구강 악성 흑색종에서 PCNA 발현에 관한 면역조직화학적 연구

황경균,남윤우,이재일,이종호,심광섭,김명진 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.6

Malignant melanoma arising from the mucosa of head and neck region was rare and showed poor prognosis. Some of malignant melanoma were transformed from benign melanotic lesion. Malignant melanoma had high cellular proliferation and rapid growth. The percentage of PCNA-positive cell (labeling index) is high in many malignant tumor. So we compared the pattern of PCNA expression in the melanotic lesion. We performed the immunohistochemical study in malignant melanoma(19 cases), benign melanotic macule(24 cases) and normal mucosa(20 cases) were diagnosed in Seoul National University Dental Hospital between 1980 and 2000. Positive PCNA staining was found mainly in malignant melanoma. The mean PCNA expression in malignant melanoma, melanotic macule, normal tissue were 29.2%, 1.4%, 0%, respectively. Significant differences in PCNA expression were noted between malignant melanoma and melanotic macule(p<0.01), normal mucosa(p<0.01). These result suggested that the PCNA expression seems to be used as a diagnostic indicator for malignancy in malignant melanoma and melanotic lesion.

퇴축된 상악골에서 Le Fort Ⅰ 골절단술과 개재골 이식술을 이용한 동시적 인공치아식립술

김명진,황경균 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

The resorption pattern in the edentulous maxilla can lead to a class Ⅲ skeletal discrepancy and lack of sufficient bone volume for implant insertion. The maxillofacial restoration with bone grafts and implants should be provide the facial morphology, optimal function and esthetic acceptability. Le Fort I osteotomy with interpositional bone grafting have been usen to insert implant in severely atrophic maxilla. The five patients were performed by the same surgeon from 1992 in the SNUDH. The patients were followed up with clinical and radiographic examinations. Thirtythree implants were initially inserted in the bone grafts at the same time of Le Fort I osteotomy. Five out of the thirtythree implants were removed. The implant survival rate of this method was of 84%. We evaluated the state of graft bone in one patient using the MRP(multiplanar reformating)-CT. The mean resorption of the graft bone was 2.25㎜ between 6 months to 4 years postoperatively. In severely atrophic maxillae the Le Fort I osteotomy with simultaneous interpositional bone grafting and implant installation will provide good clinical result, optimal function and esthetic acceptability.

金屬酸化物 微粒子의 氣一液界面 吸着에 관한 硏究

李成植,崔正均,黃慶秀 동아대학교 공과대학 부설 한국자원개발연구소 1989 硏究報告 Vol.13 No.1

Removal of fine-particles of metal oxides in aquous solution by bubble-adsorption has been studied both theoritically and experimentally. Experiments were carried out using cethyltrimethy ammonium bromide, sodium lauyl sulfate, and the suspension of Fe₂O₃, CdO, CuO and MnO₂ in the batch system. The following results were obtained. 1. From the mass action law, equation for the distribution of surface charge of metal oxides in solution has been derived in terms of the hydrogen ions concentration and the point of zero charge of the metal oxides, and compared it with results of experiment. 2. The bubble-adsorption by particles of metal oxides depend on the surface charge, and well fitted at the point of zero charge of metal oxides. 3. Optimum pH of adsorption and selectivity of the removal metal oxides was expected by using sites distribution.

