정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도시 개발에 따른 기상장 변동의 3차원 수치해석에 관한 연구

이희철,이범주,이도훈,이은태 경희대학교 산학협력기술연구원 1999 산학협력기술연구논문집 Vol.5 No.-

네이티브 광고의 브랜드 및 제품 노출이 수용자의 광고 인지와 태도, 공유 의도에 미치는 영향

이수범(Lee, Soo?Bum),송민호(Song, Min?Ho),문원기(Moon, Won?Ki),신명희(Shin, Myoung?Hee) 한국광고홍보학회 2016 광고연구 Vol.0 No.111

본 연구는 60명을 대상으로 아이트래킹과 실험연구를 병행하여 네이티브 광고의 효과를 파악하기 위해 네이티브 광고에 대한 인지, 수용자 태도, 공유 의도를 검증하였다. 구체적으로 네이티브 광고를 콘텐츠와 브랜드 및 제품의 노출 형태(직접 노출/간접 노출)를 고려하여 두 유형의 네이티브 광고에 대한 시각적 주의가 피험자들의 광고 인지에 미치는 영향을 비교하였다. 또한 두 유형의 네이티브 광고에 대한 태도(콘텐츠 태도, 브랜드 태도, 공유 의도)를 측정하여 각 유형에 따른 차이를 비교하였다. 분석결과, 직접 노출 형태의 네이티브 광고의 구성 요소 중 콘텐츠 본문에 브랜드 관련 문구를 포함하였을 때 피험자들의 광고 인지에 긍정적인 영향을 미치는 것으로 나타났다. 또한 각 노출 유형별 콘텐츠 태도의 차이는 유의미하지 않았으나, 직접 노출일 때 브랜드 태도가 더 호의적인 것으로 나타났다. 마지막으로 직접 노출일 때 네이티브 광고의 공유 의도는 상대적으로 높게 나타났다. 이러한 결과를 종합하여 네이티브 광고 제작을 위한 실무적 제언을 담았다. This study explored the effects of native advertising on readers’ recognition, attitude, and sharing intention. This study used both quasiᐨexperiment and eyeᐨtracking for 60 participants to analyze advertising effectiveness (Attitudes toward contents/brands, and sharing intention) of two types native advertisements such as brand exposure (direct/indirect). According to the result of this study, direct exposure type ads had a high advertisement recognition that included brand wording in ad contents. In addition, there was no significant difference of attitudes toward contents among each ad types but direct exposure type ads had more favorable brand attitude than indirect type ads. Finally, this study also showed that the sharing intention of direct exposure type ads were higher than indirect type ads. Based on the findings, this study provided a practical implication for the production of native advertising.

계지의 항염 효과에 관한 연구

박히준,이지숙,이재동,김남재,표지희,강전모,최일환,김수영,심범상,이제헌,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : Cinnamomi Ramulus (CR), the young twing of Cinnamomi loureirii nees, has been used for treating symptoms related to pain. rheumatic arthritis and inflammation in Korean herb medicine. This study was carried out to investigate the anti-inflammatory effect of CR in vivo and in vitro. Methods : Extracts of CR were prepared and the chemical components of the extracts were examined by gas chromatography-mass spectrometry (GC-MS). The extracts were administrated to the rat paw edema model induced by carrageenan to evaluate the anti-inflammatory effect of CR. The expressions of nitric oxide (NO). prostaglandin E2(PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were also quantified in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages to survey the effect of CR in vitro. The main components were cinnamaldechyde and coumarin. Results : We examined the anti-inflammatory activity of the 80% ethanol extract of Cinnamomi Ramulus in vivo by using carrageenan-induced rat paw edema model. Maximum inhibition of 54.9% was noted at the dose of 1000㎎/㎏ after 2 hours of drug administration in carrageenan-induced rat paw edema and this showed a potent anti-inflammatory effect. Conclusions : The results showed that Cinnamomi Ramulus suppressed dose-dependently LPS-induced NO production in RAW 264.7 macrophages and also decreased iNOS protein expression. Cinnamomi Ramulus also showed a significant inhibitory effect in LPS-induced PGE2 production and COX-2 expression.

