Noradrenaline이 근방추의 흥분성에 미치는 영향

현정,남숙현,홍승길 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

The present experiment was done to determine the effects of noradrenaline on the muscle spindle in cats. The reaction site was determined by recording the changes of impulses from group Ia and group Ⅱ muscular afferents of peripheral sensory nerves and dorsal roots. The results are as follows: 1. 36 group Ia muscular afferents were recorded according to extracellular recording and 5 out of 36 showed enhancement of impulse discharge after 1-2 ㎍ noradrenaline injection, 8 showed decrease and 20 showed initial enhancement followed by decrement, but 3 gave no response at all. 2. The administration of KCI solution did not give nay influences to impulse changes of group Ia muscular afferents activated by noradrenaline, however,the injection of bradykinin diminished the decreasing effect of noradrenaline. 3. A small amount of noradrenaline slightly increased the systemic blood pressure but this kind of blood pressure changes was indifferent to the change of the excitability of group Ia muscular afferents from muscle spindle. However, a large amount of noradrenaline increased the blood pressure about 50 ㎜Hg above normal level which influenced the excitatory effect of the muscle spindle. 4. 22 out of 25 group Ⅱ muscular afferents did not show any responses to noradrenaline. Summerizing above results, it could be assumed that the initial excitatory response of group Ia muscular afferents following the injection of noradrenaline was not attributed to vasoconstriction but to direct effects on muscle stretch receptor, and its depressive response were due to the asphyxia resulted from vasoconstriction. And also, it could be suggested that noradrenaline acts on equator region of the muscle spindle, that is, the distribution area of group Ia muscular afferents.

인터넷쇼핑의 혁신성과 위험지각에 따른 의류상품 구매행동

홍병숙,오현주 중앙대학교 생활과학연구소 2001 생활과학논집 Vol.14 No.-

Various marketing strategies which enable both enterprises and consumers to internet are made possible in real time through a web of networks set up in cyberspace. Growth in the Interned market is feasible since this so-called "Internet marketing" provides both interacting parties with tangible benefits. The following will be discussed in detail. - the status of clothes purchase through e-commerce and the level of risk types perceived by consumers. - the difference of risk perception between a group with high purchasing intention and the other with low purchasing intention. - the perception of innovation in purchasing means during different purchasing intention groups and individual innovation. - the frequence in e-commerce based on purchasing intention groups and decision process of purchasing goods. Result from the study are as follows 1.72.8% of the respondents said they purchased goods on the Internet. Many of them did 3-5 times. Items purchased included CDs, computer gadgets and books as well as fashion - related goods. 2.56.4% of 송 respondents said they purchased clothes over the Net, many of whom did it once or twice. Goods included underclothes, pajamas and cheap miscellaneous goods that do not require and specific size. 3.Results show that socio-psychological risk was highly perceived among types of risk perceptions such as accomplishment, risk, socio-psycho-logical risk, time, convenience risk and economic risk 4.An analysis of the difference in risk perception between a group with high purchasing intention and the other with low purchasing intention showed the former had a low risk perception. 5.It turned out that consumers used the Internet more at the information serch and problem recognition stage than at any other stage after reviewing the influence of distinctions in e-commerce based on 5 stages of purchasing decision-making. 6. Factors affecting purchasing intention showed perceptive results in goods satisfaction, accomplishment risk, social risk and time risk. however, they did not show any sign of perceptive results in economic risk.

한국 성인에서 색도플러 초음파를 이용한 척추동맥 혈류량의 정상치

홍현숙,차장규,박성진,조준희,박재성,김대호,이혜경,안현철 대한초음파의학회 2003 ULTRASONOGRAPHY Vol.22 No.3

간질발작후 MRI 영상에서 뇌 종창을 보인 3예 보고

홍현숙,김대호,이혜경,박재성,박성진,조준희,차장규,백상현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

We report seizure induced brain swelling in three patients. MRI revealed a cortical, subcortical(3/3), and basal ganglia(2/3) high signal intensity on T2- weighted and FLAIR images. The lesion shows low signal on T1-weighted image, and enhanced after contrast administration. Follow up study after 27 days in one case revealed complete resolution of the lesion. The reversible MRI findings may be the results of a local brain swelling, breakdown of blood-brain permeability, and a defect of cerebral autoregulation during seizure activity. The transient nature of such findings have to be considered in the differential diagnosis such as reversible ischemia, migraine, inflammation and infection.

