한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

심실중격결손증-치험 1예-

조광현,우종수,황윤호,이양행,박철호,김종성,김철호,이경순,조영일,박태인 인제대학교 1985 仁濟醫學 Vol.6 No.4

A successful treatment of infants and children with congenital heart defects depends upon several factors: diagnosis must be accurate, the operative technique, including techniques of perfusion and myocardial preservation, must be suited to the needs of patients and intensive cares, including accurate anesthesia, must be applied through all stages of investigation and treatment, i.e. before, during and after the operation. Recently we performed a open heart surgery successfully for a six-years old girl who had suffered from frequent upper respiratory tract infection and mild to moderate exertional dyspnea with congenital heart defects (ventricular septal defect, Kirklin type II, with patent foramen ovale). The operation and postoperative course were very smooth. And now we report this with review of literatures.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도로변 지역의 이산화질소 확산에 따른 주택 실내공기질 영향

조준,박종안,손부순,양원호 대한보건협회 2002 대한보건연구 Vol.28 No.4

Traffic represents one of the largest sources of primary air pollutants in urban areas. Several recent studies suggest an association between automobile exhaust and increase respiratory symptoms and diminished pulmonary function. In this study, we measured the nitrogen dioxide (NO_2) concentrations at different distances from the roadside, and indoor and outdoor NO_2 concentrations in 1st floor without NO_2 source and 2nd floor with NO_2 source of multi-family house were simultaneously measured. Indoor to outdoor ratio (I/O) of NO_2 concentration ratio with indoor source such as gas range was 1.56±1.01, comparing with 0.79±0.62 without indoor source. This result suggests that the contribution of traffic to indoor NO_2 concentration be about 80%. Correlation coefficients (Spearman r) between indoor and outdoor NO_2 concentrations with and without indoor source were 0.27 and 0.88, respectively. Measured NO_2 concentrations on weekly was higher than those on weekend, and wind velocity decreased the NO_2 concentrations in accordance with distances from roadside. Estimated NO_2 source strength with indoor source using mass balance model ranged from 20.58~25.89 ppm/hr, assuming air exchanger per hour of 1~1.5 hr^-1 and NO_2 decay rate of 0.94 hr^-1.

프로축구 선수들의 포지션별 유산소성 파워능력과 슬관절 등속성 근 기능의 특성

조현철,김준호,강민철,김종규 龍仁大學校 體育科學硏究所 2004 體育科學硏究論叢 Vol.14 No.1

The purpose this study was to investigate the aerobic power and isokinetic muscular function of knee joint for korea the pro-soccer players in field position. Data were obtained from thirty one pro-soccer players. They didn't have any medical problem. They performed exercise stress test and isokinetic muscular function on treadmill and Isomed 2000. The assessment of cardiorespiratory and isokinetic muscular function were VO2max, Maximal heart, ATVO2, AT heart rate, Total Work, Average Work, Maximum Torque, Maximum Work and Flex/Ext. A two-way analysis of variance with repeated measures(two-way(2x4)RM ANOVA) was used to compare group and field position differences aerobic power and isokinetic muscular function. A Tukey post hoc test was used when significant mean differences were observed. Statistical significance was accepted as p<O.05. Aerobic power do not showed any significant difference among in field position. Hamstring muscle power was significantly higher in Forward and Middle field than Defense and Goal keeper. Muscular endurance was higher Defense and Goal keeper than Forward and Middle field. Based on the facts that we have discussed, aerobic and anaerobic power in field position do not showed any difference. However, isokinetic muscular function was significant difference in field position. Ratios of conventional and functional for isokinetic Hamsting: Quadriceps muscle strength in soccer player for prediction and decision injures, it is thought that more researches on it should be required.

