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김광원(Kwang Won Kim),최인선(In Seon S . Choi),박석채(Seog Chea Park),장안수(Ahn Soo Jang),임호(Ho Lim) 대한내과학회 1999 대한내과학회지 Vol.57 No.1
N/A Researches on the characteristics of fatality-prone asthmatics have been performed in western countries, but there are few reports in this field in Korea. The purposes of this study were to clarify the magnitude of the problem and to identify the risk factors of near-fatal asthma(NFA). Methods : The records of patients admitted due to asthma attack were analyzed retrospectively. Results :1) The subjects had NFA in 50.6% and PaCO2 > 45mmHg in 22.9%. Five(11.1%) among NFA patients and 3 out of 19(15.8%) subjects with PaCO2 > 45mmHg required mechanical ventilation. 2) There were no significant differences between NFA and non-NFA in age, sex, resident place, academic career, familial and personal history of atopic diseases, serum total IgE level, positive skin prick test to house dust mites, accompanying allergic rhinitis and aspirin intolerance, emphysema on chest high resolution computerized tomogram, dyspnea perception, previous asthma education, regular OPD follow-up, and use of antiinflammatory drugs. 3) However, cigarette smoking(62.2% vs 38.6%), accompanying paranasal sinusitis(66.7% vs 45.3%), chronic asthma severity(severe persistent: 55.5% vs 29.5%), hospitalization frequency(2.93 vs 1.58), and duration of recent asthma exacerbation(6.6 vs 18.8 days) in NFA were significantly different from those in non-NFA.4) The relative risk for NFA was high in patients with history of hospitalization > 3, severe persistent asthma, exacerbation period < 3 days, smoking, or sinusitis in the order of frequency. Conclusion : Near-fatal asthma is a prevalent problem in clinical practice and asthma admission history, severe persistent asthma, short exacerbation period < 3 days, smoking, and paranasal sinusitis are the risk factors warning near-fatal asthma attack in advance.
천식동물모델에서 디젤분진이 기도과민성과 개형에 미치는 효과
김영은 ( Young Eun Kim ),권지희 ( Ji Hee Kwon ),이신화 ( Shin Hwa Lee ),임태연 ( Tai Youn Rhim ),이영목 ( Young Mok Lee ),박춘식 ( Choon Sik Park ),송현미 ( Hyun Mi Song ),장안수 ( An Soo Jang ),안미현 ( Mi Hyun Ahn ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.1
Background: Epidemiologic and clinical investigations have suggested a strong link between particulate air pollution and asthma. The purpose of this study was to evaluate an effects of air pollutants on a murine asthma model, focusing on diesel exhaust particles (DEP). Method: The Balb/c mice were sensitized intra-perito-neally (i.p.) with ovalbumin (OVA) at days 0 and 14 and challenged intranasally with OVA at days 21, 22, and 23 (group I). The Balb/c mice were sensitized i.p. with OVA at day 0, 14 and challenged with 6 mg/10 mL of DEP at days 21, 22, and 23 (group II). Group III were sensitized with OVA at days 0 and 14, together with 0.6 mg/50 uL of DEP every other day for 14 days and challenged with 150 ug /100 uL OVA and 6 mg/10 mL of DEP at day 21, 22, and 23. Saline sensitized-challenged mice were served as sham control. The mice were subjected to whole-body plethysmo-graphy and then killed for bronchoalveolar lavage and histology. Cytokines were measured by ELISA. Expression of goblet cell hyperplasia and smooth muscle hyperplasia in the lung tissue was detected by immunohistochemical staining. Result: DEP and OVA sensitized-challenge group had a significant increase in methacholine-induced AHR, compared to sham group and group I. The levels of IL-4, IL-5, and IFN-γ tended to increase in the BAL fluid in group III. Goblet cell hyperplasia and smooth muscle hypertrophy were more observed in group III than those in sham group, groups I and II. Conclusion: This study demonstrates that DEP may aggravate airway responsiveness and remodeling in a mouse asthma model. (Korean J Asthma Allergy Clin Immunol 2006;26:70-77)
안형수,장안수,이준혁,박성우,고은석,백상현,박재성,허균,신화균,박춘식 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
We report a case of a sclerosing hemangioma of the lung with increased size during follow up, a rare benign neoplasm of the lung. A 32-year-old woman had round increased opacity in right upper lobe on posteroanterior chest radiograph. That lesion has grown slowly over four years. Computed tomographic scan showed a well circumscribed lung mass in medial aspect of right upper lobe. Radiological differential diagnosis for the lesion included inflammatory pseudotumor, atypical carcinoid, lung cancer and localized fibrous tumor of pleura. Nonspecific findings were shown by the bronchoscopy and percutaneous transthoracic needle aspiration. Anterior and apical segmentectomy was carried out and the lesion was pathologically diagnosed as sclerosing hemangioma of lung.
