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혈중 CA 125 항원의 동태에 따른 상피성 난소암 환자의 예후에견
김경태,황윤영,문형 대한부인종양 콜포스코피학회 1996 Journal of Gynecologic Oncology Vol.7 No.1
The prognostic value of serum CA 125 measurements was assessed in 68 patients with epithelial ovarian cancer. All patients received a minimum of two courses of cisplatin at the Department of Obstet~rics and Gynecology, Hanyang University Hospital. The end points of the analysis were surgically free of disease after completion of cytoreductive chemotherapy(pathological complete response: pCR) and 5-year survival rate. The positive rate of CA 125 was 78%(53/68) in patients with epithelial ovarian cancer. The prechemo-therapy level of CA 125(< or >35U/ml) was of value in predicting which patients would develop progressive disease(pCR: 100% vs 55%, 5-year survival: 100% vs 50%). We divided 53 cases( >35U/ml) into 4 groups according to CA 125 regression pattern as 1) absolute prechemotherapy CA 125 level(<100U/ml or >100U/ml), 2) sevenfold decrease after 1 month of chemotherapy(>1/7 or <1/7, 3) CA 125 level after 3 months(normal or abnormal), and 4) half life of CA 125(>20 days or <20 days). Pathological complete response rates were as follows 1) 100% vs 53%, 2) 75% vs 47%, 3) 50% vs 57%, 4) 55% vs 56%, respectively. 5-year survival rates were as follows : 1) 100% vs 41%(p= 0.004), Z) 67% vs 42%(p=0.033), 3) 50% vs 44%, 4) 57% vs 43%, respectively. In this study, absolute prechemotherapy CA 125 levels(100U/ml) and the change in CA 125 levels from before chemotherapy to 1 month later, after one course of cisplatin, could be used to divide patients into different prognostic groups in terms of survival rate. The change in CA 125 levels may indicate which patients should be offered alternative or symptomatic therapy and which should continue with the currently available toxic chemotherapy.
상피성 난소암 환자의 항암제 내성에 대한 통계학적 분석 : 콕스 모델을 이용한 다변량 분석
김경태,황윤영,나도수,박문향,이승연,이승욱 대한부인종양 콜포스코피학회 1996 Journal of Gynecologic Oncology Vol.7 No.2
Background. Several molecular-genetic alterations in epithelial ovarian cancer, including expression of glutathione S-transferase-π(GST-π), p-glycoprotein(p-gly), and metallothionein(MT), have been associated with drug resistance and poor prognosis. To deterrmine the importance of molecular-genetic factors relative to more traditional surgical-pathologic prognostic factors, a multivariable analysis was performed. Method. Immunohistochemical staining for GST-π, p-gly, and MT was performed in relation to the response to chemotherapy with cisplatin in 87 patients with primary epithelial ovarian cancer who had not received any chemotherapy before surgery. In addition, information regarding surgical-pathologic features of the cancers was obtained. Univariabe analysis was performed followed by multivariable analysis using Cox's proportional hazards model to identify variables predictive of poor prognosis. Results. With univariable analysis, age, FIGO stage, grade, MT, ascites, residual tumor, and initial value oA 125 were predictive of patient's survival. In the multivariable analysis, only age, grade, stage, histologic type and residual tumor were significant. Cox's regression model fitting stratified by stage, MT(p=0.0362) was significant on early stage of cancer, however, histologic type(p=0.0001) was significant in advanced ovarian cancer. Conclusion. Among factors for drug resistance to chemotherapy, MT was the most strongly predictive of survival in early ovarian cancer.
그래핀 산화물 분말 첨가에 의한 비스무스 텔루라이드 기지 복합재료의 열전에너지변환 특성 고찰
김경태,민태식,김동원,Kim, Kyung Tae,Min, Taesik,Kim, Dong Won 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.4
Graphene oxide (GO) powder processed by Hummer's method is mixed with p-type $Bi_2Te_3$ based thermoelectric materials by a high-energy ball milling process. The synthesized GO-dispersed p-type $Bi_2Te_3$ composite powder has a composition of $Bi_{0.5}Sb_{1.5}Te_3$ (BSbT), and the powder is consolidated into composites with different contents of GO powder by using the spark plasma sintering (SPS) process. It is found that the addition of GO powder significantly decreases the thermal conductivity of the pure BSbT material through active phonon scattering at the newly formed interfaces. In addition, the electrical properties of the GO/BSbT composites are degraded by the addition of GO powder except in the case of the 0.1 wt% GO/BSbT composite. It is found that defects on the surface of GO powder hinder the electrical transport properties. As a result, the maximum thermoelectric performance (ZT value of 0.91) is achieved from the 0.1% GO/BSbT composite at 398 K. These results indicate that introducing GO powder into thermoelectric materials is a promising method to achieve enhanced thermoelectric performance due to the reduction in thermal conductivity.
