플라즈마 이온주입기에서의 시변환 쉬스 연구

김곤호,김건우,김영우,최영도,김종식,김상진,한승희,홍문표 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

Abstract- In a plasma source ion implantation, the target is successively biased by negative voltage pulses with an intrinsic finite rise time, resulting in the time-dependent sheath formation around the target. Measurement of time-dependent sheath during the pulse rise show the ion matrix sheath development which is in proportion to square root of time and pulse rise rate over plasma density but independent of the ion mass.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

입원 중인 베트남 참전 군인의 삶의 만족도와 관련된 요인

김애리,박종,김율,노희송,박광희,김은숙,김형철,홍강식,류소연,강명근,김기순 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background and Objectives: The aim of the study was to identify the factors associated with life satisfaction of hospitalized Vietnam veterans. Material and Methods: The data were collected from 200 hospitalized Vietnam veterans of 5 veterans hospitals in Korea from September 13 to 23, 2004. Information of general characteristics, health behavior, disease history, family function, depression and life satisfaction were collected by structured questionnaire. Results: The mean of life satisfaction was 21.48(±6.03), and the mean of depression was 53.10(±9.64). The prevalence of depression was mild depression 24.0%, moderate depression 43.5% and severe depression 25.0%. Depression was associated with life satisfaction and depression was higher, life satisfaction was lower. Family function and age were positively associated with life satisfaction, Conclusion: Life satisfaction was affected by depression and family function in hospitalized Vietnam veterans. Therefore, it was thought that psychosocial approaches such as improve depression and family function in care of hospitalized Vietnam veterans is required.

Lactobacillus plantarumCLP-1이 돼지바이러스에 미치는 효과

이건희(Gun-Hee Lee),김영희(Young-Hee Kim),조현아(Hyeon-A Cho),강성기(Sung-Gi Kang),김동건(Dong-Gun Kim) 한국생물공학회 2011 KSBB Journal Vol.26 No.1

To isolate Lactic acid bacteria for animals, we have screened from Kim-chi, swine intestine, swine feces, and dairy products by random selection and anti-viral, antipathogenic bacteria test. Among them, CLP-1 shown that inhibitory effect against rotavirus, porcine epidemic diarrhea (PED) virus, Salmonella sp, and E.coli. By examining biological property, API-ZYM and identified Lactobacillus plantarum by 16S rDNAgene sequence. CLP-1 determined resistance to low pH and bile salt. Futhermore, the cell body of CLP-1 adhered to the intestinal epithelium tissue of swine and Caco-2 cell. CLP-1 was examined on cell immune system modulating activity in vitro. The whole cell and cell culture supernatant was increasing of interferon-β activity. And then, CLP-1 increased prevention effect by Salmonella enteritidis infection in SPF chickens. And we determined similar result in pigs.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 이트라코나졸 액과 플루코나졸 시럽의 예방 효과 : 전향적, 무작위, 비교 임상시험

최수미,이동건,최정현,박선희,엄기성,김유진,김희제,민창기,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

