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- 주제어 : positron emission tomography (검색결과 796 건)
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Youn, Seok Hwa,Seo, Kyung Won,Lee, Sang Ho,Shin, Yeon Myung,Yoon, Ki Young The Korean Gastric Cancer Association 2012 Journal of gastric cancer Vol.12 No.3
Purpose: The use of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography-computed tomography as a routine preoperative modality is increasing for gastric cancer despite controversy with its usefulness in preoperative staging. In this study we aimed to determine the usefulness of preoperative positron emission tomography-computed tomography scans for staging of gastric cancer. Materials and Methods: We retrospectively analyzed 396 patients' positron emission tomography-computed tomography scans acquired for preoperative staging from January to December 2009. Results: The sensitivity of positron emission tomography-computed tomography for detecting early gastric cancer was 20.7% and it was 74.2% for advanced gastric cancer. The size of the primary tumor was correlated with sensitivity, and there was a positive correlation between T stage and sensitivity. For regional lymph node metastasis, the sensitivity and specificity of the positron emission tomography-computed tomography were 30.7% and 94.7%, respectively. There was no correlation between T stage and maximum standardized uptake value or between tumor markers and maximum standardized uptake value. Fluorodeoxyglucose uptake was detected by positron emission tomography-computed tomography in 24 lesions other than the primary tumors. Among them, nine cases were found to be malignant, including double primary cancers and metastatic cancers. Only two cases were detected purely by positron emission tomography-computed tomography. Conclusions: Positron emission tomography-computed tomography could be useful in detecting metastasis or another primary cancer for preoperative staging in gastric cancer patients, but not for T or N staging. More prospective studies are needed to determine whether positron emission tomography-computed tomography scans should be considered a routine preoperative imaging modality.
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윤석화,윤기영,서경원,이상호,신연명 대한위암학회 2012 Journal of gastric cancer Vol.12 No.3
Purpose: The use of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography-computed tomography as a routine preoperative modality is increasing for gastric cancer despite controversy with its usefulness in preoperative staging. In this study we aimed to determine the usefulness of preoperative positron emission tomography-computed tomography scans for staging of gastric cancer. Materials and Methods: We retrospectively analyzed 396 patients’ positron emission tomography-computed tomography scans acquired for preoperative staging from January to December 2009. Results: The sensitivity of positron emission tomography-computed tomography for detecting early gastric cancer was 20.7% and it was 74.2% for advanced gastric cancer. The size of the primary tumor was correlated with sensitivity, and there was a positive correlation between T stage and sensitivity. For regional lymph node metastasis, the sensitivity and specificity of the positron emission tomographycomputed tomography were 30.7% and 94.7%, respectively. There was no correlation between T stage and maximum standardized uptake value or between tumor markers and maximum standardized uptake value. Fluorodeoxyglucose uptake was detected by positron emission tomography-computed tomography in 24 lesions other than the primary tumors. Among them, nine cases were found to be malignant, including double primary cancers and metastatic cancers. Only two cases were detected purely by positron emission tomography-computed tomography. Conclusions: Positron emission tomography-computed tomography could be useful in detecting metastasis or another primary cancer for preoperative staging in gastric cancer patients, but not for T or N staging. More prospective studies are needed to determine whether positron emission tomography-computed tomography scans should be considered a routine preoperative imaging modality.
