호흡곤란 증후군 미숙아에서 혈중 L-arginine 농도와 Oxygenation Index 및 폐동맥압과의 관계

정경아,이순주,성인경,전정식,Jeong, Kyong Ah,Lee, Soon Ju,Sung, In Kyung,Chun, Chung Sik 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.12

Purpose : This study was performed to observe the relationship of plasma L-arginine level and the severity of disease and pulmonary artery pressure in respiratory distress syndrome of premature infants. Methods : Peripheral blood samples were obtained at 1st, 3rd and 7th day from 21 premature infants with respiratory distress syndrome to analyze the L-arginine concentration. Oxygenation index (OI), an indicator of the severity of the disease, was calculated at the same time of the blood sampling. And pulmonary artery pressure was measured by Doppler echocardiography at each period. Plasma L-arginine level, OI and right ventricular systolic time interval(RVSTI) were analyzed. Results : Plasma L-arginine concentration of the 1st day was lower than 3rd and 7th day. OI and RVSTI were significantly correlated with each other(r=0.772, P<0.01). Plasma L- arginine level was correlated with oxygenation index(r=-0.346, P<0.01) and RVSTI(r=-0.416, P<0.01). Conclusion : Plasma L-arginine level was lowest in the 1st day during the study period. Plasma L-arginine concentration correlated significantly with the severity of respiratory distress syndrome and pulmonary artery pressure in premature infants.

다낭난소증후군 진단시 복식 초음파의 유용성에 관한 연구

정경아,이운정,정혜원,Jeong, Kyung-Ah,Lee, Woon-Jeong,Chung, Hye-Won 대한생식의학회 2009 Clinical and Experimental Reproductive Medicine Vol.36 No.4

목 적: 한국 가임기 여성의 다낭난소증후군 진단시에 복식 초음파를 이용하는 방법의 유용성과 정확도를 분석하여 국내 다낭난소증후군의 진단 기준 마련에 도움이 되고자 하였다. 연구방법: 이화여자대학교 목동병원에서 선별설문조사를 받은 15~44세 여성 8,793명에서 복식 초음파를 시행한 총 701명 중, 정상 월경을 하면서 안드로겐 과다 및 초음파의 다낭난소 소견이 없는 정상 대조군에서 복식 초음파를 시행한 185명과 초음파 검사 소견을 제외하고 NIH 진단 기준으로 다낭난소증후군을 진단 받은 248명의 환자에서 복식 초음파를 시행한 소견을 ROC (receiver operating characteristic) 곡선 분석하였다. 결 과: 정상 대조군의 평균 연령은 $23.64{\pm}4.26$세로 복식 초음파로 측정된 평균 난소 부피는 $6.03{\pm}1.89\;cm^3$, 평균 난포 개수는 $6.49{\pm}1.93$개였다. 복식 초음파를 진단에 사용할 경우 난소 부피를 이용하면 AURC (area under the ROC curve)가 0.761로 난소 부피>$9\;cm^3$ 기준일 때, 민감도 51.0%, 특이도 91.4%였다. 난포 개수에 대한 AURC는 0.733으로 ${\geq}9$개 기준일 때, 민감도 54.9%, 특이도 87.0%였으며, 난포 개수 ${\geq}10$개 기준일 때, 민감도 53.2%, 특이도 90.4%였다. 복식 초음파로 난소 부피와 난포 개수를 검사하여 다낭난소증후군의 선별 진단에 이용하기에는 부적합하였다. 결 론: 복식 초음파를 이용하여 다낭난소증후군을 진단하는 방법은 유용성과 정확도에서 신뢰할만하지 못하다. Objective: The objective of the study was to determine the diagnostic performance of transabdominal ultrasound by receiver operating characteristic (ROC) curve analysis, in order to evaluate the usefulness in establishing the diagnosis of polycystic ovary syndrome (PCOS). Methods: Questionnaires were given to 8,793 reproductive women reviewed at Ewha Womans University Mokdong hospital. Ultrasound examinations were performed in 701 women with a transabdominal transducer. Transabdominal ultrasounds were performed in 185 normal control women (normal menstruation without hyperandrogenism or PCO morphology) and 248 PCOS patients according to National Institutes of Health (NIH) PCOS diagnosis criteria. ROC curves were calculated for ovarian volume and follicle number. Results: In normal control group, the mean age were $23.64{\pm}4.26$ years old and the mean ovarian volume and follicle number were $6.03{\pm}1.89\;cm^3$ and $6.49{\pm}1.93$, respectively. The ovarian volume showed an area under the ROC curve (AURC) of 0.761. A ovarian volume decision threshold >$9\;cm^3$ had a sensitivity of 51.0% and a specificity of 91.4% for the diagnosis of PCOS. The follicle number showed an AURC of 0.733. A follicle number decision threshold ${\geq}9$ had a sensitivity of 54.9% and a specificity of 87.0% for the diagnosis of PCOS. A follicle number decision threshold ${\geq}10$ had a sensitivity of 53.2% and a specificity of 90.4%. A follicle number and a ovarian volume did not have a high diagnostic power for screening for PCOS. Conclusion: Our results suggest that transabdominal ultrasound assessment is not effective for the detection of PCOS in young women of reproductive age.

