Wearing-off 현상을 경험하는 파킨슨병 환자에서 엔타카폰의 효과 및 안정성: 다기관 무작위 위약비교 이중맹검 연구

임주혁,이종균,정선주,전범석,조진환,이명식,조은경,이원용,이은아,김재우,이명종 대한신경과학회 2005 대한신경과학회지 Vol.23 No.2

Background: The purpose of this study was to assess the efficacy and safety of entacapone, a catechol-O- methyltransferase (COMT) inhibitor in Parkinson's disease (PD) patients with wearing-off phenomenon. Methods: A total of 197 PD patients were included in this 2-month multi-center, randomized, placebo-controlled, double blind, parallel-group study. After a 2-week screening period, each patient was randomly allocated to receive either entacapone (n=98) or placebo (n=99) as an adjunct to levodopa. The efficacy was evaluated with the changes of “on” and “off” time percentage while awake, the reduction of the levodopa dose, Unified Parkinson's Disease Rating Scale (UPDRS), and the clinical global impression (CGI) by the examiner. Results: The percentage of “on” time increased by 9.4±18.0% in the entacapone group, 7.4±15.6% in the placebo group. The percentage of “off” time was reduced by 8.6±16.9% in the entacapone group, 6.6±18.2% in the placebo group. These parameters did not show a statistical significance between the two groups. However, the levodopa dose was significantly reduced in the entacapone group (51.6±154.5 mg/day) compared with the placebo group (0.7±130.0 mg/day) (p=0.009). The total and motor scores of the UPDRS were significantly decreased in the entacapone group (p=0.039, p=0.017, respectively). The most common adverse drug reactions in the entacapone group were urine discoloration (22%), dyskinesia (13%), dizziness (7%). Conclusions: Entacapone was a safe and well-tolerated drug. Although the changes of “on” and “off” time were not significant, entacapone showed an overall significant beneficial effect in the PD patients with wearing-off phenomenon. Background: The purpose of this study was to assess the efficacy and safety of entacapone, a catechol-O- methyltransferase (COMT) inhibitor in Parkinson's disease (PD) patients with wearing-off phenomenon. Methods: A total of 197 PD patients were included in this 2-month multi-center, randomized, placebo-controlled, double blind, parallel-group study. After a 2-week screening period, each patient was randomly allocated to receive either entacapone (n=98) or placebo (n=99) as an adjunct to levodopa. The efficacy was evaluated with the changes of “on” and “off” time percentage while awake, the reduction of the levodopa dose, Unified Parkinson's Disease Rating Scale (UPDRS), and the clinical global impression (CGI) by the examiner. Results: The percentage of “on” time increased by 9.4±18.0% in the entacapone group, 7.4±15.6% in the placebo group. The percentage of “off” time was reduced by 8.6±16.9% in the entacapone group, 6.6±18.2% in the placebo group. These parameters did not show a statistical significance between the two groups. However, the levodopa dose was significantly reduced in the entacapone group (51.6±154.5 mg/day) compared with the placebo group (0.7±130.0 mg/day) (p=0.009). The total and motor scores of the UPDRS were significantly decreased in the entacapone group (p=0.039, p=0.017, respectively). The most common adverse drug reactions in the entacapone group were urine discoloration (22%), dyskinesia (13%), dizziness (7%). Conclusions: Entacapone was a safe and well-tolerated drug. Although the changes of “on” and “off” time were not significant, entacapone showed an overall significant beneficial effect in the PD patients with wearing-off phenomenon.

프리스트레스트 중공 슬래브와 현장타설된 토핑콘크리트의 수평전단성능 평가

임주혁,박민국,이득행,서수연,김강수 한국콘크리트학회 2014 콘크리트학회논문집 Vol.26 No.6

프리스트레스트 중공(PHC) 슬래브는 장경간에 적합하도록 경량화된 효율적인 프리캐스트 부재이며, 국내·외에서 많이사용되고 있다. 특히, 국내에서는 현장타설콘크리트와 같이 사용되는 합성슬래브 형태로 주로 적용되고 있다. 그러나, 압출성형방식으로 제작되는 PHC 슬래브 부재는 매우 낮은 슬럼프의 콘크리트로 제작되어 타설 직후에도 표면경도가 높기 때문에 계면의거친면 처리 및 전단연결재 배치가 어려운 단점이 있다. 이 연구에서는 PHC slab 부재와 토핑콘크리트 사이의 합성성능을 고찰하기 위하여 다양한 계면상태를 변수로 직접전단실험을 수행하였으며, 기존 실험결과를 수집하여 국내·외 수평전단강도 설계기준을 평가하였다.

