증폭(蒸曝)에 의한 지황(地黃)의 성분 변화에 대한 고찰

정재우 ( Jae Woo Jung ),김한영 ( Han Young Kim ),류지효 ( Ji Hyo Lyu ),김정훈 ( Jung-hoon Kim ) 대한본초학회 2021 大韓本草學會誌 Vol.36 No.6

Objectives : ‘Steaming and drying’ is a traditional processing method that has been used to produce Suk-ji-hwang (熟地黃; Rehmanniae Radix Preparata) from Ji-hwang (地黃, the fresh root of Rehmannia glutinosa Liboschitz ex Steudel; Rehmanniae Radix). The steaming and drying process, which is proceeded in heating and moisturizing conditions, plays a crucial role in the change of therapeutic effect of Ji-hwang, presumably due to the modification of its chemical constituents. In this article, the chemical influence of the ‘Steaming and drying’ process was investigated for understanding the underlying mechanism of chemical modification of Ji-hwang. Methods : The articles regarding the modifications of chemical constituents of Ji-hwang during the ‘Steaming and drying’ process were collected and analyzed to investigate the influence of the processing to Ji-hwang. Results : The results indicated that iridoid glycosides were degraded to their aglycones and sugars, and such degradations occurred faster at a high pressure than at an atmospheric pressure during the process. The contents of catalpol, ajugol, and acteoside were decreased, while those of rehmannioside A and D were slightly increased during the repeated processing. The contents of oligosaccharides, namely sucrose, maltose, raffinose, and stachyose (except for manninotriose), were decreased, while those of monosaccharides, glucose and fructose, were increased by the repeated processing. Conclusions : These results demonstrate that the ‘Steaming and drying’ process influenced the chemical constituents of Ji-hwang and provide probable basis for the therapeutic modification of Suk-ji-hwang after the processing of Ji-hwang.

가감청영탕(加減淸營湯)에 효과를 보인 열성 아토피 피부염 환자 6례 증례 보고

서지혜,정창환,박선정,임소영,한수련,Seo, Ji-Hye,Jung, Chang?Hwan,Park, Seon-Jeong,Lim, So-Young,Han, Su-Ryun 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective : The purpose of this study is to investigate the effect of Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) for atopic dermatitis patients diagnosed as the febrile tendency. Method : This case study was done on 6 atopic patients with febrile tendency who have visited Korean Medicine Clinic from 2013.08.01. to 2014.04.30.. Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) was prescribed to all 6 patients and evaluated the symptom change through photographs and questionnaire. Objective SCORAD Index(OSI) was used to evaluate the objective symptom and VAS was used to evaluate the subjective change. Results & Conclusion : The Objective SCORAD index and VAS were decreased in all patients. The average OSI reduction score was 26.3. Most symptoms of 6 patients were improved. Gagamchengyoung-tang ($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) can be effective in patients who were diagnosed as febrile tendency.

토양환경지도 자료를 이용한 콩밭 토양의 화학성 비교

박지숙,이민진,정재원,김미혜,이서연,지윤미,한준호,김유학,공명석,한광현,노희명 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

It is important to interpret the soil chemical properties in order to effectively manage the farmland. This study was conducted to investigate the soil chemical properties of upland soybean field according to the soil series at 32 upland fields located in the parts of Gangwon-do. Soil sampling sites were selected by using the National Statistics DB and KSIS DB that is a soil environment information system provided by the Rural Development Administration. Soil samples were collected from 0~15 cm of top soil before seeding or transplanting, air-dried, passed through a 2 mm sieve, and analyzed for soil pH, EC, organic matter, available phosphorus (P2O5), exchangeable potassium, exchangeable calcium and exchangeable magnesium. The average chemical properties have exceeded the each nutrient optimum range level of RDA, except the organic matter in experimental soil 2015. And despite application of conventional fertilization, each soil series nutrient contents were change respectively. The results of this study suggest that conventional fertilization should be applied based on the analysis about the amount of accumulated nutrient contents in the soil.