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신덕섭,나호동,박재우 대한정형외과학회 2019 대한정형외과학회지 Vol.54 No.6
Purpose: Lymph node metastasis is a very important prognostic factor for all skin cancers and some sarcomas. A sentinel lymph node (SLN) biopsy is the most useful technique for identifying SLNs. Recently, a new generation of diagnostic tools, such as single photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/CT (PET/CT) enabled the detection of SLNs. This study compared the efficacy of PET/CT for detecting lymph node metastases with a SLN biopsy in a single medical center. Materials and Methods: From 2008 to 2018, 72 skin cancers of sarcoma patients diagnosed with some lymph node involvement in a whole body PET/CT reading were assessed. Patients suspected of lymph node metastasis were sent to biopsy and those suspected to be reactive lesions were observed. The analysis was performed retrospectively using the medical records, clinical information, PET/CT readings, and pathology results. Results: The age of patients ranged from 14 to 88 years and the mean follow-up period was 2.4 years. Twenty-two patients were suspected of a lymph node metastasis and confirmed. The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT images in sarcoma and non-sarcoma tumors were increased significantly when the expert’s findings were considered together. Conclusion: PET/CT is effective in detecting lymph node metastases. 목적: 악성 종양 환자에서 림프절 전이를 발견하는 것은 초기에 정확한 병기 및 예후와 관련된 정보를 알 수 있고 수술 후 보조치료(adjuvant therapy)의 필요성을 평가해서 조기에 치료를 할 수 있도록 해주기 때문에 중요하다. 본 연구를 통해 정형외과 영역의 악성 종양 환자를 평가함에 있어 양전자 방출 컴퓨터 단층 촬영기(positron emission tomography/computed tomography, PET/CT)가 sentinel lymph node biopsy와 비교하여 유용한지를 알아보고자 한다. 대상 및 방법: 2008년부터 2018년까지 악성 근골격계 종양으로 진단받고 PET/CT를 촬영한 환자 251명 중 72명의 환자를 선별하여 후향적 분석을 시행하였다. 림프절 전이가 의심되는 환자군은 조직검사를 시행하였다. 분석은 의무기록, 임상정보, PET/CT 영상 및 판독 소견, 병리 결과를 통해 시행하였으며, 임상경과 및 병리검사 결과를 PET/CT 결과와 비교하여 PET/CT의 정확도를 평가하였다. 결과: 환자의 나이는 14세에서 88세까지 분포하였고, 평균 추시 기간은 2.4년이었으며, 22명에서 림프절의 전이가 확인되었다. 육종 및 비육종 종양에서 PET/CT 영상의 민감도, 특이도, 양성예측도, 음성예측도는 전문가의 소견을 함께 고려할 경우 상당히 상승하는 것을 확인하였다. 결론:
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( Ji Young Tak ),( Gun Oh Chong ),( Ji Y. Park ),( Seung Jeong Lee ),( Yoon Hee Lee ),( Dae Gy Hong ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.5
Adult granulosa cell tumors (AGCTs) presenting with massive ascites and elevated serum CA-125 levels have rarely been described in the literature. An ovarian mass, massive ascites, and elevated serum CA-125 levels in postmenopausal women generally suggest a malignant ovarian tumor, particularly advanced epithelial ovarian cancer. AGCT has low 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography due to its low metabolic activity. In the present report, we describe a case of an AGCT with massive ascites, elevated serum CA-125 level, and low 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography.
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정윤정,팽진철,남현열,이지선,이상민,유철규,김영환,한성구,임재준 대한의학회 2014 Journal of Korean medical science Vol.29 No.3
The presence of radiographic lesions suggesting old healed tuberculosis (TB) is one of thestrongest risk factors for the subsequent development of active TB. We elucidated themetabolic activity of radiographic lesions suggesting old healed TB using18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT). This cross-sectional study included 63 participants with radiographic lesionssuggesting old healed TB and with available 18F-FDG PET/CT scans. The maximumstandardized uptake value (SUVmax) measured in the lesions, the clinical characteristics,results of the tuberculin skin test (TST) and interferon-γ release assay (IGRA) were analyzed. The SUVmax in old healed TB was 1.5 or higher among nine (14.3%) participants. Age(adjusted odds ratio [aOR], 1.23; 95% CI, 1.03-1.46), history of previous TB (aOR, 60.43;95% CI, 1.71-2131.65), and extent of the lesions (aOR, 1.34; 95% CI, 1.02-1.75) wereassociated with higher SUVmax. The positive rates for the TST and IGRA were not differentbetween groups with and without increased FDG uptake. Increased FDG uptake on 18F-FDGPET/CT was observed in a subset of patients with radiographic lesions suggesting old healedTB. Given that the factors associated with increased FDG uptake are known risk factors forTB development, the possibility exists that participants with old healed TB lesions withhigher SUV on 18F-FDG PET/CT scans might be at higher risk for active TB.
