Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

通度寺 進入空間을 통해서 본 傳統景觀의 現代的 受容에 관한 考察

鄭基浩,韓炳權,全美璟 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

Traditional landscapes were effected on the characteristics of nature and culture and have created distinct landscapes, while todays such attributes are becoming obscure as technology. In aspect of the contermperary applications of traditional landscapes, the cognitive qualities of observers was researched, which is about the components of entrance space in Tongdo Teple by phenomenological approach. The results of this can be summarized as follows : 1. Old components were not perceived and effected on the behavior of observers. 2. Cognitive qualities were varied from the attributes of space in and out. 3. Artificial features that related to contemporary life were perceived easily. As there were old and contemporary features to gether, the existence of old things is to be obscure relatively.

초음파 수침법을 이용한 터빈베어링 Babbitt 금속 박리 검사 기술

정계조,박상기,조용상,박병철,길두송 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

이 연구는 터빈베어링의 신뢰성을 평가하기 위하여 초음파 C-Scan 방법을 적용한 기술이다. 수침법에 관한 연구는 실험실과 현장검사 적용에 광범위하게 사용되는 기술이다. 여기에서는 C-Scan 방법을 이용하여 베어링의 모재와 Babbitt 금속간 경계부의 상태를 평가하였다. 수침법 C-Scan 방법에 의한 초음파 영상은 베어링 경계부의 상태를 확인하는데 효과적인 방법으로 사용될 수 있었다. 초음파 영상의 분해능을 높이기 위하여 집속형 탐촉지를 사용하고, Babbitt 금속과 베어링 모재간의 접합경계면에서 발생하는 초음파 음압 반사율을 측정하여 결함의 검출과 면적을 추정할 수 있었다. 초음파 수침법은 베어링 접합부의 박리위치와 박리면적의 경계면을 결정하여 크기를 계산하는데 아주 유용하게 사용될 수 있는 기술이며, 이 연구에서 개발된 기술은 화력발전소에서 사용되고 있는 터빈베어링의 건전성을 확보하는데 적용되었다. This study is aimed for the implementation of ultrasonic method to assess the reliability of turbine bearings. A modified ultrasonic immersion technique was carried out in both laboratory experiment and field application. From the laboratory results, we confirmed that the condition of interface layer between the babbitt and base metal be monitored by the C-Scan. The C-Scan image by the ultrasonic immersion test can be used successfully to observe the condition of interface layer. The testing with a focused transducer provides a promising approach for estimating the extent of the damaged region and observing the interface layer effectively. The difference of the ultrasonic reflection ratio between the bonding and debonding area at the interface layer is one of the key parameters for assessing the extent of the damaged area; additionally, the reflection amplitude exhibits a favorable correlation with the overall damage level. The technique developed in this study was applied to the inspection of the turbine bearings at several power plants in Korea whereby the applicability in the filed can be ascertained.

실험동물에서의 내분비계 교란물질인 DEHP, DBP의 생체내 영향

정지윤,이성호,박영석,박병권,김병수,김상기,박창식,강경선,이영순 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The major protocol features of the rodent uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. The rodents were ovariectomized under general anesthesia via bilateral flank incisions and randomly assigned to groups of 5 animals. This study investigated the estrogenic effects of phthalates, which are DEHP and DBP, suspected as endocrine disruptors. It is concluded that three daily subcutaneous administration of test chemicals, which are di-ethylhexyl phthalate(DEHP) and di-n-butyl phthalate(DBP), to 9 week-old rodents. The results revealed that DEHP & DBP show similar uterotrophic activity in the rat and the mouse, using subcutaneous administration. DEHP and DBP failed to affect any of these parameters, which are body weight, mammary gland, vaginal and uterus histopathology. but, DBP increased uterus weight to only one rat of 1.0 g/kg group. The results conform the need for rigorous attention to experimental design and criteria for assessing estrogenic activity.

Al 2024-T3재의 Crack Opening Point의 평가에 관한 연구

최병기,국중민 한국공작기계학회 2002 한국공작기계학회 춘계학술대회논문집 Vol.2002 No.-

This paper aims to synthesize the research on fatigue mechanisms of high strength aluminum alloys which are widely used in motorcars or airplanes to prevent accidents. To measure the data of crack opening ratio, the same materials and methods are used for evaluating the fatigue crack propagation rate as an effective stress intensity factor. But, many researchers have brought different results. An exact crack opening ratio was, therefore, proposed for getting a more accurate fatigue crack propagation rate.

