Effect of Juglans sinensis Dode extract on chemical hypoxia-induced cell injury in human glioma cells

윤현민,허재영,안창범,Youn, Hyoun-min,Heo, Jae-yeong,Ahn, Chang-beohm The Korean AcupunctureMoxibustion Medicine Society 2003 대한침구의학회지 Vol.20 No.2

이 논문(論文)은 활성 산소(ROS)의 작용(作用)을 규명하고 호도약침액(胡桃藥鍼液)이 인간의 신경교종 세포인 A172에서 화학적(化學的) 저산소증(低酸素症)으로 유발된 세포 사멸에 대해 효능이 있는지를 연구(硏究)한 것이다. 화학적(化學的) 저산소증(低酸素症)은 세포내 미토콘드리아의 전자 수송을 방해하는 antimycin A를 가진 배양세포에 의해 유발(誘發)하였다. 화학적(化學的) 저산소증(低酸素症)에 노출된 세포(細胞)는 시간과 그 양에 따라서 세포 사멸의 결과(結果)가 다르게 나타난다. 화학적 저산소증에 의해서 ROS의 생산이 증가하는데 이것은 $H_2O_2$ 소거(消去) Catalase(과산화수소를 물과 산소로 분해하는 효소)에 의해 방지(防止)된다. Catalase는 화학적 저산소증에 의해 유발(誘發)된 세포 사멸을 방지하는데 비해 DMTU는 효과적이지 않다. 지질(脂質)에 녹는 산화방지제 DPPD와 물에 녹는 산화방지제 Trolox는 세포사멸을 방지하는데 효과(效果)가 없다. 호도약침액(胡桃藥鍼液)은 그 양(量)에 의존적으로 저산소증에 의해 유발된 세포 사멸을 방지하는 효과가 있다. 즉 화학적 저산소증으로 유도된 ROS의 발생을 막고, $H_2O_2$로 유도된 세포사멸을 방지하는데 이것은 화학적 저산소증과 $H_2O_2$의해 유도된 세포사멸에 대해 호도약침액(胡桃藥鍼液)이 방지효과(防止效果)가 있다는 것을 의미한다. 이러한 결과(結果)들은 $H_2O_2$가 지질 과산화와는 무관한 메카니즘으로 저산소증(低酸素症)으로 유발(誘發)된 세포사멸을 중재하고, 따라서 호도약침액(胡桃藥鍼液)은 지질막의 과산화를 방지하기 보다는 ROS를 직접적으로 소거(消去)함으로써 방지 효과가 있다는 것을 의미한다. 더구나 화학적(化學的) 저산소증(低酸素症)은 caspase와 무관한 메카니즘으로 apoptosis를 유발(誘發)한다.

대하(帶下)의 침구치료(鍼灸治療)에 관(關)한 고찰(考察)

윤현민,Youn, Hyoun-min 대한침구의학회 2004 대한침구의학회지 Vol.21 No.2

Objective : To review was to study acupuncture and moxibustion treatments for abnormal leukorrhea. Normal leukorrhea is always secreted in female vagina. It increased usually by infection (Trichomoniasis and Candidiasis), turmor and so on. Methods : We extracted the parts and acupuncture and moxibustion leukorrhea from ancient and modern oriental medical literature. We have got compared and analyzed 45 kinds of books since Nei Jing(內經). Results and Conclusion : In acupuncture therapy meridians of Bladder, Stomach, Spleen and Conception vessel were mostly used for them in connection with the functions of each meridians. The acupoint used on acupunture only were 78 acupoints. In particular, Chung-guk(cv3), Kwan-won(cv4) point of Conception vessel Meridian and Samum-gyo point of Spleen meridian are frequently applied in leukorrhea.

胡桃藥鍼이 人間의 신경교종 細胞에 유발된 低酸素症에 대한 防禦效果

尹炫珉,許宰榮,安昌範 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

胡桃藥鍼이 人間의 신경교종 細胞에 유발된 低酸素症에 대한 防禦效果

帶下의 鍼灸治療에 關한 文獻的 考察

尹炫珉,安昌範 동의대학교 한의학연구소 1999 동의한의연구 Vol.3 No.-

The purpose of this reivew was to study acupunture and moxa treatments for abnormal leukorrhea. Normal leukorrhea is always secreted in female vagina. It increased usually by infection(Trichomoniasis and Candidiasis), turmor and so on. In acupunrure therapy meridians of Bladder, Stomach and Spleen were mostly used for them in connection with the functions of each meridians. In particular, Chung-guk(cv3), Kwan-won(cv4) points of Conception vessal Meridian and Samum-gyo point of Spleen meridian are frequently applied in leukorrhea.