광주의 한 이차병원에서 조사한 결핵약제 내성과 관련인자

조준호,김강,최상철,이경록,정종필,고영춘 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

연구목적: 우리나라의 결핵약제에 대한 내성은 지속적으로 감소되고 있음에도 불구하고 여전히 적지 않은 환자를 보유하고 있는 상황에서 치료 실패의 중요한 요인이 되고 있다. 이에 결핵 내성률에 영향을 미칠 수 있는 인자들을 파악하고 이에 대한 예방 대책을 수립하는 것이 내성률 발생의 예방에 도움이 될 것으로 사료된다. 이에 저자들은 광주 소재의 한 2차 병원에서 결핵 약제 내성률 및 위험인자로 판단되는 요소들과의 상호관계를 조사하였다. 대상 및 방법: 2005년 3월 부터 2006년 2월 까지 광주 기독 병원 내과에서 치료받은 결핵 환자중 객담 결핵균 배양 검사상 양성으로 판명되어 약제 감수성 검사를 확인할 수 있었던 346명을 대상으로 의무기록, 면담 등을 통한 후향적 조사를 시행 하였다 결과: 346명중 한가지 이상의 약제에 내성을 보인 경우는 150명(43.4%)였고, 다제 내성 결핵은 72명(20.8%)였다. 조사 요인의 유무별로 약제 내성률을 조사하였을 때 흉부 사진의 침범 정도에 따른 약제 내성률 및 다제 내성률은 경증에서 36.3%와 6.2%, 중등도에서 36.1%와 22.6%, 중증에서 61.0%와 35.0%였다. 병변의 공동성 병변 유무에 따른 약제 내성률은 공동이 있는 군에서는 49.8%, 공동이 없는 군에서는 34.0%였다. 과거의 치료력 여부에 따른 약 제 내성률은 치료력이 없는 군에서는 19.7%였고, 치료력이 있는 군에서는 81.2%였다. 항 결핵제 복용의 규칙성 여부에 따른 약제 내성률은 규칙적 복용군은 31.7%, 불규칙적 복용군은 59.7%로 나타났다. 결론: 광주 소재의 한 2차 병원에서 조사한 약제 내성률 및 다제 내성률은 전국 평균치를 훨씬 상회하였다. 한편 과거 치료병력 및 약제의 불규칙 복용은 약제 내성률을 높이는 데에 기여하는 인자가 될 것으로 사료된다. 흉부방사선 사진 상의 폐 침범 정도, 공동성 병변의 존재도 약제 내성률 증가와 관련이 있는 것으로 보이나 보다 정확한 선후관계 분석을 위해서는 추가적인 전향적 연구가 필요하다. Background and objectives: Drug resistance is a major obstacle to the treatment of pulmonary tuberculosis (TB). This study was conducted to determine the prevalence of drug-resistant tuberculosis and its associated factors at a secondary hospital in Gwangju. Materials and Methods: A retrospective one-center analysis was conducted, with 346 pulmonarytuberculosis patients who underwent drug susceptibility tests for M. tuberculosis at Gwangju Christian Hospital from March 2005 to February 2006. Results: The following percentages of subjects were found to be resistant to at least one drug and to have multidrug-resistant tuberculosis (MDR-TB), respectively: 43.4% and 20.8% of all the subjects; according to the severity of the chest X-ray findings, 36.3% and 6.2% in the mild group, 36.1% and 22.6% in the moderate group, and 61.0% and 35.0% in the far- advanced group; according to the presence of a cavitary lesion, 49.8% in the cavitary-lesion group and 34.0% in the noncavitary-lesion group and according to the history of previous tuberculosis treatment, 81.2% in the group who have had treatment and 19.7% in the group who have never had treatment. The resistance rate according to the regularity of antituberculosis drug medication was 31.7% in the regular medication group and 59.7% in the irregular medication group. Conclusion: The drug resistance rate was increased by the history of previous tuberculosis treatment and the irregular medication. As to whether the severity of chest X-ray findings and the presence of cavitary lesions have a correlation with drug resistance, prospective studies are needed for more accurate results.

단일 단계 접착제의 변연 미세누출

조영곤,정진호,기영재,최희영,진철희,유상훈,김종욱,박병철 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.2

This study evaluated the marginal microleakage of five single step adhesives. Class V cavity preparations with occlusal margins in enamel and gingival margins in dentin were prepared on both buccal and lingual surfaces of extracted human molar teeth. Prepared teeth were randomly divided into five groups and restored using one of the single step adhesives and composite resins: Prompt L-Pop/Filtek Z-250 (Group 1), AQ Bond/Metafil CX (Group 2), One-Up Bond F/Palfique Toughwell (Group 3), Futurabond/Admira (Group 4), Xeno III/Spectrum TPH (Group 5). The restored teeth were thermocycled. Microleakage was assessed by dye penetration using 2% methylene blue dye solution. The teeth were bisected buccolingually and evaluated for microleakage under steromicroscope. The data were statistically analysed by Kruskal-Wallis test and Mann-Whitney tests. The results of this study were as follows; 1. Microleakage of enamel margins in group 3 was statistically higher than that in groups 1, 2, 4, 5 (p < 0.05) 2. Microleakage of dentin margins in group 1 was statistically higher than that in groups 2, 5, and that in group 3 was statistically higher than that in groups 2, 4, 5 (p < 0.05). 3. Dentin marginal microleakage was higher than enamel marginal microleakage in all experimental groups. In conclusion, Prompt L-Pop showed the least leakage at enamel margin, and AQ Bond showed at dentin margin in this study. Marginal miroleakage in dentin was higher than that in enamel.

건강한 노년여성의 보행의 삼차원적 보행분석

조유미,이종삼,송창호 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The purpose of this study is to present the basic reference data of age and specipic gait parameters for elderly healthy women. The basic gait parameters were extracted from 15 elderly healthy women, using VICON 370 Motion Analysis System. The results were as follows; 1. The mean Cadence were 114.46±11.02steps/min(Lt), 114.03±11.40steps/min(Rt) 2. The mean Walking speed were 1.05±1.13m/s(Lt), 1.06±1.13m/s(Rt). 3. The mean Stride Length were 1.10±0.08m(Lt), 1.11±0.09m(Rt). 4. The mean maximal angles of joint on the pelvic tilt were 15.51±3.56˚(Lt), 16.21±3.41˚(Rt) 5. The mean maximal angles of joint on the hip flexion motion were 38.31±4.8˚0(Lt). 37.13±4.83˚(Rt) 6. The mean maximal angles of joint on the knee flexion motion were 48.60±12.95˚(Lt), 40.45±15.31˚(Rt) 7. The mean maximal angles of joint on the ankle dorsiflexion motion were 10.31±5.07˚(Lt), 9.49±5.38˚(Rt) 8. The mean maximal angles of joint on the ankle plantar flexion motion were 14.19±4.31˚(Lt), 15.93±7.07˚(Rt)