자기 주도 학습을 위한 컴퓨터 구조론의 웹 기반 학습시스템 설계 및 구현
김경태,임동균,신승중 한국인터넷방송통신학회 2010 한국인터넷방송통신학회 논문지 Vol.10 No.6
시대의 흐름이 점차 정보화 시대로 변함에 따라 정보화 시대를 대표하는 컴퓨터와 통신기술의 발달에 대한 가치가 매우 중요시하게 되었다. 이중 컴퓨터 통신의 사용에서 가장 많은 사용 비중을 차지하는 것은 인터넷이고 이런 인터넷의 발전은 정보가 상호 작용하는 수단으로 자리매김하였다. 논문은 웹 기반교육이 학습자에게 효과적인 교육 시스템으로서의 역할을 하기 위해 기존의 학습시스템 문제점을 찾아내어 개선하고, 시간과 공간의 제약을 받지 않고 양방향의 상호 작용이 가능하도록 웹 기반학습을 사용하여 컴퓨터 구조론의 학습이 가능 하도록 하였다. 웹 기반학습을 이용한 컴퓨터 구조론 학습 방법은 학습자가 시간과 장소의 제한을 받지 않고 인터넷의 브라우저를 통해 실시간 학습과 평가를 가능하게 하며 학습자 개개인에게 알맞은 교수-학습 과정으로 연계하여 학습자 개인별 자기 주도 학습이 가능하도록 하는 역할을 담당할 것이다. The flow gradually into the Information age to the Information age has changed, leading to the development of computer and communication technology was very important for the value. Of these the most used in computer communication using the Internet, and this proportion accounts for the development of the Internet, the information was established as a means of interaction. In this paper, to improve these problems without the constraints of time and space to allow two-way interactions using web based learning system to enable Computer Architecture were learning. Learn how Computer Architecture using Camtasia the learner, without limitation of time and place of the browser through the Internet to enable real-time learning and assessment appropriate to individual learners and teaching - learning process in conjunction with individual learners can be self-directed learning will play a role in that.
초음파로 위치판별이 가능했던 흉막에 발생한 단독성 섬유성 종양: 증례 보고
김경태,전용선,조순구,김광호,이경희 대한초음파의학회 2010 ULTRASONOGRAPHY Vol.29 No.1
현재 흉부에 발생한 병변에 대해서는 단순흉부촬영과 컴퓨터단층촬영이 진단적 검사로 널리 쓰이며, 초음파검사는다른 인체부위에서는 널리 이용되나 흉부에서는 제한적으로 사용되고 있다. 저자들은 다른 영상기법으로는 감별진단이 어려웠던 하부 흉막에 발생한 섬유성 종양의 진단에있어서 초음파검사를 이용하여 정확히 위치를 판별하여종양에 대한 감별진단을 좁힐 수 있음을 경험하였기에 이를 보고하고자 한다. Plain radiography and computed tomography are widely used in the field of chest disease. Yet ultrasonography has a limitation as a diagnostic tool, except in the case of pleural effusion and chest wall lesion. We experienced a case of solitary fibrous tumor of the diaphragmatic pleura, and the origin of this tumor could be exactly localized by ultrasonography, but not by other imaging modalities.
김경태,장시훈,김은수,조성록,박준건,문덕수,김현주,Kim, Kyung-Tae,Jang, Si-Hun,Kim, Eun-Soo,Cho, Sung-Rok,Park, Jun-Kun,Moon, Deok-Soo,Kim, Hyeon-Ju 해양환경안전학회 2007 海洋環境安全學會誌 Vol.13 No.1
동해의 해양 심층수 자원 기반 환경 연구의 일부로 청결기술을 적용하여 해수 중의 용존 미량금속(Cd, Co, Cu, Ni, Pb, Zn) 농도 분포와 변화를 조사하였다. 강원과 경북 지역에 총 6개 정점을 선정하고, 각 지역마다 최대 채수 수심 각각 200-300m와 500m까지 시료를 채취하였다. 본 연구의 미량금속을 위한 연안해수 표준물질(CASS-4)의 분석 결과 각 원소 평균 회수율은 Co의 89.4%에서 Cd의 99.8%의 범위였다. 용존 미량원소의 분포는 해역 및 시기적인 변화가 다양하게 나타났다. Cd, Ni, Zn의 경우는 영양염 의존형으로 표층에서 낮고 저층으로 갈수록 증가하는 경향이 뚜렷하였다. 그러나 Co, Cu, Pb은 수직적으로 불규칙적인 분포를 나타내었다. 본 연구의 동해 심층수 원수의 중금속 농도는 해역별 수질 기준과 먹는 물 기준을 만족하였다. In order to develop the deep ocean water, the characteristics of vertical distribution of dissolved trace metals(Cd, Co, Cu, Ni, Pb, Zn) were investigated from Apr. to Oct., 2005 in the East Sea. Total six sampling sites were selected in Gangwon-Do and Gyeongsangbuk-Do. Accuracy of the analytical procedures was assessed by the SRM(CASS-4) for dissolved metals in seawater. The mean recoveries cf CASS-4 ranged from 89.4% for Co to 99.8% for Cd. In this study, the dissolved metal concentrations varied with space, time and element. The metal concentrations showed wide range in the surface. Cd, Ni and Zn showed a nutrient-type profile with surface depletion and enrichment at depths. However, Co, Cu and Pb were irregular in the vertical distribution. All metal concentrations studied in this study are lower than the criteria cf Korean drinking water.