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조미연,이광길,이기범,정현주,정우희,Cho, Mee-Yon,Lee, Kwang-Gil,Lee, Kyi-Beom,Jeong, Hyeun-Joo,Jung, Woo-Hee 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.1
We present the cytologic features of a case of solid and papillary neoplasm of the pancreas. Cytologically, the tumor was composed of a monotonous population of polygonal cells containing eccentrically located round nuclei with one or two distinct small nucleoli and a finely stippled chromatin pattern. The tumor cells were similar to those of the islet cell tumor and showed isolated loosely aggregated and solid sheets or large cell clumps. The large cell clumps revealed a branching papillary structure containing fibrovascular central core, which is characteristic histologic feature of solid and papillary neoplasm of the pancreas. This case was confirmed by tissue examination including histochemical, immunohistochemical and electron microscopical studies. Ultrastructurally, the tumor cells contained a few membrane- bound electron dense granules.
악성 흉선종의 세침흡인 세포학적 소견 - 침윤성 흉선종 2례와 흉선암종 2례 -
조미연,박영년,이광길,Cho, Mee-Yon,Park, Young-Nyun,Lee, Kwang-Gil 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.1
We report 4 cases of malignant thymoma which were composed of 2 cases of invasive thymoma and 2 cases of thymic carcinoma. The cytologic findings of invasive thymoma were similar to those of benign thymoma. The distinctive cytologic features of thymic carcinoma were necrotic background, irregular clusters and individually scattered arrangement of anaplastic epithelial cells, and some scattered mature small lymphocytes. These findings may be found in the Hodgkin's lymphoma, seminoma, and metastatic squamous ceil carcinoma, undifferentiated carcinoma, and large ceil carcinoma of the lung. But, the feature of irregular clustering of anaplastic epithelial cell haying scanty cytoplasm was different from Hodgkin's lymphoma and seminoma. Clinical and radiologic findings as well as cytologic finding were helpful in differential diagnosis of thymic carcinoma from metastatic carcinoma.
늑골에 발생한 맥관육종의 세침흡인 세포학적 소견 - 1예 보고 -
김희정,조미연,정순희,이광길,Kim, Hee-Jung,Cho, Mee-Yon,Jung, Soon-Hee,Lee, Kwang-Gil 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.2
Angiosarcoma of the bone is rare with an incidence of 0.13%. It may be solitary or multiple. Its cytologic findings by FNA have rarely been reported. We report a case of angiosarcoma of the rib in a 66 year-old man. FNA revealed single or clusters of round to oval shaped cells in a hemorrhagic and myxoid background. The large central nuclei had irregular nuclear membrane, chromatin clumping and prominent nucleoli. The cytoplasm was scanty with an eosinophilic distinct cytoplasmic border. Erythrophagocytosis by malignant cells was also found. Histopathologic examination confirmed the diagnosis of angiosarcoma revealing irregular and complex anastomosing vascular channels lined by malignant round tumor cells, protruding into the lumen. Immunohistochemical staining revealed diffuse strong positive reaction to factor VIII-related antigen and CD31.
경추에 발생한 척삭종의 세침흡인 세포학적 소견 - 1예 보고 -
양경무,조미연,정순희,봉정표,Yang, Kyung-Moo,Cho, Mee-Yon,Jung, Soon-Hee,Bong, Jeong-Pyo 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1
A case of cervical chordoma diagnosed by fine needle aspiration is discussed. A 41year-old male was admitted due to dyspnea on neck flexion. Radiologic image revealed a retrotracheal superior mediastinal solid mass. Aspiration cytology showed many clusters of oval or large polygonal cells having abundant eosinophilic or bubbly cytoplasm in an amorphous blue-gray mucoid background. The nuclei were round and showed size variation, coarse granular chromatin, and indistinct nucleoli. Some cells contained brown granular pigments in the cytoplasm. Mitoses were rarely found. The cytoplasm was strongly positive for PAS stain. Immunohistochemical stains using cell block revealed positive reaction for cytokerain, EMA, vimentin, and S-100 protein. The confirmative diagnosis was made by following excisional biopsy. Electron microscopic study revealed large pools of intracytoplasmic glycogen and microfilaments. This is the first case of cervical chordoma diagnosed by aspiration cytology to our knowledge in Korean literature.