목적 : 조혈모세포이식 환자에서 호중구 감소 기간 동안 이트라코나졸 액(ITZS)과 플루코나졸 시럽(FCZS)의 진균 감염에 대한 예방 효과를 전향적으로 비교해 보고자 하였다. 재료 및 방법 : 2001년 8월부터 2002년 6월까지 가톨릭 조혈모세포이식센터에 입원하여 동종 조혈모세포이식을 받은 만 18세 이상의 환자들을 각각 ITZS와 FCZS군으로 무작위 배정하여 침습성 진균 감염 발생과 약제 관련 부작용을 전향적으로 조사하였다. 결과 : ITZS군에 40명, FCZS군에 38명이 배정되었고, FCZS군 환자의 평균 나이가 더 많았다. 시험 약제 평균투여기간은 ITZS군 16.4일, FCZS군 21.9일로 ITZS군이 더 짧았다. 이는 ITZS군에서 소화기 부작용으로 인한 약제 중단이 더 많았기 때문으로 보인다. 시험 약제 투여 후 총 빌리루빈 수치의 유의한 증가가 관찰되었으나, 약제 관련 부작용은 모든 환자에서 가역적이었다. 호중구감소 기간동안 표재성 진균 감염은 두 군에서 모두 발생하지 않았고, 침습성 진균 감염은 ITZS군 5명(12.5%), FCZS군 8명(21.1%)으로 FCZS군에서 많았으나, 통계학적으로 유의하지 않았고, 사망률에도 유의한 차이는 없었다. 결론 : 침습성 진균 감염에 대한 이트라코나졸 액과플루코라졸 시럽의 예방 효과에 유의한 차이는 없었으나, 앞으로 더 많은 환자를 대상으로 잘 짝지어진 대조군 연구가 필요할 것으로 보인다. 부작용 중 간독성과 관련하여 이식시 투여되는 여러 약제들과의 상호작용에 대한 연구도 필요할 것이다. Background : Though fluconazole is widely used for antifungal prophylaxis, it is ineffective against mould infections including Aspergillus species. Itraconazole has a broader spectrum than fluconazole but the capsule form shows erratic bioavailability in neutropenic patients. In this study, we compared itraconazole oral solution (ITZS) with fluconazole syrup (FCZS) for the prevention of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant recipients. Materials and Methods : Adults receiving allogeneic hematopoietic stem cell transplantation (HSCT) from september 2001 to June 2002, were randomly allocated to either the ITZS group or the FCZS group. We prospectively evaluated the safety and efficacy of each drug. Results : Out of 78 patients (40 patients in the ITZS group and 38 patients in the FCZS group) who were eligible for this study, 37 patients completed the course of prophylaxis without any evidence of IFI. The mean duration of prophylaxis was 16.4 days for the ITZS group and 21.9 days for the FCZS group (P<0.006). Drug-related adverse events occurred in 28 patients (70.0%) and 19 patients (50.0%) in the ITZS group and the FCZS group, respectively. Common adverse events of ITZS were nausea, vomiting, and diarrhea. Drug-related reversible hepatotoxicity occurred in 4 patients in the ITZS group. There was a significant elevation of total bilirubin level in the ITZS group. The incidence of suspected IFI occurred in 5 patients (12.5%) who received ITZS, compared with 8 (21.1%) who received FCZS (P=0.372). There were no proven IFIs or superficial (oral/vaginal) fungal infections in both groups. Overall mortality was not different between the two groups (2.5% in the ITZS group versus 5.3% in the FCZS group, P=0.610). Conclusion : ITZS and FCZS showed similar protection against IFI during pre-engraftment period. Poor tolerability due to gastrointestinal troubles of ITZS might limit its success as prophylactic therapy. Well matched controlled study with large number of patients will be required in the future.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

혈액투석 환자의 희망과 삶의 질

김정희,박점희,김현미,장군자 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 혈액투석 환자의 희망과 삶의 질 정도를 파악하고, 이 두 변수들 간의 상관관계를 규명하여 희망이 삶의 질을 향상시키는 중요한 개념임을 밝혀서 혈액투석 환자들을 간호하는데 필요한 기초자료를 제공하고자 시도되었다. 대상 및 방법 : 연구대상은 대구시 소재 3개 대학병원, 1개 종합병원의 인공신장실에 주기적으로 내원하여 혈액투석 치료를 받는 환자 100명이었으며, 연구도구는 Miller가 개발한 희망 측정도구와 노유자가 개발한 삶의 질 측정도구를 이용하였다. 구조화된 질문지를 이용한 면담을 통해 자료수집을 하였으며, 수집기간은 1996년 11월 7일부터 1997년 1월 8일까지였다. 수집된 자료는 SAS프로그램을 이용하여 전산처리하였으며, 백분율, 평균, t-test, ANOVA를 이용하여 분석하였다. 결과 : 혈액투석 환자의 희망 정도는 평균평점 3.09, 삶의 질 정도는 평균평점 2.97로 나타났고, 대상자의 희망과 삶의 질은 유의한 순상관관계가 있는 것으로 나타났다(r=0.681, p<0.001). 대상자의 일반적 특성별 희망 정도는 연령, 결혼상태, 교육정도, 가족 월수입, 건강지각 수준에서, 삶의 질 정도는 교육정도, 가족 월수입, 건강지각 수준에서 유의한 차이가 있었다. This study was designed to identify the relationship between the hope and the quality of life of hemodialysis patients. The subjects of this study were 100 hemodialysis patients who obtained from 3 unirersity hospitas and I general hospital in Taegu. Hope was measured by the questionnaire that has been developed by Miller. Quality of life was measured by the questionnaire that has been developed by Ro, You-Ja. The data was collected during the period from Norember, 7, 1996 to January, 8, 1997. The data was analyzed by percentage, mean, t-test, ANOVA. The results were as follows. The item mean score of hope scale was 3.09. There were significant association between hope and age, marital status, education level, monthly income, perception status of health. The item mean score of qualify of life was 2.97. Of the 6 dimensions of the quality of life ; the score for family relationship was the highest(3.39), which is followed by relationship with neighbors(3.36), self-esteem(3.08), emotional.

