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RNA Metabolism in T Lymphocytes
최진욱,함정현,황수석 대한면역학회 2022 Immune Network Vol.22 No.5
RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during T cell phase transition. Thymic selection, quiescence maintenance, activation, differentiation, and effector functions of T cells are dependent on selective RNA modulations. Recent technical improvements have unveiled the complex crosstalk between RNAs and T cells. Moreover, resting T cells contain large amounts of untranslated mRNAs, implying that the regulation of RNA metabolism might be a key step in controlling gene expression. Considering the immunological significance of T cells for disease treatment, an understanding of RNA metabolism in T cells could provide new directions in harnessing T cells for therapeutic implications.
하악골의 불연속 결손부 재건 시 비혈행화 장골이식술의 골흡수율에 관한 연구
최진욱,이충오,황희돈,김진욱,권대근,김진수,이상한,Choi, Jin-Wook,Lee, Chung-O,Hwang, Hee-Don,Kim, Jin-Wook,Kwon, Tae-Geon,Kim, Chin-Soo,Lee, Sang-Han 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.6
Purpose: Mandible resection and discontinuity defect created lead to aesthetic and functional problems. The iliac crest bone graft exhibits relative ease for bone harvesting, possibility of two team approach, ability to close the wound primarily, large amount of corticocancellous bone and relatively few complications. Whereas the use of free vascularized flaps has donor site morbidity and worse-fitting bone contour, the use of nonvascularized iliac bone graft has advantages in the operation time and patients' recovery time. So, nonvascularized iliac bone graft could be an attractive option. Methods: Twenty-one patients (M:F=1:1.1) underwent iliac crest bone harvesting for reconstruction of mandibular discontinuity defect (mean length : $61.6{\pm}17.8$ mm), from May 2005 to October 2011 at the Department of Oral and Maxillofacial Surgery in Kyungpook National University. The average age was $44.1{\pm}16.4$ years and the mean follow up periods was $28.2{\pm}22.7$ months. Bone resorption rate, according to age, sex, primary lesion, location and distance of defect, type of fixation plate, time of graft and pre-operative radiation therapy, were measured in each patient. Results: The mean bone resorption rate was $16.1{\pm}9.0%$. Bone resorption rate was significantly increased in mandibular defect that is over 6 cm in size (P=0.015, P<0.05) and the cases treated pre-operative radiation therapy (P=0.017, P<0.05). All was successfully fixed and maintained for the long-term follow-up. There were a few donor site complications and almost all patients were shown favorable outcome without severe bone resorption in this study. Conclusion: The nonvascularized iliac bone graft seems to be a reasonably reliable treatment option for reconstruction of mandibular discontinuity defects.
해외건설 수주경쟁력 향상을 위한 ODA (Official Development Assistance) 활용방안
최진욱,김재준,이한승,전낙근,Choi, Jin-Wook,Kim, Jae-Jun,Lee, Han-Seung,Jeon, Rak-Keun 한국건설관리학회 2007 건설관리 : 한국건설관리학회 학회지 Vol.8 No.5
The domestic construction market is recently daunted because of the sustainable real estate regulation policy by the government. In other aspect, after the WTO(World Trade Organization)system opened overseas construction is growing continuously with grow of international economy and opening of market through world. Therefor needs to establish strategy on expansion or over seas construction competitive power. The purpose of this research is expansion on over seas construction competitive power by suggesting project cost guarantee methods to Owner and cost guarantee methods are Official Development Assistance(ODA). Accordingly, this research analyzed a developed $country^{\circ}{\phi}s$ ODA and domestic ODA. Moreover, survey to Expert of related field about over seas construction and ODA for identified problems. Especially, based on the results it intends to analyzed domestic ODA competitive power and improve strategy to competitive power of receive an order on over seas construction. 정부의 지속적인 규제 정책으로 인해 국내 건설시장은 위축되어 있는 반면 해외 건설시장은 꾸준한 성장세를 보이고 있고, WTO(World Trade Organization)체제 출범 이후 국제적인 개방화가 가속되고 있다. 따라서 우리나라의 해외건설도 과거의 단순 입찰방식을 지양하고 해외건설 수주경쟁력 확대를 위한 전략 수립이 필요한 실정이다. 본 연구는 해외건설 분야에서 사업초기에서부터 발주처에게 프로젝트의 재원확보 방안을 제시함으로써 수주경쟁력을 증대시키는 것을 연구의 주제로 삼았으며 재원확보 방안으로 양허성(원조성격)을 지닌 공적개발원조(ODA)를 대상으로 하였다. 본 연구에서는 선진국 및 우리나라의 공적개발원조를 분석하고, 관련 분야 전문가를 대상으로 해외건설 및 공적개발원조에 대한 설문조사를 실시하여 현황 및 문제점을 알아보았으며, 이를 바탕으로 우리나라 공적개발원조의 경쟁력을 분석하고 해외건설 수주경쟁력 확대를 위한 전략을 제안하였다.