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임종국,김철호,조경희,손윤희,배만종,남경수 경산대학교 생명자원개발연구소 2000 생명자원과 산업 Vol.4 No.-
쑥 양침액의 투여와 관련된 변화를 관찰한 결과, 전 시험기간을 통해 단회투여 후 14일 동안 일반증상, 치사율, 체중변화, 부검소견, 장기중량변화, 혈청생화학적 분석등의 각종 지표에 의한 안전성을 평가했을 때 1× 실험군에서는 대조군에 비해 유의한 변화를 관찰할 수 없었으며 10×쑥약침액 투여 후 관찰된 체중의 감소, 혈정생화학적 수치의 유의한 변화는 과용량의 시험물질에 의한 영향으로 생각된다. 한편, 5×, 10×의 쑥약침액을 투여한 실험군에서 활동력 저하, 호흡수 감소, 졸음 및 무기력등의 임상증상이 관찰되었는데 이는 중추신경계 억압에 의한 증상으로 보고??되어 있다. 또한, 혈액내 혈청을 분리하여 간세포 이상의 지표로 사용하고 있는 GOT, GPT를 측정하였고 혈청 중의 total enzyme을 측정하여 LDH의 활성치를 계산, 이것을 심폐질환, 혈액질환, 간질환의 유무를 알아내는 지표로 사용하였으며 간염, 간경변, 골질환의 유무를 알아내는 지표로 사용하는 ALP-s를 측정하였다. 농도에 따른 쑥 약침액의 영향을 알아본 결과 쑥 약침액을 대조군에 비하여 단회투여시 1×의 농도에서는 대조군에 비해 유의한 차이를 나타내지 않았으나 5×, 10×의 농도의 실험군에서는 상당히 유의한 차이를 나타냄으로써 쑥 약침액의 과용량의 투여는 마우스의 간세포, 골세포, 심폐기관 등에 유해작용을 일으킬수 있음을 알 수 있었다. 본 실험을 통해 1×의 쑥 약침액의 용량은 급성 독성시험 결과 무해한 용량으로 판단되며, 5×이하의 용량군을 세밀히 나누어 검토할 필요가 있다고 판단된다. Acute toxicity of Artemisia Nakai Aqua-acupuncture Solution(ANAS) as studied in ICR mice. Mice were injected inrtapeitoneally with single dose of 1×, 5×, 10× ANAS and toxicological responeses were observed for consecutive 14 days. Mortality, clinical signs, body weight changes, organ weight, and serum chemistry were performed. The mortality and body weight changes of mice treated with 1× and 5× ANAS were not affected during the experimental periods. With the 10? ANAS treatment, dead animals and changes of body weight, organ weight and serum biochemical values were observed during the experimental period. There results suggest that 1× ANAS causes no toxicity that 10× ANAS causes toxicity in acute toxicity test.
임수연 ( Soo Yeun Lim ),나영주 ( Young Joo Na ) 한국감성과학회 2004 추계학술대회 Vol.2004 No.-
This study aimed to classify the lifestyles of 1020 college students, and to analyze the effect of the lifestyles on the usages of credit card, price perception, purchasing satisfaction and the number of new clothing. The number of credit cards, total payment of credit cards and the attitude to credit card were different by the 7 clusters of college students, but the frequency of credit card use, the amount of cash service and arrear ages were not different. The perception to the apparel price, purchasing satisfaction, and the degree of clothing purchasing varied according to the lifestyle clusters. For example, 6th cluster being highest in the pursuit of appearance showed the highest amount of credit cards usage significantly and tendency of highest arrearage, and used credit cards mostly in clothing purchase.
( Yeun Seoung Choi ),( Jung Soo Lim ),( Woocheol Kwon ),( Soon Hee Jung ),( Il Hwan Park ),( Myoung Kyu Lee ),( Won Yeon Lee ),( Suk Joong Yong ),( Seok Jeong Lee ),( Ye Ryung Jung ),( Jiwon Choi ),( 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.
Choi, Yeun Seoung,Lim, Jung Soo,Kwon, Woocheol,Jung, Soon-Hee,Park, Il Hwan,Lee, Myoung Kyu,Lee, Won Yeon,Yong, Suk Joong,Lee, Seok Jeong,Jung, Ye-Ryung,Choi, Jiwon,Choi, Ji Sun,Jeong, Joon Taek,Yoo, The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.
