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액시드 캅셀(니자티딘 150 mg)에 대한 넥스 캅셀의 생물학적 동등성
김지만,이상봉,전성실,신영희 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
The purpose of the present study was to evaluate the bioequivalence of two nizatidine capsules, Axid (Lilly Korea Pharm. Co., Ltd.) and Nex (Bi-nex Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The nizatidine release from the two nizatidine capsules in vitro was tested using KP Apparatus method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). The dissolution profiles of two nizatidine capsules were very similar at all dissolution media. Twenty four normal male volunters were divided into two groups with a randomized 22 cross-over study. After two capsules (300 ㎎ nizatidine) were orally administrated, blood as taken and the concentrations of nizatidine in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as AUC_(t), C_(max) T_(max) were determined. The result showed that the differences in AUC_(t), C_(max) and T_(max) between two nizatidine capsules absed on the Axid were-6.16%, -8.26% and -1.82%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.91) ∼log(0.97) and log(0.85)∼log(0.99) for AUC_(t) and C_(max), respectively), indicating that Nex capsule is bioequivalent to Axid capsule.
Nam, Hae-Seong,Jeon, Kyeongman,Um, Sang-Won,Suh, Gee Young,Chung, Man Pyo,Kim, Hojoong,Kwon, O. Jung,Koh, Won-Jung Elsevier 2010 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES Vol.14 No.6
<P><B>Abstract</B></P><P><B>Objectives</B></P><P>Chronic necrotizing pulmonary aspergillosis (CNPA) is uncommon, and the optimal therapeutic regimen has not been established. In a retrospective cohort study, we investigated the clinical characteristics and treatment outcomes of patients with CNPA.</P><P><B>Methods</B></P><P>We reviewed the medical records of all patients who had been diagnosed with CNPA at our institution over the last 10 years.</P><P><B>Results</B></P><P>Forty-three patients were identified. Their median age was 60 years (interquartile range (IQR) 45–65 years), and 34 (79%) of the patients were men. The most common underlying lung disease was pulmonary tuberculosis (<I>n</I>=40, 93%). After CNPA was diagnosed, all patients were treated with antifungal drugs, including oral itraconazole (<I>n</I>=39, 91%) or intravenous amphotericin B (<I>n</I>=4, 9%). Seventeen (40%) patients discontinued therapy early (<3 months), 14 patients due to death and three to loss of follow-up. Twenty-six (60%) patients received oral itraconazole at a daily dose of 200–400mg for more than 3 months. The median treatment duration was 6 months (IQR 6–12 months). In these 26 patients, clinical improvement was observed in 15 (58%) and radiological improvement was observed in 11 (42%). Ten (38%) patients showed no improvement. Twenty-two (51%) patients died, including 18 (42%) CNPA-related deaths, during a median follow-up of 15 months (IQR 2.5–32 months). The median survival time was 62 months.</P><P><B>Conclusions</B></P><P>CNPA is difficult to treat and often has a poor outcome. Further studies with more patients are needed to identify the optimal therapy for patients with CNPA.</P>
한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사
조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3
Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.
Polymerizations of Propylene with Unsymmetrical ($\alpha$-Diimine)nickel(II) Catalysts
Jeon Man-Seong,Han Chul-Jong,Kim Sang-Youl The Polymer Society of Korea 2006 Macromolecular Research Vol.14 No.3
New unsymmetrical ($\alpha$-Diimine)nickel(II) catalysts having different pendent groups at the ortho positions on aromatic rings were synthesized and subjected to propylene polymerizations with MAO (methylaluminoxane). Structural analyses of the resulting polypropylenes by $^1H\;and\;^{13}C\;NMR$ showed that the ortho substituents on aromatic rings of ($\alpha$-diimine)nickel(II) catalyst affected significantly the polypropylene microstructure. While $C_s$ symmetric catalyst afforded a syndiotactic polypropylene (rr triad content=66%) due to the syndiospecific chain end control, $C_1$ symmetric catalysts produced much less stereoregular polypropylenes (rr triads content <50%), presumably because of collision of the isospecific site control with the syndiospecific chain end control.
