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조윤호,한상기,김준형 중앙대학교 기술과학연구소 1999 기술과학연구소 논문집 Vol.29 No.-
외국의 설계 지침을 근간으로 콘크리트 포장을 설계하고 있는 국내 포장 기술자들은 흙의 지지력 계수 추정에 어려움을 겪고 있다. 길바탕흙(Roadbed Soil)의 평판재하실험 결과(??)를 선택층 및 하나 혹은 여러 층위의 지지력계수(??)로 변환하는 것은 현 설계 지침에 상세한 과정이 없으므로 혼란이 가중되고 있다. 이에 대하여 본 논문은 흙의 지지력계수 산정과정 전반에 걸쳐 국내의 문제점을 살펴보고, 바람직한 설계 방향을 제시하였다. 국내에 존재하는 포장의 형식을 조사하여 대표적인 보조기층재료와 두께 따라 ??값에서 ??값을 추정하는 설계 입력변수 변환 모형을 제시하였는데, 포장 거동 해석 모형은 AASHTO 추정식에 사용했던 다탄성 해석이론인 ELSYM5가 사용되었다. 역학적 모형 해석에 어려움을 겪는 기술자들이 간편하게 사용할 모형을 개발였는데 기층 및 보조 기층의 두께 및 재료 물성에 따라 총 990회의 거동 해석이 진행되었고, 회귀 분석을 이용하여 추정모형을 선정하였다. 또한 제시된 회귀식은 기존의 개발 모형과 비교를 통해 실무 적용이 타당하다고 판단하였다. Design of concrete pavement in Korea is mainly based on the guide developed from the AASHTO. However, many input parameters were not calibrated for the materials used in the highway. Subgrade modulus for the rigid pavement could not be correctly estimated due to lack of procedure to transfer modulus of subgrade reaction(??) to composite modulus of subgrade reaction(??), for example. This paper describes the way how to develop transforming equation and the model for estimating ??. Typical concrete sections were selected from the survey of pavement constructed in airport and highway. A layered elastic model, ELSYM5, that shows the behavior of concrete pavement under traffic loading was adapted for calculation of theoretical subgrade modules. Total 990 of calculation were performed. Regression model was suggested for the design based purely on analytical work so that further research work to verify the model from the field should be carried out.
말기신부전 환자의 혈액투석에 있어서 혈관 성숙기간이 동정맥루 생존율에 미치는 영향
박규용(Ky Yong Park),김근호(Guen Ho Kim),김형직(Hyung Jik Kim),채동완(Dong Wan Chae),노정우(Jung Woo Noh),구자룡(Ja Ryong Koo),조진원(Jin Won Cho),여미애(Mi Ae Yeo),양형원(Hyung Won Yang),김경희(Kyung Hee Kim),이기성(Ki Sung Lee),전로원 대한내과학회 1999 대한내과학회지 Vol.57 No.1
N/A Arteriovenous fistula(AVF) has been the most important, primary mode of achieving vascular access for chronic hemodialysis by this time. In general, maturation period over 4 to 8 weeks after operation for the formation of AVF has been recommended for the long-term survival of AVF, and so insertion of central venous catheter without using AVF being matured has been primarily recommended whenever hemodialysis is needed. But not infrequently, serious complications have been reported in association with the insertion and the use of central venous catheter. So earlier use of AVF is regarded as a good method of avoiding serious complications with regard to the insertion and the use of central venous catheter. But early use of AVF has not been generally recommended, for early use of AVF has been regarded to be associated with early failure of AVF. But few studies have reported the correlation between maturation period and AVF survival. And in practice, early use of AVF has already been performed frequently by not a few nephrologists or nurses of dialysis units. So authors tried to examine the correlation between maturation period and AVF survival rate, and to find the validity of early use of AVF if it is regarded usable for the hemodialysis by experienced hemodialysis nurses and nephrologists. Methods : A retrospective analysis using 88 AVF cases which had been created in 85 patients from Oct. 1986 through June 1996, and from which authors could get enough information for this study was done. Authors compared one year survival rates of AVF according to the maturation period, the presence of DM, and condition of AVF assessed clinically by doctors and experienced nurses in hemodialysis units. Also from the cases with AVF obstruction, authors examined the 1st, 2nd, and 3rd year survival rate of AVF according to the maturation period. Results : One year survival rate of AVF with maturation period less than 4 weeks was higher than that with maturation period more than 4 weeks, but there was no statistical significance. One year survival rate, irrespective of the length of maturation period for AVFs, of AVF regarded to be usable and good for hemodialysis was higher than that of AVF regarded to be usable but not good for hemodialysis. In the study with the AVF obstruction group only, one year survival rate of AVF with maturation period less than 4 weeks was higher than that of AVF with maturation period more than 4 weeks but there was no statistical significance. And one year AVF survival rate was higher in non DM group(94.1%) than DM group(60%) regardless of maturation period of AVF(P<0.05). Conclusion : On the contrary to the views that longer maturation period of more than 4 weeks will be necessary for the long-term survival of AVF, our results suggest that shorter maturation period for AVF less than 4 weeks does not necessarily mean early failure of AVF once AVF is regarded to be usable for hemodialysis. So it is suggested that early use of AVF instead of inserting central venous catheter is a reasonable approach for getting an adequate vascular access for hemodialysis in chronic renal failure patients who were subjected to receive hemodialysis on waiting peroid of AVF maturation.
