2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

도시고형폐기물의 성분분석에 관한 연구

선정화,김희택,배성렬,강신춘 한양대학교 에너지·환경기술연구소 1994 에너지·環境技術論文集 Vol.1 No.-

도시지역에서 배출되는 일반폐기물에 대한 성분분석결과 밀도는 250∼300㎏/㎥, 수분함량은 중량비로 평균 51.83%, 가연성분 42.09%, 회분 6.08%로 각각 측정되었다. 한편, 저위발열량은 주거지역이 700∼1,700㎉/㎏, 상업지역이 2,000㎉/㎏이상으로 측정되어 상업지역이 주거 지역보다 발열량이 높은 폐기물이 배출됨을 알 수 있었는데 이는 수분함량이 높은 주개류의 배출이 상업지역이 주거지역보다 적으며 소비자 포장지로서 종이, 비닐, 플라스틱류 등의 사용이 많은데 기인하는 것으로 생각되어 진다. 한편, 분리수거, 유가품에 대한 자원 재활용, 연탄재 배출의 감소추세 등의 효과로 폐기물 중 불연성 함량은 줄어들고 반면 종이, 비닐, 플라스틱류 등의 가연성 폐기물의 함량은 크게 늘어 전체적으로 폐기물의 질이 향상되고 있음을 알 수 있다. The analysis results of components of municipal solid wastes are as follows : ① Density ranged from 250㎏/㎥ to 300㎏/㎥. ② Water content, combustible content and ash content measured 51.83%, 42.09%, 6.08% respectively. ③ Low calorific value was ranged from 700 to 1,700㎉/㎏ in residential area and measured 2,000㎉/㎏ in commercial one. Therefore, it was known that calorific value of wastes in residential area is smaller than that in commercial area. Also, the quality of wastes was improved by increase of combustible content which results from vitality of valuable recycling, reduction trend of briquette ash generation rate and increase of paper, plastic consumption as wrapping materials.

저 출산 원인에 대한 통계적 분석

정선희,권계화 서울여자대학교 2010 여성연구논총 Vol.25 No.-

Today, Korean society is faced with a serious low birthrate issue. Many scholars, including those in women's studies, have studied the issue and proposed solutions.  Unemployment rate, women's participation rate in economic activities and high educational fees are among the main causal factors that have been suggested to be accountable for women's low birthrate in Korea.  In this research, I established and made use of “Transfer Function Model” with the abovementioned factors as input variables to test if there is a statistical significance between these factors and the monthly birthrate data collected by the Korean Statistical Information Service (KOSIS) from the January of 1992 to December of 2008. I could confirm that these models have a high forecasting power for birthrate. In particular, the model with unemployment rate as its input variable showed the highest forecasting power. 기획재정부가 공개한 2010년 국가경쟁력보고서에 따르면 여성 한 명이 가임기간 중에 낳는 평균출생아수인 합계출산율이 1.19명에 불과해 경제협력개발기구 OECD회원 33개국 가운데 30위를 차지하였다. OECD 평균 합계출산율이 1.71명인 것을 감안하면 단순한 순위만아니라 수치 자체가 현저히 낮은 것이다. 이미 한국은 2006년도 합계출산율 1.13의 세계 최저 수준을 보임으로서 저 출산 문제는 심각한 사회문제가 되고 있지만, 다른 선진국들에 비해 전례 없는 짧은 기간에 출산율이 급속하게 감소했다는 데에 문제의 심각성이 있다. 우리나라는 1960년 합계출산율이 6.0명으로 고 출산 사회이었으나 경제개발계획 실시와 더불어 강력한 인구증가억제정책으로 1970년에는 4.5명, 1980년에는 2.7명으로 출산율이 저하하다가 마침내 1990년에 1.71명, 2010년 1.19명으로 지난 50년간 우리 사회의 출산율이 얼마나 급속하게 저하되어 왔는지를 알 수 있다. 출산율 감소세가 지속될 경우에 생산가능인구가 감소되어 생산력 저하는 물론 소비 및 투자위축 등을 야기시켜 국가의 경제성장이 저하되고 산업의 국제경쟁력이 약화되는 결과를 초래하게 된다. 또 다른 사회적 문제는 인구구조의 고령화이다. 인구구성에 있어서 부양해야 할 노인인구의 비중이 커지므로 노동인력 부족과 함께 노인 부양부담의 증대라는 경제적 사회적 이중의 불안요소를 안을 수밖에 없게 된다. 이렇듯 저 출산 문제가 중요한 사회문제가 되면서 저 출산에 관련하여 많은 연구들이 행해지고 있다.