김건욱(Kuhn Uk Kim),조미연(Mee Yon Cho),조남천(Nam Cheon Cho),윤광수(Kwang Soo Yoon),김대성(Dae Sung Kim),노병선(Byoung Seon Rhoe) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
Adenosquamous carcinoma of the pancreas has a mixture of adenocarcinoma and squamous cell carcinoma components and is uncommon. We presents one case of adenosquamous carci- noma of the pancreas in old man aged 76. His chief cornplains were intermittent abdorninal discomfort and pain. Physical examination revealed huge abdominal mass in left upper quad- rant abdomen. All laboratory data were not significant. Abdominal ultrasonography and CT scan revealed a well demarcated cystic and solid mass which was located at the tail of the pancreas. Successful resection of the tumor by splenectomy, total gastrectomy and segmental resection of transverse colon were carried out. Cut section of the resected specimen reveals a huge cyst locating between the serosal surface of the stomach and pancreas and an oval round solid mass with infiltrating margin of the distal pancreas. Histopathologically, the tumor was composed of adenocarcinorna, well differentiated squamous cell carcinoma and anaplastic car- cinoma with transition areas. The cyst was partly lined by mesothelial cells and poorly differentiated squamous cell carcinoma. The patient was discharged without specific prob- lem. But he died 6 months after operation.(Korean J Gastroenterol 1994; 26: 885 891)
이동성 홍반의 피부 병변으로 내원한 환자들에 대한 고찰
오윤석 ( Yoon Seok Oh ),엄민섭 ( Min Seob Eom ),조미연 ( Mee Yon Cho ),김종배 ( Jong Bae Kim ),최응호 ( Eung Ho Choi ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.5
Background: Lyme disease, an infection caused by Borrelia(B.) burgdorferi, has been reported in many countries. But in Korea, only 5 cases of serologically diagnosed lyme disease have been reported. Because several strains of B. burgdorferi were isolated from Ixodes ticks which were captured in Kangwon and Chungbuk province, there might be more cases of serologically undiagnosed lyme diseases presenting with erythema migrans. Objective: To understand the clinical patterns and laboratory findings of erythema migrans in Korea. Methods: A clinical survey was retrospectively performed on 9 patients with erythema migrans which occurred after tick bites. Results: Among 9 patients with erythema migrans, 3 patients were male and 6 patients were female. The onset age of erythema migrans ranged from 26 to 71 years old (mean, 51.3 years old). The mean duration of erythema migrans after tick bite was 26.4 days and the diameter of the lesion ranged from 6 to 34 cm (mean, 18.3 cm). All cases developed from May to September and systemic symptoms such as fatigue, fever and/or chills, myalgia, palpitation, headache, arthralgia and dyspnea were present at the time of hospital visits of 3 patients. Clinically, 3 patterns of erythema migrans were seen; typical target pattern, homogenous and erythematous plaque pattern, and linear solitary plaque pattern with central postinflammatory pigmentation. Only 2 of the 7 patients (28.6%) were seropositive for IgM and IgG antibody titers by enzyme-linked immunosorbent assay in consecutive serologic tests. PCR for Borrelia DNA in paraffin-embedded tissue showed full negativity in 6 patients with erythema migrans. Conclusion: Although lyme disease is not endemic in Korea, some patients with erythema migrans might be undiagnosed as lyme disease serologically with erythema migrans. To take into consideration false negative serelogic results in early erythema migrans, early oral tetracycline therapy should be included through clinical and historical diagnosis. (Korean J Dermatol 2008;46(5):596∼603)
황성관,박희전,윤여승,나중호,오진록,김기호,김동진,양경무,조미연,Hwang, Sung-Kwan,Park, Heui-Jeon,Yoon, Yeo-Seung,Rha, Jung-Ho,Oh, Jin-Rok,Kim, Ki-Ho,Kim, Dong-Jin,Yang, Kyung-Moo,Cho, Mee-Yon 대한근골격종양학회 1998 대한골관절종양학회지 Vol.4 No.1
Osteosarcoma is the most common primary bone tumor except for multiple myeloma. Hematogenous spread of osteosarcoma presents the t1susal route of dissemination. Lung metastasis is the most common, however the lymph node involvement is quite rare. In addition, according to Mirra, radiologically detectable involvement of lymph node is an extremely rare manifestation of osteosarcoma. The authors had experienced a patient with an osteosarcoma of the right distal femur which spread to the right inguinal lymph node and lung. After preoperative chemotheraphy, a limb salvage operation was performed around the lesion of right distal femur and the right inguinal lymph nodes were dissected. A adjuvant postoperative chemotheraphy was performed. After the treatment, there was no recurrence of osteosarcoma or any other metastatic evidence for two years and 8 months.