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Positron Emission Tomography/Computed Tomography in the Staging of Colon Cancer
이재형,이민로 대한대장항문학회 2014 Annals of Coloproctolgy Vol.30 No.1
Purpose: Accurate preoperative staging of colon cancer is essential for providing the optimal treatment strategy and evaluating the expected prognosis. The aim of this study is to assess the value of positron emission tomography/computed tomography (PET/CT) over conventional studies in the staging of colon cancer. Methods: A total of 266 colon cancer patients diagnosed between January 2008 and December 2010 were assessed with both PET/CT and conventional studies. Discordance with PET/CT and conventional studies were evaluated, and changes in the management strategy were assessed for each stage. Discordant findings were verified by using intraoperative examination, pathology reports, and follow-up imaging studies. Results: Multidetector computed tomography (MDCT) and PET/CT showed similar accuracy in detecting lymph node metastasis in patients with clinical stage III (36.2% vs. 42%, P = 0.822) and stage IV (60.3% vs. 63.5%, P = 0.509) disease. PET/CT led to a change in management strategy for 1 of 40 patients (2.5%) with clinical stage I, 0 of 25 patients (0%) with stage II, 9 of 138 patients (6.5%) with stage III, and 8 of 63 patients (12.7%) with stage IV disease. Conclusion: PET/CT changed the management plan in 6.5% of patients with clinical stage III and 12.7% of patients with clinical stage IV colon cancer. Our findings suggest that PET/CT may be considered as a routine staging tool for clinical stage III and IV colon cancers.
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이주영,윤순만,김정태,김기배,김미진,박재근,이택구,이상전,궁성수,한정호,채희복,박선미,윤세진 대한장연구학회 2017 Intestinal Research Vol.15 No.2
Background/Aims: 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has beenused for preoperative staging of colorectal cancer (CRC). However, the diagnostic accuracy of FDG-PET/CT for detection oflymph node or distant metastasis and its prognostic role have not been well established. We therefore evaluated the diagnosticand prognostic value of FDG-PET/CT in comparison with conventional CT for CRC. Methods: We investigated 220 patientswho underwent preoperative FDG-PET/CT and CT, followed by curative surgery for CRC. The sensitivity, specificity, accuracy,positive predictive value, and negative predictive value of FDG-PET/CT and CT for detection of lymph node metastasis anddistant metastasis were evaluated. In addition, we assessed the findings of FDG-PET/CT and CT according to outcomes, includingcancer recurrence and cancer-related death, for evaluation of prognostic value. Results: For detection of lymph nodemetastasis, FDG-PET/CT had a sensitivity of 44%, a specificity of 84%, and an accuracy of 67%, compared with 59%, 65%, and62%, respectively, for CT (P =0.029, P =0.000, and P =0.022). For distant metastasis, FDG-PET/CT had a sensitivity of 79%, a specificityof 94%, and an accuracy of 93%, compared with 79%, 87%, and 86%, respectively, for CT (P =1.000, P =0.004, and P =0.037). In addition, positive findings of lymph node metastasis and distant metastasis on FDG-PET/CT were associated significantlywith cancer recurrence or cancer-related death (P =0.009, P =0.001, respectively). Conclusions: Preoperative FDG-PET/CT hada higher specificity and accuracy compared to CT for detection of lymph node metastasis and distant metastasis of CRC. In addition,FDG-PET/CT could be a valuable prognostic tool for CRC.
