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( Yeong Hun Choe ),( Min Suk Kim ),( Mi Hee Kang ),( Yu Jeong Oh ),( Yoon Chae Lee ),( Seung Yong Park ),( So Ri Kim ),( Seoung Ju Park ),( Heung Bum Lee ),( Yong Chul Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: It is known that the prevalence and social burden related to chronic obstructive pulmonary disease is increasing. Previous survey published at 2008 demonstrated that 13.4% of subjects aged over 40 years had airfiow obstruction (FEV1/FVC <0.7) in Korean population. However, current status of prevalence and characteristics of elderly who have obstruction airway disease (OAD) is not well investigated yet. Methods: A total of 2566 adults (1109 of male and 1457 of female; mean age 73.4±6.4) were included from public health survey during 3 years. Pulmonary function was measured by portable fiow-volume device. A standard questionnaire (CAT score), smoking status, respiratory symptoms such as cough, sputum, dyspnea, and comorbid illness were collected. Results: The prevalence of person with OAD which was defined as FEV1/FVC <0.7 was 18.5% (Male 29.2%, Female 10.4%). Mean FEV1 change was -33mL per year in both men and women. There was significant correlation between age and prevalence of OAD. Former or current smoking was significantly more common in group of OAD. Among persons with OAD, 56.2% have FEV1 below 80% of predicted. The proportion of person according to GOLD stage A-D was 50.6%, 37.9%, 4.6%, and 6.9% respectively. Comparing GOLD stage A with B, persons with GOLD stage B were tent to have low BMI and comorbid illness such as hypertension and diabetes. In multivariate analysis, factors associated with higher CAT score in OAD were advanced COPD stage, history of smoking, and female gender. Conclusions: Our data indicate that the prevalence of COPD in elderly is still high and large number of person is undiagnosed and untreated.
( Yeong Hun Choe ),( Min Suk Kim ),( Mi Hee Kang ),( Yu Jeong Oh ),( Yoon Chae Lee ),( Seung Yong Park ),( So Ri Kim ),( Seoung Ju Park ),( Heung Bum Lee ),( Yong Chul Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.0
Background: It is known that the prevalence and social burden related to chronic obstructive pulmonary disease is increasing. Previous survey published at 2008 demonstrated that 13.4% of subjects aged over 40 years had airflow obstruction (FEV1/FVC <0.7) in Korean population. However, current status of prevalence and characteristics of elderly who have obstruction airway disease (OAD) is not well investigated yet. Methods: A total of 2566 adults (1109 of male and 1457 of female; mean age 73.4±6.4) were included from public health survey during 3 years. Pulmonary function was measured by portable flow-volume device. A standard questionnaire (CAT score), smoking status, respiratory symptoms such as cough, sputum, dyspnea, and comorbid illness were collected. Results: The prevalence of person with OAD which was defined as FEV1/FVC <0.7 was 18.5% (Male 29.2%, Female 10.4%). Mean FEV1 change was -33mL per year in both men and women. There was significant correlation between age and prevalence of OAD. Former or current smoking was significantly more common in group of OAD. Among persons with OAD, 56.2% have FEV1 below 80% of predicted. The proportion of person according to GOLD stage A-D was 50.6%, 37.9%, 4.6%, and 6.9% respectively. Comparing GOLD stage A with B, persons with GOLD stage B were tent to have low BMI and comorbid illness such as hypertension and diabetes. In multivariate analysis, factors associated with higher CAT score in OAD were advanced COPD stage, history of smoking, and female gender. Conclusions: Our data indicate that the prevalence of COPD in elderly is still high and large number of person is undiagnosed and untreated.
