Effect of Beverage Containing Fermented Akebia quinata Extracts on Alcoholic Hangover

정수한,이상훈,송영선,이서연,김소영,고광석 한국식품영양과학회 2016 Preventive Nutrition and Food Science Vol.21 No.1

The present study was conducted to investigate the effects of beverages containing fermented Akebia quinata extracts on alcoholic hangover. For this study, 25 healthy young men were recruited. All participants consumed 100 mL of water (placebo), commercial hangover beverage A or B, fermented A. quinata leaf (AQL) or fruit (AQF) extract before alcohol consumption. After 1 h, all participants consumed a bottle of Soju, Korean distilled liquor (360 mL), containing 20% alcohol. Blood was collected at 0 h, 1 h, 3 h, and 5 h after alcohol consumption. The plasma alanine transaminase (ALT) activity was highest in the placebo group. Compared with the control group, the AQL and AQF groups showed decreased ALT activity at 5 h after alcohol consumption. Plasma ethanol concentration was increased after alcohol intake and peaked at 3 h after alcohol consumption. Compared with the control group, the A group showed a higher plasma ethanol concentration at 1 h (P<0.05). At 3 h after alcohol consumption, the AQF group showed the lowest mean plasma ethanol concentration compared to the other groups; however, there were no statistical differences. After 5 h of alcohol consumption, the AQL and AQF groups showed lower plasma ethanol concentrations compared with the B group. The sensory evaluation score for the fermented A. quinata fruit extract was lower than for the commercial hangover beverages. In conclusion, the present intervention study results suggest that fermented A. quinata extracts alleviate alcoholic hangover and reduce plasma ethanol concentrations.

Cellular Antioxidant and Anti-Inflammatory Effects of Coffee Extracts with Different Roasting Levels

정수한,김민형,박재희,정윤화,고광석 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.6

During roasting, major changes occur in the composition and physiological effects of coffee beans. In this study, in vitro antioxidant effects and anti-inflammatory effects of Coffea arabica green coffee extracts were investigated at different roasting levels corresponding to Light, Medium, City, and French roast. Total caffeine did not show huge difference according to roasting level, but total chlorogenic acid contents were higher in light roasted coffee extract than other roasted groups. In addition, light roasted coffee extract had the highest antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. To determine the in vitro antioxidant property, coffee extracts were used to treat AML-12 cells. Intracellular glutathione (GSH) concentration and mRNA expression levels of genes related to GSH synthesis were negatively related to roasting levels. The anti-inflammatory effects of coffee extracts were investigated in lipopolysaccharide-treated RAW 264.7 macrophage cells. The cellular antioxidant activity of coffee extracts exhibited similar patterns as the AML-12 cells. The expression of mRNA for tumor necrosis factor-alpha and interleukin-6 was decreased in cells treated with the coffee extracts and the expression decreased with increasing roasting levels. These data suggest that coffee has physiological antioxidant and anti-inflammatory activities and these effects are negatively correlated with roasting levels in the cell models.

Development of a clinical scoring system for appendicitis in children with presumed appendicitis

정수한,정진희,곽영호,김도균,정재윤,이진희,권혁술,박중완 대한소아응급의학회 2018 대한소아응급의학회지 Vol.5 No.2

Purpose: To develop a clinical scoring system for children with presumed appendicitis who visit the emergency department. Methods: A registry based-retrospective study was conducted in the pediatric emergency department between September 2015 and December 2016. Patients aged 4 to 17 years who had a > 1 of 5 Likert scale for possibility of appendicitis were included. Multiple logistic regressions based on Akaike information criterion were performed using variables regarding clinical features and inflammatory markers to develop the clinical scoring system. Results: A total of 233 patients were included, and 93 (39.9%) had the final diagnosis of appendicitis. The final model with the lowest Akaike information criterion (171.7) consisted of 5 variables, including vomiting (1 point), absence of watery diarrhea (1 point), duration of symptoms ≤ 3 days (1 point), rebound tenderness (1 point), and white blood cell count > 10.0 × 109/L (2 points). If the clinical score was ≥ 4 of 6 points, the area under the receiver operating characteristic curve was 0.78 (95% confidence interval, 0.71-0.86) with a 78.9% sensitivity, 66.7% specificity, positive and negative predictive values of 70.0% and 76.2%, respectively, and positive and negative likelihood ratios of 2.4 and 0.3, respectively. Conclusion: The 5-item clinical scoring system shows a fair performance for prediction of pediatric appendicitis. This simple tool could be applied to predict the pediatric appendicitis, and to avoid the use of potentially unnecessary computed tomography.