Pyridine 용액에서 네자리 Schiff Base Cobalt (II) 착물들의 산소첨가 생성물에 대한 전기화학적 성질 (제 3 보)
조기형,서성섭,전동철,Ky Hyung Cho,Seong Seob Seo,Dong Chul Chon 대한화학회 1989 대한화학회지 Vol.33 No.3
네자리 Schiff base cobalt(II) 착물로서 Co(SND) 및 Co(SOPD)을 합성하여 pyridine용액에서 산소를 반응시켜 산소첨가 생성물로서 $[Co(SND)(Py)]_2O_2$ 및 $[Co(SOPD)(Py)]_2O_2$ 을 합성하였다. 이 착물들은 원소분석과 cobalt 정량, IR spectra, T.G.A. 및 자화율을 측정하여 확인하였으며, 산소 : cobalt(II) 착물의 결합비가 1:2이고, 네자리 Schiff base cobalt(II)와 pyridine 및 산소가 6배위로 결합함을 알았다. 0.1M TEAP-pyridine 용액에서 순환전압전류법에 의한 $Co(SND)(Py)_2$ 및 $Co(SOPD)(Py)_2$ 들의 Co(II)/Co(III)와 Co(II)/Co(I) 산화환원 과정은 가역 및 준가역적으로 일어난다. 산소첨가 생성물의 착물들은 비가역적으로 일어나며, 이들의 산소에 대한 환원과정은 $E_{pc} \;=\;-0.96{\sim}-1.03V$에서, 산화과정은 $E_{pa}\;=\;-0.78{\sim}-0.80V$ 범위에서 일어나며, 이들 산화환원 과정은 준가역적으로 일어남을 알았다. Tetradentate Schiff base cobalt(II) complex; Co(SND) and Co(SOPD) were synthesized, and these complexes were allowed to react with dry oxygen to form oxygen adducts cobalt(III) complexes such as $[Co(SND)(Py)]_2O_2$ and $[Co(SOPD)(Py)]_2O_2$ in pyridine. These complexes have been identified by IR specta, T.G.A., magnetic susceptibilities measurements and elemental analysis. It has been found that the oxygen adducts coblat(III) complexes have hexacoordinated octahedral configuration with tetradentate Schiff base cobalt(II), pyridine and oxygen, and the mole ratio of oxygen to cobalt(II) complexes are 1;2. The redox reaction processes of $Co(SND)(Py)_2$ and $Co(SOPD)(Py)_2$ complexes were investigated by cyclic voltammetry with glassy carbon electrode in 0.1M TEAP pyridine. The result of redox reaction processes of Co(III)/Co(II) and Co(II)/Co(I) for $Co(SND)(Py)_2$ and $Co(SOPD)(Py)_2$ complexes are reversible or quasi reversible process but oxygen adducts complexes are irreversible processes. Redox process for oxygen of oxygen adducts complexes was quasi reversible and redox range of potential was $E_{pc}\;=\;-0.96{\sim}-1.03V$ and $E_{pa}\;=\;-0.78{\sim}-0.80V.$
Roh, Tae Hoon,Park, Hun Ho,Kang, Seok-Gu,Moon, Ju Hyung,Kim, Eui Hyun,Hong, Chang-Ki,Ahn, Sung Soo,Choi, Hye Jin,Cho, Jaeho,Kim, Se Hoon,Lee, Seung Koo,Kim, Dong Seok,Kim, Sun Ho,Suh, Chang-Ok,Lee, Ky Williams & Wilkins Co 2017 Medicine Vol.96 No.27
<P><B>Abstract</B></P><P>The present study analyzed outcomes of surgery followed by concomitant chemoradiotherapy (CCRT) with temozolomide (TMZ) in patients with newly diagnosed glioblastoma (GBM) at a single institution. Outcomes were retrospectively reviewed in 252 consecutive patients with newly diagnosed GBM who underwent surgery followed by CCRT with TMZ at the authors’ institution between 2005 and 2013. At initial operation, 126 (50.0%), 55 (21.8%), 45 (17.9%), and 26 (10.3%) patients underwent gross total resection (GTR), subtotal resection, partial resection (PR), and biopsy, respectively. Their median overall survival (OS) was 20.8 months (95% confidence interval [CI] 17.7–23.9 months) and their median progression-free survival was 12.7 months (95% CI 11.2–14.2 months). The O<SUP>6</SUP>-methylguanine-DNA methyltransferase (MGMT) promoter was methylated in 78 (34.1%) of the 229 patients assayed, and an isocitrate dehydrogenase 1 mutation was detected in 7 (6.6%) of the 106 patients analyzed. Univariate analyses showed that patient age, involvement of eloquent areas, involvement of the subventricular zone, presence of leptomeningeal seeding, Karnofsky Performance Status, extent of resection (EOR), MGMT promoter methylation, and presence of an oligodendroglioma component were prognostic of OS. Multivariate analysis showed that age, involvement of eloquent areas, presence of leptomeningeal seeding, EOR, and MGMT promoter methylation were significantly predictive of survival. OS in patients with GBM who undergo surgery followed by CCRT with TMZ is enhanced by complete resection. Other factors significantly prognostic of OS include that age, involvement of eloquent areas, presence of leptomeningeal seeding, and MGMT promoter methylation.</P>
재발성 상피성 난소암 환자에서 Gemcitabine 단독 항암화학요법을 사용한 4예
박용주 ( Yong Joo Park ),이철민 ( Chul Min Lee ),서형주 ( Hyung Joo Seo ),이혜주 ( Hye Joo Lee ),김정선 ( Jaung Sun Kim ),고지경 ( Ji Kyung Ko ),조용균 ( Yong Kyoon Cho ),최훈 ( Hoon Choi ),김복린 ( Bok Rin Kim ),이홍균 ( Hong Ky 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.11