LC-MS/MS를 이용한 S.D. Rat 혈장 중 Arctiin 분석법 개발

송병정,채정우,백현문,권광일 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

KIOM-MA128 is a novel oriental herbal medicine which is for atopic dermatitis and asthma. The purpose of this study was to develop on analytical method of arctiin in rat plasma after oral administration of KIOM-MA128. Analyte was separated on a Atlantis dC18 reverse phase column, using gradient mobile phase (A:B = acetonitrile: 0.1% formic acid in water) at a flow rate of 0.3 mL/min. Detection was performed by electrospray positive ionization mass spectrometry using multiple reaction monitoring of the transitions of arctiin at m/z 552.4 → 372.8 and internal standard (carbamazepine) at m/z 237.0 → 194.5. The limit of quantification was 1 ng/mL for arctiin. The precisions were lower than 15% and the accuracy was between – 12.21 and 3.2%. The maximum concentration found in plasma samples was 4.1 ng/mL. The present method was successfully developed for detecting arctiin in plasma and this results would be utilized to the further study.

뇌실내출혈로 인한 급성 수두증에서 관찰된 해리증후군

김광기,이경민,이정주,오종배,안태범,정상욱,남현우,박성호 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

분산 CMY 디더링을 이용한 BNM 하프토닝

정광민,윤성현,김현기 慶南專門大學 2001 論文集 Vol.29 No.1

다채널 광정렬 장치에서의 다자유도 회전 스테이지 동작 특성에 관한 연구

정상화,차경래,김현욱,최석봉,김광호,박준호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In recent years, as the demands of VBNS(Very high speed Backbone Network Service) and VDSL(Very high-data rate Digital Subscriber Line) increase, the development of kernel parts of optical communication such as PLC(Planar Light Circuit), Coupler, WDM elements increase. The alignment and the attachment technology are very important to fabricate the optical elements for communication. In this paper, the mechanism of rotational stage are studied. with the three different method and the results of them are applied to the design of the system. The performance test of resolution and travel is performed.

류마티스 관절염과 동반된 궤양성 대장염 1예

정종필,김윤아,서강석,김태현,김춘호,박정복,이광욱 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

The gastrointestinal involvement in rheumatoid arthritis may be broad and includes many causes: drug induced colitis, colitis associated with infectious agents, vasculitis in gut, autoimmune disease located in gut. Rheumatoid arthritis is a chronic multisystemic disease of unknown cause. Although a number of mixed autoimmue disease exist, there were rare reports about Ulcerative colitis with Rheumatoid arthritis associated. We report one case of Rheumatoid arthritis patient who diagnosed as Ucerative colitis by colonoscopic and histologic finding with review of literature.

불소함유 교정용 레진이 법랑질 인공우식과 재석회화에 미치는 영향에 관한 연구

정광조,한세현,이상훈 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.1

To study the effect of fluroide-containing orthodontic resin on the artificial caries susceptibility and remineralization of enamel around bracket, Direct Bonding System brackets were bonded to the buccal surfaces of the 24 sound extracted teeth. 1. The findings of the artificially induced enamel lesion were; the surface zone and intact enamel showed negative birefringence while the subsruface area showed positive birefringence in both control and experimental group. 2. Experimental group of the artificially induced enamel lesion showed more intact, weak birefringence surface zone and lower depth of the subsurface demineralization area than control group. The pattern of the progression of the demineralization was regular. 3. Control group of the artificially induced enamel lesion showed partially destructed, strong birefringence surface zone and deeper depth of the subsurface demineralization area than experimental group. The pattern of the progression of the demineralization was irregular. 4. After remineralization, the experimental group showed more intact, thicker sufrace zone and lower depth of subsurface demineralized area than control group.

Gilbert-Elliott 채널 모델에서의 BCH 코드를 이용한 무선 ATM의 오류 정정 부호

정재욱,문병현,권광영 大邱大學校 科學技術硏究所 2001 科學技術硏究 Vol.8 No.2

In this paper, the use of BCH code is considered to improve the bit error probability and cell loss probability for wireless ATM over Gilbert channel model. The Performance of the wireless ATNI with BCH code and interleaving is compared with the one without interleaving. As a result, the wireless ATM system without imerleaving is unable to reach the reguired BER with appropriate forward error correction. When the leaving is used, the required BER is obtained for reliable communication, The parameter of the Gilbert channel model and the BCH codes are determined for the reliable wireless ATM communication.