파킨슨병의 치료

임주혁,강지훈,이명종 대한신경과학회 2001 대한신경과학회지 Vol.19 No.4

CORBA 기반의 Application Service System을 위한 부하 공유 서비스의 설계 및 구현

임주혁,박세명,강흥식 인제대학교 2001 仁濟論叢 Vol.16 No.1

근간 분산된 객체에 대한 부하분산의 목적으로 OMG의 CORBA를 많이 이용하고 있지만 CORBA의 일반적인 기본 서비스는 특정 시스템에서 최적의 기능을 발휘하지 못한다. 이에 본 논문에서는 화상 회의를 하는 특정 시스템의 분산된 이미지 처리 객체(IPO)에 대해 CORBA를 기반으로 하여 어떻게 작업 반환 시간을 최소화 할 수 있는가에 대한 방법을 제시하였다. 이는 동일한 처리를 하는 IPO가 여러 개 존재할 경우 어떤 IPO를 선택하여 이미지 처리를 시키는 것이 가장 적합한지에 대한 것이다. 즉, Client의 이미지 처리 요청이 있을 때 Object Manager는 작업 반환 시간을 최소화 할 수 있는 IPO를 선택하여 작업을 의뢰하기 위해 Object Manager는 IPO가 탑재된 머신의 하드웨어적 성능, 실행되고 있는 IPO의 개수, 해당 IPO가 현재 처리 가능한지의 여부 그리고 처리할 이미지와 처리 후의 이미지의 크기를 고려하여 최적의 성능을 낼 수 있는 IPO를 선택하였다. 결과적으로, IPO의 상태를 고려한 경우가 CORBA의 기본 기능만을 사용한 경우보다 작업 반환 시간에 대해 9∼22% 정도 성능이 개선되었다. Recently, CORBA by OMG is widely adopted as a middleware for constructing distributed object system, but the basic services on CORBA do not appropriate for the operations on a specific distributed object system. particularly in managing the distributed image processing objects on MICS(Medical-Image Conference System). In this paper, We propose and implemented Object Manager with the load distributing policy for CORBA-based MICS to minimize the response time for a particular image processing requests. Object Manager collects and manages the informations such as the processing speed on a particular system, number of IPOs currently executing on a particular system, availability of IPO, and the size of image being requested to be processed, and returns most appropriate IPO with the minimum job response time expected on a given image. We showed with experiments that the improved MICS with the proposed Object Manager has much more shorter job response time about 9 ∼ 22 % than the system using CORBA basic services.

원산지별 홍삼투여에 따른 백서의 자연살해세포 활성도 변화에 대한 연구

임주혁,조인영,민경윤,이혜영,김슬지,박영주,류재환,이범준,김성욱,주일우,Im, Ju-Hyuk,Cho, In-Young,Min, Kyoung-Yoon,Lee, Hae-Yong,Kim, Seul-Ji,Park, Young-Ju,Lew, Jae-Hwan,Lee, Beom-Joon,Kim, Sung-Wook,Joo, Il-Woo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4

Objectives : The purpose of this experiment is comparing the difference on natural killer cell activity through Korean red ginseng and Chinese red ginseng by $^{51}Cr$ release assay. Methods : Thirty rats were equally divided into a Korean red ginseng group, a Chinese red ginseng group and a control group. Korean and Chinese red ginseng were administrated to the rats at 200mg daily for a weak, while 0.9% normal saline was given to the control. Percent specific lysis (PSL) and lytic units (LU) were calculated from spleen cells by $^{51}Cr$ release assay. Results : Percent specific lysis of the Korean red ginseng group was significantly higher than that of the control in the ratio of 100:1, effector cell:target cell (p<0.05). Percent specific lysis of Korean red ginseng group was also significantly higher than that of the Chinese red ginseng group in the ratio of 25:1, effector cell:target cell (p<0.05). Chinese red ginseng showed no effect on NK cell activity. Conclusions : These findings suggest that Korean red ginseng improves immunologic function and shows superior effects than Chinese red ginseng.