3차원 정상상태의 드리프트-확산 방정식의 해석 프로그램 개발

윤현민,김태한,김대영,김철성 대한전자공학회 1997 電子工學會論文誌, D Vol.d34 No.8

The device simulator (BANDIS) which can analyze efficiently the electrical characteristics of the semiconductor devices under the three dimensional stationary conditions on the IBM PC was developed. Poisson, electon and hole continuity equations are discretized y te galerkin method using a tetrahedron as af finite element. The frontal solver which has exquisite data structures and advanced input/output functions is dused for the matrix solver which needs the highest cost in the three dimensional device simulation. The discretization method of the continuity equations used in BANDIS are compared with that of the scharfetter-gummel method used in the commercial three-dimensional device. To verify an accuracy and the efficiency of the discretization method, the simulation results of the PN junction diode and the BJT from BANDIS are compared with those of the commercial three-dimensiional device simulator such as DAVINCI. The maximum relative error within 2% and the average number of iterations needed for the convergence is decreased by more than 20%. The total simulation time of the BJT with 25542 nodes is decreased to about 60% compared with that of DAVINCI.

도인기공체조가 여성의 肩臂痛에 미치는 效果

윤현민,김미영,김이순,임진섭 대한침구의학회 2005 대한침구의학회지 Vol.22 No.1

Objective : This study intends to identify the effects of the Doin Gigong Exercise on the shoulder-arm pain in Women. Methods : The study was performed with nonequivalent control group pretest-posttest design. A total of 45 subjects were divided into 25 persons in experimental groups and 20 persons in contrastive group by convenience sampling. The data were collected by using questionnaires and measured values from June, 2004, to August, 2004. Results : The results of the study are as follows: 1. The homogeneity testing revealed that most study variables were equally distributed between experimental and control groups. 2. The first hypothesis: The experimental group who performed the Doin Gigong Exercise and who decreased on the subjective symptom scale was supported(t=10.245, p=.000). 3. The scond hypothesis : The experimental group who received Doin Gigong Exercise and who decreased on the subjective pain(VAS) was supported(t=6.816, p=.000). 4. The third hypothesis: The experimental group who received Doin Gigong Exercise and who decreased on the muscular stiffness measured techniques(UNIQUE) was supported (t=7.114, p=.000). Conclusion : Based on the results described above, it is considered that the Doin Gigon Exercise is clearly effective in all an values of the 5 measured. Therefore, the Doin Gigong Exercise can be thought of as effective nursing intervention for the reduction of shoulder-arm pain in women.

아동을 위한 지능형 서비스 로봇 활용 방안

윤현민 한국어린이미디어학회 2010 한국어린이미디어학회 학술대회 자료집 Vol.2010 No.6

MOSFET의 Capacitor 에 관한 연구 ( A study on the Capacitor of MOSFET )

윤현민,이상목,김학선 한국통신학회 1992 한국통신학회 학술대회논문집 Vol.11 No.1

耳鍼療法이 아동의 肥滿度에 미치는 效果

윤현민,김미숙,이지원 대한침구의학회 2005 대한침구의학회지 Vol.22 No.5

Objectives : The purpose of this study was to examine the effects of Auricular acupressure with semen sinapis in obese children over a specific period of time. Methods : The study subjects included 27 obese children who were evaluated as such using Broca's Index at an elementary school located in M city. The data was collected throughout March 2, to May 31, 2005. In order to collect data, as a pre-test, characteristics of obesity and general characteristics were examined. Experimental treatments were used on Shinmun, Kijeom, Wijeom, Bijeom and Naebunbijeom. Among the auricular spots, one pill of semen sinapis was placed and pressed for five seconds at a time with exerted force and the subjects endured pain. This procedure was conducted ten times every morning, noon and evening for a period of six weeks. As a post-test, the degree of obesity were examined two weeks, four weeks and six weeks after acupressure had been applied. The data was collected and analysed using the SPSS/WIN 10.0 program by number, percentage, mean, standard deviation, and Repeated Measure ANOVA. Results : The first hypothesis that ‘The obesity of the children who had auricular acupressure with semen sinapis will show no difference over time’ (two weeks, four weeks and six weeks after acupressure had been applied) was rejected(p=.000). A statistically significant difference in the obesity of the children who had auricular acupressure with semen sinapis was shown over time. The children's obesity degree reduced from 35.85% before auricular acupressure with semen sinapis to 28.67% six weeks after acupressure. Thus after six weeks of acupressure the relative degrees of obesity were reduced by 7.18%. Conclusion : Based on the above results, it can be determined that auricular acupressure with semen sinapis can be used as an effective method of treatment in Korea, for reducing degrees of obesity in children.

봉약침요법으로 발생한 Anaphylaxis에 대한 임상보고

윤현민 대한침구의학회 2005 대한침구의학회지 Vol.22 No.4

Objective : This study is designed to observe anaphylatic reaction in two patients, who visited Dong-Eui University Oriental Medicine Center for Bee-Venom Acupuncture. Methods ; Anaphylaxis is a clinical syndrome cheracterized by the acute system reaction of multiple organ systems to an IgE-mediated immunologic mediator release in previously sensitized individuals. Anaphylatic reaction of two patients treated by Bee-Venom Acupuncture were observed in order to analysis the clinical form. Results and Conclusion ; One case of Anaphylatic reaction was expressed clinically hypotension drowsy mentality, dizziness muscle contraction and so on. The other case was expressed ulticaria, itching sensation, nausea and erythema. Especially ulticaria erythema are end points of increased vascular permeability and vasodilatation at the extreme of the clinical spectrume.