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bFGF의 서방형 방출거동을 가지는 Alginate/PCL 패치를 이용한 고막천공의 재생
임성묵,오세행,김아영,조진생,김진만,이진호 한국생체재료학회 2007 생체재료학회지 Vol.11 No.4
Damage of tympanic membrane (ear drum) is one of common diseases in otorhinolaryngology fields which is frequently arisen as a result of either otitis media or trauma. In recent years, basic fibroblast growth factor (bFGF) which can enhance fibroblast growth and angiogenesis has been employed into the various patches to improve restoration rate of damaged thympanic membranes. However, daily administration of growth factor has been considered as a critical limitation. In this study, we fabricated hydrophilized polycaprolactone (PCL) nanofiber patchs by electrospinning and the following oxygen plasma treatment. The patchs were impregnated and crosslinked by bFGF/alginate/CaSO4 mixture solution to provide the sustained release of bFGF. The mechanical strength and bFGF release behavior from the bFGF/alginate/PCL patches were investigated. To compare thympanic membrane regeneration through the various patches (PCL, alginate/PCL, and bFGF/alginate/PCL), in vivo animal study was also conducted using a guinea pig (acute damaged thympanic membrane model). The regeneration behavior of the thympanic membrane was evaluated by histological observations (H&E staining). From the bFGF release experiment, we observed that the bFGF is continuously released from the alginate/PCL patch, up to 700 ng during 21 days. For the animal study, the bFGF/alginate/PCL patch showed faster thympanic membrane regeneration than the other groups, probably due to the continuous release of the bFGF. From the results, we conclude that the bFGF/alginate/PCL patch can be a good candidate as an effective thympanic membrane regeneration patch.
박경호,박시내,김부영,배성천,김준규,성용해,이창훈,배민영,이병훈,장기홍,백지혜,여상원 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.1
Tympanic membrane perforation is an important clinical problem found in various populations of the world. In large number of cases, acute traumatic perforations heal spontaneously, and in the healing process, stem cells appear to play an important role. However, no studies have been reported regarding somatic stem cells in the tympanic membrane. Herein, we tried to show that guinea pig’s tympanic membrane contains cells that display the characteristic features of stem cells. Materials and Method:The tympanic membrane was obtained from the guinea pig. The cells were cultured in a medium with epidermal growth factor (EGF) and fibroblast growth factor (FGF). Proliferating cells were checked with stem cell markers, bromodeoxyuridine (BrdU) and nestin. Differentiated cells from stem cells are checked with βIII tubulin and S-100. Results:We observed that some of the cultured cells from the tympanic membrane were stained with both stem cell markers, BrdU and nestin. And we observed that these cells differentiated into neuron and gilal cells, which expressed βIII tubulin and S-100, respectively. Conclusion: These results suggest that the tympanic membrane of guinea pigs may have neural stem cells. Further study is needed for finding the origin of stem cells. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:28-32)
김영주,권아영,김형미 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.4
Benign vascular lesions are rarely found on the tympanic membrane. To date, only 21 cases restricted to tympanic membrane and/or external auditory canal have been reported, and all cases are hemangioma. We recently experienced a case of a vascular lesion arising from the atrophic tympanic membrane, which did not respond to initial CO2 laser therapy. Subsequent surgical excision of the vascular lesion was successfully performed. The clinical manifestations and management of benign vascular lesion of tympanic membrane are discussed with a review of literature.
video otoscope로 관찰한 급성 중이염 소아 환자의 고막상태와 치료기간과의 연관성에 대한 연구
유현정,최인화,Yu, Hyun-Jung,Choi, In-Hwa 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3
Objective: In children with acute otitis media, we investigated the relationship between state of tympanic membrane and treatment period by video otoscope. Methods: Ten children(6 boys, 4 girls) with acute otitis media were assigned to one of three groups. In the grade I, there were redness in the tympanic membrane. In the grade II, there were bulging, effusion with exudate, dark color in the tympanic membrane. In the grade III, there were effusion with purulent exudate or cholesteatoma with serous exudate. And we investigated the treatment period in each group. Results: Overall, the $mean{\pm}S.D.$ on the treatment period in the grade I was shorter than grade II. It was $12.6{\pm}5.18$ in the grade I versus $26{\pm}2.83$ in the grade II. That in the grade II was shorter than grade III. It was $26{\pm}2.83$ in the grade II versus $148{\pm}43.03$ in the grade III. Conclusions: Although we couldn't have enough cases in each group. we could predict the conclusion that there was the relationship between treatment period and state of tympanic membrane.
