학교소음이 학업성취에 미치는 영향

정경훈,박상일,강영주,위환,염동익 조선대학교 환경공해연구소 2006 環境公害硏究 Vol.19 No.1

The reason for the school noise problem located in the city is due to the fact that this noise is aroused by the development of industrial facilities that give too much importance to certain provinces and the cityward tendency of the population and so on. which is scattered nearby school, In addition, the indoor noise caused by the students themselves is loud. It damages the environment as would a loudspeaker, and the noise from the school itself compounded with the noise from outside raises a serious problem. Measure and analysis of the actual condition of this school noise shows its influence and effect on scholastic achievement. Noise can be felt through a man's sense, and it can be felt differently according to an individual's habit, and the time and place. That's why the physical amount, which is measured by a measuring instrument, can't display the grades of noise. The results of a survey show that students' attitudes toward noise and the students' psychological reactions are more apparent in those who take part in classes located in the south building, which is exposed to a large amount of noise from highway traffic. One important factor in the different degrees of school noise is that it becomes louder as one travels higher within the building. We can determine the different effects by comparing the scores of students from various classes. For instance, the scores of students who are exposed to this noise will be compared with those who are not. To survey how much the students themselves are effected by the noise in their studying atmospheres, we selected the north building, which the noise does not penetrate as readily as it would another building and where the measure of the noise amount(Leq, 10 min.). As a result, the classes' records will show the data between the areas where the amount of noise is high and those where the amount of noise is low. It is economically and actually difficult to make a countermeasure for the schools that are influenced by noise, but we should make plans to allocate flexible arrangements of classes and time tables, and to create a good environment for teachers to utilize their professionalism in their own subjects, a variety of teaching skills and the teaching techniques necessary to work with the various levels of the students.

흰민들레 (Taraxacum coreanum) 추출물이 급성 수은 중독된 생쥐의 간에 미치는 효과

정민주,윤중식,허진,노영복,최영복,김종세,이현화 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.1

본 연구는 급성 수은 독성에 대한 민들레의 효과를 알아보기 위하여 시도되었다. 30 g 내외의 생쥐를 대상으로 대조군, 수은(5mg/kg) 투여군, 수은 투여 후 민들레(3 g/kg)를 구강투여 한 후 다시 24, 48, 72, 96시간, 1주일군으로 세분하여 간장 손상 억제 효과를 알아보기 위하여 생화학적 및 조직학적 실험을 실시하였다. 혈액중 aspartate amiotransferase (AST)와 alanine aminotransferase (ALT)의 수치는 민들레 투여군이 수은 투여군보다 감소되었다. 또한 간조직의 SOD와 catalase 활성도 역시 민들레 투여군이 수은 투여군에 비하여 감소하였으나 통계학적 유의성은 없었다. 간 조직의 광학현미경적 관찰에서 심한 조직괴사가 관찰되지만 민들레 투여군에서는 문맥주위의 약간의 괴사와 심한 호중구 침윤현상이 관찰되었다. 전자현미경적 관찰 결과, 간장에서 수은 투여군은 간세포의 핵이 함입되어 불규칙했으며 미토콘드리아와 조면소포체의 수조가 팽대되고, 리보솜의 탈락이 관찰되었다. 민들레 투여군은 핵이 정상적인 상태로 관찰되었고, 전자밀도가 높은 미토콘드리아가 분포되어 있었으며, 리보솜이 부착된 상태로 층판구조를 형성하는 조면소포체가 관찰되었다. 이상의 연구 결과로 보아 민들레가 수은으로 유발된 간손상을 보호하는 효과가 있는 것으로 사료되며 민들레에 대한 다양한 연구가 필요할 것으로 사료된다. Dandelion has been frequently used as a remedy for women’s disease, inflammatory diseases and disorders of the liver and gallbladder. Dandelion extracts water extract, an herbal medication, may have an effect on the activity of hepatic antioxidant enzymes in diabetic rat. This study aims demonstrate the effect of dandelion extracts, one of the natural chelator, on the biochemical and enzyme activity changes in the mouse liver caused by HgCl₂. Mice approximately 30 gm in weight were grouped into the control, mercury chloride-treated, and the dandelion extractstreated after mercury chloride groups. HgCl₂ (5 mg/kg) and dandelion extracts (3 g/kg) were delivered orally. Serum AST and ALT were measured, enzyme activity of liver were examined by spectrophotometer and ultrastructural alteration of liver were examined by light and electron microscopy. Dandelion extracts were decreased the increase of serum AST and ALT level induced by mercury. The catalase activity was decreased in the dandelion extracts group. The activity of SOD was dereased, but did not show significant differences. Mercury chloride-treated hepatic cell were irregular nucleus, enlarged and reduced number of mitochodria, enlarged rough endoplasmic reticulum, loss of ribosomes. Cells treated with dandelion extracts were similar to those of the control group. In conclusion, dandelion extracts may protect the mercury-induced toxicity on Liver.

