조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

원전 저압케이블 열화도 평가를 위한 초음파 음속계측에 관한 연구

김경조,강석철,구철수,김진호,박재석,주금종,박치승 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

원자력발전소에는 여러 종류의 케이블이 전력공급, 감시 및 제어신호의 전달을 위해 열악한 환경하에서 이용되고 있다. 발전소의 안전한 운전을 위해서 이 케이블이 어느 정도 열화 되었는지 확인할 필요가 있다. 특히, 원자력발전소의 수명 연장과 더불어 저압 케이블을 장기간 사용함에 따라서 저압케이블의 열화를 평가하기 위한 방법이 필요하게 되었다. 저압케이블의 열화를 측정하는 파라미터로는 주변 온도, 절연재질의 경도, 파단시 연신률(EAB, Elongation At Breaking Point)등이 있다. 그러나, 온도나 경도를 계측하는 검사는 정량적인 판단기준의 설정이 곤란하고 진단의 정밀도가 낮으며, 부분적으로 샘플링하는 방법은 샘플링되는 케이블에 연결된 부하를 정전시켜야 하고 장소와 시간적인 제약이 있으며, 전기적 측정법은 노화 초기부터 중기까지의 열화정도를 확인하기 어렵다. 본 연구에서는 재료의 열화에 따라서 초음파의 음속이 변화한다는 이론적인 배경 [1,2]를 바탕으로 저압 케이블 재료의 열화에 따른 초음파의 음속을 측정하였다. 이를 위해, 원자력발전소에서 사용되는 저압케이블을 가속 열화시켰으며, 저압케이블의 피복재에서 초음파의 음속을 측정할 수 있는 장비를 개발하여, 초음파의 음속측정 후 인장시험을 통해 파단시 연신률을 측정하였다. 파단시 연신률이 증가함에 따라서 음속이 선형적으로 감소 하였으며, 초음파의 음속은 열화의 정량적 평가 파라미터로서의 사용 가능성을 확인할 수 있었다. Several kinds of low voltage cables have been used in nuclear power plants for the supply of electric power, supervision, and the propagation of control signals. These low voltage cables must be inspected for safe and stable operation of nuclear power plants. In particular, the degradation diagnosis to estimate the integrity of low voltage cables have recently been emphasized according to the long use of nuclear power plants. In order to evaluate their degradation, the surrounding temperature or hardness is not useful because of the absence of quantitative criteria; the inspection of a sample requires turning off of the power plant power; and, the electrical inspection method is not sufficiently sensitive from the initial through the middle stage of degradation. In this research, based on the theory that the ultrasonic velocity changes with relation to the degradation of the material, we measured the ultrasonic velocity as low voltage cables were degraded. To this end, an ultrasonic degradation diagnosis device was developed and used to measure the ultrasonic velocity with the clothing on the cable, and it was confirmed that the ultrasonic velocity changes according to the degradation of low voltage cables. The low voltage cables used in nuclear power plants were degraded at an accelerated rate, and EAB was measure in a tensile test conducted after the measurement of ultrasonic velocity. With the increasing degradation degree, the ultrasonic velocity decreased, whose potential as a useful parameter for the quantitative degradation evaluation was thus confirmed.

CBCT 영상에서 무치악부 임프란트 매식체 주위골 골밀도(HU)의 정량적 평가

구종국,김진수,김재덕 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.1

Purpose : The primary aims of this retrospective study were to compare subjective bone quality and bone quality based on the Hounsfield scale in different segments of the edentulous jaw, and to establish quantitative and objective assessment of the bone quality. Materials and Methods : Twenty eight randomly selected cone-beam computed tomographic (CBCT) scans were analyzed. For evaluation one hundred and twelve edentulous areas were selected. Implant recipient sites were evaluated visually for Lekholm and Zarb classification. The same sites were subsequently evaluated digitally using the Hounsfield scale with Vimplant2.0, and the results were correlated with visual classification. Data was subject for statistical analysis in order to determine correlation between recorded HU and the regions of the mouth with the Kruskal-Wallis test. Results : The highest unit/mean density value (311 HU) was found in the anterior mandible, followed by 259 HU for the posterior mandible, 216 HU for the anterior maxilla, and 127 HU for the posterior maxilla. These results demonstrate a strong correlation for HU depending on the region of the mouth (p<0.001). The relationship between HU and type 4 bone was found to be significant (r=0.74). Conclusion : Knowledge of the Hounsfield value as a quantitative measurement of bone density can be helpful as a diagnostic tool by using CBMercuRay with Vimplant software.