일학습병행 교육훈련과정 이수자와 중단자간의 특성에 대한 차이 분석
전성준(Jeon Seong-Jun),전승환(Jeon Seung-Hwan),조한진(Jo Han-Jin),하지만(Ha Ji-Man) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.11
본 연구의 목적은 일학습병행 교육훈련과정 이수자와 중단자간의 차이의 특성을 비교하여 일학습병행 학습근로자의 참여를 활성화시키기 위한 정책 대안을 제시하는 것이다. 자료 수집은 온라인 설문조사를 통해 일학습병행 교육훈련과정을 이수하거나 중단한 자 912명을 대상으로 이루어졌다. 자료 분석은 SPSS 22.0을 사용하였으며, 빈도분석, 교차분석, t-test로 확인하였다. 본 연구의 결과는 다음과 같다. 첫째, 개인 특성에 속하는 성별, 학력, 진로포부, 경력몰입 정도에서, 가정 배경 특성에 속하는 가족의 지원 정도에 따라 이수여부의 차이가 통계적으로 유의미하게 나타났다. 둘째, 사전경험특성에 속하는 참여 동기, 사업에 대한 이해도, 직무내용 및 전공과 교육훈련과정의 일치도에 따른 이수여부의 차이가 통계적으로 유의미하게 나타났다. 셋째, 학습 경험에 속하는 교육훈련과정 적응도, 사회적 시각, 직무 만족도, 조직 몰입도, 교육훈련 만족도에 따른 이수여부의 차이가 통계적으로 유의미하게 나타났다. 넷째, 기업특성에 속하는 기업 규모, 기업현장교사의 역량, 기업의 사회적 명성 등에 따른 이수여부의 차이가 통계적으로 유의미하게 나타났다. 다섯째, 사업특성에 속하는 급여 정도에 따른 이수여부의 차이가 통계적으로 유의미하게 나타났다 본 연구의 결과를 바탕으로 이수자와 중단가간의 특성 차이에 대한 해석과 학습근로자가 훈련과정을 지속할 수 있는 정책적 방안과 더불어 후속으로 필요한 연구에 대해 제시하였다. This study aims to propose a policy alternatives for activating the participation of work-study dual system course by comparing the characteristic of the differences between those who have completed work-study dual system and those who are discontinued. The data collection was conducted on 912 persons who completed or discontinued the work-study course through an online survey. Besides, statistical technique, it was used to consult with experts in VET field. In summary, the result of the study, according to personal specialty, home background, prior experience, learning experience, characteristic of a company and work-study dual system, there were significant differences between them. Based on the resulted, the policy alternatives offered by this study. It is hoped that this study will activate people who will participate in the course or is participating at present.
통상성 간질성 폐렴과 비특이성 간질성 폐렴의 치료에 있어 Cyclophosphamide의 역할
전경만 ( Jeon Gyeong Man ),정만표 ( Jeong Man Pyo ),신성철 ( Sin Seong Cheol ),유창민 ( Yu Chang Min ),고원중 ( Go Won Jung ),서지영 ( Seo Ji Yeong ),김호중 ( Kim Ho Jung ),권오정 ( Kwon O Jeong ),김태성 ( Kim Tae Seong ),이경수 ( 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.55 No.2
Man Yeong Ha,Chung Hwan Jeon,Doo Seong Choi,Hae-Jin Choi 대한기계학회 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.10
We investigate the triboelectrostatic separation of polyvinylchloride (PVC) from mixed plastics in the laborartory scale triboelectrostatic separation system. The flow and electric fields in the precipitator are obtained from the numerical solution of finite volume method. Using these flow and electric fields. we solved the particle motion equation considering the inertia. drag. gravity and electrostatic forces acted on the particles. The particle trajectories arc obtained using a Lagrangian method as a function of different important variables such as Reynolds number, Stokes number, electrostatic force, electric charge and electric field distribution. inclined angle of plane electrodes. particle rebounding. particle charge decay rate after impact on the electrode surface. etc., in order to determine the optimal design conditions. The present predicted results for the cumulative yield represent well the experimental ones.