Squalene Adjuvant를 이용한 단백질 항원의 세포성 면역반응 유도

도현주,김성열,안종성,하영주,이승찬,오재택,장명호,정홍석,문홍모,박해준 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

To investigate the role of adjuvant for cytotoxic T lymphocytes (CTL) induction, squalene-based adjuvant was studied its capability eliciting to the induction of cellular immunity as well as humoral immunity to exogeneous proteins. Ovalbumin (OVA) was used as model proteins. It was demonstrated that antigen formulation consisted of metabolizable oil squalene mixed with Tween 80 and pluronic L121 (S/TJ121) could induced the antigen specific CTL responses and antibodies irrespective of immunization routes in mice. We also demonstrated that this antigen formulation was a inducer of CD8+, major histocompatibility complex(MHC) class I-restricted, and antigen-specific C;1'Ls. These data suggest that the squalene-based emulsion system is a potent adjuvant inducing cellular immunity as well as humoral immunity.

전신마취 후 발생한 악성고열증 환자의 치료 경험

이근무,정승환,이정한,정순호,최영균,김영재,신치만,박주열,이영민 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Malignant hyperthermia is the disorder of calcium regulation within skeletal muscle associated predominantly with anesthesia. It is triggered by volatile anesthetics and depolarizing neuromuscular blocking agents. We experienced a case of malignant hyperthermia. 50 years old female patient was transferred to our emergency room that she was developed tachyarrhythmia and high fever. She was taken arthroscopic examination under the general anesthesia with enflurane and succinylcholine. We suspected malignant hyperthermia and promptly treated her with dantrolene sodium. She was developed disseminated intravascular coagulopathy and acute renal failure then we were intensive care to her. She was discharged without sequela. We experienced successful management of malignant hyperthermia.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

Influences of Phosphogypsum Application on Soil Property and Yield and Quality of Onion (Allium cepa L.)

Young-Nam Kim,Ju Young Cho,Young-Eun Yoon,Hyoen Ji Choe,Mi Sun Cheong,Mina Lee,Kwon-Rae Kim,Yong Bok Lee 한국토양비료학회 2021 한국토양비료학회지 Vol.54 No.2

Phosphogypsum (PG) is a by-product obtained in the process of manufacturing phosphoric acid (H₃PO₄). In general, PG is characterized mainly by gypsum, phosphate, sulphate, fluoride etc. Considering the nutritional composition, PG has been globally used as soil fertilizer or amendment in agriculture for decades. This study aimed to investigate effects of PG application on soil properties and yield and quality of onion (Allium cepa L.) and to seek proper rate of PG application in a field. We applied PG into a field with four different levels: 0% (control), 50% (PG50, 104 ㎏ 10a<SUP>-1</SUP>), 100% (PG100, 208 ㎏ 10a<SUP>-1</SUP>), and 150% (PG150, 312 ㎏ 10a<SUP>-1</SUP>). Also, oyster shell (OS) included as a comparable and chemical fertilizer (N-P-K = 8.4-37.9-8.0 ㎏ 10a<SUP>-1</SUP>) was supplied into soil of all treatments. Following onion cultivation for 7 months, there was a significant change in soil pH. Indeed, PG application was more likely to lower pH relative to control. With increase in PG application rate, soil EC increased and the maximum value (1.93 dS m<SUP>-1</SUP>) was found in soil of PG150. In PG100 and PG150, concentration of exchangeable Ca (Ex. Ca) increased by 5% and 10%, respectively, whilst other treatments representing reduction in the Ex. Ca concentration. In addition, PG application affected concentration of water soluble Ca across the soil profile (up to 70 cm depth) and, in particular, the higher the PG application rate the higher the concentration of water soluble Ca. Similarly, water soluble S had same trend with water soluble Ca in the present study. With increase of PG application rate, yield of onion increased but decreased in PG150 which is the highest rate of PG application. Also, the plant’s uptake for N, P, Ca, K, and S affecting yield, resistance to pathogen and pest, and quality of the crop increased in PG50 and PG100. Moreover, concentrations of total amino acids, cysteine and methionine in onion bulbs that are strongly associated to S uptake increased by PG applications. The increased concentrations of amino acids with PG applications might improve yield, quality, and favor of onions. These results suggest that PG supply could have a potential to enhance soil fertility, contributing to improvement of yield and quality of onions. Further studies are needed to maximize efficiency of PG supply in agricultural lands.

