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흉부 대동맥류에서 좌쇄골하동맥 보존을 위한 주문 제작된 천공형 대동맥 스텐트 그래프트의 치험
허 균 순천향대학교 순천향대학교 순천향의학연구소 2012 Journal of Soonchunhyang Medical Science Vol.18 No.2
Endovascular repair for thoracic aortic aneurysm is widespread and recently, the advent of new device-fenestrated stent graft enables endovascular repair for aortic aneurysm to be close or involved in the orifice of left subclavian artery. However, fenestrated stent graft is not available in Korea. We report herein a case in which endovascular repair for thoracic aortic aneurysm closed to the orifice of left subclavian artery using custom made fenestrated stent graft. The aneurysm was successfully repaired by a total endovascular approach without open surgical repair.
Mechanism of ADAM33 expression regulation in the pathogenesis of IPF.
Sung-Woo Park,Choon Sik Park 순천향대학교 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1
ADAM33 has been identifiedas a novel asthma susceptibility gene in genome-wide screening and association studies. Recently, ADAM-33 regarded as lung function gene,not asthma specific. High-level expression in smooth muscles and fibroblasts suggest that ADAM33 plays a rolenot only airway remodeling in asthmatics but may involved fibrosis of lung. The ADAM33 protein was identified in the BAL fluids of IPF(idiopathic pulmonary fibrosis) and normal controls by western blotting using antibody against the catalytic and cytoplasmic domain. In this analysis of the BAL fluids from the IPFs using ASP2 antibody, an intense band of approximately 70 kDa appeared. And, this band also appeared in the conditioned medium of primary fibroblast from IPF. When the levels of ADAM33 protein in the BAL fluids were measured by dot blotting, theirlevels were increased significantly in UIP and NSIP, as compared to normal control subjects (p= 0.003 and p=0.001, respectively). ADAM33 localization was analyzed using immunohistochemical staining of lung specimens. ADAM33 was expressed in the smooth muscles, interstitium and fibroblastic foci inalmost all the IPF, but was absent in the normal controls. ADAM33 mRNA expression are regulated by cytokines were shown using RT-PCR. This PCR-amplified product represented at predicted and up-shift size. Interestingly, up-shift product contained intron. This form is an alternative splicing form of ADAM33. More interestingly, most of this alteration is mainly in catalytic domain. IL-13,IL-4 upregulate and making alternative splicing whereas IFN-r inhibit m-RNA expression in catalytic domain. Using western blotting, we confirmed that ADAM33 protein regulated by this cytokines, too. In conclusion, the levels of soluble ADAM33 protein are related to IPF severity and ADAM33 expression are regulated by cytokines such as IL-4, IL-13.
Five-Year Incidence of NIDDM Among the Periodic Health Examinees
Joo Ja Kim,Kyung Jae Lee 순천향대학교 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1
OBJECTS --- To investigate the incidence rate of NIDDM in the cohort subjects. METHODS --- The cohort subjects were the examinees for regular check-up at yearly base. Total 484 subjects who had initially no past history for diabetes mellitus and fasting blood sugar less than 140 mg/dl were selected and followed-up for 5 years. The subjects were divided into 3 subcohort groups (normal, IGT-I, IGT-II). And also changes of the level of fasting and 1 hour postprandial blood sugar, risk factors, behavioral factors were investigated. RESULTS --- The incidence rate of NIDDM was 4.8% (5.2% in male, 3.0% in female) after 5 year follow-up. But the incidence rates were 0.3% in Normal group, 6.3% in IGT-I group, 63.2% in IGT-II group. The incidence rate was sharply increasing in the level of the fasting blood sugar 100.0-109.9 mg/dl group (from 0.6% to 4.6%), and in the level of the 1 hour postprandial blood sugar 200.0-219.9 mg/dl group (from 1.4% to 2.4%). Among the risk factors, age, fasting blood sugar, 1 hour postprandial blood sugar, relative body weight, triglyceride, total cholesterol were increasing according to the subcohort groups and also during follow-up periods. CONCLUSIONS --- The incidence rate of NIDDM was very high in Korea. More intensive interventions (such as screening, health education etc.) are needed to the IGT-II group. The cutoff levels recomended for intensive interventions were 100.0 mg/dl for fasting blood sugar and 200.0 mg/dl for 1 hour postprandial sugar.
아메드 밸브 삽입술 후 장치의 노출에 대해 보존 대퇴근막 이식으로 치료한 1예
박가희,하승주 순천향대학교 순천향의학연구소 2011 Journal of Soonchunhyang Medical Science Vol.17 No.2
We report one case of implant plate exposure after Ahmed valve implantation, treated with preserved fascia lata transplantation. Exposure of implant occurred in 47-year-old patient with Ahmed glaucoma valve implantation. She was treated with preserved fascia lata graft and amniotic membrane transplantation. No recurrent implant plate exposure has been found since then. Intraocular pressure has been maintained well for 3 months of follow-up. In cases of implant plate exposure, additional preserved fascia lata graft and amniotic membrane transplantation can improve surgical success.