조대술에 의한 하마종의 치료

강동균,황경문,김은정,김현정,김영진,남순현 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

하마종은 구강저에 발생하는 점액 남종으로 주로 설하선과 관련된다. 즉, 하마종은 설하선 분비도관의 파열로 인하여 타액이 분비도관에서 빠져나와 주위의 연조직 내에 저류됨으로써 발생하는 가성 낭으로 정의 되며, 원인은 설하선 도관의 파열이나 폐색이다. 하마종의 임상소견은 청색의 투명한 종창이 구강저의 소대를 중심으로 편측으로 발생하며, 무통성이며, 촉진시 파동성을 나타낸다. 조직소견은 결합 조직 내 와동이 형성되지만, 낭 벽은 상피세포가 아닌 육아조직으로 구성되는 가성 낭을 관찰할 수 있다. 하마종의 첫 번째 치료법으로는 하마종의 내벽이 구강점막의 일부가 되도록 만들어 주는 조대술을 고려할 수 있다. 본 증례는 특징적인 하마종의 임상소견을 보이는 환아에게 gauze-packing등을 동반한 조대술을 이용하여 치료한 증례로써 양호한 치료결과를 보여 보고하고자 한다. Ranula is a mucocele which occurs at the mouth floor and mostly related to sublingual gland. In other words ranula is definded as a pseudocyst which occurs as the secretion duct of sublingual gland is destructed there as the saliva from the the secretion duct flows out and retention in the soft tissue. The cause of ranula is destruction or obstruction of the duct. The clinical findings of ranula is a painless, unilateral bluish transparent swelling around the frenum and shows fluctuation when palpated. Histological finding represent a formation of cavity inside the connective tissue. but a pseudo-cyst can be seen which the wall of the cyst is composed of granulation tissue rather than epithelial cells. The first treatment of ranula can be considered as marsupialization. which induces the inner wall of the Ranula to be a part of oral mucosa. This case report shows a treatment of marsupialization with gauze packing in a young patient representing a clinical finding of characteristic ranula.

Impairment Evaluation of Trigeminal Nerve Injury

Hwang, Kyung-Gyun Korean Academy of Dental Science 2012 Journal of korean dental science Vol.5 No.2

Impairment Evaluation of Trigeminal Nerve Injury

Kyung-Gyun Hwang 대한치의학회 2012 Journal of korean dental science Vol.5 No.2

Prognostic significance of preoperative kidney volume for predicting renal function in renal cell carcinoma patients receiving a radical or partial nephrectomy

Jeon, Hwang Gyun,Gong, In Hyuck,Hwang, Jin Ho,Choi, Don Kyung,Lee, Seung Ryeol,Park, Dong Soo Blackwell Publishing Ltd 2012 BJU international Vol.109 No.10

<P>Study Type – Prognosis (case series)</P><P>Level of Evidence 4</P><P><B>What's known on the subject? and What does the study add?</B></P><P>At present, many studies have been executed to identify predictors for chronic kidney disease or renal insufficiency after radical nephrectomy or partial nephrectomy. We examined whether preoperative kidney volume is a predictor for renal function after radical or partial nephrectomies in RCC patients. To our knowledge, this is the first study to report on the relationship between preoperative kidney volume and changes in renal function in RCC patients who underwent radical nephrectomy or partial nephrectomy performed by one surgeon.</P><P><B>OBJECTIVE</B></P><P><P>To investigate whether preoperative kidney volume is a prognostic factor for predicting the postoperative glomerular filtration rate (GFR) in renal cell carcinoma (RCC) patients.</P></P><P><B>PATIENTS AND METHODS</B></P><P><P>We included 133 patients who underwent radical (<I>n</I>= 83) or partial (<I>n</I>= 50) nephrectomy for RCC.</P><P>Kidney parenchymal volume was measured using personal computer‐based software and GFR was estimated before and after surgery at 6 and 12 months.</P><P>We evaluated the change in kidney volume after radical and partial nephrectomy and used regression analysis to identify predictors of lower post‐surgical GFR at 12 months.</P></P><P><B>RESULTS</B></P><P><P>The mean volume of the normal side kidney for the radical nephrectomy group increased from 142.4 mL to 166.0 mL (17.2%) and 171.5 mL (21.2%) after surgery at 6 and 12 months, respectively.</P><P>In the partial nephrectomy group, the volume of the normal side kidney increased from 127.2 mL to 138.8 mL (9.1%) and 140.6 mL (10.9%) after surgery at 6 and 12 months, respectively.</P><P>The volume of the operated side kidney decreased from 128.5 mL to 102.3 mL (20.1%) and 101.8 (20.6%) after surgery at 6 and 12 months, respectively.</P><P>In the radical nephrectomy group, older age (<I>P</I> < 0.001), preoperative volume of the normal kidney (<I>P</I>= 0.022) and preoperative GFR for the normal side kidney (<I>P</I>= 0.045) were significant predictors of lower post‐surgical GFR at 12 months.</P><P>In the partial nephrectomy group, older age (<I>P</I>= 0.001) and preoperative volume for both kidneys (<I>P</I>= 0.037) were significant predictors of lower post‐surgical GFR at 12 months.</P></P><P><B>CONCLUSION</B></P><P><P>Preoperative kidney volume is an independent predictor of GFR in RCC patients who underwent radical or partial nephrectomy.</P></P>