동아시아 국내 이주 여성의 정상 월경에 필요한 체질량 지수와 체지방율에 관한 연구

정경아 ( Kyung Ah Jeong ),김환지 ( Hwan Ji Kim ),김정명 ( Jung Myung Kim ),정혜원 ( Hye Won Chung ) 대한폐경학회 2009 대한폐경학회지 Vol.15 No.3

Objectives: The objective of the study was to evaluate the critical body mass index and critical percent body fat of East Asian immigrants with normal menstrual cycles. Methods: The subjects included 1,710 east Asian women (Vietnamese and Cambodians, etc.) who immigrated to Korea for marriage. Their menstrual status was examined by questionnaires and interviews. The age, body mass index and waist-hip ratio were calculated and the percentage of body fat was measured using In body 230. Results: The mean age was 23.7±4.7 years. In 1,065 east Asian immigrants with normal menstrual cycles, the mean body mass index was 20.99±2.56 kg/m2. The 5th, 10th, 90th and 95th percentiles of the body mass index were 17.35 kg/m2, 17.99 kg/m2, 24.57 kg/m2, and 25.94 kg/m2, respectively. The mean waist-hip ratio was 0.824±0.051. The 5th, 10th, 90th, and 95th percentile of the waist-hip ratio were 0.744, 0.759, 0.892, and 0.910. The mean percent body fat was 29.57±6.15%. The 5th, 10th, 90th and 95th percentiles of body fat were 19.28%, 21.75%, 36.70%, and 39.00%, respectively. Conclusion: Our results suggest that both body mass index and percent body fat were significantly associated with menstruation, but the critical percent body fat for normal menstruation was lower in the east Asian immigrants in Korea. (J Korean Soc Menopause 2009;15:193-199)

수은으로 중독된 흰쥐의 간독성에 대한 키토산의 효과

노영복,윤중식,정경아,정민주,김영호,Roh, Young-Bok,Yoon, Jung-Sik,Chung, Kyung-Ah,Chung, Min-Ju,Kim, Young-Ho 한국현미경학회 2001 Applied microscopy Vol.31 No.2

This study aims demonstrate the effect of chitosan, one of the natural chelator, on the ultrastructural changes in the mouse liver caused by $HgCl_2$. The experimental group was divided in two groups; group A and group B. The group A administrated $HgCl_2$ (5.0 mg/kg) to the oral. The group B treated with $HgCl_2$ (5.0 mg/kg) and chitosan (3%) solution, 2 times/day). Each group was observed 24, 48, 72 and 96 hours after treated $HgCl_2$ and chitosan. Histological changes of the livers were investigated by electron microscope. 1. Croup A Nuclear membrane was shrinked. The inner and outer membrane of the mitochondria were dilated. Destruction of lamellae of rough endoplasmic reticulum showed. Smooth endoplasmic reticulum showed over cytoplasm. 2. Group B Nuclear membrane was more rounded, The cristae of the mitochondria were almost normal shape and electron-density showed compacted. Dilation of inner cavity of rough endoplasmic reticulum showed at the pre-time but formed typical lamellae at the 48Hrs. Smooth endoplasmic reticulum showed over cytoplasm. Therefore, we concluded that chitosan has significantly protective effects in liver to harmful $HgCl_2$.