현훈(眩暈)을 동반한 보행장애(步行障碍)를 가진 환자에 형방사백산과 형방도적산 투여 경과 치험 1례 - 부제 : 소양인(少陽人) 비수한표한병(脾受寒表寒病) 결흉증(結胸證) 환자에 대한 치험례

임주혁,소형진,허홍,민경륜,이혜영,최순영,류재환,조인영,Im, Ju-Hyuk,So, Hyung-Jin,Heo, Hong,Min, Kyoung-Yoon,Lee, Hae-Yong,Choi, Soon-Young,Ryu, Jae-Hwan,Cho, In-Young 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3

We made a comparative study, A patient who had suffered dizziness and ataxia took Hyungbangsabaek-san(荊防瀉白散) at first and next took Hyungbangdojeock-san(荊防導赤散). He was diagnosed as a Soyangin suffering chest knotting syndrome(結胸證) by Sasang constitutional medicine(四象醫學) and took two kinds of herbs in a row. We observed his phase of dizziness and ataxia with the conditions of stool and urine excavation, pink eye, sweating, and tongue color and tongue coating. When he took Hyungbangdojeock-san these conditions improved more than when he took the other one and his dizziness and ataxia also improved. Hyungbangdojeock-san was more useful when the severity of the disease was shallower and he had more exterior syndromes than Hyungbangsabaek-san.

파킨슨병에서 레보도파의 보조요법으로서 로피니롤의 치료 효과

임주혁,하정호,조인숙,이명종 대한신경과학회 2001 대한신경과학회지 Vol.19 No.2

급속 응고 된 Bi2Te3-PbTe계 열전소재의 미세구조와 열전 특성

임주혁,정규호,유현우,김광천,김진상 한국전기전자재료학회 2010 전기전자재료학회논문지 Vol.23 No.6

In order to design nano structured materials with enhanced thermoelectric properties, the alloys in the pseudo-binary Bi2Te3-PbTe system are investigated for their micro structure properties. For this synthesis, the liquid alloys are cooled by the water quenching method. Micro structure images are obtained by using an electron probe micro analyzer(EPMA). Dendritic and lamellar structures are clearly observed with the variation in the composition ratio between Bi2Te3 and PbTe. The increase in the Bi2Te3 composition ratio causes to change of the structure from dendritic to lamellar. The Seebeck coefficient of sample 5, in which the mixture rate of Bi2Te3 is 83%, is measured as the highest value. In contrast, the others decrease with the increase of the Bi2Te3 composition ratio. Meanwhile, p-type characteristics are observed in sample 6, at 91%-Bi2Te3 mixture rate. The power factors of the all samples are calculated with the Seebeck coefficient and resistivity.

두꺼운 프리스트레스트 중공 슬래브의 전단성능 평가

임주혁,박민국,이득행,김강수,서수연 대한건축학회지회연합회 2014 대한건축학회연합논문집 Vol.16 No.5

PHC 슬래브는 제작특성상 전단철근을 배치할 수 없기 때문에 복부전단에 매우 취약하다. 이에 현행 기준에서는 기존에 수행된 실험적 연구에 근거하여 최소전단철근량이 배치되지 않은 두께 315 mm 이상의 중공을 갖는 부재에 대해 전단강도를 산정할 때 기준에 의해 산정된 전단강도의 1/2 값 이하로 설계하중을 제한하도록 규정하고 있다. 이는 PHC 슬래브의 적용확대에 큰 걸림돌이 되고 있다. 따라서, 이 연구에서는 315 mm 이상의 두께를 갖는 PHC 슬래브의 전단강도 성능실험을 수행하였으며, 이와 더불어 여러 문헌으로부터 실험결과들을 수집하여 현행기준의 전단강도식을 평가하였다. Prestressed hollow-core (PHC) slab is disadvantageous in web-shear strength because it is very difficult to provide shear reinforcement due to its unique production method. In current shear design provisions, it is newly regulated that the web-shear capacity of PHC slab members exceeding 315 mm in depth without minimum shear reinforcement should be reduced by half based on recent experimental studies. This new limitation on the PHC slab member becomes an obstacle for the application of PHC slabs in market. Therefore, in this study, the web-shear tests on the PHC slabs with thickness over 315 mm were conducted, and a large number of shear test results on the PHC slab units were collected from literature, by which the shear strength equations in design codes were evaluated.

자연발생 엽상 뇌출혈에 대한 임상적 고찰

임주혁,홍승봉,윤병우,노재규,이상복,명호진 대한신경과학회 1993 대한신경과학회지 Vol.11 No.4