서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus <i>Aspergillus</i> sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines

Kim, Dong-Cheol,Cho, Kwang-Ho,Ko, Wonmin,Yoon, Chi-Su,Sohn, Jae Hak,Yim, Joung Han,Kim, Youn-Chul,Oh, Hyuncheol MDPI AG 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.4

<P>In the course of searching for bioactive secondary metabolites from marine fungi, TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus <I>Aspergillus</I> sp. SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by lipopolysaccharides (LPS) as well as neuroprotective effect against glutamate-stimulated neurotoxicity in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS) generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells. Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were associated with upregulated expression of heme oxygenase (HO)-1 and nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. We also found that TMC-256C1 activated p38 mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1 activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of the p38 MAPK and PI3K/Akt pathways.</P>

최근 5년간 급성 A형 간염으로 입원한 환자들에 대한 입원 내용 분석

장재영,유병욱,조용진,오정은,홍성호,조주연 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1

Abstract Background : Due to improvements in Korea's sanitary conditions, antibody rates to the hepatitis A virus is decreasing rapidly and admission due to the disease is increasing, Patients who were admitted for hepatitis A during the last 5 years were selected and yearly differences in admission, clinical picture, medical fees, and differences according to age and gender were analyzed. Methods : Patients who were admitted to the Seoul Soonchunhyang University Hospital during the 5 year period between May of 2003 and April of 2008 and tested positive for IgM anti-HAV were selected and their medical records retrospectively analyzed. Results : 156 subjects [91 male (58%), 65 female (42%) were selected. The average age was 29.2 years (range; 21.4-37), average admission period 12.6 days (range; 12.5-1 7.7) days, and average medical fees 2,295,151 (range; 932,097-3,658,205) KRW(Korean Won), Yearly incidence rates were as follows : 10 for May, 2003 to April, 2004, 14 for May, 2004 to April, 2005, 23 for May, 2005 to April, 2006, 69 for May, 2006 to April, 2007, and 41 for May, 2007 to April, 2008, The maximum value median of AST, ALT, and bilirubin during admission was 989 IU/L, 1999 IU/L, and 5.6 mg/dL each, Each factors were all positively correlated with the patient's age. Conclusions : Recent decrease in antibody positivity of the hepatitis A virus and subsequent surge of acute hepatitis A is a cause of rising socioeconomic costs. A large scale epidemiologic research on whether HAV vaccination should be made mandatory and health insurance applied seems to be needed. Key words : Hepatitis A, Age, Medical fees, Vaccination

단백질흡착을 막는 소프트콘택트렌즈에 관한 연구

조종수,정영일,나재운,김성호 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

양말단에 이크릴레이트를 갖는 폴리에틸렌글리콜 미크로마(PEG macromer)와 또한 PEG macromer와 폴리하이드록시에칠메타아크릴레이트[P(HEMA)] 혹은 폴리(하이드록시에칠메타아크릴레이트-하이드록시프로메타아크릴레이트-비닐피롤리돈)[P(HEMA-co-HPMA-co-NVP)]와 상호침투된 망상구조의 시료가 소프트콘텍트렌즈의 알부민의 흡착을 막기위하여 제조되었다. PEG macromer의 중합으로 macromer의 다관능성기로 인하여 가교된 겔이 형성되었다. P(HEMA-co-HPMA-co-NVP)/PEG IPN계 콘텍트렌즈에서 PEG분자량이 중가할수록 알부민의 흡착량은 감소되었다. 또한 IPN제조시의 PEG의 농도가 짙을수록 알부민의 흡착량은 감소되었다. PEG macromer와 IPN하기전의 P(HEMA)계 및 P(HEMA-co-HPMA-co-NVP)계의 콘텍트렌즈에 비하여 PEG macromer와 IPN함으로서 렌즈의 착용감이 훨씬 상승되었다. Poly(ethylene glycol)(PEG) macromers terminated with diacrylate groups and interpenetrating polymer networks(IPN) composed of poly(hydrowyethyl methacrylate)(PHEMA) or poly(hydrowyethyl methacrylate-co-hydroxypropyl methacrylate-co-N-vinyl pyrrolidone)[P(HEMA-co-HPMA-co-NVP)]and PEG macromer were synthesized with the aim of abtaining protein adsorption resistant soft contact lens. Polymerization of PEG macromer. Crosslinked p(HEMA)or P(HEMA-co-HPMA-co-NVP) chains were interpenetrated into the cross-linked three-dimensional networks of PEG. It was found that albumin adsorption onto the contact lens prepared by P(HEMA-co-HPMA-co-NVP)/PEG IPN decreases with an increase of molecular weight of PEG. Also, it was found that albumin adsorption onto the both contact lens decreases with an increase of concentration of PEG macromer in the IPN preparation. There are also more adequate in the biointerness for the contact lens by P(HEMA)/PEG IPN or P(HEMA-co-HPMA-co-NVP)/PEG IPN than that by P(HEMA) or P(HEMA-co-HPMA-co-NVP).

하악골에 발생된 Low grade 골육종:증례보고

조현이,정종철,김호성,최재욱,성대경,서지훈,김성범,이계혁 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Osteosarcoma is a primary malignant tumor arising most often in the long bone, but rare in jaw bone. Especially osteogenic sarcoma of the mandible is a rare tumor, comprising less than 0.5% of all head and neck tumors. Osteosarcoma occurs cheifly in young persons, and presenting very survival rates. Histopathologically this tumor can be classified three types, osteoblastic, fibroblastic, chondroblastic and classified from low grade to high grade by anaplasia or mitosis of the tumor cells. Sometimes, the exact diagnosis of osteosarcoma is difficult especially in low grade osteosarcoma, even if clinical or radiographical findings suggest to osteosarcoma. So suspcious to malignant bone tumor in clinical or radiological findings, biopsy should be taked from deep portion and multiple area, and sharing the patient history and radiographs with pathologist will assist in the development of the diagnosis. We report a case of low grade osteosarcoma on the mandible initially difficulty in accurate diagnosis. The patient visited our hospital for routine dental treatment but radiographic findings displayed ill-defined radiolucency with osteoid formation on the mandible. Final diagnosis was difficulty in initial biopsy but subsequent biopsy taked from deep portion presented infiltrative growth and mitosis of the tumor cell in some area with small osteoid bone formation, so we could reach final diagnosis as low grade sarcoma. We treated this patient with bloc resection of the mandible and immediate reconstruction with iliac corticocancellous block.