만성신부전 환자에서 발생한 파종결핵

정가영,나선경,윤혜원,송하응,류정화,류동열 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.1

Patients with chronic renal failure (CRF) are known to be more susceptible to tuberculosis infection due to impairment of the host defense mechanism. Although extrapulmonary tuberculosis is more prevalent in those subjects and it may induce dismal outcome, its diagnosis has been challenging since there is no specific symptoms of the disease and the clinical course is usually atypical. Herein, We report a case of disseminated tuberculosis diagnosed by ultrasound-guided liver biopsy in a 31-year-old CRF patient presenting sustained fever despite broad-spectrum antimicrobial therapy and progressive cholestatic jaundice.

肢발생중 세포 증식성에 미치는 Etretinate의 영향에 관한 연구

황정연,김은영,박선화,전용혁 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.1

Cell proliferation in the developmental sequence of fore-limb in the DDY mouse with the adverse effect of single dose of etretinate (Tigason®) on it correlated to the drug-induced dysmorphogenesis was studied by measns of argyrophil technique for nucleolar organizer regions(AgNORs) and expression of proliferating cell nuclear antigen(PCNA). The number of AgNORs per nucleus displayed regional differences in the limb bud on day 11 of gestation, as higher values in apical ectodermal ridge(AER) and growing tip but decreased rapidly thereafter compared with those in the other parts of epithelia and subepithelial mesenchyme, while in core mesenchyme where the higest in its value on day 11, the numbers decreased depend not on the age but on the chondrified stage specific. Antibody reaction to PCNA expressed in almost all of the cells, stronger in mesenchyme than in epithelia on day 11 and then decreased gradually with the development proceed. Siver reactions to NORs as well as PCNA expression were decreased sharply by etretinate but recovered gradually from 24 hours after treatment except the value of AgNORs in the chondrified mesenchyme. The results Indicate that growth conducted by AER with subridge mesenchyme and chondrification in the core mesenchyme are two of major processes in the early development of limb, and the adverse effects of etretinate on proliferation and differentiation persist longer in the chondrified area but decreased expression of proliferative activities by the drug do not appear to be the result subsequent to the drug-induced cell death. The results suggest that temporal inhibition or interruption of the proliferation could deprive the programmed sequence of development of its appropriate timing with subsequent disturbance of the pace in growth which might be a role of limb dysmorphogensis but the drug's affinity to the chondrified cells remains a question.

서울 가로경관의 시대적 변천 : 세종로와 태평로를 중심으로

이선화,김유일,정기호 경희대학교 부설 디자인연구원 1998 예술· 디자인학연구 Vol.1 No.1

The purpose of this study is to find out the changes of the landscape of the Sejong Street and the Taepyung street from 1945 to 1998 by using the 'KBS YOUNGSANGSILLOCK'. A Phenomenological Model was adapted and reinterpreted by way of historical connection. The characteristic of landscape change of them are as follows; 1. After liberation the width of road, the terminal of vista, the height of buildings were the main determinant factors of urban space structure. 2.Each landscape changes were associated with the political and social situation. The landscape before the liberation (1945) was a colonial shape which showed the urban scene of the Chosun Dynasty. The landscape of The Confusion Period (1946-1951) under age of the political unrest and the Korean War showed a depressive urban shape. And the landscape of the city became the base of a modern city form the influence of American aid at The Recovery Period(1952-1964). During The High Grown Period(1965-1974), the road sides were covered with the tall buildings as the result of the economic growth and it became the frame of present street landscape. During The Modernization Period(1975-1984), the traditional type of a building such as the Sejong Cultural Center was in a tend. After The Stabilization Period(1985-1994), the street landscape appeared to the shape of present. The city has been observed as time passes but the changes of landscape have been analized by historical books and two dimensional pictures. The "KBS Youngsangsilock" is objective data which is consistent with historic situation and made this study to overcome the limitation of two dimensional method.

