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Kang, Youngnam,Kim, Jeesu,Park, Junbeom,Lee, Yeong Mi,Saravanakumar, Gurusamy,Park, Kyeng Min,Choi, Wonseok,Kim, Kimoon,Lee, Eunsung,Kim, Chulhong,Kim, Won Jong Elsevier 2019 Biomaterials Vol.217 No.-
<P><B>Abstract</B></P> <P>Nitric oxide (NO) is widely known as an effective vasodilator at low concentrations. Drug delivery systems combined with NO can dilate blood vessels surrounding tumor tissues, and the drug accumulation in tumors is accelerated by the enhanced permeability and retention effect, leading to an improvement in the anti-tumor effect. N-heterocyclic carbene-based NO donors (e.g., 1,3-bis-(2,4,6-trimethylphenyl)imidazolylidene nitric oxide (IMesNO) have been developed for stable NO storing in air and water, and NO release by thermolysis. Herein, we demonstrated on-demand NO release by high-intensity focused ultrasound (HIFU) as a stimulus, which generated high heat and exerted an ablation effect when treated <I>in vivo</I>. We demonstrated IMesNO to be a HIFU-responsive NO donor and its potential application <I>in vivo</I> using IMesNO-loaded micelles. Moreover, IMesNO-loaded micelles mixed with drug-loaded micelles (IMesNO/DOX@MCs) showed acceleration of drug accumulation in tumor sites and enhanced tumor growth inhibition. Thus, our findings suggest a potential clinical bioapplication of NO-releasing drug-loaded micelles owing to the therapeutic function of NO and HIFU treatment for anti-cancer therapy.</P>
논토양에서 질소비종 및 벼 재배양식이 메탄가스 발생에 미치는 영향
강위금,강항원,고지연,박향미,임동규,박경배 한국환경농학회 1998 한국환경농학회지 Vol.17 No.3
논토양에서 질소비종 및 재배양식에 따른 메탄배출양상과 질소비종이 담수토양의 pH와 Eh에 미치는 영향을 조사한 결과는 아래와 같다. 1. 중묘이앙재배에서 질소비종에 따른 메탄배출총량은 요소 32.9gm^(-2)$gt;유안 30.3$gt;완효성비료 26.4gm^(-2)의 순이었으며, 건답직파재배에서는 요소 24.7gm^(-2)$gt;유안 16.7gm^(-2)$gt;안효성비료 22.8gm^(-2)의 순이었다. 2. 질소비종에 따른 메탄배출량은 요소시비구보다 유안은 18.4%, 안효성비료는 15.9% 저감되었다. 3. 재배양식별로는 건답직파재배는 중묘이앙재배보다 29.7%의 메탄발생량이 저감되었다. 4. 질소비종에 따른 담수토양의 pH는 요소$gt;완효성비료≒무비$gt;유안의 순으로 높았는데 이는 질소비종별 메탄배출량의 순서와 일치하였다. 토양 Eh는 유안$gt;완효성비료$gt;무비$gt;요 소의 순으로 높아 pH 및 메탄배출량과 반대경향이었으며, 토양용액내 SO₄농도는 유안$gt;완효성비료$gt;요소$gt;무비의 순으로 높았다. To mitigate the methane emission from rice paddy fields, effects of nitrogen fertilizers source and cultural patterns were evaluated on silty loam soils. And a pot experiment was carried out to find out the effects of nitrogen fertilizers on soil pH, Eh, sulfate concentration of soil water in flooded soil. In transplanting cultivation, the total methane emission depending on fertilizers was 32.9gm^(-2) for urea ; 30.3gm^(-2) for ammonium sulfate ; 26.4gm^(-2) for coated urea. Methane emitted in direct seeding on dry soil was 24.7gm^(-2) for urea ; 16.7gm^(-2) for ammonium sulfate : and 22.8gm^(-2) for coated urea. Thus, the methane emission rate of direct seeding on dry soil was 29.7% lower than transplanting. According to the nitrogen fertilizers, the methane emission rate by ammonium sulfate and coated urea were reduced 18.4 and 15.9% in comparison with urea, respectively. In pot experiments, pH in flooded soils depending on nitrogen fertilizers dereased in order of urea$gt;coated urea≒no fertilizer$gt;ammonium sulfate and the order was coincided with that of total CH₄emission from flooded soil. Soil Eh was highest in ammonium sulfate application followed by coated urea, no fertilizer, urea. And sulfate concentrations of soil water were in order of ammonium sulfate$gt;coated urea$gt;urea$gt;no fertilizer.