신이식 후에 발생한 이상자궁출혈 환자에서 시행한 자궁경하 자궁내막 절제술의 효과에 관한 연구

정다정 ( Da Jung Chung ),박기현 ( Ki Hyun Park ),정경아 ( Kyung Ah Jeong ),신종승 ( Jong Seung Shin ),배상욱 ( Sang Wook Bai ),이병석 ( Byung Seok Lee ),조동제 ( Dong Jae Cho ),송찬호 ( Chan Ho Song ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6

Objective : To assess the effectiveness and safety of hysteroscopic endometrial ablation as a surgical management of abnormal uterine bleeding developed in renal transplant patients. Methods : Data were collected retrospectively from 62 patients referred

동아시아 국내 이주 여성의 월경과 골밀도에 관한 연구

김현진 ( Hyun Jin Kim ),정경아 ( Kyung Ah Jeong ),정혜원 ( Hye Won Chung ) 대한폐경학회 2009 대한폐경학회지 Vol.15 No.2

Objectives: This study is to investigate the correlation between menstruation and bone mineral density among East Asian immigrants in Korea. Methods: The subjects were 1,078 East Asian women (vietnamese and Cambodian) who immigrated to Korea for marriage. The age, height, weight, and body mass index (BMI) were measured. Body composition was evaluated by In body 230 and Bone mineral density (BMD) of distal radius was measured by peripheral DEXA. Their lifestyles and history of menstruation were examined by questionnaires and interviews. Blood samples for hormonal assay were drawn in participants during early follicular phase. Results: The mean age was 23.6±4.9 years. The mean height (154.7±5.1 cm) and weight (49.8±6.9 kg) were smaller than Korean women. BMI was 20.8±2.7 kg/m2 and body fat mass was 14.5±4.8 kg. The mean BMD was 0.45±0.06 g/cm2. The age-related BMD-Z score was -0.71±0.95, which is lower than Korean women. BMD were decreased (Z<-2.0) in 9.43% of immigrants. The body fat mass (Pearson coefficient 0.211. P=0.01), BMI (Pearson coefficient 0.312, P=0.01) and weight (Pearson coefficient 0.288, P=0.01) significantly correlated with BMD. There were no significant correlations found between the BMD and menstrual frequency, regular exercise, alcohol and smoking. Their menstrual status and hormonal levels were normal. Conclusion: The number of East Asian immigrants is rapidly growing in Korea. Since their BMD is quite low even in the age reaching peak bone mass, it is important to take account of the relation with menstrual status and body fat mass in order to prevent from osteoporosis.

승마와 St. John`s wort 복합제 (지노플러스(R))의 갱년기 증상에 대한 이중 맹검, 무작위, 위약 대조, 다기관 임상 연구

정다정 ( Da Jung Chung ),박기현 ( Ki Hyun Park ),정경아 ( Kyung Ah Jeong ),이성기 ( Sung Ki Lee ),이여일 ( Yu Il Lee ),허성은 ( Sung Eun Hur ),조민선 ( Min Sun Cho ) 대한폐경학회 2006 대한폐경학회지 Vol.12 No.1

다낭난소증후군으로 인한 사회경제적 비용에 관한 연구

김한나 ( Han Na Kim ),정경아 ( Kyung Ah Jeong ),정혜원 ( Hye Won Chung ),배근량 ( Geun Ryang Bae ),한복기 ( Bok Ghee Han ),김형래 ( Hyung Lae Kim ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12

Objective: The objective of the study was to estimate socioeconomic burden of polycystic ovary syndrome (PCOS) during the reproductive life span using current definitions and prevalence or incidence data. Methods: Questionnaires were given to 8,588 reproductive women reviewed at Ewha Womans University Mokdong hospital. The PCOS affected approximately 10.4% of reproductive-aged women (11 million women in Korea, prevalence rate according to 1990 National Institutes of Health PCOS diagnosis criteria). We tied general societal cost data for the different health consequences to reproductive-age PCOS costs, using prevalence data. Results: We estimated the mean annual cost of the initial evaluation to be ￦76 hundred million, that of hormonally treating menstrual dysfunction, providing infertility care, diagnosis/treatment of endometrial hyperplasia, GDM, type 2 DM, and hypertension to be ￦280 billion. The total annual socioeconomic cost of evaluating and providing care to reproductive-aged PCOS women in Korea is ￦350 billion. Conclusion: Because the cost of the diagnostic evaluation accounted for a relatively minor part of the total socioeconomic costs, more widespread screening for PCOS appears be a cost-effective strategy, leading to earlier diagnosis and intervention and possibly the amelioration and prevention of serious sequelae.