안경착용자의 안경착용에 대한 이미지 연구 : Q-방법론적 연구 Q-methodological Approach

정수정,정혜경,김경희,권혜진 韓國學校保健學會 1999 韓國學校保健學會誌 Vol.12 No.1

This study attempts to identify the self-image of eyeglass wearers with Q-methodology. Preliminary Q-statements were collected through personal and telephone interviews and based in consultation with reference books, eyeglass wearers, an optician and an oculist. Finally,34 Q-samples were seleted. The results were analyzed by a Q-factor with a PC QUANL Program. The sell-image of eyeglass wearers were found to revolve around three types: Type 1. They feel that eyeglasses have a negative inf1uence on image and that they uncomfortable. In addition, other people have a negative bias toward people who wear eyeglasses. As a result of these negative prejudices and inconveniences, there is a tendency to wear contact lens or have laser operations. Type 2. They feel less uncomfortable comparatively', when explained that classes can help improve their image. When explained as a fashion accessory, negative prejudices almost disappeared. Type 3. They show a positive reaction when explained that spectacles are also rosed for sight protection. However, they are sensitive to changes in their complexion as a result of eyeglass wear and place much importance in the design of glass frames. The significance of this study is to suggest basic data for a mediation device that improve the image of eyeglass wearers discovery and analysis of these three types.

주성분분석을 이용한 사면의 위험성 평가

정수정,김용수,김태형 한국지반공학회 2010 한국지반공학회논문집 Vol.26 No.10

To detect abnormal events in slopes, Principal Component Analysis (PCA) is applied to the slope that was collapsed during monitoring. Principal component analysis is a kind of statical methods and is called non-parametric modeling. In this analysis, principal component score indicates an abnormal behavior of slope. In an abnormal event, principal component score is relatively higher or lower compared to a normal situation so that there is a big score change in the case of abnormal. The results confirm that the abnormal events and collapses of slope were detected by using principal component analysis. It could be possible to predict quantitatively the slope behavior and abnormal events using principal component analysis.

서브 클러스터 기법을 이용한 효과적인 USN 라우팅 프로토콜

정수형(Jeoung, Su-Hyung),유해영(Yoo, Hae-Young) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.6

USN 환경에서 제안된 라우팅 프로토콜 중에서 PEGASIS 프로토콜은 LEACH 프로토콜과 비교해 볼 때 노드의 에너지 소비량 감소에 효과적이다. 하지만, PEGASIS 프로토콜은 센서 네트워크의 특성인 BS 노드의 빈번한 변경으로 인한 센서 네트워크망 구성의 변화에 취약성을 가지고 있다. 이에 본 논문에서는 이를 해결하기 위해서 작은 단위의 클러스터 헤드를 선출해 중간노드의 역할을 하게 하고자 한다. 이를 통해 PEGASIS 알고리즘이 가지고 있는 취약점을 보완할 수 있음을 보이고 이에 대한 시뮬레이션 결과를 보인다. The PEGASIS protocol is more effective about energy consumption more than LEACH in USN environment. However, PEGASIS is weakness enemy in change of sensor network net composition because It changes BS node frequently. Therefore, we propose new routing protocol that use Sub-Cluster Chaining to solve this problem in this paper. It can reduce overhead that happen in election of middle node doing so and reduce energy consumption. Also, It can supplement limitation that PEGASIS has. This is treatise shows that new protocol that propose than existent PEGASIS through simulation is superior.

초등 수학 영재 프로그램 평가 : 서울시 A 교육청 평가 사례를 중심으로

정수지,김민경 한국초등수학교육학회 2014 한국초등수학교육학회지 Vol.18 No.1

우리나라 영재교육의 양적 성장과 더불어 영재교육 프로그램에 대한 개선과 질적 향상을 위해 초등학교 수학 영재 교수-학습 프로그램의 내용영역을 영재교육과정에서 제시하는 영역별로 살펴보고 수학 영재 교수-학습 프로그램을 기존의 평가 틀을 수정·보완하여 수정된 평가 틀을 사용하여 서울시 A 교육청에서 운영 중인 영재교육원 프로그램을 평가하였다. 그 결과 수학 영재 교수-학습 프로그램의 목표는 명확하고, 차별화 되어 있었으며, 내용영역의 편성은 심화 영역이 더 많았고, 수와 연산, 도형, 규칙성과 문제해결 영역이 주를 이루고 있었다. 내용은 심화 영역에 해당하는 부분이 많았고, 최신 연구 내용이 고르게 반영되어 있었다. 수학적 사고 전략을 고르게 사용하도록 되어 있었고, 문제해결에 대한 평가지표를 만족하였고, 창의적 사고와 수학적 태도는 대부분의 프로그램이 적절하였으며, 참고서적은 명확하게 제시된 프로그램이 없었으나 자료의 제시는 구체적이고 적절한 것으로 평가되었다. 교수-학습 방법은 문제중심학습, 협동학습으로 수업을 하고 있었으며, 평가는 수행평가를 활용하고 있었다.