IgY 함유 계란의 항헬리코박터 치료효과에 관한 연구

서정일,배만종,김병기 경산대학교 생명자원개발연구소 2002 생명자원과 산업 Vol.6 No.-

면역물질인 IgY가 함유된 다기능성 계란 섭취로 인체에서 H. pylori 제균치료에 어떠한 효과를 나타내는지 알아보고자 H. pylori 양성인 위염환자 63명을 대상으로 임의로 IgY 함유 계란 투여군(17명), 항생제 투여군(17명) 및 항생제와 IgY 함유 계란 병합투여군(16명)으로 나누고 2주간 치료하였고 IgY 정제 투여군(13명)은 1개월간 치료하였다. 치료후 H. pylori 박멸률, ^13CO_2 변화율(Δ^13CO_2) 및 updated sydney system에 따른 H. pylori 균체 밀도, 급만성 염증 활성도, 장상피화생을 비롯한 위축도 등의 조직학적 변화에 대한 시험결과는 다음과 같다. 1. IgY 함유 계란 투여군, 항생제 투여군, 항생제 와 IgY 함유 계란 병합 투여군 및 IgY 정제 투여군에서 H. pylori 박멸률은 각각 0%, 88%, 94% 및 0%로 IgY 함유 계란을 항생제와 병합투여했을 때 항생제만 투여할 때보다 H. pylori 박멸률이 높게 나타났지만 유의성은 없었다. 2. IgY 함유 계란 투여군 17명 중 1명이 Δ^13CO_2이 감소하는 경향을 보였지만 나머지는 변함이 없었다. 3. 항생제와 IgY 함유 계란 병합투여군 16명 중 15명에서 치료 1주째 Δ^13CO_2이 모두 4이하로 치료전보다 유의하게 감소하였으며 (p<0.05), 나머지 1명도 치료 1주와 2주째 Δ^13CO_2이 치료전에 비해 감소하는 경향을 보였다. 4. IgY 함유 계란 투여군과 IgY 정제투여군에서 위전정부의 급성 염증 활성도가 유의하게 감소하였다(p<0.01). 5. IgY 함유 계란 투여군과 IgY 정제 투여군에서 위전정부의 H. pylori 균체 밀도가 유의하게 감소하였다(p<0.05). 6. IgY 정제 투여군에서 위체부의 만성 염증 활성도가 감소하는 경향을 보였다. 7. IgY 함유 계란 투여군에서 위전정부 및 위체부의 장상피화생과 위축도는 치료전후 변화가 없었다. 8. IgY 정제 투여군의 1예에서만 치료 전 위전정부에 경도의 장상피화생이 관찰되었으며 치료후 정상으로 호전되었다. 위점막 위축은 대상환자 모두에서 치료전후 변화가 없었다. This study was conducted to investigate the effect of chiken egg containing IgY againt H. pylori in patients with gastritis. Sixty three H. pylori-infected volunteers (20-43 year, Male:Female=49:14) were randomized into four groups which were treated with one chiken egg containing IgY b.i.d. (IgY group:n=17) or omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 500mg b.i.d. (OAC group:n=17) or omeprazole 20mg b.i.d. amoxicillin 1.0g b.i.d., clarithromycin 500mg b.i.d. and one chiken egg containing IgY b.i.d. (OAC with IgY group:n=16) for 2 weeks or lyophilized IgY 1g b.i.d (lyophilized IgY group) for 1 month. Δ^13CO_2 before and after treatment, the eradication rate of H. pylori and histologic change including H. pylori density, acute and chronic inflammation activity, intestinal metaplasia and glandular atrophy by updated sydney system were evaluated. 1. Eradication rate of OAC with IgY group (94%) was higher than IgY group(0%), lyophilized IgY group(0%) and OAC group(88%). 2. Δ^13CO_2 at 2 weeks after treatment in one patient of IgY group was decreased. But that was not changed in the other patients. 3. Δ^13CO_2 at 1 week after treatment in 15 patients of OAC with IgY group was significantly lower than pretreatment level (p<0.05), and Δ^13CO_2 at 1 week and 2 week after treatment was decreased in the other patient. 4. Acute inflammation activity at antrum was significantly decreased after treatment in IgY and lyophilized IgY group(p<0.01). 5. H. pylori density at antrum was significantly decreased after treatment in IgY and lyophilized IgY group (p<0.05). 6. Chronic inflammation activity at body was decreased after treatment in lyophilized IgY group. 7. Intestinal metaplasia and grandular atrophy at antrum and body were not changed after treatment in IgY group. 8. Mild intestinal metaplasia in one patient of lyophilized IgY group changed to normal after 1 month treatment. Gandular atrophy at antrum and body were not changed after treatment in lyophilized IgY group.

