TNF-α로 유도된 혈관내피세포의 혈관염증에 미치는 오적산(五積散)의 억제 효과

한병혁 ( Byung Hyuk Han ),윤정주 ( Jung Joo Yoon ),김혜윰 ( Hye Yoom Kim ),안유미 ( You Mee Ahn ),홍미현 ( Mi Hyeon Hong ),손찬옥 ( Chan Ok Son ),나세원 ( Se Won Na ),이윤정 ( Yun Jung Lee ),강대길 ( Ho Sub Lee ),이호섭 대한본초학회 2018 大韓本草學會誌 Vol.33 No.4

Objectives : Ojeoksan, originally recorded in an ancient Korean medicinal book named “Donguibogam” and has been used for the treatment of circulation disorder of blood which was called blood accumulation (血積) in Korean medicine. Therefore, this study was carried out to investigate the beneficial effect of OJS on vascular inflammation in HUVECs. Methods : We evaluated the effect of OJS on the expression of cell adhesion molecules and protective role in HUVEC stimulated by TNF-α by using Western blot. Results : Pretreatment with OJS decreased the adhesion of HL-60 cells to TNF-α-induced HUVEC. OJS suppressed TNF-α-induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and endothelial cell selectin (E-selectin). Moreover, OJS significantly decreased TNF-α-induced production of intracellular reactive oxygen species (ROS); and inhibited the phosphorylation of IκB-α in the cytoplasm compared to the experimental group. Pretreatment with OJS inhibited the trans-location of NF-κB p65 to the nucleus. OJS also inhibited phosphorylation of MAPKs compared to the experimental group. OJS significantly increased the protein expression of Nrf2 and HO-1. Conclusions : Ojeoksan has a protective effect on vascular inflammation, and might be a potential therapeutic agent for early atherosclerosis.

전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.

機械 構造用鋼(SM45C)의 彈塑性破壞試驗時 AE에 의한 破壞特性 硏究

安秉旭,曺萬鎬 大田産業大學校 1994 한밭대학교 논문집 Vol.11 No.0201

The estimation of elasto-plastic fracture toughness [J_IC] is nessary for design and manufacturing of machine and structure. In this study, R-curve method are used to detect the onset of crack extension of SM45C. In addition to the these moth(14 an Acoustic Emission(AE) method is used for the present investigation. As the result of the test. the following results were obtained. Acoustic Emission method is economic and reliable method for identifying the fracture mechinism using sincle specimen J_IC estimation. AE mathod can find accurately the signal of the crack initation point. The J_IC value method by Acoustic Emission method was less that using ASTM method.

양측 쇄골하동맥 및 양측 신동맥 협착을 동반한 Takayasu 동맥염 1예

임선호,임수빈,오석규,이재홍,정진원,박양규,박옥규,소병준,노병석 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

자기권 서브스톰 확장기의 극전리층의 전자기적 특성

安炳鎬 경북대학교 과학교육연구소 1993 科學敎育硏究誌 Vol.17 No.-

Vatious electodynamic quantities in the polar ionosphere during the early phase of the magnetospheric substorm which occurred at 1850 UT on April 1, 1986 are estimated through the KRM method (Kamide et al., 1981). The ground magnetometer data from a total of 75 norhern hemisphere stations and the ionospheric conductivity distribution inferred from simultaneous auroral images taken from the Viking satellite (Robinson et al., 1989) are utilized. Since the Scandinavian and Russian chains of magnetometers were located in and near the midnight the Scandinavian and Russian chains of magnetometers were located in and near the midnight sector during this time interval and the inferred conductivity distribution was an instantaneous one, it provides us a unique opportunity to examine some longstanding ambiguities associated with spatial and temporal variations of substorm electrodynamic parameters over the midnight sector. Several important results obtained from this study are summarized as follows: (1) During the growth phase of the substorm no appreciable intensification of either ionospheric current or electric field is noticed. Both quantities began to increase only with the initiation of the substorm expansion phase. (2) During the expansion phase the enhanced electric field seems to play as important role as enhanced conductivity does in intensifying the DP-1 current system. (3) The global Joule and particle heating rates are very small and quite comparable with each other until the onset. But the former shows a marked intensification while the latter increases moderately during the expansion phase of the substorm, indicating that the Joule heating is more effective than particle heating in dissipating the solar wind-magnetosphere coupling energy over the auroral latitudes.