Decline in non-smoking workers’ urine cotinine levels after increased smoking regulation in Korea
Ju-Hyoung Park,Chae-Kwan Lee,Se-Yeong Kim,Chunhui Suh,Kun-Hyung Kim,Jeong-Ho Kim,Byung-Chul Son,Jong-Tae Lee,Seung-Do Yu,Wookhee Choi,Hosub Im 대한직업환경의학회 2015 대한직업환경의학회지 Vol.27 No.-
Objectives: To identify any association between implementing smoking regulation policies and workers’ urine cotinine concentration levels in Korea. Methods: From the first stage of the Korean National Environmental Health Survey conducted by the National Institute of Environmental Research from 2009 to 2011, 2,475 non-smoking workers selected. We analyzed the trend in the changes of cotinine concentration in urine using the general linear model and linear regression, in various jobs as categorized by the National Center for Health Statistics (NCHS) and Korea Standard Classification of Occupations (KSCO). Results: The urine cotinine concentration tended to decrease every year (2.91 ng/ml in 2009, 2.12 ng/ml in 2010, and 1.31 ng/ml in 2011), showing a decreasing trend (P < 0.001). The total subjects’ decreased cotinine concentration in urine between 2009 and 2011 was 2.72 ng/ml (54.1 % relative decrease). The changes in each subgroup’s urine cotinine concentration ranged from 1.59 to 6.03 ng/ml (33.2 to 77.5 %). All groups except for the managerial group (n = 49), which had a small sample size, had statistically significant negative regression coefficients (p < 0.05). The ranges of the decrease in urine cotinine were 2.75 ng/ml (53.6 %) for males and 2.72 ng/ml (54.9 %) for females. The negative slope in urine cotinine level was statistically significantly greater in men than women. The changes in urine cotinine by occupation as classified by the NCHS occupational categories ranged from 2.43 to 3.36 ng/ml (46.6 to 61.5 % relative decrease). The negative slopes in urine cotinine levels of the white-collar and farm workers were statistically significantly greater than those of the service workers and blue-collar workers. The change by occupation as classified by the KSCO ranged from 1.59 to 6.03 ng/ml (a 33.2 to 77.5 % relative decrease). The negative slopes in urine cotinine levels of the professionals and related workers and clerks were statistically significantly greater than those of the service workers and plant and machine operators and assemblers. Conclusions: The cotinine concentration in urine among non-smoking worker groups tended to decline from 2009 to 2011. Such a result may be an indirect indicator of the effectiveness of smoking regulation policies including the revision of the National Health Promotion Act.
Ju, Ji Hyeon,Heo, Yu‐,Jung,Cho, Mi‐,La,Jhun, Joo‐,Yeon,Park, Jin‐,Sil,Lee, Seon‐,Yeong,Oh, Hye‐,Jwa,Moon, Su‐,Jin,Kwok, Seung‐,Ki,Park, Kyung‐,Su Wiley Subscription Services, Inc., A Wiley Company 2012 Vol.64 No.11
<P><B>Abstract</B></P><P><B>Objective</B></P><P>To investigate the impact of STAT‐3–mediated regulation on Th17 differentiation in patients with rheumatoid arthritis (RA).</P><P><B>Methods</B></P><P>CD4+ T cells isolated from peripheral blood (PB) and synovial fluid (SF) were stimulated to differentiate into Th17 cells or Treg cells. The activity of STAT‐3 was knocked down by transfecting CD4+ T cells with small interfering RNA (siRNA). After 3 days in culture, the proportions of Th17 cells and Treg cells were measured by flow cytometry, and the production of interleukin‐17 (IL‐17) was measured by reverse transcriptase–polymerase chain reaction and enzyme‐linked immunosorbent assay.</P><P><B>Results</B></P><P>The levels of IL‐17, IL‐6, IL‐23, IL‐1, and tumor necrosis factor α were significantly higher in RA SF and synovial tissue than in SF and synovial tissue from osteoarthritis patients. In RA synovial tissue, the expression of STAT‐3 increased in proportion to the severity of synovitis, as shown by stromal cellularity, intimal hyperplasia, and inflammatory infiltration. The degree of Th17 differentiation was highest in RA SF, followed by RA PB, and lowest in normal subjects. In CD4+ T cells, transfection with STAT‐3 siRNA prevented Th17 differentiation of mononuclear cells from RA PB and SF but increased the proportion of Treg cells. In contrast, inhibition of STAT‐5, the transcription factor for Treg cells, increased the proportion of Th17 cells and reduced that of Treg cells.</P><P><B>Conclusion</B></P><P>Our findings indicate that modulation of STAT‐3 in CD4+ T cells affects the differentiation of Th17 cells and Treg cells in patients with RA. This role of STAT‐3 in RA synovial T cells may provide a new therapeutic target for the management of RA.</P>