정신분열병 환자의 인지과제수행에서 삼차원적 시공간-운동 방해자극 처리의 특성

정혜정,김재진,박성혁,전종희,김지혜,염태호,이장한,김선일,구정훈,조원근,안석균,이홍식 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : Abnormalities of cognitive responses to verbal and visual distracter in schizophrenia have been demonstrated in numerous studies but little is known about three dimensional visuospatial-motor distracter processing. The purpose of this study was to investigate the vulnerability of patients with schizophrenia to three dimensional visuospatial-motor distracter. Methods : 14 patients with schizophrenia and 14 normal volunteers were assessed on three dimensional maze tasks requiring on working memory and reasoning ability in the virtual reality environment. Performances were compared according to with- or without-distracter conditions. Results : Patients with schizophrenia showed significantly lower performances than normal control group on cognitive flexibility, simple motor function or motor control and motor coordination, working memory span and delayed performance times. The performance index tended to be more deteriorated, but not significantly, in with-distracter condition than in Without-distracter condition in schizophrenia. Conclusions : Patients with schizophrenia tend to be vulnerable to visuospatial-motor distracter which simulate the real world of three dimensional environment.

전자제품 조립업체 근로자에게 직무 요구, 직무 조직, 경력 개발, 역할 압력, 경제력 압력등의 직무 스트레스가 업무관련 상지 근골격계 질환에 미치는 영향

한상환,조수현,김지영,성낙정 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.3

목적: 직무스트레스를 직무 요구, 직무 조직, 경력개발, 역할 압력, 경제적 압력 등 요인별로 구분한 후 업무관련 상지 근골격제 질환과의연관성이 높은 직무 스트레스 요인을 도출하기 위한 목적으로 본 연구를 시도하였다. 방법: 이동전화기 부품 조립 업체 여성 근로자 112명, 전수, 냉장고 조립 업체 3개 부서 남성 근로자 237명 전수, 그리고 사무직 근로자 87명 전수 등 총 436명을 대상으로 업무관련 상지 근골격계 증상과 직무 스트레스에 관한 설문 조사를 실시하였다, 물리적 작업 요인은 작업 과정을 인간공학적 평가서로 평가하였다. 근골격계 증상과 직무 스트레스 평가서에 제대로 응답하지 않은 53명을 제외한 총 382명을 최종 분석대상으로 하여, 직무스트레스 요인에 대한 요인분석을 실시하고 적합성이 높은 요인별로 직무스트레스 요인을 구분한 후 로짓 희귀 분석으로 상지 근골격계 질환과의 연관성을 분석하였다. 결과: 각 연구 대상군에서 목과 어깨 부위의 증상 호소율이 가장 높았으며, 손목과 손가락 부위, 팔꿈치 부위 순이었다. 목과 어깨 부위와 손목과 손가락 ㅂ위에서 부적절한 작업 자세와 힘 요인의 연관성이 관찰되었으며, 직무의 단순성, 직무 구분의 모호성, 직무의 자율성 부재, 경제적 압력, 승진 장애, 퇴직 압력 등의 직무 스트레스 요인이 유의한 것으로 나타났다. 여서 조립 작업자에서 증상 호소율이 더 높았으며, 근골격계 질환과 직무 스트레스의 연관성의 강도는 남성 조립 작업자보다 여성 조립작업자와 사무직 근로자에서 더 높은 것으로 나타났다. 결론: 본 연구 결과 물리적 작업 요인에 의한 영향을 보정한 후에도 사무직 근오자와 생산직 근로자 모두에서 직무 스트레스가 업무관련 상지 근골격계 질환에 영향을 미치는 것으로 해석할 수 있었으며, 특히 경제적 요인과 경력 개발 요인 들의 중요성이 부각되었다. 따라서 향후 직무 스트레스와 업무관련 상지 근골격계 질환에 대한 다양한 직종에서의 경험적 연구결과가 축적외어 우리 나라의 조직문화적 특성을 고려한 직무 스트레스 위험 요인 파악이 필요하다고 하겠다. Objects: To evaluate the association od upper extremity musculoskeletal disorders with job demand-control and effort-reward related job stress. Methods: Questionnaires concerning symptoms, psychosocial factors and work conditions were completed by 436 workers from a refrigerator assembly line, mobile phone assembly line, and an office, musculoskeletal conditions of the upper extremities were defined by the frequency, duration, and intensity of symptoms. A walk-through survey was performed to evaluate various physical work factors. Data were analyzed with the use of logistic regression. Results: A total of 32 workers completed the survey, for whom neck and shoulder symptoms were the most frequently reported, followed by finger and wrist, and then elbow symptoms. Both awkward working posture and forceful exertion were associated with an imcrease in shoulder/neck and finger/wrist symptoms. In addition, job stress factors such as monotony, low job clarity, low job control, low promotion prospect, economic issues, and retirement pressures were associated with increased neck/shoulder, elbow, and finger/wrist conditions. Women were more likely to report symptoms, and the association between musculoskeletal conditions and job stress factors was stronger in female assembly line workers and office workers than in male assembly line workers. Conclusions: The results suggest that musculoskeletal conditions of the upper extremities are associated with not only physical work factors but also job stress factors. In particular, economin issues and career development factors are important influences on workers in Korea.