國內産 山野草의 化學的인 組成 : 第1報 南方型 草種에 對하여 Ⅰ. Chemical Composition of Southern type herbages

安炳弘,金丙鎬,韓仁圭 진주농과대학 1970 진주농과대학 연구논문집 Vol.- No.9

國內産 山野草의 一般成分을 調査하기 위하여 本試驗을 實施했는 바 그 結果는 다음과 같다. 1. 禾本科野草의 6月 以後의 固形物含量은 90% 以上이었다. 2. 禾本科野草의 蛋白質含量은 平均 10% 內外인데 時期가 지날수록 相當히 感少되었다. 3. 禾本科野草의 粗纖維含量은 平均 31.5% 內인데 時期가 지날수록 漸次 增加되었다. 4. 禾本科野草의 脂肪, 灰分 및 NFE 含量은 大體로 年中 비슷한 含量이었다. 5. 荳科野草의 6月 以後의 固形物 含量은 91% 以上이었다. 6. 荳科野草의 蛋白質含量은 平均 17% 內外인데 時期가 지날수록 漸次 感少되었다. 7. 荳科野草의 粗纖維含量은 平均 29% 정도인데 時期가 지날수록 漸次 增加되었다. 8. 荳科野草의 脂肪, 灰分 및 NFE의 全量은 大體로 年中 비슷한 含量이었다. 9. 차풀의 蛋白質은 平均 14%정도였다. To investigate the chemical composition of native herbages in korea, this experiment was carried out. The results obtained here are as follows: 1. The contents of dry matter in the wild grasses after June was above 90%. 2. protein contents in the wild grasses was approximately 10% and that of protein decreased as the stage of maturity progressed. 3. The contents of crude fiber in the wild grasses was 31.5% on an average and that of crude fiber increased considerably as the stage of maturity advanced. 4. But, the contents of fat, ash and NFE in the wild grasses did not highly changed through the year. 5. The contents of dry matter in the wild legumes after June was above 91% approximately. 6. protein contents in the wild legumes was higher than 17% but that of protein decreased progressively as the stage of maturity advanced. 7. The contents of crude fiber in the wild legumes was 29% on an average and that of crude fiber increased considerably as the stage of maturity progressed. 8. However, the contents of fat, ash and NFE in the wild legumes did not highly changed through the year. 9. The contents of protein in the Cassia nomame was 14% approximately.

銀河의 分類와 進化

安炳鎬,金敬益 경북대학교 1978 논문집 Vol.10 No.-

There are many kinds of galactic classification schemes, but none of these shows a clear evolutionary sequence of galaxies. In order to examine possible evolutionary sequences, the published classification schemes were compared with each other, and particularly the properties of SO and Irregular galaxies were examined. From the comparision of the well known four classification schemes and observed properties of galaxies, a new classification scheme which suggests three possible evolutionary sequences is presented; that is, Irregular S evolves to SO galaxies either through normal spirals and anemic spirals or through barred spirals and anemic spirals, and Irregular E evolves to elliptical galaxies directly. In this new galactic classification scheme two new types of galaxies are introduced to make the continuity of classification sequence. One of these is Irregular E, which is considered as an incipient type of elliptical galaxies and the other type is Irregular S, which is considered as the beginning type of spiral galaxies. These two galactic types, which are considered as a little evolved stage from protogalaxy, are different from the ordinary irregular types of Hubble, Sandage and de Vaucouleurs, and also their initial physical conditions are different from each other.

1990년대 평생교육 정책에 관한 고찰

안병환,이영호 대진대학교 1998 大眞論叢 Vol.6 No.-

This study analyzes the policy of Lifelong education in 1990's. Especially, in order to explore the direction of policy, it is focused on the problems of bachelor's degree examination for the self-educated, credit account system. In addition, it is examined difference between social education act and life-long education act, and the major cotents of life-long education act in order to suggest the orientation of life-long education policy.

雙曲線軌道를 運行하는 星團의 潮汐에너지 獲得(Ⅱ)

安炳鎬,金敬益 慶北大學校 1978 論文集 Vol.25-26 No.-

Tidal energy gains of a star cluster moving along various orbits around the galaxy were examined by many authors. In this paper, we derive the expression for the tidal energy gain taking account of the effects of a two- body orbit and internal motion of the cluster. (ⅰ) We show that the expression obtained for the gain of internal energy of a star cluster on the assumption of impulsive approximation does not differ from that obtained by Spitzer for the uniform rectilinear motion within a factor of 2. (ⅱ) We derive the expression for the tidal energy gain of a star cluster more explicitly in the case of slow encounter.

자동차 폐촉매의 재활용을 위한 재생방법에 관한 연구

안호근,최병민,김병훈 順天大學校 1999 論文集 Vol.18 No.1

The recovery of the platinum group metals on the spent automotive catalysts is economically very important because of their high value and stable supply, but the spent autocatalysts still keep the inherent oxidation activity. The regeneration method was studied by treating with various acid solutions and/or air stream, the regenerated activity was investigated in the ethylene oxidation in a flow reactor. The oxidation activity showed maximum at 0.01vol% HNO₃solution, and was decreased with increasing the HNO₃concentration because the active metals or supports were dissolved into acid solution. Also, the activity was enhanced with increasing the air treatment temperature, and decreased at higher temperature than 300℃. The maximum activity was obtained at 300℃. Therefore, the oxidation activity of the spent autocatalysis could be effectively regenerated by the treatment of nitric acid solution and air stream.