국내 혈액질환 환자에서 침습성 아스페르길루스증의 구제치료로서 Voriconazole의 효과와 안전성

권재철,김시현,최수미,최재기,이동건,박선희,최정현,유진홍,신완식 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Invasive aspergillosis (IA) is associated with significant morbidity and mortality in patients with hematologic malignancies. We investigated the efficacy and safety of voriconazole (VCZ) when used as salvage therapy for IA in Korean adults with hematologic malignancies who had not responded to prior antifungal therapy. Materials and Methods: We retrospectively reviewed data, collected from January 2007 to October 2008, from patients with proven or probable cases of IA. All were probable IA cases, except for one proven case. All cases were refractory or intolerant to antifungal therapy prior to administration of VCZ. Efficacy and safety were assessed in patients treated with VCZ for more than 3 days and for more than one dose, respectively. A favorable response [complete (CR) or partial (PR)] was defined by significant improvement of all clinical symptoms, signs, and radiologic abnormalities. Results: Fifty patients who met the inclusion criteria were enrolled. There were 27 male and 23 female patients with mean age of 44.4 years (range, 15-65 years). Underlying diseases were acute leukemia (35 cases), chronic myelogenous leukemia (4 cases), myelodysplastic syndrome (3 cases), lymphoma (3 cases) and other hematologic diseases (5 cases). Twenty-two patients had received chemotherapy and 13 patients had undergone hematopoietic stem cell transplantation. The lung was the main infection site (94%) followed by the sinus (6%). Amphotericin B deoxycholate alone was the most frequent previous antifungal therapy. The mean duration of antifungal therapy prior to VCZ therapy was 13.9±8.8 days (2-44 days). The median duration of VCZ therapy was 19 days (interquartile range, 49 days). Sixteen patients (32.0%) showed favorable responses (CR:PR=8:8) at the end of VCZ therapy. The numbers of patients with stable disease, progression and death were, 6 (12%), 6 (12%) and 22 (44%) respectively. Most of those with unfavorable responses had relapsed underlying malignancies or refractory graft versus host diseases. Twelve patients developed drug-related adverse events but only one patient stopped VCZ treatment prematurely. Conclusions: VCZ demonstrated an acceptable level of toxicity in patients with hematologic malignancies but further studies are required to prove its efficacy as salvage therapy.

농촌지역 노인들의 우울증상에 관련된 요인들의 특성

송미숙,전기홍,송현종,김정은,박승구,신상건,이동훈,정성현,최연주,최완철,최민규,황재철,홍지만 아주대학교 1997 아주의학 Vol.2 No.2

This study was performed to identify risk factors for depression among the elderly in a rural area. A survey was done for the elderly living in Gosam-myenn, Ansung-kun during the period of July 28, 1997 and July 30, 1997. Demographic and sodoeconornic characteristics, and functional and health Status were assessed using a structured questionnaire, and the level of depression was measured by GDS score. The data obtained were analyzed by frequencies, percentage, t-test, ANOVA, and multiple regression, and the results were as follows: 1. The total sample consisted of 133 elderly. Of them, 47 elderly (35.4%) showed significant depressive Symptoms. 2. The GDS score was the highest for the group over 85 years of age (p < 0.05). Those living alone or widowed showed lower GDS score than those living with someone or married (p < 0.05). 3. The GDS score was the highest in the absolutely dependent group, followed by the partially dependent group, and the independent group (p < 0.01). The elderly who perceived their health Status as excellent showed the lowest GDS score. In contrast, those who had more than five chronic diseases showed the highest GDS score. 4. The elderly receiving financial and emotional support from their family or friends showed lower GDS score compared to those without any support. 5. The economically dependent group showed higher GDS score than that of independent group. 6. The elderly who involved in leisure activities showed lower GDS score than those without any involvement. 7. In terms of risk factors for depression, we found that perceived health Status, subjective economic Status, leisure activities, living arrangement and financial support were inversely associated with GDS score, whereas labor support was positively associated with GDS score. Based upon the above findings, this study suggests that these risk factors for depression in the elderly should be taken into consideration for a comprehensive mental health program for the elderly living in the rural area.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

숫자 음성 인식을 위한 효율적인 LPNN

최재호,홍광석 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.1

In this paper, we proposed an algorithm that improve the ability of Linked Predictive Neural Network, which considered both the non-linear time alignment of speech signals and the time varying property of adjacent frame. The proposed algorithm presented a new constrainted path in LPNN by using pre-processed segment informations of phoneme. As the result, the prediction error of MLP predictor was reduced in phoneme transition boundary and the recognition rate was increased. Moreover, for the test, the recognition system used combined model of phoneme and diphone in consideration of the effect of phoneme segmentation. This experiment have been carried out by using seven male speakers pronounced Korean digit every 10 times. As a result of this experiment, the recognition performance improved by 0.33% and 14.25% for speaker-dependent and speaker-independent respectively. In case of used the combined model of phoneme and diphone, we achieved better performance by increasing 1% and 8% respectively.