회전수에 따른 발레 삐루엣 앙드올 동작의 분석

김은희,이건범,이기청 한국운동역학회 2001 한국운동역학회지 Vol.11 No.3

The purpose of this study was to investigate the difference between the performance and the increase of the number of turn in Ballet Pirouette en de hors. Single turn, double turn, triple turn, and maximum turn of four Ballerinas, who have more than ten-year experience in Korea Ballet Company, was filmed by two 16mm high speed cameras, and used AMTI force platform. DLT method was employed to obtain 3-D coordinates. The results were as follows: 1. The COP displacement was more larger as increases of the number of turn. 2. It is importance to maintain the COG highly as possible, at initial step for the effective multiple turn. 3. In order to perform multiple turn effectively, it would be desirable to maintain consistent position regardless of the number of turn and to which the angle of elbow at the touchdown phase. 4. If the time required of turn were reduced at the starting point and the speed were kept to final interval, the movement of multiple turn could be performed smoothly.

당 함유 식품 섭취 증가가 어린이 건강에 미치는 영향에 관한 연구

김시경,황은선,김건희 덕성여자대학교 자연과학연구소 2007 자연과학 논문집 Vol.13 No.-

우리나라는 지난 20년간 설탕소비량이 무려 20% 가까이 증가했고, 간식으로 인한 설탕 섭취량 증가는 아동의 식생활을 변화시킨 중요한 요인이 되었음에 불구하고 우리나라 아동의 설탕섭취에 대한 연구는 매우 미흡한 실정이다. 식품에 첨가되는 설탕은 열량만을 낼 뿐 그 외의 영양소는 들어 있지 않으므로 "빈(empty) 영양소"라고 불리며, 많이 섭취하게 되면 상대적으로 영양소가 풍부한 다른 식품의 섭취가 적어져 영양불균형 상태를 초래할 수도 있다. 설탕으로부터 손쉽게 얻는 과도한 열량은 체지방으로 쉽게 축척되어 1차적으로 비만을 야기할 뿐 아니라, 당뇨병, 고지혈증, 충치, 과잉활동장애와 같은 2차적 문제들에 대한 심각성이 보고되고 있다. 우리나라 당류 소비현황과 어린이 기호식품의 당함량 실태에 대한 조사 결과를 바탕으로 문제점 분석 및 향후 발전 방향을 제시하고자 한다. 현재 우리나라 가공식품의 총당(total sugars) 함량표시는 의무화되어 있지는 않으며 과다한 당 섭취를 막고 과잉의 당 섭취로 인한 비만 등의 질병을 예방하기 위해서 총당(total sugars) 함량 표시는 시급하다. 어린이 및 청소년의 건강관리, 비만예방을 위한 당 함량 및 영양성분표시의 의무화가 필요하며, 어린이 기호 식품에 대한 정보를 어린이가 이해하기 쉽게 표기하여야 한다. 나아가 어린이는 올바른 식습관을 형성하는 시기인 만큼 바람직한 정책제시와 올바른 교육을 통하여 무분별한 당 섭취로 인한 어린이의 건강의 문제발생을 예방하고자 한다.

지능기법을 이용한 가공시스템의 설계 및 모니터링에 관한 연구

金永卓,文熙根,金秀貞,金寬衡,李尙培 한국해양대학교 산업기술연구소 2003 연구논문집 Vol.20 No.-

본 논문은 지능 기법과 영상처리기법을 이용하여 특정 대상물의 절단위치를 검색하는 방법을 제시한 것으로서, 최근에는 기존의 아날로그 센서를 대신한 CCD(Charge-Couple Decive)카메라로 얻어진 화상 데이타(data)를 이용하여 물체의 정보를 추출하는 방법이 많이 응용되고 있다. 최근에 영상의 형태학, 신경망, 지식기반의 영상 해석 시스템에 대한 관심이 높아지면서, 거의 모든 분야에 화상처리기법들이 사용되어지고 있다. 따라서 본 논문에서는 실시간 그레이 레벨의 입력 화상에 대하여 영상처리기법을 이용하여 특정 물체의 특정위치검출 방법을 제안하고, 실제의 시스템에 적용한 예를 제시하려고 한다. In this paper proposed detecting specific position of the object using intelligent method and image processing. Recently instead of classifying the object by shade using existing analog sensor, app.y a theory to detect of the object information by using image data from CCD camera. It takes interest in the morphology of image, neural networks and image analysis system on knowledge base. and now days, image processing method was used in the most part of field. So, In this paper proposed detecting method on specific position of specific object about real time gray level input image using image processing method and application case in real system.