Gamma 線이 鉤蟲幼蟲 및 宿主의 抵抗力에 미치는 影響

曺載浩 연세대학교 의과대학 1969 연세의대논문집 Vol.2 No.1

LANDSTAT 자료를 이용한 유출곡선지수의 추정

조홍제,황재호 울산대학교 2001 공학연구논문집 Vol.32 No.1

수치고도모델을 이용하여 유역의 지형학적 특성을 분석하고, LANDSAT 위성영상을 이용하여 유역의 토지피복상태를 분류한 후 유출곡선지수를 추정하였다. 특히, 우리나라는 유역의 대부분을 산림이 차지하는 피복특성이 있으므로 식생의 다중반사특성을 응용하여 산림지역을 분류하고 유출곡선지수 추정에 응용하였다. 산림지역은 식생의 건강 상태나 밀도에 따라 유출특성이 변화하는데, LANDSAT 위성영상의 다중분광자료를 사용하여 산출한 식생지수는 산림지역을 밀도나 건강상태에 따라 분류하는데 유용하였다. 또한 식생지수를 사용하여 산림지역을 분류한 후 산출한 유출곡선지수는 산림지역을 분류한 후 산출한 유출곡선지수에 비하여 감소하는 것을 확인할 수 있었다. Having analyzed the topographical quality of the basin using Digital Elevation Model and classified land uses by LANDSAT Satellite image, we estimated Runoff Curve Numbers. Most of the basins are characterized by the forest, therefore multiple reflex qualities were used to classify the forest and to estimate Runoff Curve Numbers. Because runoff changes according to the vegetative health and density, the vegetation index derived from the multispectral data of LANDSAT satellite images was useful to classify the forest by its health and density. It was observed that Runoff Curve Number decreased when the vegetation index was taken into account. In conclusion, the mulispectal image was useful to observe special quality and classification of the land.

폴리에스테르아마이드에 관한 연구

趙淳彩,姜濚義,崔在炅 全北大學校 1985 論文集 Vol.27 No.-

Polyesteramide(PEA) was prepared by the polymerization of caprolactam and 6-amino-caproic acid with oligomer of polyethylene terephthalate, which was prepared by the reaction of terephthalic acid with ethylene glycol, and characterized by melting point, molecular weight and whiteness. The results are summarized as follows. (1) Molecular weight has no relation to melting point of PEA. (2) Molar fraction of caprolactam of stoichemistry has no relation to molecular weight of PEA. (3) Melting point of PEA decreased with the molar fraction of oligoester of stoichiometry and was still lower than that of polyethylene terephthalate. (4) Whiteness of PEA decreased with the molar fraction of oligoester of stoichiometry and superior to that of PEA from hexamethylenediamine and oligoester, in respect of whiteness.

White luminescence of Ho3+/Tm3+/Yb3+-codoped CaWO4 synthesized via citrate complex route assisted by microwave irradiation

CHO, Hyun,HWANG, Seok Min,LEE, Jae Bin,KA, Dong Hyun,KIM, Tae Wan,LEE, Bo Seul,LEE, Ji Young,LEE, Jung-Il,RYU, Jeong Ho Elsevier 2014 Transactions of Nonferrous Metals Society of China Vol.24 No.suppl1

스포츠 가치의식에 영향을 미치는 스포츠의식에 관한 연구

조재호,조만태,안영필 東亞大學校附設스포츠科學硏究所 1998 스포츠科學硏究論文集 Vol.16 No.-

The emergence of a new phenomenon called sports value consciousness and its diversification make itself a meaningful research task, in that it demands a change of healthy human consciousness according to various social structures. The present study, therefore, aims to establish a reasonable standard of sports value consciousness as well as a new social system of value paradigms regarding all sports phenomena by revealing the consciousness patterns and related factors affecting the sports value consciousness sports activities. For this purpose, 533 subjects were chosen by the systematic stratified cluster random sampling method from among the population of athletes and leaders in high schools and universities in Pusan as of 1997. The questionnaire for this research was adopted from the studies of Niwa (1985), Uesugi (1987, 1990), Kusaka (1988), and Asanuma (1990). The original inquiry items underwent two preparatory tests for the judgment of validity and reliability before actual administration. The entire data went through χ²test, discriminant analysis to minimize Wilk's λ. The following conclusions were made from this study: 1. As to sports consciousness, the more educated and the older one was, the more one was likely to develop Recreation (or Secular) orientation. 2. Concerning sports value consciousness, the tendency toward Ascetic and Agon orientation was stronger when one was older, more schooled or one's parents had specialized occupation. As a differentiation of sports value consciousness, 60.5% belonged to Ascetic orientation, 39.5% Agon orientation, 90.6% Leisure (or Play) orientation, and 9.4% Recreation orientation. 3. In the relationship between sports consciousness and sports sense of value, such factors as the principles of discipline, training, continutiy, spiritualism, development, and concentration affected Ascetic of Agon orientation. In addition, the factors or principles of development, spiritualism, and focus on sports had an influence on Leisure or Recreation orientation.