자궁근종과 성호르몬 대사물과의 연관성

배상욱,정병화,정봉철,전진동,이현정,권한성,정경아,김세광,박기현,Bai, Sang-Wook,Jung, Byung-Hwa,Chung, Bong-Chul,Jeon, Jin-Dong,Lee, Hyun-Jung,Kwon, Han-Sung,Chung, Kyung-Ah,Kim, Sei-Kwang,Park, Ki-Hyun 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.4

Objective: To elucidate 1) whether there are any differences in the urine concentrations of steroid hormone metabolites between patients with leiomyoma and normal controls 2) the correlation between urinary profiles of steroid hormones and leiomyomas of the uterus according to their type, location, volume, and weight. Materials of Methods : The study population consisted of 37 premenopausal patients with uterine leiomyoma and the control group consisted of 25 premenopausal normal volunteer women without uterine leiomyoma. Confirmation of the existence of uterine leiomyoma was done by ultrasonography and histopathological examination after surgery. The volume of the leiomyoma was estimated by trans-abdominal and/or trans-vaginal ultrasonography. The Leiomyomas were divided into 3 types (subserosal, intramural and submucosal). Seventeen patients had subserosal type of leiomyoma, 10 with the intramural type and 10 with the submucosal type. The locations of the leiomyoma were also divided into 3 groups (fundus, body and isthmus). Seventeen patients showed a fundus location, 10 in body, and 10 in isthmus. We compared urinary profiles of the endogenous steroids between patients with leiomyomas and normal controls, and also investigated the relationship between urinary profiles of the endogenous steroids and leiomyomas according to their type, location, volume and weight by using highly sensitive Gas Chromatography-Mass Spectrometry (GC-MS) system. Results: The mean ages of the patients with leiomyomas and the control group were $43.1{\pm}5.6$ and $40.6{\pm}7.2$ years, the weights were $63.4{\pm}7.3$ and $59.4{\pm}8.1\;kg$, and their heights were $155.4{\pm}4.8$ and $159.3{\pm}4.8\;cm$ respectively. Seventeen patients had subserosal, 10 had intramural, and 10 had submucosal leiomyomas. There were 17 patients with leiomyoma located in fundus, 10 in body and 10 in isthmus. $17{\beta}$-estradiol, 5-AT, 11-keto ET, $11{\beta}$-hydroxy An, $11{\beta}$-hydroxy Et, THS, THA, THE, a-cortolone, a-cortol, $\beta$-cortol, $11{\beta}$-OH Et/$11{\beta}$-OH An and E2/E1 were significantly increased in patients with leiomyoma than in the control group. $17{\beta}$-estradiol was significantly increased in the intramural and the submucosal types than in the subserosal type. There was no significant difference in the concentrations of urinary steroids according to the locations of leiomyomas. There was no significant relationship between the concentration of urinary steroids and the volume of the leiomyomas. $17{\beta}$-estradiol significantly decreased as the weight of uterus increased (r=-0.322, p=0.04). Conclusion: The concentrations of steroid hormone metabolites were generally increased in patients with leiomyoma but were not significantly related to the volume and weight of the leiomyomas. Our study suggests that steroid hormones may be involved in the initiation of leiomyomas but may not be involved in their progression. In addition, the concentrations of steroid hormone metabolites are not related to the leiomyoma type and location.

다낭성 난소증후군의 항뮐러관 호르몬에 관한 연구

유시연 ( Si Yeon You ),박소연 ( So Yun Park ),양가영 ( Ga Young Yang ),정경아 ( Kyung Ah Jeong ),김영주 ( Young Ju Kim ),정혜원 ( Hye Won Chung ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.5

Objective The aim of this study is to investigate the relationship between anti-Mullerian hormone (AMH) and parameters related to polycystic ovary syndrome (PCOS). Methods We measured serum AMH levels in 100 women with PCOS by Rotterdam European Society for Human Reproduction and Embryology criteria. We conducted somatometry, blood test and transvaginal or transrectal ultrasound test. We compared and analyzed AMH and parameters in terms of insulin resistance according to PCOS related phenotypes. We divided phenotypes into four groups by polycystic ovarian morphology (PCOM) and hyperandrogenemia (total testosterone [TT], free testosterone [fT]). Results AMH levels ranged from 4.1 to 21.0 ng/mL and the mean level was 10.4 ± 4.1 ng/mL. Signifi cant differences in parameters of insulin resistance were not observed among low (4 to 8 ng/mL), moderate (8 to 12 ng/mL), and high (>12 ng/mL) levels of AMH. Significant differences in AMH were not observed among groups according to PCOS related phenotypes. Weight, body mass index, waist-hip ratio, TT, fT, sex hormone binding globulin, 2-hour insulin and homeostasis model assessment of insulin resistance index were different signifi cantly according to PCOS related phenotypes. TT, ovarian volume and follicle number were positively correlated with AMH. Conclusion Increased serum AMH levels in PCOS are correlated with TT and PCOM.