위 (胃) 내시경 (內視鏡) 검사 (檢査) 14 , 389 예에 대한 임상 (臨床) 연구

함준수(Joon Soo Hahm),박경남(Kyung Nam Park),이민호(Min Ho Lee),이성준(Seong Joon Lee),오수철(Soo Chun Oh),한덕호(Duck Ho Han),이종철(Jong Chul Lee),기춘석(Chun Suhk Kee) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1

N/A Clinical studies were carried out on 14,389 cases who had taken gastrofiberscopic examination, biopsy and X-ray from May, 1969 to May, 1984 in Han-Yang University Hospital. The results obtained were as follows; 1) Of total 14,389 cases, 7,916 were male and 6,473 were female. 55.1%, of the cases were in the 3rd and 4th decade. 2) Of total 14, 389 cases, 13, 615 showed abnormal endoscopic findings. In abnormal cases, male to female ratio was l.2: l.3) The incidence of single organ involved was 84.8% and multiple organs involved was In single organ involved cases, the most common site of disease was stomach and in multiple organ involved cases, the prevalent sites of lesions were stomach and duodenum. 4) The most frequent disease of stomach was gastritis followed by gastric ulcer. In the cases of duodenum, the most common disease was duodenal ulcer and the next was duodenitis. 5) The most prevalent disease was the chronic gastritis, and the frequency of the other upper gastrointestinal diseases was acute gastritis, gastric ulcer, stomach cancer and duodenal ulcer in orders. 6) The most frequent type of chronic gastritis was superficial gastritis. 7) Among the total cases which had been taken blood-typing, the incidence of most upper gastrointestinal diseases was not related to each blood type. But blood group 0 was common in peptic ulcer disease and blood group A in stomach cancer. 8) The clinical symptoms and signs were of no significant aid for the differential diagnosis of the various upper gastrointestinal diseases.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

반측안면소체증의 측두골 전산화 단층촬영소견

한종규,한경렬,백병준,김형환,배원경,김일영 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Hemifacial microsomia(HFM) is a craniofacial disorder and complex malformation syndrome with a variable and asymmetric malformation involving first and second pharyngeal arch derivatives. Multiple etiological mechanisms for HFM have been considered. Mechanisms proposed include genetic factors, early embryogenesis insults involving abnormal neural crest development and migration, and stapedial artery hematoma. HFM is the second most common craniofacial malformation but has been rarely reported in korea, and we report five cases of HFM in temporal bone CT findings. The temporal bone CT findings of five patients aged 6 days and 19 years(mean, 9 years) with hemifacial microsomia were reviewed and evaluated. Particular attention was focused on auricular malformation, external auditory canal, volume of middle ear cavity, ossicular anomaly, facial nerve anomaly and inner ear anomaly. In all patients, temporal bone CT scans revealed the stenosis or atresia of external auditory canals, decreased middle ear cavities, matoid underdevelopment and ossicular anomalies including ossicular ankylosis, but only one patient showed facial nerve or inner ear anomaly. In conclusion, temporal bone CT scan is a useful diagnosis modality of hemifacial microsomia, which is especially more useful in preoperative evaulation and estimation of postoperative prognosis that demonstate middle and inner ear anomalies.

디자인혁신에 있어서 유사성 판단에 관한 연구 : 의자, 시계, Facade를 중심으로 concentrated on the identity of chair, clock, Facade

