.5 to the day 16.5 of gestation, daily. 3. The congenital anomalies induced by retinol palmitate in this experiment were anencephaly, exencephaly and severe underdevelopment. According to the above results, it is considered that the retinol palmitate induces intrauterine fetal death caused by major congenital anomalies such as exencephaly and anencephaly, and delay the fetal growth by inhibition of differentiation and proliferation during organogenesis. But the exact mechanism of action cannot be known. And it is necessary to study the effects of retinol palmitate on the growth of fetuses with its congenital anomalies should be done with changing the dose, method of administration and the duration of treatment.

에탄올성 간손상 흰쥐의 유해산소 생성효소계에 미치는 칡 추출물의 영향

조수열,김명주,박은미,박지윤,장주연 한국노화학회 2001 한국노화학회지 Vol.11 No.1

전남 일부지역 고등학생의 라면소비실태에 관한 연구

조희숙,안명수 성신여자대학교 생활문화연구소 1993 生活文化硏究 Vol.7 No.-

幼兒自閉症의 單一光子放出電算化斷層撮影所見과 精神病理와의 相互關係에 關한 硏究

曺洙哲,李明哲,金相殷 서울醫大 1990 精神醫學 Vol.15 No.1

사업장 소음 폭로에 의한 일과성 역치 상승과 회복

조수헌,하미나,한상환,주영수,성주헌,강종원,윤덕로,송동빈,이명학,김선태 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

To determine the recovery time from noise-induced temporary threshold shift(TTS), a prospective field study was conducted at three worksites where workers are known to be exposed high level of noise. Subjects were selected according to answers on a questionnaire which inquired about otological history and previous noise exposure, including avocational, military and occupational exposures. After excluding employee with past otologic problems, recent exposure to high level noise, and under medications, total 92 employees participated in the study. Among 92 participants, complete consecutive audiometric examinations were carried out at 0∼2 hours, 5∼7 hours, 14∼16 hours after worktime noise exposure on 26 participants wearing hearing protectors and 22 participants wearing no protective devices. The difference between the hearing level 0∼2 hours after noise exposure and 5∼7 hours is statistically significant by paired t-test(p<0.01). The median recovery times calculated from the data of 22 participants wearing no protective hearing devices are 15.6 hours at 4000Hz, and 7.7 hours, 10.3 hours, 8.4 hours at 1000Hz, 2000Hz and 8000Hz respectively. These data suggest that when measuring the pure tone audiometry for noise exposed workers, at least 16 hours noise-free interval is required.

廣域光陽灣地域의 機能配置에 關한 硏究

金明洙,盧春變,趙南勳 순천대학 새마을연구소 1987 새마을硏究論文集 Vol.3 No.-

The wide area of kwangyang Bay will be, in the 2000s, developed into a met­roploise with the main functions such as those of manufacturing industry, shipp­ing industry and harbor works, tourist and service industry. Such a development of the said area but to the development of national economy through attempting a balanced development of our country and solving the social disadvantages caused by centralization and accumulation. With this development of the area of kwanghang Bay, Sunchon-city not only as a center of culture, education and distribution but also as a comprehensive resea-rch complex of agriculture and industry should carry out a head function in the wide area of kwnagyang Bay. It should also establish Yeochon-city as stronghold of tourism and marine transportation and make the city at the rear of kwangyang Bay carry out the synthesized function as both a port and industrial city. Yeochon city should be developed into a residential area in the back of Yeo-chon Industry Complex : the city in the back of Yulchon should be developed in to the city with the function of a garden city. In addition, with the view of meeting the great increase in tourism demand, recreation facilities should be provided, and a closer connection with the sight-seeing areas of Jiri Mountain and Hanryosudo should be also built up. For the rational distribution and the full use of all functions of the wide area of kwangyang Bay, the expansion of social indirect capital such as the de-velopment of road, harbor, airport should be given the precedence.

열처리 시간에 따른 니켈전기도금층의 집합조직 변화

김인수,홍상철,조경식,오명훈,김인기 金烏工科大學校 1999 論文集 Vol.20 No.-

Ni electrodeposits having preferred orientation can be obtained by various electrolysis conditions. Ni electrodeposits were annealed at 580℃ with various time. Ni electrodeposits having (100) texture did not change, (110) texture changed to various texture after recrystallization