Prevalent Expressions of Stage-specific Embryonic Antigens(SSEAs), Alkaline Phophatase, and Nestin in Mouse Bone Marrow Cells and Skin Cells

Cheong, Young Seon,Hong, Ju Young,Lee, Hwang,Choi, Sung Sik,Lee, Sang Ho 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Association of Uncoupling Protein-1 Haplotypes with Body Fat Area

Kim, Young-Joo,Cheong, My-Young,Cha, Min-Ho,Choi, Sun-Mi,Kim, Jong-Yeol,Kim, Kil-Soo,Shin, Seung-Uoo,Park, Young-Kyu,Kim, Hyun-Ju,Suh, Soong-Hyuck,Yoon, Yoo-Sik Korean Society for Bioinformatics and Systems Biol 2009 Interdisciplinary Bio Central (IBC) Vol.1 No.4

Obesity is a major cause of morbidity and mortality and is associated with risks for type 2 diabetes mellitus, heart disease, metabolic syndrome, hypertension, stroke, and certain forms of cancer. The glutamate decarboxylase 2 (GAD2), insulin-induced gene 2 (INSIG2), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), melanocortin 4 receptor (MC4R), fresh touring origination (FTO), and uncoupling protein-1 (UCP-1) genes have been investigated for their association with obesity. Since the A-3826G SNP in the UCP-1 gene was first shown to be the key genetic determinant of obesity and body fat accumulation, many studies have been performed in various populations to measure the association of the G allele of this SNP with obesity phenotypes. The association of the A-3826G SNP with obesity has been controversial, however, suggesting that one SNP does not sufficiently explain the effects of genomic variation on body fat accumulation. In this study, 9 SNPs were newly identified in the 5'-flanking region of the UCP-1 gene by direct sequencing of genomic DNA from 21 Korean subjects, and 6 haplotypes were obtained by SNP genotyping and haplotype reconstruction. According to our haplotype analysis, ht2 of the G allele of A-3826G, was significantly associated with overall fat measures after age and body weight were adjusted. Ht6 of the A allele of A-3826G, was significantly linked to reduced fat accumulation. These results provide an explanation for the controversies that have been reported in many obesity association studies and suggest that haplotype associations between polymorphic loci and neighbor loci that harbor functional sequence variants can be exploited to identify disease-predisposing alleles.

광 및 온도가 새싹보리의 사포나린 함량 변화에 미치는 영향

윤영은(Young-Eun Yoon),최현지(Hyeon Ji Choe),김송엽(Song Yoeb Kim),쇼흐라 하젤(Chohra Hadjer),조주영(Ju Young Cho),정미선(Mi Sun Cheong),김영남(Young-Nam Kim),이용복(Yong Bok Lee) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11