大學生들의 Sport 選好度에 관한 硏究

鄭漢鍾,蔣址奎 진주산업대학교 1992 論文集 Vol.31 No.-

Questionnaires were sent to 1,096 College students and Collected them. The data was analyzed with percentage according to the each question of the questionaire used for this study. The result of the study wrer as follows. l. In general the students are interested in sports and physical activities but sports facilities of Colleges. Couldn't meet the their meeds. 2. The most favorite sports among students are normally base ball. soccer, Volley ball, and basket ball. They are also interested in lift time sports activities such as tennis base ball, swimming and badminton. 3. The student want not only back ground principles on sports and physical activities but also sex education. specially. They want to build the Gymnasium for society. 4. The students want to need in lift time sports for base ball and swimming. 5. The girl students want to choose the swimming for life time sports. 6. They don't want to provide golf course. becouse the country land limited the place of the plain.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

고교권투선수의 체격체력 및 성격특성에 관한 연구

鄭漢鍾,蔣址圭,丁小鳳 진주산업대학교 1985 論文集 Vol.23 No.-

The basic purspose of this study was to measure of physique, physical strength and peronality of high school boxer. Above three type tests were given to the outstanding boxer of 50(10 of fly weight, 10 of bantam weight, 10 of feather weight, 10 light weight, 10 of welter weight) who participated in reinforced training camp prepared for the national game in 1984. Physique tests were standing height, body weight, chest circumference sitting height, uperlimb length and hip circumference. Physical strength tests were grip strength, situps, 3㎞ runing, standing board jump, 100m sprint, shuttle run, Burpee test, Trunk flexion and Trunk extention. Personality tests were general activity, Dominance Emotional stability, Impulsiveness, Masculinity, Objectivity, Reflectiveness and Sociality. The result of this study pointed out the followings; 1. Physuque measure: The fly weight of right boxer's standing height 2㎝ of average thean left boxer. feather weight of left boxer is standing height 2㎝ of average than right Boxer. Bantam, light weight of left boxer's chest circumference 5㎝ of average than right boxer. 2. Physical strength measure; The fly weight of right boxer's Trunk flexion 3㎝ of average than left boxer. welter weight of right boxer's Trunk extention 1.4cm of average than left boxer.