( Yu Mee Song ),( Hyun Ji Lee ),( Seung Ah Yoo ),( Jae Yeon Ryu ),( Yeong Ho Kim ),( Ju Hee Han ),( Chul Hwan Bang ),( Young Min Park ),( Jun Young Lee ),( Ji Hyun Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
A 43-year-old man came to our clinic suffering from a malodorous fistulating tract of the lower extremities and a purulent draining sinus of the groin embedded in keloidal tissue. He was diagnosed with Keratitis-ichthyosis-deafness (KID) syndrome via sequencing analysis 11 years prior. A punch biopsy of lesion on the lower extremities was done. Clinically and histologically, Hidradenitis suppurativa (HS) was diagnosed in association with KID syndrome. Previous therapies with antibiotics and isotretinoin did not produce satisfactory improvements. We started adalimumab with an induction dose of 160 mg followed by 80mg and a maintenance dose of 40 mg every weeks. After 8 weeks on adalimumab therapy, the lesion showed marked improvement. Modified Sartorius scores showed progressive improvement during treatment, from 43 at the first visit to 17 after 8 weeks of treatment with adalimumab. Hurley stage was also improved from 3 to 2. Despite appropriate treatment, HS recurs frequently. KID syndrome is a rare congenital disorder of the ectoderm that gives rise to keratitis, erythrokeratoderma and neurosensory deafness. In addition to xerosis, HS has rarely been reported as a skin symptom accompanying KID. Antibiotics, acitretin, retinoids and anti-TNF drugs have been reported to treat it, but cases of severe HS are usually refractory to treatment. Herein, we report a case of HS in association with KID syndrome treated with adalimumab.
Validation Study of an Operational Tolerance Signature in Korean Kidney Transplant Recipients
Yu Ho Lee,Jung-Woo Seo,Yang Gyun Kim,Ju-Young Moon,Jin Sug Kim,Kyung-Hwan Jeong,Bo-mi Kim,Kyoung Woon Kim,Chul Woo Yang,Chan-Duck Kim,Jae Berm Park,Yeong Hoon Kim,Byung Ha Chung,Sang-Ho Lee 대한면역학회 2018 Immune Network Vol.18 No.5
Ju, Sunmi,Lee, Tae Won,Yoo, Jung-Wan,Lee, Seung Jun,Cho, Yu Ji,Jeong, Yi Yeong,Lee, Jong Deog,Kim, Ju-young,Lee, Gi Dong,Kim, Ho Cheol The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4
Background: The aim of this study was to examine the influence of body mass index (BMI) on the development of acute kidney injury (AKI) in critically ill patients in intensive care unit (ICU). Methods: Data of patients admitted to medical ICU from December 2011 to May 2014 were retrospectively analyzed. Patients were classified into three groups according to their BMI: underweight (< $18.5kg/m^2$), normal ($18.5-24.9kg/m^2$), and overweight (${\geq}25kg/m^2$). The incidence of AKI was compared among these groups and factors associated with the development of AKI were analyzed. AKI was defined according to the Risk, Injury, Failure, Loss of kidney function, and End-stage (RIFLE) kidney disease criteria. Results: A total of 468 patients were analyzed. Their mean BMI was $21.5{\pm}3.9kg/m^2$, including 102 (21.8%) underweight, 286 (61.1%) normal-weight, and 80 (17.1%) overweight patients. Overall, AKI occurred in 82 (17.5%) patients. The overweight group had significantly (p<0.001) higher incidence of AKI (36.3%) than the underweight (9.8%) or normal group (15.0%). In addition, BMI was significantly higher in patients with AKI than that in those without AKI ($23.4{\pm}4.2$ vs. $21.1{\pm}3.7$, p<0.001). Multivariate analysis showed that BMI was significantly associated with the development of AKI (odds ratio, 1.893; 95% confidence interval, 1.224-2.927). Conclusion: BMI may be associated with the development of AKI in critically ill patients.