수소 자기 공명 분광 영상으로 확인된 후두엽성 중첩성 복합 부분 간질에 의한 뇌신경 세포의 손상

서범천,김옥준,김현숙,최철희,김서현,이병인 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

조환에서 "거꾸로 매달리기"를 "어깨 바꾸어 팔뻗쳐 매달리기"로 바꾸는 동작에 관하여

이희범 군산대학교 1969 群山水産專門大學 硏究報告 Vol.3 No.1

At the rings, on the steps changing downward hanging into heaving hanging with other circulated shoulder, the result upon the principle of anatomical and dynamic analysis was obtained. 1.The center of gravity in the mid-step related to the main step was applied by cleans of the physical element. 2.In order to make out the limit of mobility; the motion domain and axis, and the pliability of three joints such as wrist, elbow and shoulder were examined. 3.The skeletal muscle was especially observed and the ether which is related are little mentioned. 4.To take a harmomy with the strength the main step was established through a circuit and strict training.

폐 내 병변으로 인한 소아 급성 호흡부전의 원인 질환과 예후

이혜영,박지숙,최희라,서지현,김점수,임재영,최명범,박찬후,우향옥,윤희상 대한소아과학회 2004 小兒科 Vol.47 No.5

수도권 지역 대학병원과 재활병원의 인턴물리치료사간 인턴 만족도 비교

강순희,전수진,정민현,정은송,이범승,최용진 韓國交通大學校 2013 한국교통대학교 논문집 Vol.48 No.-

The purpose of this study was to compare internship satisfaction of intern physical therapists working in the university hospitals with that of them working in the rehabilitation hospitals in Seoul metropolitan area. The questionnaire for internship satisfaction survey that amended from vocational interest test [Strong Interest Inventory(SII)] was used to examine satisfaction of intern physical therapists and the questionnaire was used to ask general characteristics, educational and work environment. Thirty nine intern physical therapists working in university hospital and fifty nine intern physical therapists rehabilitation hospital in Seoul metropolitan area responded. Frequency analysis, χ² test and independent t-test were conducted to evaluate differences between groups about variables of internship satisfaction survey, general characteristics, work and educational environments with using the PASW 18.0 statistical program. The results of the study were as follows. There were significant differences of intern physical therapists between university hospitals and rehabilitation hospitals in overall scores of internship satisfaction and scores of all sub-items such as duty, supervision, working condition, work mates and wages. Intern physical therapists working in the university hospitals showed higher satisfaction than that of Intern physical therapists working in the rehabilitation hospitals.

교재용 사교춤의 영상자료 제작(1집)

이희범 홍익대학교 1999 弘大論叢 Vol.31 No.-

The purpose of this production of video materials was to offer not only a opportunity as a lifetime exercise with right posture and attitude but also step up to dance more easily. This material was made for as a teaching material for college students to have an experience healty dance culture. So, it was made not fortraining professional people or showing audience. it was produced for students enjoying themselves simplily easily. Especially, dancing is a beneficial activity which can provide healthy body, joyful, self-confidence and self admiration among many recreational programs. In this study, origin of dance, history of ballroom dance, popularization process, changes of 19th century dances, jazz music and dance, developxent of dance and roles of church and lastly practice of ballroom dance were explained. In this video, 8 kinds of ballroom dance were showed; waltz, polka, tow-step, jive(jitterbug or swing), samba, fox-frot, and tango. xveryonyone could be aearned easily through the tapeexplanation.

12주간의 써키트 웨이트트레이닝이 중ㆍ장년기 남성의 건강관련체력에 미치는 영향

이규성,김문희,오경택,김범수 한국체육대학교 체육과학연구소 2000 韓國體育大學校附屬 體育科學硏究所論文集 Vol.19 No.1

The purpose of this study is to examine the change of health related physical fitness. The study conducted the experiment with 24 participants; three groups fo eight participants in each age group(40, 50 and 60's) The subjects are members of the G sports center. The results of this study are as followed. According to comprehensive results of the research, circuit weight training for 12 weeks appears to give a positive effects on middle aged men's health, and that large increase in body fat and lower strength is not an unavoidable result of aging but the result of an unhealthy life style. Putting the proper training for the middle-aged group into systematic and regular practice, exercise can delay the normal aging process and also maintain relative good health physiologically. I think we need to develop more rational and scientific exercise programs to build up physical strength and improve health.