Yoon, Jong-Yun,Kim, Gi-Woo Elsevier 2019 Mechanical systems and signal processing Vol.116 No.-
<P><B>Abstract</B></P> <P>This study presents an initial assessment of a newly shaped biomimetic diaphragm aimed at mimicking the function of the tympanic membrane (TM) of the human auditory system. The TM consists of three parts, namely, the malleus, pars tensa, and pars flaccida, and its dynamic behavior is typically known to be different from other common, thin membranes. The constructed membrane has a curved conical shape with the apex pointing medially, and with an initially bucked shape. The malleus is also firmly attached to the medial surface of the membrane at its center. In addition, the TM is connected to a surrounding annulus ligament (muscle) and is concave at its deepest part (the umbo). As a result, the TM does not move as a normal flat and thin diaphragm. In this study, we investigated the bilinear nonlinearity of an elliptic and conical shaped diaphragm similar to the actual TM of the human auditory system to deliver improved vibrating characteristics. It is reported that the proposed adaptively diaphragm structure fabricated by using 3D printing technology can exhibit bilinear nonlinearity when the sound pressure level (SPL) of the incoming sound is high, thus resulting in a flat sensitivity and a broad frequency response.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A newly shaped biomimetic diaphragm mimicking the tympanic membrane of human is for the first time investigated. </LI> <LI> The proposed diaphragm was fabricated by using 3D printing technology to validate the function of oval and elliptic shape of biomimetic diaphragm. </LI> <LI> The bilinear nonlinearity of new diaphragm can be harnessed to deliver the improved frequency response. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Cavernous Hemangioma of the Tympanic Membrane
장철호,최현석,홍용성,조용범 대한이비인후과학회 2011 Clinical and Experimental Otorhinolaryngology Vol.4 No.2
Cavernous hemangioma seems to most frequently arise in the posterior portion of the external auditory canal. However, they rarely occur in the tympanic membrane. A 49-year-old male patient was referred for evaluation of right-sided pulsatile tinnitus that he’d experienced for the previous 2 years. Temporal bone computerized tomography showed an isolated soft tissue mass just lateral to the tympanic membrane. There was no evidence of bony erosion or middle ear invasion. The patient underwent excision of the mass using a postauricular approach. The mass was removed en bloc and the defect of the tympanic membrane was repaired by tympanoplasty type I. There was no recurrence after 1 year of follow-up.
정상 고막과 기도골도차를 가지는 비외상성 난청의 임상양상과 측두골 Computed Tomography 분석
전승연,안용휘,윤라경,심현준 대한이비인후과학회 2023 대한이비인후과학회지 두경부외과학 Vol.66 No.11
Background and Objectives This study aimed to investigate the causes, clinical manifes-tations, temporal bone CT findings, and audiologic results of outpatients with non-traumatichearing loss with air-bone gaps and intact tympanic membranes. Subjects and Method The medical records from 2014 to 2022 of 66 patients (77 ears) withnormal tympanic membranes but who had the air-bone gap of more than 20 dB over two con-secutive frequencies were reviewed. Results The mean age of the patients was 46.8±17.0 years old. The mean air-bone gap was24.8±10.3 dB. Of the 77 ears (66 patients) studied, 10 ears were surgically diagnosed with oto-sclerosis (6 ears), ossicular discontinuity (2 ears), superior semicircular canal dehiscence (1 ear),and unknown etiology (1 ear). Additionally, 29 more ears (28 patients) were clinically diagnosedwith silent otitis media (7 ears), otosclerosis (5 ears), thickened tympanic membrane (5 eras),E-tube dysfunction (4 ears), ossicular anomaly (4 ears), semicircular canal dysplasia (2 ears),and endolymphatic hydrops (2 ears). Temporal bone CT images showed normal findings in 33ears (54.1%) and abnormal findings in 28 ears (45.9%). Patients with abnormal CT findingshad a poorer speech discrimination score than those with normal findings ( p<0.05). The air-bone gap was significantly decreased postoperatively from 30.5±12.7 dB to 6.4±4.0 dB, witha tendency to decrease greater at a low frequency than at a high frequency. Conclusion Among patients with air-bone gap and intact tympanic membrane, otosclerosiswas the most commonly confirmed diagnosis through surgery, while silent otitis media wasthe most frequently observed diagnosis based on clinical evaluations.