몇가지 β-lactam 항생제의 약효평가를 위한 Minimum Inhibitory Concentration(MIC)의 비교

洪淳德,金鐘國,李東善,河相哲,李相瀚,李載蘭,安賢淑 慶北大學校 1991 論文集 Vol.51 No.-

In order to screen the new β-lactam antibiotics for clinical use. we were compared MIC values of various β-lactam antibiotics. We also tested the influence of pH, inoculum size, stability of antibiotics in medium and some kinds of media on MIC value. As a result, cefotaxime, cefoperazone, piperacillin, cefamandole, cephaloridine, cephapirin, cefazolin, cephalothin, cephaioylycn were scored in antimicrobial activity of MIC data.

소아 급성 부비동염의 진단에 Water's view촬영이 충분한가?

홍현숙,이혜경,박재옥 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

The purpose of this study was to examine the utility of the Water's view in the diagnosis of acute sinusitis in children. The records of all pediatric patients who underwent sinus radiography for suspected acute sinusitis between Oct. 1995 and Apr.1996 was reviewed. All radiographs were reviewed by an attending radiologist and the interpretation of the Water's(occipitomental) view alone was compared to that of a 3 view PNS series(AP Caldwell, lateral, Water's view). 86 PNS series were obtained on 76 pediatric patients during the study period. When compared to 3 view series, the single Water's view had a sensitivity of 84%, specificity is 79%, positive predictive value of 87%, negative predictive value of 84%, overall accuracy of the Water's view in diagnosing childhood acute sinusitis was 85%. The authors conclude that the Water's view is usually sufficient in the evaluation of suspected acute sinusitis in children.

사업장 근로자의 건강위험 평가도구 개발

홍윤철,임현술,하은희,정규철,조희숙,박혜숙,이용애 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of death or acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps; one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

전위된 상악 견치 및 하악 측절치의 치험례

권해숙,현홍근,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

Tooth transposition is an anomaly of eruption characterized by the interchanged positions of two adjacent teeth, which is divided into complete and incomplete transposition. There are three common approaches for treating transposition: aligning the involved teeth in their transposed positions, moving them to their correct anatomic position in the arch and extracting one of the transposed teeth. Considerations in treatment plans are esthetic, function, risk of jeopardizing the roots and damaging the supporting structures, position of the root apex, developmental stages of teeth and expected compliance. The presented case reports described one maxillary canine-the first premolar transposition and two mandibular lateral incisor-canine transpositions. The former transposed teeth were arranged in their transposed position, and the latter transposed teeth were rearranged into their normal position. 치아전위란 인접한 두 치아의 위치가 서로 바뀐 치아 위치 이상을 말하며, 치관과 치근의 위치에 따라 완전전위와 불완전전위로 나눌 수 있다. 하악보다는 상악에 편측성으로 호발하며, 특히 상악 견치에서 자주 발생한다. 전위는 발견 시기와 전위된 양상에 따라 치료방법이 달라질 수 있다. 본 증례는 상악 견치와 제1소구치 간의 전위가 일어난 10세 7개월의 환아와 하악 측절치와 견치 간의 전위가 일어난 8세 11개월 환아와 8세 9개월 환아의 교정치료에 대한 것으로 양호한 치료 결과를 얻었고, 증례 별로 치료방법의 차이점에 관한 고찰을 하였기에 이를 보고하는 바이다.