디젤분진이 백서 뇌에 미치는 영향 : Nitric Oxide 및 Nitric Oxide Synthase 아형 발현
박선아,장안수,이보람,박정호,양광익,이태경,박춘식,성기범,안무영 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1
Background: The possible neurotoxic effect of diesel exhaust particles (DEP), a particulate material from an automobile engine and toxic air pollutant, has been suggested. However, the investigations about it have been rare. Objectives: To examine the possible harmful effect of the inhaled DEP on nervous system we focused on the expression of nitric oxide synthase (NOS) isofonns and nitric oxide (NO) level in the rat brain. Methods: The morphological analysis was performed using neuronal and microglial markers eight days after DEP exposure through nasal cannula-route. In addition, the expression of three NOS isoforms was evaluated by western blot. Nithte and nitrate, a major NO metabolites, were measured using Griess method. Results: We did not find any morphological changes after DEP exposure in terms of the expression of neuronal and microglial markers. And the expression of inducible NOS, neuronal NOS, and endothelial NOS was not altered. There was no change in any of the level of nitrate and nitrite, major NO metabolites. Conclusion: In contrast to the response of lung to DEP, the brain did not show any changes in the level of NOS isoforms, nitrate, or nitrite in this model, It suggests that short-term DEP inhalation may not result in morphological change and alter NO pathway in the brain.
조절된 만성천식 환자에서 스테로이드 흡입제 중단에 의한 실험적 천식 악화
임호,고영일,최인선,장안수,천정학 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.1
Background:It has been recognized that cessation of treatment with inhaled corticosteroids evokes a recurrence of symptoms in most asthmatics within a month. Objective: To examine whether a useful model of asthma for studies on effects of new antiasthmatic drugs can be induced by discontinuation of inhaled corticosteroids treatment. Method : Twenty five patients with controlled asthma on inhaled corticosteroids were enrolled in this study. Spirometric measurements were performed before and 2 weeks after cessation of treatment with inhaled budesonide. Peak expiratory flow rates(PEFR), asthma symptom scores, and short-acting inhaled β2 agonist requirements were checked during 2-week period before and during 2-week period after the cessation of inhaled budesonide. Results : Discontinuation of treatment with inhaled budesonide resulted in significant falls in FEV1, and morning and evening PEFRs, and significant increase in diurnal variability of PEFR (40% of patients showed diurnal variability of ≥ 20%). Theirmptom scores and the days required for salbutamol use were also significantly increased. However, the mean fall in FEV1 was 6.9% and the maximum fall 29%, and a significant fall (≥15%) occurred in only 29% of patients. Conclusion : These findings demonstrate that asthma exacerbation can be safely induced by discontinuation of treatment with inhaled corticosteroids in controlled asthmatics, suggesting that this experimental model of mild asthma exacerbation can be used for studying the effects of new antiasthmatic drugs.
조직검사에서 metachromasia를 보인 한냉두드러기 1례
유훈,김윤경,김정석,장안수,최수인,김용철,오성희,이지신,박재홍 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.2
The patient was a 24-year-old male who complained of urticaria upon exposure to cold air and after showering in cold water. Allergic skin tests were positive for cockroach. To determine whether he had cold urticaria, we performed an ice cube test. The patient complained of pruritus, erythema, and wheals appeared at 10min. Skin biopsy specimens collected 10 minutes after ice-cube test showed perivascular mononuclear cell infiltration and edema in hematoxylin and eosin stains, and metachromatic cell and degranulation in toluidine blue stain.