전통 장류 유래 Bacillus subtilis SCJ4의 특성확인 및 통계학적 방법을 이용한 배양조건 최적화

정수지,양희종,정성엽,정도연,Jeong, Su-Ji,Yang, Hee-Jong,Jeong, Seong-Yeop,Jeong, Do-Youn 한국미생물학회 2015 미생물학회지 Vol.51 No.1

612 strains isolated from Korean traditional fermented food in Sunchang and their investigated biochemical characterization and ability of biogenic amines non-producing. We selected the SCJ4 having various activity by measurement of extracellular enzyme, antioxidant and antimicrobial activities. Selected strain SCJ4 by 16S rRNA sequencing and biochemical characterization was named Bacillus subtilis SCJ4. And then, we investigated cell growth of SCJ4, and optimized of culture medium constituents using response surface methodology as statistically method. Response surface methodology used Plackett-Burman experimental design for screening of medium constituent. Tryptone, peptone and $MgSO_4$ as medium constituent improving cell growth selected. In order to find out optimal concentration on each constituent, we carried out central composite design. Consequently, optimized concentrations of tryptone, peptone and $MgSO_4$ were predicted to be 15.35 g/L, 12.235 g/L, and 3.5 g/L respectively. Through the model verification, we confirmed about 1.28-fold improvement of the dried cell weight from 0.8767 g/L to 1.1222 g/L when compared to basal medium.

USN 환경에서 거리 가중치를 사용한 개선된 HEED 프로토콜

정수형(Jeoung, Su-Hyung),유해영(Yoo, Hae-Young) 한국산학기술학회 2009 한국산학기술학회논문지 Vol.10 No.2

최근 USN 환경에서 다양한 센서 네트워크 활용 가능성이 높아지고 있다. 하지만 기존에 제안되었던 센서네트워크 라우팅 프로토콜들이 현실적으로 어려움 점이 있다. 본 논문에서는 대표적인 계층적 라우팅 프로토콜인 HEED가 가지는 생존성과 부분 클러스터 생성의 문제를 해결하고자 에너지 거리 가중치를 사용한 개선된 HEED 라우팅 프로토콜을 제안하고자 한다. 본 논문에서 제안한 개선된 HEED 프로토콜은 기존의 HEED보다 각 노드들의 잔존 에너지양과 거리 가중치를 두어 새로운 CH를 초기에 선정하고 선출된 CH노드의 잔존 에너지양이 50%가 되는 시점을 기준으로 교체해 주는 방식을 제안하였다. 이를 통해서 클러스터 내의 모든 노드들이 에너지 소비를 공평하게 함으로써 전체 클러스터의 생존율을 약 30% 가량 향상시킬 수 있었다. 또한 CH를 교체 선출함에 있어서도 응답시간을 기준으로 기존의 CH노드와 가장 가까운 곳에 위치하는 노드로 교체하도록 하는 기법을 적용하였다. " Recently, Study for routing protocol is gone vigorously in the Ubiquitous Sensor Network. A hierarchical routing protocol is being practical and received interest among them. Therefore we analyze a weak point of HEED. And I suggest the new protocol that solved a weak point of HEED. The new protocol that we propose puts weight in the energy remainder amount than HEED and. elect CH. And elected CH is designed to change by new node when quantity of energy leftover becomes less than 50%. Therefore all nodes come to use energy fairly. The protocol that we proposed can prove the cluster survival rate about 30%. And CH is more effective because when elect CH replace, response time selects small node."

소아에서 복막투석도관 삽입시 복강경을 이용한 방법과 기존의 수술법에 따른 초기 합병증 발생의 차이

정수인,이현영,이철구,서정민,이석구,김수진,곽민정,진동규,백경훈,Jeong, Soo-In,Lee, Hyun-Young,Lee, Cheol-Gu,Seo, Jeong-Meen,Lee, Suk-Koo,Kim, Su-Jin,Kwak, Min-Jung,Jin, Dong-Kyu,Paik, Kyung-Hoon 대한소아신장학회 2007 Childhood kidney diseases Vol.11 No.1

Purpose : To assess the early complication of laparoscopic peritoneal dialysis catheter implantation in children. Methods : Medical record review was carried out on 21 laparoscopic and 16 conventional peritoneal dialysis catheter implantations which were performed in 31 children under 18 years of age between 2002 and 2006. All medical records were retrospectively analyzed. The patients were followed until 2 months after catheter placement. Patient characteristics and catheterrelated complications, such as significant bleeding, leakage, obstruction, migration, insertion site infection and peritonitis during the first 60 days after implantation were recorded. Results : After conventional operation, dialysate leakage occurred in 2 of 16 cases and all cases improved after conservative management. In 1 case, significant bleeding occurred and re-operation was performed. Three cases of obstruction due to migration were reported, 2 cases underwent reoperation and 1 case improved without intervention. After laparoscopic surgery, outflow obstruction occurred in 1 out of 21 cases, which was caused by adhesion after several reinsertions of the catheter and recurrent peritonitis. No migration was noted after laparoscopic surgery. There was no significant difference in the complication rate between the two groups. Conclusion : Laparoscopic peritoneal dialysis catheter placement is feasible in children of all age groups, with at least equivalent functional results compared to conventional surgery. The additional advantage of laparoscopic catheter insertion is the option to identify and eliminate anatomical risk factors, such as intra-abdominal adhesions, and to perform partial omentectomy without additional incisions.