Nortriptyline 제제의 생물학적 동등성에 관한 연구

신재국,차인준,장인진,정원석,김용식,박찬웅,신상구 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.1

산업대학 건축공학과 교육과정 개발에 관한 연구

김진원,한인웅,이승준,박재호,조방현,정구용,한기원 三陟大學校 1999 論文集 Vol.32 No.2

Education of technology should renew itself according to the demand of the change of times. Especially college of industrial technology is encouraged to develop diverse educational methods and continual educational process for the purpose of offering life-time educational opportunities, bringing up professional technicians, and re-educating the work-forces in the industry sector. Therefore, to make the education of architectural engineering substantial, the department of architectural engineering is working to develop a practical educational process by taking the following several things into consideration: job analysis of industrial society, development of educational process in the line of special necessities of college of industrial technology, actualization of subject course, industrial-academic cooperation secure of training equipment, readjustment of educational period.

産業大學 建築設計學科 敎育課程開發에 關한 硏究

金鎭源,鄭求用,林應贊,林相奎,李在允 三陟大學校 1995 論文集 Vol.28 No.1

To serve the objectives of Architectural Design Course, that is, to develop professional worker our country and society keenly need, this study was carried out as a program to ensure the special domain of vocational educational institution. To carry out such and education, a practical curriculum should be developed and according to it education should be effectively accomplished so that students could find it easy to seek for work on leaving school, and that they could make progress their field.

十二經脈의 經脈名에 관한 考察

구성태,조명수,황재호,변기원,김경식,손인철 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

In the present study, we aimed. to consider the name of twelve main Meridian in order to understand the concept of the Meridian system and to applicate acupuncture theory in the clinical field properly and fundamentally. We referred to several literatures on the matter and we found out that the name of present twelve Meridian was not settled until the period of Yellow Emperor's Classic. In the time of Yellow Emperor's Classic, the two theory of Internal Organ and Meridian system were combined and added new theory of 'WoonGi'. The general rule of combination is that the component of name of Meridian consist of 'Hand' or 'Foot', 'three Eum and Yang' and internal organ. The internal organ coupled with the root ki or middle ki of 'three Eum and Yang' and the 'Hand' or 'Foot' depend on the location of internal organ that belongs to meridian. The name of Twelve Meridian is a kind of system formed to analyze the two concepts organically and dynamically. One is material internal organ and the other is immaterial meridian system.

황화수소 중독증 2례

김종구,이경종,이세휘,박재범 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

평택시에 위치한 펄프 회사에서 탱크 내부를 청소하고자 근로자가 탱크 속으로 들어가는 도중 의식을 잃었다. 펄프제지 과정에서 유기물질의 발효로 인하여 유해한 가스가 발생한다. 발생할 수 있는 가스의 종류에는 이산화탄소(CO₂), 일산화탄소(CO), 암모니아(NH₃), 황화수소(H₂S) 그리고 메틸 머캅탄(methyl mercaptans, CH₃SH) 등이 있다. 작업환경 측정전 이러한 가스들이 존재할 것으로 추정하였으나 실제적으로 황화수소와 일산화탄소만 검출되었을 뿐 암모니아와 메틸 머캅탄은 측정되지 않았다. 그런데 상기 환자들에 있어서 HbCO이 정상 범주이므로 일산화탄소의 중독은 배제할 수 있었다. 따라서 황화수소 중독에 의한 의식소실임을 알 수 있었다. Hydrogen sulfide poisoning is frequently encountered in the workplace. Two workers lost their consciousness In an underground tank at a factory producing paper. The tank contained liquid mixture of used paper, sodium oxygenate chloride (NaOCl), and sodium thiosulfate pentahydrate(Na₂S₂O₃.□H₂O). A worker(worker A; 36-year-old man) entered tank to remove sludge. When worker A lost his consciousness, worker B entered the tank to rescue worker A, however he lost consciousness inside the tank. We discuss in detail the clinical features of this condition. Hydrogen sulfide poisonings have occurred in industries involving petroleum refining, the manufacture of heavy water, tanning of hides, vulcanization of rubber, and the manufacture of rayon. And it is necessary to stress the health education for workers and managers in these industries.

Mn₃O₄의 합성과 CO₂흡착에 관한 연구

김승호,박영구,고재철 三陟大學校 2000 論文集 Vol.33 No.2

In this study, we synthesized Mn₃O₄ by the different equivalent ratio, investigated XRD, SEM, TG-DTA, BET, and the amount of adsorption of carbon dioxide. As the results, we surveyed that XRD main peak was Mn₃O₄, some peak was MnO₂ and Mn??O??, SEM was globular-shape of the majority, some neele-shape, TG-DTA had weight-loss from 100℃ to 400℃ and endothermic reaction over 400℃, BET was 14.16∼29.63㎡/g and the amount of chemisorption of carbon dioxide was 2.885∼19.628cc/g. Optimal equivalent ratio was 1.00 to the physi-chemisorption of carbon dioxide.