항암화학요법 중 호중구감소증이 발생한 저위험군 발열 환자들을 대상으로 한 경구 항균제 요법의 임상적 유용성 및 안정성에 대한 연구

김연숙,이혁,기현균,김춘관,김신우,김성민,백경란,김원석,윤성수,이홍기,강원기,박찬형,박근칠,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 항암화학요법 중 호중구감소증을 동반한 발열이 발생하는 암환자들을 치료하기 위한 다양한 항균제와 여러 가지 방법들이 시도되고 있는 가운데, 합병증과 사망률의 발생가능성이 적은 저위험군 환자들을 대상으로 초기 72시간동안 정주 항균제를 투여한 이후 경구 항균제로 전환하는 요법의 유용성과 안정성을 평가해보고자 본 연구를 시행하였다. 방법 : 1998년 2월부터 1999년 9월까지 본원에서 항암화학요법 중 호중구감소증과 발열이 발생한 환자들 가운데 기저 암질환이 고형암이거나 림프종이고, 입원당시 패혈증의 증후가 없으며 입원 72시간이내에 해열되고 백혈구수치가 증가 추세인 환자들을 대상으로 하여 72시간 동안 정주 항균제를 투여한 이후 경우 ciprofloxacin 750㎎을 하루 2회씩 투여하여 총 4일간 투여하였다. 모든 환자들은 열이 떨어지고 호중구감소증이 회복될 때까지 입원하도록 하였다. 결과 : 총 38명 환자의 40예가 등록이 되었고, 환자들의 기저암 질환은 고형함이 72.5%, 림프종이 27.5%였다. 입원당시 평균 호중구치수는 156/㎕였고, 호중구수치가 100/㎕미만인 경우는 65%였으며, 호중구감소증이 지속된 기간의 평균은 2.4일이었다. 40예 중 39예가 항균제의 변형이나 추가 없이 호중구감소증과 발열로부터 회복이 되어 97.5%의 성공율(95% 신뢰구간: 86.8-99.9%)을 보였다. 부작용으로 피부발진이 있었던 경우가 한 예 있었는데, 증상이 경하여 경구 항균제를 지속할 수 있었다. 심와부의 동통으로 복용을 지속할 수 없어서 대상에서 제외된 예가 또 한 예 있었다. 결론 : 항암요법 중 호중구감소증과 발열을 동반한 환자들 가운데 저위험군 환자들에서 항균제 72시간정주 이후 경구 항균제로의 전환요법은 효과적이고도 안전한 치료방법이라고 할 수 있다. Background : Oral antibiotic therapy following empirical intravenous antibiotics may be effective and safe for febrile neutropenic patients with lowrisk for complications. Methods : We conducted a prospective clinical trial of oral antibiotic therapy in the patients with neutropenia and fever during chemotherapy for cancer. Underlying malignancies were solid tumor or lymphoma with short duration of neurtropenia and the patients had no evidence of clinically or microbiologically documented infections. Oral ciprofloxacin was given to the patients who lacked signs of sepsis on admission, had a rising tendency of neutrophil count (ANC >100 /㎕ ) at 72 hours, and were afebrile at 72 hours. All patients were hospitalized until neutropenia and fever resolved. Results : A total of 40 episodes of 38 patients were enrolled from February 1998 to September 1999. The mean neutrophil counts on admission were 156/㎕ and the mean duration of neutropenia was 2.4 days. The episodes which had neutrophil count below 100 /㎕ were 26 (65%). Treatment was successful in 39 of 40 episodes (97.5% : 95 % confidence interval, 86.8% to 99.9%). Adverse reactions of oral ciprofloxacin were skin rash and epigastric soreness in two cases, respectively. There were no deaths during the study. Conclusions : For low-risk febrile patients with neutropenia during cancer chemotherapy, switch therapy to oral ciprofloxacin at 72 hours following intravenous broad-spectrum antibiotics is effective and safe,

화학적으로 활성화된 GroupⅢ와 GroupⅣ구심성 근신경의 Gamma Motoneuron에 대한 반사효과

방대홍,홍승길,남숙현 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.3

In decerebrated cats the effects of fine muscle afferents (groups Ⅲ and Ⅳ) upon gamma motoneurons were studied. The efferent activity was exracellularly recorded from small filaments of ventral roots or from filaments of musole nerves. Fine muscle afferents were selectively activated by bradykinin, potassium and serotonin. For comparison, succinylcholine was administrated to activated muscle spindle afferents. Forty gastrocnemius-soleus gamma motoneurons were recorded. Thirty-six (90%) of them had a tonic background discharge in the absence of intentional stimulation. A high susceptibility to an increased activity in fine muscle efferents was found for the gamma motoneurons. Practically all neurons both to homonymous extensor and antagonistic flexor muscles responded with an excitation to at least one of the algesic substances applied. Only two out of fifteen gamma motoneurons responded to succinylcholine. Thus indicationg a weak convergence from muscle spindle afferents. Control experiments demonstrated that the responses to bradykinin and potassium are entirely due to the nervorus outflow from the gastrocnemius-soleus muscle. In contrast, serotonin influencing the gamma motoneurons has unknown additional sites of action. The results indicate that muscular group Ⅲ and/or group Ⅳ units activated by algesic substances evoke excitatory effects upon gamma motoneurons.