전립선 기질세포의 증식과 COX-2 발현에 대한 프로게스테론의 영향

정수련,김성한,최이화,박지은,전은미,강영진,이광윤,최형철 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

전립선비대증은 노인 남성에서 흔히 유발되는 질환이며, 노화가 진행될 수록 빈도가 높아지는 특징을 가진다. 이 질환의 원인은 전립선기질세표의 과도한 증식으로 유발된다고 알려져 있지만 그 자세한 기전에 대해서는 잘 알려져 있지 않다. 전립선비대증에서 progesterone 수용체 양성 세포가 다른 전립선 종양에 비해서 많고, progesterone은 testosterone에서 DHT로 전환되는 것을 감소시키는 역할을 가진다고 알려졋다. 또한 남성 전립선 평활근의 과증식에 의한 질환이므로 평활근 세포의 증식과 관련성이 있다고 보고된 COX-2의 전립선비대증에 대한 영향에 대한 연구가 필요하다. 전립선 기질세포에 progesterone을 3일간 투여하여 배양한 경우 기질세포 증식은 차이가 없었다. Progesterone을 단독 또는 DHT와 같이 투여한 기질세포에서 남성호르몬 수용체 mRNA 발현은 비처리군과 비교하여 유의한 차이가 없었다. 또한 progesterone과 DHT 동시 투여에 의한 COX-2 mRNA 발현에도 차이가 없었다. 그러나 progesterone에 의한 남성 호르몬 수용체와 COX-2 단백 발현에서는 대조군과 비교하여 유의하게 감소시켰다. 이상의 결과는 progesterone은 남성호르몬 수용체에 대해 전사 후 반응 (post-transcriptional response)에 효과를 나타내어 남성호르몬 수용체 발현을 감소시키는 작용은 가지며, COX-2 발현 억제효과를 나타내므로 전립선비대증의 치료에 이용될 수 있을 것으로 사료된다. Background: Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by 5α-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. Materials and Methods: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. Results: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. Conclusion: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.

성장기 아동의 single tooth scissors bite의 교정 치료: 증례 보고

김지인,현홍근,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

A scissors bite in the posterior teeth occurs when the upper teeth are positioned totally buccal to the lower teeth in centric occlusion, either unilaterally or bilaterally. This malocclusion can result from either excessive width of the maxilla or deficient width of the mandible, or sometimes combination of the both. Scissors bite, when left untreated without a proper dental intervention, interferes with the normal mandibular growth leading to a state where consequent disharmony in dental arch width evokes occlusal disturbances. Therefore, early preventive orthodontic treatment is necessary in patients with scissors bite. Scissors bite rarely involves anterior and posterior sites concuttently across the dental arch but usually affect single tooth. Even in the single tooth scissors bite cases, more likely to be met in the clinical fields, immediate dental intervention is indicated because continuous occlusal forces that exacerbate the already adverse axis of the posterior teeth. In this case study, patients with single tooth scissors bite, each 7, 14, 12, and 16 years old, were each treated with criss-cross elastic, fixed appliance, removable appliance, and miniscrews. With the proper selection of appliances appropriate to each specific cases, good treatment outcome can be achieved without resulting any side effects. 중심교합위의 상태에서 편측 혹은 양측으로 상악 구치부의 치아가 하악 구치부의 협측으로 위치한 경우를 scissors bite라 고 한다. 이는 상악의 폭경이 크거나 하악의 폭경이 좁은 경우 발생한다. Scissors bite의 경우 방치하게 되면 하악의 성장이 방해받게 되고 그 결과, 악궁 폭경의 부조화가 심해져 저작 장애를 일으킬 수 있으므로 조기 차단 교정이 반드시 필요하다. 실제 임상에서는 여러 치아의 scissors bite보다 최후방 구치 혹은 그 외 하나의 구치만의 single tooth scissors bite(STSB)을 보이는 경우가 많다. 이러한 STSB의 경우도 방치하게 되면 저작력으로 인하여 구치의 각도가 더욱 악화되므로 즉각적인 치료가 필요하다. 본 증례에서는 STSB를 보이는 7세, 14세, 12세, 16세의 환자에게 각각 criss-cross elastic, 고정성 장치, 가철성 장치, miniscrew를 사용하여 치료한 증례를 보고하였다. 각 환자의 증례에 적합한 장치를 잘 선택하여 사용한다면 치아를 정출시키는 등의 부작용을 야기하지 않고 양호한 결과를 얻을 수 있을 것이다