In situ hybridization과 염색체 미세해부에 의한 특정 염색체 띠에 대한 유전자 발굴

홍기정,김현수,전용혁,김현,박선화 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.1

Recently surmountable amounts of genes are being cloned but it is hard to define the chromosomal location and functions of these genes. In this study, a new technique was developed for cloning genes expressed in the developing human brain with confirmed chromosomal location. The mRNAs were extracted from 18 week old human fetal brain, cDNAs were made by reverse transcription from these mRNAs and Uni-amp cDNAs having Uni-amp adapters a t both ends were made for subsequent PCR. To observe the distribution of the Uni-amp cDNAs on the chromosome, fluorescent in situ hybridization was performed with biotin labeled Uni-amp cDNAs. Among the chromosome bands showing strong hybridization with the cDNAs, lq21, lq25, lq32 and lq42 were microdissected from the chromosome hybridized with unlabeled Uni-amp cDNAs and amplified by PCR with Uni-amp primers. These amplified cDNA fragments were subcloned to plasmid vectors and the nucleic acid sequences were analysed. As a result 18 different clones were confirmed the chromosomal localization. They were categorized as 4 clones of well characterized genes, 3 clones showing low homology with known genes, 5 clones of simply registered uncharacterized human cDNAs, and 6 clones of unknown genes. The evidence suggests that the technique is very useful to clone the genes that express in the developing human brain, with confirmed chromosomal location. In addition, this cloning technique can be used to discover the new genes related with neuronal development in combination with functional screening method.

남제주 화력발전소의 증설과 저감대대책의 영향 분석

이화운,김유근,정우식,오은주,임헌호,노순아,반수진,최현정,김민선,김헌숙 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-

In the view of the results investigated the effect of air pollutants that is emitted from a new generator facilities, the total estimated concentration which is the summation of a contributional concentration and observational concentration is much less than that of atmospheric environment criterion for the air pollutants. So we can predict that the operation of the new generator facilities with mitigation equipment don't seriously affect around environment. At the same time, we compared the contributional concentration of before mitigation equipment with that of after it to examine the decreasing amount due to mitigation equipment. The result showed that the concentration of SO2, NO2 and PM-10 is reduced to 25%, 30% and 26% of original value, respectively.

태양광 발전의 효율 향상을 위한 새로운 태양추적 알고리즘 개발

최정식(Jung-Sik Choi),고재섭(Jae-Sub Ko),강성준(Sung-Jun Kang),백정우(Jeong-Woo Baek),장미금(Mi-Geum Jang),김순영(Sun-Young Kim),정동화(Dong-Hwa Chung) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.10

This paper proposes a novel solar tracking algorithm for improving of photovoltaic(PV) efficiency with tracking method. A novel solar tracking algorithm calculates the global latitude and longitude of earth with sun. Also, it considers the refraction of atmosphere, annual oscillation and perturbation of moon. Proposed algorithm is applied the PV generation unit with tracking method and observes the azimuth and altitude. Observed data compare to korea astronomy observatory and conventional position solar algorithm(PSA) data and analyzes the accuracy. Therefore, the validity of this paper proves by analyzed data.

시금치(Spinacia oleracea L.)엽록체의 광합성 전자전달 활성에 미치는 linolenic acid의 영향

鄭華淑,鄭培善 慶北大學校 師範大學 1990 敎育硏究誌 Vol.32 No.-

The effect of unsaturated fatty acids on photosynthetic electron transport reaction in isolated choroplasts is investigated to clarify the changes of PS Ⅱ and PS Ⅰ electron transport rates, Chl. a fluorescence intensity, and photosynthetic oxygen evolution. In photosystem Ⅰ, an increase in the electron transport rates occurs in the presence of 10 to 80 μM linolenic acid, followed by a decline in rate from 100 to 300 μM linolenic acid. In photosystem Ⅱ, a decrease in the electron transport rates occurs in the presence of 10 to 20 μM linolenic acid. The efficiency of C_18 unsaturated fatty acids/linolenic (C_(18:3)). linoleic(C_(18:2)) oleic(C_(18:1)) on PS Ⅱ and PS Ⅰ electron transport rates is established in order C_(18:3)>C_(18:2)>C_(18:1) At a low concentration(10-80 μM) of linolenic acid a decrease in Chl. a fluorescence yield was due mostly to the inhibition on the donor side of PS Ⅱ. At a high concentration (100-300 μM), an increase in Chl. a fluorescence yield was due additionally to the inhibition on the acceptor side of PS Ⅱ.