프레이리(Freire)의 ‘대화’ 관점에서 본 유아미술활동의 교사-유아 상호작용연구
임부연(Lim, Boo Yeun),최수빈(Choi, Soo Bin),최윤경(Choi, Yoon Kyeong) 한국미술교육학회 2020 美術敎育論叢 Vol.34 No.2
본 연구는 유아미술활동에서 나타나는 교사-유아의 상호작용을 프레이리(Freire)의 ‘대화’를 중심으로 살펴보고자하였다. 유아미술활동에서 교사와 유아의 대화는 어떠한 양상으로 나타나고 있는지, 유아미술활동에 대화가 어떠한 영향을 미치는지 알아보았다. 연구기간은 2018년 8월부터 10월까지 3개월간 이루어졌으며, 연구기관 및 참여자는 p시에 소재한 사립유치원 두 곳의 만 5세반 교사 2인이었다. 연구자료는 각 기관마다 8회씩 총 16회의 참여관찰과 심층면담을 통해 수집되었고, 이를 분석한 연구자일지를 분석 자료로 선정하였다. 연구결과 교사와 유아의 상호작용은 ‘교사-유아의 대화에서 발현되는 만남: 진정한 마주보기’, ‘주체들의 만남에서 오는 진정한 배움: 의식화’로 제시되었다. 논의점으로 첫째, 교사와 유아의 대화가 진정한 만남으로 이루어질 때 유아는 활동을 즐기며 주체자로서 유아미술활동에 참여하고 있었다. 둘째, 유아의 경험과 상상력이 활동 속에서 발현되었으며 이는 교사와 유아의 대화를 통해서 가능함을 살펴볼 수 있었다. 마지막으로 교사의 변혁 의지가 교사와 유아의 진정한 대화로 이끈다는 것을 알 수 있었다. In this study, I tried to look at teacher-child interaction displayed in infant art activities, focusing on Freire s dialogue . We investigated how conversations in art activities look, and how they affect art activities. The research period was conducted for three months from August to October 2018, and the research institute and the participants were two private teachers at the time. Data collection was conducted through a total of 16 attendance observations and 8 in-depth interviews per teacher, and various materials used in artistic activities as researcher were selected as research analysis materials. As a result of the research, the interaction between the teacher and the child was presented as encounter expressed in the teacher-infant conversation: a true spread , comes from the subject s encounter and true learning: consciousness . First of all, at the point of discussion, children, who have a true conversation between the teacher and the child, participated in the art activity as the subject of a fun classroom. Secondly, I was able to see that the experience and imagination of children in art activities were expressed in the activities, and this was possible through the dialogue between teachers and children. Finally, I was able to know that the teacher s willingness to change is capable of realizing a true dialogue between the teacher and the child.
Ji Yeun Kim,Ji-Soo Kwon,Hye Hee Cha,So Yun Lim,Seongman Bae,Sung-Han Kim 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.6
Background/Aims: The rapidity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific memory B or T cell response in vaccinated individuals is important for our understanding of immunopathogenesis of coronavirus disease 2019 (COVID-19). We therefore compared the timing of adequate immune responses between the first and booster doses of COVID-19 vaccines in infection-naïve healthcare workers. Methods: We enrolled healthcare workers who received two doses of either the BNT162b2 vaccine or the ChAdOx1 vaccine, all of whom received the BNT162b2 vaccine as the booster (the third) dose. Spike 1 (S1)-immunoglobulin G (IgG) antibodies and interferon gamma producing T cell responses were measured at 0, 7, 14, and 21 days after the first dose, and at 0 and between 2 to 7 days after the booster dose. Results: After the first-dose vaccination, the S1-IgG antibody responses were elicited within 14 days in the BNT162b2 group and within 21 days in the ChAdOx1 group. After the booster dose, the S1-IgG antibody responses were elicited within 5 days in both groups. The SARS-CoV-2-specific T cell responses appeared at 7 days after the first dose and at 4 days after the booster dose. Conclusions: SARS-CoV-2-specific immune responses by memory B cells and T cells may be expected to appear around 4 to 5 days after the booster dose.
Effects of Deep Sea Water on Mammalian Cells in the Nervous System
So Yeun Kim,Jae-Hee Jang,Yoon Hee Park,Jonghyun Kim,Yun-Ju Park,Jeong Ok Lim,Cheil Moon,Hyung-Soo Han,Yun-Hee Shon,Kyung-Soo Nam 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
We investigated the effects of deep sea water of South Korean East Sea in various cells of the mammalian nervous system. Deep sea water has been collected from 1,100 m of South Korean East Sea seabed, demineralized and concentrated, and then utilized. Hardness of the deep sea water was adjusted by adding minerals at hardness 4,000. The deep sea water showed protective effects on mammalian retinal and olfactory cells under metabolic stress in hardness dependent manners. In contrast, the deep sea water could not protect the retinal cells against oxidative stress, whereas it reduced the production of reactive oxidative species in the retinal cells in the hardness dependent manner. It also showed a minute inhibitory effect on inflammatory responses. Of our interest, the deep sea water suppressed formation of β-amyloidal fibril which is one of pathological action of the Alzheimer's disease. In summary, the deep sea water exhibits various neuroprotective effects, implying its pharmaceutical use.
[P5-35] Prevalence and characterization of Bacillus cereus in baby and young children foods
Chi-Yeun Cheung,Young-Bin Song,Chang-Yong Yoon,Woo-Young Jung,Soo-Yeul Cho,Soo-Yeul Cho,Mi-Gyeong Kim,Ju-Hee Kuk,Jin-Ha Lee,Jin-Ha Lee,Jong Mi Lim,Kyu Heon Kim,Ho-Il Kang,Ok-Hee Kim,Chan-Soon Kang 한국식품영양과학회 2008 한국식품영양과학회 학술대회발표집 Vol.2008 No.10