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유승수,강효경,최진은,최선하,이소연,유승수,이신엽,이재희,차승익,김창호,석양기,이응배,조석기,전상훈,박재용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.0
Recently, it has been reported that variants of mitosis-related genes can be affect chromosome stability. We evaluated the association between these variants and survival outcome in patients with non-small cell lung cancer (NSCLC). In total, 766 patients with NSCLC who underwent curative surgery were enrolled. Seventy-three variants form 25 mitosis-related genes were genotyped and their associations with survival outcome were analyzed. BUB3 rs7897156 C>T and AURKB rs1059476 G>A were significant associated overall survival under a recessive model (adjusted hazard ratio [aHR], 1.58, 95% confidence interval [CI] 1.07-2.33, P = 0.02 and aHR 0.64, 95% CI 0.41-0.99, P = 0.05, respectively). PTTG1 rs1895320 T>C and RAD21 rs1374297 C>G were associated with worse disease-free survival under a recessive model (aHR 2.46, 95% CI 1.43-4.23, P = 0.001 and aHR 1.32, 95% CI 1.00-1.75, P = 0.05, respectively). We conducted functional analysis of the BUB3 rs7897156 C>T using luciferase reporter assay. Relative luciferase activity of BUB3 rs7897156 T allele was higher than C allele in H1299 and A549 cell line (P = 0.02 and 0.003, respectively). The BUB3 mRNA expression level in normal tissue also higher in rs7897156 CT or TT genotypes than in rs7897156 CC genotype (P = 0.04). These results suggest that four variants of mitosis-related genes (BUB3 rs7897156 C>T, AURKB rs1059476 G>A, PTTG1 rs1895320 T>C and RAD21 rs1374297 C>G) may affect prognosis of surgically resected NSCLC.
TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
유승수,도숙경,최진은,이신엽,이재희,차승익,김창호,박재용 대한의학회 2015 Journal of Korean medical science Vol.30 No.10
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR] = 1.38, 95% confidence interval [CI] = 1.05-1.81, P = 0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR = 1.73, 95% CI = 1.18-2.54, P = 0.005) and adenocarcinoma (OR = 1.50, 95% CI = 1.07-2.07, P = 0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.
유승수,( Su Man Lee ),( Hyo-sung Jeon ),( Shin Yup Lee ),( Jae-hee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Dong Sun Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Natural antisense transcripts (NATs) constitute a class of non-coding RNAs that have emerged as important regulators of gene expression in an epigenetic manner. Tumor suppressor P53 plays an important role in the cell-intrinsic responses to genome instability, including a transient cell cycle arrest, senescence and apoptosis. A Wrap53α (WD40-encoding RNA anti-sense to p53) that transcription initiated from exon 1α is required for p53 induction upon DNA damage. However, involvement of Wrap53α in lung cancer has not been reported to date. We determined the methylation status of Wrap53α genes in primary lung tissues using a methylation-specific PCR (MSP) and evaluated their relationship with clinicopatholgial features and sur-vival in patients with non-small cell lung cancer (NSCLC). Wrap53α promoter was unmethylated in most malignant and corre-sponding nonmalignant tissues. Wrap53α methylation was detected in 19 (13.3%) of 146 tumor tissues and 12 (8.2%) of 146 normal tissues. In addition, Wrap53α methylation in normal and non-malignant tissues was frequently detected in p53 muta-tion-negative patients and in patients with stages II-IV. Patients with Wrap53α methylation in normal tissues exhibited sig-nificantly worse overall survival, while methylation in tumor tissues did not affect the survival outcome of patients. These findings suggest that Wrap53α methylation play a role in lung carcinogenesis. However, further studies with a large number of cases are needed to confirm this.
유승수,홍미정,최지은,이장혁,백선아,이원기,이소연,이신엽,이재희,차승익,김창호,조석기,박재용 대한의학회 2016 Journal of Korean medical science Vol.31 No.3
Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.
GPS L1 C/A 신호를 위한 심층신경망을 이용한 단일 연속파 재밍 검출기법
유승수,이준형,김선용 제어·로봇·시스템학회 2020 제어·로봇·시스템학회 논문지 Vol.26 No.8
. In this paper, a novel deep neural network-based single continuous wave jamming detection scheme is proposed for Global Positioning System (GPS) L1 Coarse/Acquisition (C/A) signals, which are used most frequently in civilian satellite-based navigation systems. The main environmental variables considered are as follows: The effective jamming power-to-noise spectral density ratio (J/N0) has a range of 34 dB-Hz to 64 dB-Hz; the center frequency and Doppler frequency of a single continuous wave jamming occur uniformly within ± 1 KHz and within ± 10 KHz, respectively, based on the center frequency of the GPS L1 C/A signal. The designed deep neural network consists of six hidden layers and one SoftMax layer. In order to assess the performance of the proposed scheme, the energy detection scheme that is frequently used for the detection of single continuous wave jamming at pre-correlation level is considered as a conventional scheme. When the false alarm probability is set to 10-5 via simulation, it was confirmed that the detection probability of the proposed scheme is approximately 98% or higher, while that of the conventional scheme is approximately 78% at an effective J/N0 of 61 dB-Hz.
유승수,방혜정,김선용,공승현,지규인,이장규,김진원 에스케이텔레콤 (주) 2008 Telecommunications Review Vol.18 No.2
본 논문에서는 휴대인터넷 시스템의 무선측위 가능성을 분석한다. 무선측위는 이동통신망에서 기지국과 단말기 사이의 송수신 신호를 이용해 단말기의 위치를 결정하는 기술이다. 이를 위해 먼저 현재 휴대 인터넷 표준에 정의된 정보 가운데 무선측위를 위해 사용 가능한 메시지 및 신호를 파악하고, 이 신호가 최소 3개 이상의 기지국으로부터 단말기에 수신되는 정도, 즉 가청성(hearability)을 분석한다. 끝으로 휴대인터넷 표준 정립 시 기고된 각 기법의 평가를 위해 사용한 페이딩 채널을 사용한 모의실험을 통해 측위 정확도를 보인다.
유승수,김선용 제어·로봇·시스템학회 2022 제어·로봇·시스템학회 논문지 Vol.28 No.3
Frequency hopping binary offset carrier (FH-BOC) signals use a wider band than other BOC signals, resulting in high signaltracking accuracy and low ambiguity for their correlation functions. Even with these improved metrics, ambiguities remain in correlationfunctions and could lead to false locking during code tracking. The FH-BOC signal is obtained from a time division multiple combiningmultiple BOC signals with different frequencies through a process called frequency hopping. This report outlines the common pulsecomponent between several sub-carriers of the FH-BOC signal. This pulse is correlated with the received signal and combined to design anunambiguous correlation function for the FH-BOC signal. Compared to the FH-BOC signal’s correlation function, the designedunambiguous correlation function is less affected by multipaths because more power is concentrated at the main peak. .