http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 이한새 (검색결과 9 건)
- 무료
- 기관 내 무료
- 유료
-
음낭 외상 환자에서 치료 방법에 따른 고환 구제율의 비교
이한새,김태범,김계환,정한,윤상진 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.11
Purpose: The purpose of this study was to compare the testicular salvage rate, visual analogue pain scale, and hospital stay according to treatment method in patients with scrotal trauma. Materials and Methods: We retrospectively reviewed the medical records of 103 patients who visited the emergency department with scrotal trauma between January 1996 and February 2009. Treatment methods for scrotal trauma were divided into four groups (total orchiectomy, partial orchiectomy, simple suture, and conservative treatment) for patients with testicular rupture and two groups (exploration and hematoma evacuation, conservative treatment) for patients with scrotal hematoma. We analyzed the testicular salvage rate, visual analogue pain scale, and hospital stay of each group. Results: The study included 58 patients with testicular rupture and 45 patients with a scrotal hematoma. The patients’ mean age was 26.8 years, and most cases occurred during the second decade of life. The main cause of scrotal trauma was assault, which included 41 cases (39.8%). Immediate surgical intervention for testicular rupture improved the testicular salvage rate, reduced the duration of hospital stay, and was associated with less pain. For patients who underwent partial orchiectomy and conservative management, the length of hospital stay and the reported pain were greater than for patients who had total orchiectomy and simple suturing. In addition, the testicular salvage rate in patients who underwent a partial orchiectomy or conservative management was lower than in cases with simple suturing. For scrotal hematoma, the testicular salvage rate in patients who underwent exploration and hematoma evacuation was 100%. Conclusions: Because the testicular rupture patients treated by partial orchiectomy showed worse results than did the patients treated by other methods, a patient’s status such as age, marital status, and number of children need to be carefully considered before a decision is made to perform a partial orchiectomy. For scrotal hematoma, patients treated by exploration and hematoma evacuation exhibited a higher testicular salvage rate than did patients treated with conservative management. Purpose: The purpose of this study was to compare the testicular salvage rate, visual analogue pain scale, and hospital stay according to treatment method in patients with scrotal trauma. Materials and Methods: We retrospectively reviewed the medical records of 103 patients who visited the emergency department with scrotal trauma between January 1996 and February 2009. Treatment methods for scrotal trauma were divided into four groups (total orchiectomy, partial orchiectomy, simple suture, and conservative treatment) for patients with testicular rupture and two groups (exploration and hematoma evacuation, conservative treatment) for patients with scrotal hematoma. We analyzed the testicular salvage rate, visual analogue pain scale, and hospital stay of each group. Results: The study included 58 patients with testicular rupture and 45 patients with a scrotal hematoma. The patients’ mean age was 26.8 years, and most cases occurred during the second decade of life. The main cause of scrotal trauma was assault, which included 41 cases (39.8%). Immediate surgical intervention for testicular rupture improved the testicular salvage rate, reduced the duration of hospital stay, and was associated with less pain. For patients who underwent partial orchiectomy and conservative management, the length of hospital stay and the reported pain were greater than for patients who had total orchiectomy and simple suturing. In addition, the testicular salvage rate in patients who underwent a partial orchiectomy or conservative management was lower than in cases with simple suturing. For scrotal hematoma, the testicular salvage rate in patients who underwent exploration and hematoma evacuation was 100%. Conclusions: Because the testicular rupture patients treated by partial orchiectomy showed worse results than did the patients treated by other methods, a patient’s status such as age, marital status, and number of children need to be carefully considered before a decision is made to perform a partial orchiectomy. For scrotal hematoma, patients treated by exploration and hematoma evacuation exhibited a higher testicular salvage rate than did patients treated with conservative management.
-
-
Prostatic Ductal Adenocarcinoma
정한,이한새,윤상진,김계환 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.4
Prostatic ductal adenocarcinoma is a rare neoplasm that develops from the prostatic urethra. We present an 85-year-old man with an exophytic lesion in the prostatic cavity, which was diagnosed after transurethral resection of the prostate. Histopathologically, the tumor was diagnosed as a ductal adenocarcinoma with endometrioid features and a Gleason score of 6.