Geun Tae Park,Dae Won Jeon,Kwang Ho Roh,Hee Sig Mun,Chang Hwa Lee,Chan Hyun Park,Kyeng Won Kang,Sang Mok Kim,Jong Myeng Kang,Han Chul Park 대한내과학회 1999 The Korean Journal of Internal Medicine Vol.14 No.1
Most reports on serious MTX toxicity have focused on hepatic abnormalities, while other effects, including hematologic reactions, have not been emphasized. We experienced a case of pancytopenia secondary to MTX therapy in a patient with RA and renal insuff
Botrytis cinerea 에 의한 멜론 잿빛곰팡이병
권진혁,강수웅,손경애,배동원,박창석 한국균학회 1999 韓國菌學會誌 Vol.27 No.4
A new disease on mask melon grown under plastic film houses was found in Namhae area in May of 1999. Gray to dark brown mold were grown on the surface of matured fruits and infected inside tissues were discolored and rotten. Basal part of the fruit and blossom-end were frequently infected and colonized by fungi. About 2.2% of matured fruits were infected in the surveyed plastic film houses. The causal organism was isolated from the lesion and identified as Botrytis cinerea. The conidia in mass were hyaline or gray, 1-celled, mostly ellipsoid or ovoid and sized 8.8∼21.2×6.5∼13.1 ㎛. Hyaline or pigmented conidiophores were tall, slender and determinated and, sometimes branched irregularly in upper part. Enlarged or rounded apical cells bear conidial cluster and sized 18.4∼81.1×4.3∼11.4 ㎛. Optimum temperature for mycelial growth was recorded at 15∼25℃. This is the first report on gray mold of melon caused by Botrytis cineria in Korea.
폐렴을 동반한 15 세 남자 환자에서 발견된 선천성 낭포성 유선종 폐기형 1 예
한영숙,김의숙,이원석,이정아,장지정,선우인철,김대하,이광섭,백영주,이강룡,김신응,지미경 대한내과학회 1997 대한내과학회지 Vol.52 No.1
Congenital cystic adenomatoid malformation(C.C. A.M.) is a rare variant of congenital pulmonary cystic diseases. C.C.A.M. was first distinguished from other pulmonary cystic lesions by Ch'in and Tang in 1949. It is characterized by cessation of bronchiolar maturation with an overgrowth of mesenchymal elements and proliferation of polypoid glandular tissue in the absence of normal alveolar differentiation. In 80% to 95% of cases, C.C.A.M. of the lung is confinded to a single lobe and there is no lobe predilection and right and left predominance. The clinical presentation may be widely variable, ranging from intrauterine fetal death secondary to nonimmune hydrops fetalis to discovery in childhood after recurrent pulmonary infections. Definitive treatment is removal of affected lobe. In rare instances, there is cases of myxosarcoma, embryonal rhabdomyosarcoma. Bronchoalveolar carcinoma arising in C.C.A.M.. So, resection is recommended even if they are asymtomatic. We have experienced a case of congenital cystic adenomatoid malformation (type II) of the lung in 15 year old man with pneumonia. After the improvement of pneumonia, surgical operation was performed. A brief review of the related literature is presented.
절수에 의한 Mongolian gerbil 신장조직의 변화에 관한 형태학적 연구
김무강,이근좌,정영길,송치원,이경열,박일권,이철호,이기훈,현병화,김길수,Kim, Moo-Kang,Lee, Keun-Jwa,Jeong, Young-Gil,Song, Chi-Won,Lee, Kyeng-Youl,Park, Il-Koun,Lee, Chul-Ho,Lee, Ki-Houn,Hyun, Byung-Hwa,Kim, Gil-Soo 한국현미경학회 1997 Applied microscopy Vol.27 No.4
Mongolian gerbil (Meriones unguiculatus) has been as an animal model for studing the neurological diseases such as stroke and epilepsy because of the congenital incompleteries in Willis circle, as well as the investigation of water metabolism because of the long time-survival in the condition of water-deprived desert condition, compared with other species animals. In order to accomplish the this research, first of all another divided the laboratory animals 5 groups of which each group include the 5 animals. In this study were investigated the histological structure in the kidney, measured the plasma osmolalities at the time of sacrifice of indivisual animals, and the body weights every day during water-deprived. The results obtained in this study were summarized as followings: 1. The body weights and decreasing rates of the body weight in water-deprived mongolian gerbil groups were continuosly decreased. 2. The plasma osmolalities were increased from the 5th water-deprived day, after then the gradually increasing reached nearly its equilibrium state at the 10th water-deprived day. 3. The urine volumes were abruptly decreased from the 2th water-deprived day, after then the gradually decreasing patterns were reached nearly its equilibrium state at the 10th day, and stopped the 11th day. 4. In the light microscopical observation of the kidney, glomerular capillary loop thickening, mesangial matrix increasing, sclerosis, glomerular cystic atrophy, interstitial fibrosis, tubular dilatation, mononuclear interstitial inflammation, interstitial mineralization, and hyperplasia of the collecting duct epithelium in the cortex area, were observed from the 10th water deprived day, and the lesions were gradually severe changed as the time lapse. 5. In the electron microscopical findings of the kidney, the degenerative changes of endothelial cell, podocyte and mesangial cell in glomeruli were initially observed on the 10th water-deprived day as well as the degeneration of microvilli and intracellular organelle in the renal tubules.