한정완,차경준,오희권,류제선 한국디자인과학학회 1999 디자인과학연구 Vol.2 No.-

신제품이 개발 출시되어 크게 성장 할 수 있다는 것은 그것을 채택, 수용해 줄 수 있는 혁신층과 조기수용자 층의 소비자 구조를 가지고 있어야만 한다. 신제품 수용자의 조기 확보는 신제품 개발에 소요된 비용은 조기에 보충할 수 있고, 많은 고객을 확보하여 매출의 증대가 용이하고, 마케팅비용의 감소를 가져올 수 있으며. 시장에서 리더십을 가짐으로써 효과적 시장 진입이 되기도 한다. 이와 같이 신제품의 수용과 확산의 연구에서 혁신성이 차지하는 중요도가 매우 높기 때문에 많은 관심을 끌어 온 것이 사실이다. 그러나 이러한 혁신과 수용성 연구의 중요성에 비추어 혁신성에 대한 발견 사실의 모호성과 함께 관련변수에 관한 끊임없는 논의가 지속되어 왔고, 동시에 혁신성 연구가 지금까지 취하여 왔던 방향과 주제에 관련해서도 많은 비판이 이루어져 온 것도 사실이다. 이러한 관점에서 본 연구에서는 아직 논리적으로나 실체적으로 방법론이 확립되어 있지 않은 디자인 혁신의 개념을 새롭게 정립하고 그 특징과 요소를 분석하고 객관적인 기준으로 변한 할 수 있는 지표를 찾는다. 또한 디자인 혁신에 있어서 유사성 판단에 관한 실험을 통해 제품 집단의 유형과 기준을 명확히 파악하고 각 샘플의 공간 해석과 함께 시자극적 특성을 정량적으로 평가하는 실험적 이론으로 사용하고자 한다. 이는 디자인에 있어서의 혁신을 인지하고 각 제품 속에 속한 샘플들을 특징별로 지각하는 보다 과학적인 디자인 접근방법에 관해 새로운 방향을 모색할 수 있도록 하였다. If a new product Is devised and to be sold, it Should possess the group of people who are inclined to change and accept the product, and the group of consumers who can buy them. If you occupy the consumers to buy the products earlier, you car make up with the expenditure that you have spent to devise and make products, facilitate the raise of the sales, decrease the marketing expenditure, and have effective access to the market by going ahead of others. Like this the Innovation has great influence in the accepting and spreading of the products. However in spite of these Innovation and acceptance, there have kept the ceaseless disputes about finding the Innovation and related function, at the same time the study of innovation has been criticized about the direction and the theme we have taken until now. From this point of view, the methodology has not been established In the area of logic and its reality, and this study tries to set up the concepts and analyze the characteristic and the elements and find the standard to change those characteristics and elements in to objective standard. In addition, through the judgment of the similarity In the design innovation, it tries to identify clearly the types and the standard of the set of the products, Interpret the space of each sample, and use it as the experimental theory to evaluate the visual characteristics, Thus it can perceive innovation of the design. perceive the characteristics of the samples in each products, and find the new direction in the more scientific access to design.

백서 급성 심근경색 모델에서 Adenylate Kinase 3의 혈청학적 동태 연구

한재승,김효준,김혁,김경수 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

단선사고보상기능을 갖는 능동전력필터에 관한 연구

한경희,박인석,이정준,오봉환 명지대학교 대학원 1999 대학원논문집 Vol.3 No.-

Recently, for increasing consumed power and informational society, confidence of power supply is demanded. Beside, owing to most of these loads are nonlinear, utility line is polluted by these components. therefore, it is demanded compensation of harmonic current. In times past, special order of harmonic current is only compensated by passive filter, but active power filter compensate whole harmonic current. Therefore, this paper propose uninterruptable power supply(UPS) with performance of active power filter.

Eisenmenger씨 증후군 산모의 긴박 제왕절개술시 전신마취 경험

김준,고우석,정종달,유병식,임경준,소금영,안태훈,한승룡 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Eisenmenger's syndrome describes a situation in which the left-to-right intracardiac shunt is reversed as a result of increased pulmonary vascular resistance. The patients with Eisenmenger's syndrome are poorly tolerated and markedly increased maternal mortality to 30 - 50% during pregnancy, Physiological change of pregnancy decreases systemic vascular resistance that further aggravates the bi-directional or left shunt associated with Eisemnenger's syndrome. We report a case of 37 weeks a pregnant woman with an urgent cesarean section under general anesthesia for preterm labor. She was a pregnant patient with Eisenmenger's syndrome and did not receive antenatal care during pregnancy. Anesthesia was induced with ketamine-midazolam-fentanyl and maintained with ketamine-midazolam. The patient was ventilated with 100% O₂. Blood pressure was maintained with intravenous phenylephrine, crystalloid solution, and blood. Phenylephhne was used to maintain systemic vascular resistance (SVR). Even though the patient was carried rapid and adequate medical management, the patient was transferred to the ICU in an intubated state and died 2 days after surgery. We conclude that the parturients with Eisenmenger's syndrome require more regular, careful antenatal care, monitoring, and adequate management.

임신 입덧에 의해 발증한 베르니케뇌증 환자에서 스테로이드 다량요법과 FLAIR MR기법

한영민,유도성,김영주,허필우,조경석,김달수,강준기 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.12

雙發航空機의 單發運用 安全度 分析

朴溶寒,李璟埈 한국항공대학교 1981 論文集 Vol.18 No.-

本 考察은 雙發 輕航空機의 機關故障으로 因한 單發飛行性能을 分析하고 이에 適合한 航空機 操作을 考察하였다. 특히 危險한 離陸初期段階에서 單發機關이 되었을 때 操縱士들이 航空機의 性能, 操作, 心理的인 面을 잘 應用해서 安全하게 歸還할 수 있도록 함에 硏究에 焦點을 두었다. This paper is to analyze the single engine flight performance resulting from the engine failure of a twin light airplane, and to examine aircraft control applicable to this circumstance. Particularly, this research is centered around the study of proper methods of returning to the base in safety by means of the application of the flight performance, aircraft control and psychological factors on the part of a pilot when the airplane is to be with a single engine immediatly after take off.

Monte Carlo 방법을 이용한 대기오염 배출률 예측의 불확실성 평가

정효준,김은한,서경석,황원태,한문희 한국환경과학회 2006 한국환경과학회지 Vol.15 No.4