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이영재,김용만,Phill-Seung Jung,,이종진,김정곤,김영탁,남주현 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.3
Objective: The aim of this study was to evaluate the diagnostic value of integrated 18F-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) for suspected recurrence of epithelial ovarian cancer (EOC) with non-disseminated lesions. Methods: We retrospectively reviewed the medical records of recurrent EOC patients who underwent secondary cytoreduction from January 2000 to December 2013. A total of 134 patients underwent secondary cytoreduction after imaging with either 18F-FDG-PET/CT or contrast-enhanced computed tomography (CECT). Results: In a patient-based analysis of 134 patients, 124 (92.5%) were confirmed to be positive for malignancy. Among 72 patients with suspected non-disseminated recurrence on 18F-FDG-PET/CT, 65 (89.0%) were confirmed to have recurrence, giving 98.5% sensitivity, 87.7% accuracy, and 88.9% positive predictive value (PPV). In the 65 patients with recurrence, residual tumor remained in 14 patients, giving an accuracy of patient selection for secondary cytoreduction of 69.4% (50/72) and it is higher than that of CECT (64.0%). In 169 lesions removed from patients who underwent preoperative 18F-FDG-PET/CT, 135 (79.9%) were confirmed to be positive for malignancy and 124 were accurately detected by 18F-FDG-PET/CT, giving 91.9% sensitivity, 81.1% accuracy, and 85.5% PPV. Foreign body granuloma was found in 33.3% of 21 lesions with false-positive 18F-FDG-PET/CT findings (7/21). The mean preoperative cancer antigen 125 (CA-125) level in false-positive patients was 28.8 U/mL. Conclusion: Compared with CECT, 18F-FDG-PET/CT shows higher sensitivity in lesion-based analysis and better accuracy of patient selection for secondary cytoreduction. However, there is still a need for integration of the results of 18F-FDG-PET/CT, CECT, and CA-125 levels to aid treatment planning.
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박주영,이인호,송창준,김경희,김성수 대한영상의학회 2011 대한영상의학회지 Vol.65 No.2
Here in, we report two cases of organized hematoma in the maxillary sinus mimicking inverted papilloma. These cases presented as heterogeneously enhancing, expansile masses on computed tomography and magnetic resonance imaging, and also evidenced mild uneven hypermetabolism on positron emission tomography-computed tomography. Organized hematoma should be included in the differential diagnosis of inverted papilloma.
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Choi, Hongyoon,Han, Jeong Hee,Lim, Sue Yeon,Lee, Inki,Cho, Young-Seok,Chun, Eun Ju,Lee, Won Woo MIT PRESS 2017 MOLECULAR IMAGING Vol.16 No.-
<P>Positron emission tomography (PET)/computed tomography (CT) using sodium [<SUP>18</SUP>F]fluoride (Na[<SUP>18</SUP>F]F) has been proven to be a promising hot-spot imaging modality for myocardial infarction (MI). We investigated Na[<SUP>18</SUP>F]F uptake in ischemia–reperfusion injury (IRI) of rats and humans. Sodium [<SUP>18</SUP>F]fluoride PET/CT was performed in Sprague-Dawley rats that had IRI surgery, and it readily demonstrated prominent Na[<SUP>18</SUP>F]F uptake in the infarct area post-IRI. Sodium [<SUP>18</SUP>F]fluoride uptake was matched with negative 2,3,5-triphenyl-2<I>H</I>-tetrazolium chloride staining results, accompanied by myocardial apoptosis and associated with positive calcium staining results. Furthermore, area at risk was negative for Na[<SUP>18</SUP>F]F uptake. Cyclosporine A (CysA) treatment reduced standardized uptake value of <SUP>18</SUP>F over the infarct area, and a significant decrease in infarct size was also observed by the CysA treatment. In humans, Na[<SUP>18</SUP>F]F PET/CT readily demonstrated increased Na[<SUP>18</SUP>F]F uptake in the 2 patients with MI post-percutaneous coronary intervention. In conclusion, this study sheds light on the potential utility of Na[<SUP>18</SUP>F]F PET/CT as a hot-spot imaging modality for myocardial IRI.</P>
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