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내성세균의 치료: 새로운 균, 오래된 약제, 새로운 접근
최영화 대한의사협회 2014 대한의사협회지 Vol.57 No.10
Rapidly increasing antimicrobial resistance and lack of effective antibiotics are dilemma in the treatment of infectiousdiseases. Clinicians are now considering the use of old antibiotics such as colistin, fosfomycin because of limitation oftherapeutic options. The unique pharmacokinetic and pharmacodynamics properties of these antibiotics have led thenew therapeutic approaches, such as the combination of agents and newer dosing regimens. Colistin has becomethe last drug of the treatment of multidrug resistant gram-negative bacteria and the loading dose and high dosemaintenance has been suggested. Tigecycline is licensed for the treatment of complicated skin and intra-abdominalinfections and has broad activity against gram-positive and gram-negative pathogens but cautious use in the treatmentof bloodstream infection and pneumonia is recommended. Oral and intravenous fosfomycin may be effective treatmentoptions in the case of resistant gram-negative infections but clinical studies are limited.
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최영화,허영우 한국섬유공학회 1980 한국섬유공학회지 Vol.17 No.2
This study has been designed to investigate the influence of drawing and heating conditions affecting on the change of fine structures by x-ray and birefringence measurements (in particular, on the degree of orientation in crystalline and amorphous phases) and on the mechanical properties of PET fibers. In a crystalline region, relationship between birefringence contribution, ncx, and breaking stress is expressed by a linear function, and clear structural discontinuities are observed between ncx and yield stress. In an amorphous area, relationship between birefringence contribution, na(1-x), and yield stress shows a linearity and that between na(1-x) and breaking stress is indicated by a quadratic curve. The existence of structural transformational region could easily be presumed by the fact that an inflection and tensile characteristics exists at the range of draw ratio 2.0~2.5. Particularly, it is found that an inflection phenomenon of yield stress is under the contol of a crystalline region and that of breaking stress is swayed by an amorphous area.
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