-
Different Molecular Phenotypes of Progression in BRAF- and RAS-Like Papillary Thyroid Carcinoma
임진선,이한새,박지윤,김경수,김수경,조용욱,송영신 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.4
Background: Papillary thyroid carcinoma (PTC) can be classified into two distinct molecular subtypes, BRAF-like (BL) and RASlike (RL). However, the molecular characteristics of each subtype according to clinicopathological factors have not yet been determined. We aimed to investigate the gene signatures and tumor microenvironment according to clinicopathological factors, and to identify the mechanism of progression in BL-PTCs and RL-PTCs. Methods: We analyzed RNA sequencing data and corresponding clinicopathological information of 503 patients with PTC from The Cancer Genome Atlas database. We performed differentially expressed gene (DEG), Gene Ontology, and molecular pathwayenrichment analyses according to clinicopathological factors in each molecular subtype. EcoTyper and CIBERSORTx were used to deconvolve the tumor cell types and their surrounding microenvironment. Results: Even for the same clinicopathological factors, overlapping DEGs between the two molecular subtypes were uncommon, indicating that BL-PTCs and RL-PTCs have different progression mechanisms. Genes related to the extracellular matrix were commonly upregulated in BL-PTCs with aggressive clinicopathological factors, such as old age (≥55 years), presence of extrathyroidal extension, lymph node metastasis, advanced tumor-node-metastasis (TNM) stage, and high metastasis-age-completeness of resection-invasion-size (MACIS) scores (≥6). Furthermore, in the deconvolution analysis of tumor microenvironment, cancer-associated fibroblasts were significantly enriched. In contrast, in RL-PTCs, downregulation of immune response and immunoglobulin-related genes was significantly associated with aggressive characteristics, even after adjusting for thyroiditis status. Conclusion: The molecular phenotypes of cancer progression differed between BL-PTC and RL-PTC. In particular, extracellular matrix and cancer-associated fibroblasts, which constitute the tumor microenvironment, would play an important role in the progression of BL-PTC that accounts for the majority of advanced PTCs.
-
-
김선욱(Sun Uk Kim),이한새(Han Sae Lee),전재호(Jae Ho Jeon),용준범(June Beom Yong),고한서(Han Seo Ko) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11
In this study, an optimized Air-Curtain Device(ACD) was developed by Computational Fluid Dynamics(CFD). Case studies were performed with two variables: a discharged velocity and an angle. The factors that affect the air curtain formation are the discharged velocity and temperature. The CFD was used to determine the optimum deflection modulus of the ACD, and the analysis was verified by comparing it with the experimental results. In the case of an open type smoking booth using an air curtain, the Reynolds number and the discharge angle of the air are very significant factors. The optimized efficiency of the ACD is shown at the Reynolds number of 6542 and the degree of 30.
-
-
이슬기,권종범,박은정,이한새,Ye Seul Lee 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.1
The formation of -H2AX foci after DNA double strand breaks (DSBs) is crucial for the cellular response to this lethal DNA damage. We previously have shown that BRG1, a chromatin remodeling enzyme, facilitates DSB repair by stimulating -H2AX formation, and this function of BRG1 requires the binding of BRGI to acetylated histone H3 on -H2AX-containing nucleosomes using its bromodomain (BRD), a protein module that specifically recognizes acetyl-Lys moieties. We also have shown that the BRD of BRG1, when ectopically expressed in cells, functions as a dominant negative inhibitor of the BRG1 activity to stimulate -H2AX and DSB repair. Here, we found that BRDs from a select group of proteins have no such activity, suggesting that the -H2AX inhibition activity of BRG1 BRD is specific. This finding led us to search for more BRDs that exhibit -H2AX inhibition activity in the hope of finding additional BRD-containing proteins involved in DNA damage responses. We screened a total of 52 individual BRDs present in 38 human BRD-containing proteins, comprising 93% of all human BRDs. We identified the BRD of cat eye syndrome chromosome region candidate 2 (Cecr2), which recently was shown to form a novel chromatin remodeling complex with unknown cellular functions, as having a strong -H2AX inhibition activity. This activity of Cecr2 BRD is specific because it depends on the chromatin binding affinity of Cecr2 BRD. Small interfering RNA knockdown experiments showed that Cecr2 is important for -H2AX formation and DSB repair. Therefore, our genome-wide screen identifies Cecr2 as a novel DNA damage response protein.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