고부가가치 작물에 관한 관심이 증가함에 따라 기능성 물질은 함유한 새싹작물에 대한 수요가 급증하고 있다. 그중에서도 새싹보리는 항상화, 간기능 개선, 항염증 작용을 하는 사포나린을 많이 함유하고 있다. 사포나린은 이차대사산물로 식물이 비 생물학적 스트레스에 대한 방어기작으로 축적하는 물질이다. 따라서 본 연구에서는 환경요인 중 광 및 온도가 새싹보리 내 사포나린 함량에 미치는 영향에 대하여 연구하였다. 생육온도에 의한 영향은 서로 다른 온도 (5, 10, 20, 30℃)에서 재배한 새싹보리의 사포나린 함량을 분석하여 비교였으며, 일교차가 없는 처리구 (DTR 0)와 일교차가 각각 5 (DTR 5), 10 (DTR 10), 15 (DTR 15)인 처리구, 그리고 일조시간이 12 (12H), 18 (18H) 시간인 처리구에서 재배한 새싹보리의 사포나린 함량을 분석하였다. 생육온도에 따른 새싹보리 중 사포나린 함량은 5, 10, 20, 30℃에서 각각 554, 617, 601, 545 mg 100g<SUP>-1</SUP> 으로 10, 20℃에서 재배한 새싹보리가 5, 30℃보다 더 높은값을 나타냈다. 또한, 생육온도에 따른 생육일수는5, 10, 20, 30℃에서 각각 24, 21, 12, 8일로 나타났으며, 20℃에서 재배한 새싹보리의 생육일수가 10℃에서 재배한 새싹보리의 생육일수보다 9일 더 짧았다. 일교차에 의한 영향은 DTR 10 처리구에서 673 mg 100g<SUP>-1</SUP>로 가장 높았으며, DTR 0 대비 약 7% 증가하는 결과를 나타냈다. 일조시간에 의한 영향은 12H, 18H에서 사포나린 함량이 각각 609, 737 mg 100g<SUP>-1</SUP> 으로 일조시간이 18H 일 때 사포나린 함량이 16% 더 증가하였다.

사포나린 함량변화에 영향을 미치는 환경요인: 수분스트레스

윤영은(Young-Eun Yoon),최현지(Hyeon Ji Choe),김송엽(Song Yoeb Kim),조주영(Ju Young Cho),이윤정(Yoon Jung Lee),정미선(Mi Sun Cheong),김영남(Young-Nam Kim),이용복(Yong Bok Lee) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11

생산량을 중시하던 농업에서 품질중심의 농업으로 패러다임이 변함에 따라, 고부가가치 작물의 수요가 점점 증가하고 있다. 고부가가치 작물은 온실재배에 특화된 파프리카, 토마토, 딸기 중심에서 기능성 물질을 포함한 새싹작물로 관심이 이동하면서 다양한 연구가 진행되고 있으며, 그 중 새싹보리에 대한 관심이 특히 커지고 있는 실정이다. 새싹보리 내 기능성 물질인 사포나린은 폴리페놀류 화합물로 식물이 환경적 스트레스에 대한 방어기작으로 합성 및 축적하는 이차대사산물이다. 따라서 본 연구에서는 환경적 스트레스 중 수분이 사포나린 함량 변화에 미치는 영향에 대해 연구하였다. 수분스트레스에 의한 영향은 스트레스를 주는 기간과 시기로 세분화하여 실험을 진행하였다. 스트레스를 주는 기간은 새싹보리가 10 cm 일 때 각각 0 (DS0), 1 (DS1), 2 (DS1), 3 (DS1)일 물공급을 중단하였으며, 재공급 후 회복된 새싹보리를 수확하였다. 또한, 스트레스를 주는 시기는 새싹보리가 각각 5 (DS5c), 10 (DS10c), 15 (DS15c) cm 일 때 물공급을 2일간 중단하고, 재공급 후 회복된 새싹보리를 수확하였다. 스트레스를 받고, 회복하는 상태는 수분포텐셜 값을 측정하여 확인하였다. 수분포텐셜 값은 수분 스트레스를 받기 전 -0.7 ~ -0.8 Mpa 수준에서, DS1, DS2, DS3 에서는 각각 -1.2, -2.4, -3.1 Mpa 수준이었으며, DS5c, DS10c, DS15c 에서는 각각 -2.6, -2.3, -2.3 Mpa 수준으로 감소하였다. DS1, DS2 처리구의 사포나린 함량은 각각 1,237, 1,220 mg 100g<SUP>-1</SUP>로 스트레스를 받지 않은 DS0 처리구 (1,089 mg 100g<SUP>-1</SUP>)에 비해 약 12, 10% 증가하였다. 또한, DS5c 처리구의 사포나린 함량은 1,333 mg 100g<SUP>-1</SUP>로 스트레스를 받지 않은 Control 처리구 (1,111 mg 100g<SUP>-1</SUP>)에 비해 약 19% 증가하였다.