염화콜린 및 유사물질이 녹두유묘의 생장 및 발근에 미치는 영향

이정명,민병훈,박영기 경희대학교 부설 식량자원개발연구소 1992 硏究論文集 Vol.13 No.-

Experiments were conducted to investigate the effect of choline chloride and its analogues on the rooting of mungbean cuttings. Major results can be summarized as follows. 1. Rooting of mungbean cuttings was significantly promoted by choline chloride a t 10-1,000ppm even though there were considerable variations depending upon the environmental conditions at the time of experiment. 2. Toxicity symptoms were occasionally found in the seedlings soaked in choline chloride solutions of higher concentrations. The toxicity symptoms were appeared to be related with the speed of choline chloride uptake immediately following the treatment. 3. Considerable variations in effectiveness were found among the different formulations of choline chloride. Though the response was greatly affected by the environmental conditions, the formulations containing surfactants gave the most sensitive response. 4. Among the tested choline chloride analogues, chlorocholine chloride (chlomequat or CCC) and choling (choline salt of maleic hydrazide) showed inhibition of rooting whereas significant rooting promotion was obtained with phosphocholine chloride, acetylcholine chloride, and S-butyrylthiocholine chloride. 5. Among the various vitamines tested, vitamin K 3 was found to be most efective in promoting root differentiation in mungbean cuttings. 6. Addition of vitamin B5 to choline chloride significantly increased the rooting of mungbean cuttings, though it alone had little or no effect.

순수 Ti 용접재의 기계적 특성 및 피로크랙 성장특성에 관한 연구

최병희,이종범,정장만,장경천,최병기 朝鮮大學校 機械技術硏究所 2007 機械技術硏究 Vol.10 No.2

In this study, fatigue fracture often occurs due to the fatigue crack in the machine and welding structure and this is the result of severe operational environment, operational condition, and design condition caused by the large scaled and light weighted machine and structure in recent days. Therefore, safety and reliability should be secured to prevent the fatigue fracture of machine and structure, and the use of titanium has been increased in the metal material for the safety and reliability. The purpose of this thesis was to investigate the welding characteristics and fatigue crack growth characteristics of titanium, commonly using power station, aircraft and ship. The experimented material was TIG welded in order to look over the characteristics according to the notch position and compare with other material. The results, at the same welding condition, 4 pass specimen which had the smallest number of welding pass had the highest tensile strength with 51kgf/㎟ and the tensile strength of 4 pass specimen was 10% higher than the one of 7 pass specimen, and its elongation reduced about 30%. The initial fatigue crack growth characteristic is slower in this order, boundary zone < welding zone < HAZ < base metal. Especially boundary zone's growth speed is slower about 30 times than base metals.

두개인두종의 치료성적과 조직학적 유형 및 PCNA지수의 연관성에 대한 연구

김기정,오창완,조병규,김정선,지제근,최길수 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

Craniopharyngiomas exhibit benign histologic features. However, such tumors have a relative high incidence of recurrence after surgical removal. In order to device reliable and efficient methods in identifying craniopharyngiomas with increased risk for recurrence after surgical removal, proliferating cell nuclear antigen(PCNA) expression as well as histological characteristics of the tumor were analyzed. There were 43 patients who had been surgically confirmed and had paraffin-embedded tissue from June, 1984 to May, 1993 avaliable for analysis from our department. Of the 43 patient, eighteen cases were in children(age of 15 years or less) and 25 cases were in adults. The mean follow-up period was 42.7 months. The histologic types were adamantinous in 30 cases, squamous papillary in 9 cases and mixed in 4 cases. There was no case of tumor recurrence in the squamous papillary group, while the recurrence rate was about 55% in the adamantinous group after surgical removal alone. The mean age of the adamantinous group was younger than that of the squamous papillary group(17.5 vs. 37.9 years old. P=0.0012), and the squamous papillary type was found only in adults(age over 20). In the group of 30 patients treated by surgical removal without radiation, the PCNA labelling index, calculated by counting the basal cell layer only, was significantly higher in the group with recurrence than without recurrence(9.51 vs. 6.58, P=0.001). However, the PCNA labelling index obtained by counting all cells in the four high-power (×400) fields failed to demonstrate any correlation with tumor recurrence. With a reference value of 8, PCNA index of the basal cell layer demonstrated the predictive sensitivity of 81.8% and specificity of 84.2% for tumor recurrence. There was no significant difference in PCNA labelling indices between adamantinous and squamous papillary types. As PCNA labelling index of the basal cell layer, as well as the histologic type, are sensitive indicators for prediction of tumor recurrence after surgical removal of craniopharyngiomas, therefore they should be considered as an index for biologic behavior of the tumor.