β-TCP를 이용한 상악동 점막거상술

황경균(Kyung-Gyun Hwang),송승일(Seung-Il Song),김상우(Sang-Woo Kim),이성훈(Sung-hoon Lee),김영면(Young-Muen Kim),심광섭(Kwang-Sup Shim) 대한구강악안면외과학회 2004 대한구강악안면외과학회지 Vol.30 No.5

Sinus floor augmentation has been proven an effective treatment procedure to increase bone volume in the posterior edentulous maxilla. Autogenous bone considered to be the best material for reconstructive bone surgery and has been successfully used as a graft material to augment posterior maxilla. However, the collection of autogenous bone required extra risks for morbidity and complaints. So, various bone graft materials included β-tricalcium phosphate(β-TCP) has been introduced for replacing the autogenous bone. The objective of this clinical study was to determine the predictability of endosseous implant placed in a maxillary sinus with β-TCP grafting. We performed sinus elevation with β-TCP to install the implant in the 10 maxillary cases. The prosthetic procedure was performed 6-9 months after. The implant-prosthetics was checked about 1 year. We checked the implant and measured the maximum bite force to evaluate the function of the implant. There was not observed the specific problem and complication in dental implant and maxillary sinus in the grafted materials. The maximum bite force was 558N in case of natural tooth, 365N in implant without grafting, 318N in implant with β-TCP grafting. There was no significant difference between with and without sinus grafting on maximum bite force(p>0.05). As though the long term check-up is needed, the grafting of β-TCP as a osteoconductive materials can expand the volume and induce dense new bone formation in maxillary sinus. So, this short-term results support that β-TCP can be a suitable material for sinus augmentation.

가토 두개부 골결손에서 맥동전자기장이 골형성에 미치는 영향에 관한 연구

황경균(Kyung-Gyun Hwang),이종환(Jong-Hwan Lee),김명진(Myung-Jin Kim),심광섭(Kwang-Sup Shim),김종원(Jong-Won Kim) 대한구강악안면외과학회 2002 대한구강악안면외과학회지 Vol.28 No.4

Pulsed electromagnetic field (PEMF) was used first to induce osteogenesis in 1974. The appliance which was consisted of the Helmholtz coil configuration have used to osteogensis. The objective of this study was to determine whether PEMF, a frequency of 100 Hz and magnetic field strength of 38 gauss applied to the calvarial defect in rabbit, could affect the induction of osteogenesis and the healing of the graft bone. This field should not produce excitation of nerve or muscle and heating the tissue. To evaluate the effect of PEMF on osteogenesis, 16 rabbit under the same condition was divided into 8 experimental groups and 8 control groups. 10 mm calvarial bone defects were formed around sagittal suture. The defect of left side was left without graft while the defect of right side was grafted by bone harvested from left side. A pulsed electromagnetic field was applied for 8 hours per day. Each group was sacrificed after 1 week, 2 weeks, 4 weeks, 8 weeks. Microscopic specimens were obtained from the calvarial bone defects and surrounding tissue using Hematoxylin-Eosin staining method. The results were as follows. 1. In the group which pulsed electromagnetic field was applied, new bone formation filled up the defect was observed after 4 and 8 weeks effectively. 2. There are no difference in the healing period for the fusion between the bone and graft bone. According to the result, the PEMF with 38 Gauss, 100 Hz was very effective in the healing of bone defect and new bone formation. So The PEMF will be useful in clinical aspect for oseteogenesis.

비스포스포네이트(Bisphosphonate)를 복용하는 환자에서 발생하는 골괴사증

황경균(Kyung-Gyun Hwang) 대한치과의사협회 2011 대한치과의사협회지 Vol.49 No.7

Bisphosphonates are widely used in the management of osteoporosis patients. Many reports and clinical studies have published a relationship between necrotic bone lesions localized to the jaw and the use of chronic bisphosphonate therapy. This osteonecrosis named bisphosphonate-related osteonecrosis of the jaw(BRONJ). This article described the mechanism, chemical structure, indication, risk factor of the bisphosphonate