경두개도플러초음파술을 이용한 중뇌동맥협착의 추적조사 : 예비연구

이재홍,최충곤 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

체외 충격파 쇄석기에 의해 발생된 음향 흐름 현상 연구

최민주,이승환,홍경진,김호찬,박재우,이헌주 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

Acoustic streaming produced by an extracorporeal shock wave lithotripter was visualized for the first time in the present study. It was observed that the streaming velocity increased with the shock wave amplitude and was reaching up to 3 cm/s at the highest output setting of the lithotripter.

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

다중 공유 링크들을 위한 세션 할당 알고리즘

최경희,심재홍 朝鮮大學校 電子情報通信硏究所 2003 電子情報通信硏究所論文誌 Vol.6 No.2

본 논문에서는 다중 공유 링크를 가진 스위치를 위한 다중 링크 스케줄링 모델을 정의하고 세션 연결 설정 시 이를 어떤 링크에 할당할 것인지를 결정하는 경험적 세션할당 알고리즘을 제안한다. 제안 알고리즘은 서비스 클래스들에게 사전에 예약된 대역폭을 제공하고, 동일한 서비스 클래스에 속한 세션들에게는 서로 다른 공유 링크를 통해 전송되어도 가능한 비슷한 지연을 제공하고자 한다. 이를 위해 제안 알고리즘은 새로운 세션이 소속된 서비스 클래스의 각 링크에 할당된 세션들의 예측된 지연들 중 가장 작은 예측 지연을 가진 링크에게 새로운 세션을 할당한다. 다른 세션할당 알고리즘에 비해 제안 알고리즘은 부클래스들의 예측지연 특성을 직접적으로 활용함으로써, 동일한 클래스에 속한 세션들에게 서로 다른 공유 링크를 통해 전송되어도 가능한 비슷한 서비스 지연을 제공한다는 것을 모의실험을 통해 확인했다. 또한 동일한 클래스의 세션들을 어느 한 링크에 상대적으로 과도하게 또는 적게 할당하는 것을 방지하여 총 대역폭을 보다 공정하게 할당하고, 총 부하를 링크들에게 균형 되게 분산하여 과부하 시 링크 자원들을 충분히 활용하는 보다 높은 처리율을 제공했다.

대구시 建築審議制度 變遷에 관한 硏究

최판길,박영홍,하재명 대한건축학회 2004 대한건축학회논문집 Vol.20 No.5

This study focuses on the change of the architectural design-review system that is pointed of committee members, object and criteria of the review in Daegu. Members of the committee were seen to grow up each year. It related with the addition of review-objects and the separation of two committee that intended to proceed the review equitably. The review-objects were more and more easily adjusted in design review. Because it was an intention of the activating construction and administrational changes from city government to its sub-government. The review-criteria were also gradually simplified and changed to be based on the law and regulations. This paper draws four complements through the change of the review system : First, the major and vocation of the committee are needed to control. It is equally needed in each parts of committee members, and it is needed to participate experts in new parts. Second, the review-objects are needed to strengthen the city regulations that present object is over 21 stories and the area is 100,000 square meters. So the important commercial building of the roadside will be included in the review-object. Third, the more objective review-criteria is needed. Because most of the architects want to know the design criteria which the committee consider continuously. Fourth, an addition of the sustainable criteria is needed. These changes are more helpful set of a progressive review system and they will improve the architectural design and its environment.

4주 agility ladder 운동프로그램이 초등학생의 신체조성과 기초체력에 미치는 영향

최문기,김태운,전재영,김진홍 釜山大學校 附設 體育科學硏究所 2006 體育科學硏究所 論文集 Vol.22 No.1

The aim of this study was to evaluation the effect of 4weeks agility ladder exercise on body composition and physical fitness. Primary school students(n=7) participated in the aerobic exercise and agility Ladder exercise program(HRmax 60~80%, 55min/day, 5days/week). We measured their body composition and physical fitness items such as body weight(BW), Na+/K+, body cell mass(BCM), total body water(TBW), fat mass(FM), percent body fat(%BF), fat free mass(FFM), muscle mass(MM), basal metabolic rate(BMR), body mass index(BMI), flexibility, balance and hand grasping power......