약진의 임상적 고찰

김지현,김문정,조소연,황규광,함정희 梨花女子大學校 醫科大學 醫科學硏究所 1999 EMJ (Ewha medical journal) Vol.22 No.4

연구목적 : 본 연구는 입원환자 및 외래환자를 대상으로 약진의 임상양상 및 의심되는 유발 약물에 대해 알아보고자 하였다. 방법 : 1994년 1월부터 1999년 5월까지 본원 피부과 외래환자와 본과에 피부병변으로 의뢰되었던 타과 입원환자 중 약진으로 진단되었던 131명을 대상으로 하였다. 약진으로 진단된 131명을 대상으로 현병력 및 과거력을 검토하였고, 문진, 이학적 검사소견, 일반 혈액검사, 간기능검사 및 IgE PRIST를 실시하였으며, 약진의 임상형태, 원인약제, 잠복기에 대해 조사를 하였다. 결과 : 1) 본 연구에서는 남녀간의 유의한 차이는 보이지 않았고. 연령분포는 20대와 30대에서 높은 빈도를 보였다. 2) 투약으로부터 약진발생까지의 시간, 즉 잠복기는 24시간에서 3일까지의 경우가 48예(36.6%)로 가장 많았고, 4일에서 6일까지 35예(26.7%), 7일에서 13일까지 25예(19.1%). 14일에서 20일까지, 21일에서 27일까지 6예로 나타났고. 28일 이상이 9예로 나타났다. 3) 약진환자의 임상형태는 발진형 발진이 가장 많았으며 그다음은 고정약진, 여드름양 발진, 급성 담마진, 자반, 수포성 발진, 태선양 발진, Stevens-Johnson 증후군, 그리고 AGEP 순으로 나타났다. 4) 약진환자 중 그 원인약제를 살펴보면, 항생제를 포함한 항균제가 22예로 가장 많았고, 다음은 해열진통제, 종합 감기약. 중추신경억제제, 항결핵제 순이었다. 5) 검사실 소견에서는 백혈구 증다증이 22.5%, 백혈구 감소증이 5.6%, 호산구 증다증이 14.5%, 비정상적인 SGOT/SGPT가 11.4%, 비정상적인 IgE수치는 8.3%였다. 결론 : 본 연구에서는 입원환자 및 외래환자를 대상으로 약진의 임상양상 및 의심되는 유발 약물에 대해 알아보고자 하였으며, 이전의 연구와 비교해 볼 때 연령 분포, 약진의 임상형태, 잠복기, 원인약제의 순서는 유사하거나 일치함을 확인할 수 있었다. 또한, 우리나라는 의사의 처방없이 약물을 남용, 오용하는 경향이 크고, 여러 가지 약물을 동시에 투여하는 경우도 많으며, 구성성분을 알 수 없는 한약제의 사용이 빈번하므로 약물을 처방하는데 있어서 이에 대한 고려가 필요한 것으로 생각된다. Objectives and Method : This study attempts to evaluate the clinical manifestations and causative drugs of drug eruptions at Ewha Womans University Tongdaemun Hospital by retrospective study of outpatients, inpatients and consulted patients(number : 121, duration : 1994. 1 - 1999. 5). Results : 1) Most drug eruptions occurred in patients at the age of 20 - 39 years old. 2) The cutaneous manifestations of drug eruptions in the order of frequency were as follows : exanthematous eruption, fixed drug eruption, acneiform eruption, purpura, urticaria, bullous eruption, lichenoid eruption, Stevens-Johnson syndrome, and acute generalized exanthemic pustulosis. 3) Drug eruption developed most frequently from 24 hours to 3 days of drug intake. 4) Most common causative drugs were antibiotics, followed by antipyretics and analgesics. 5) Laboratory abnormalities were leukocytosis(22.5%), eosinophilia(14.5%), abnormal AST/ALT(11.4%), abnormal IgE titer(8.3%), and leukopenia(5.6%). Conclusion : The most frequent clinical feature of the drug eruption were exanthematous in nature and the most common causative drugs were antibiotics, as suspected. Since too many patients take various unidentified drugs at drug stores in Korea, physicians need to exercise special care in prescribing drugs and evaluating patients with drug eruption.

스위칭 파워 소모를 최소화하기 위한 마이크로 오퍼레이션 인코딩

성광수,현유진,정재국 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.1

In this paper, we propose an encoding algorithm for micro-operations which minimizes output transactions of control store. The transition rates between two micro-operations are computed based on the instruction usage frequency and the symbolic micro-codes of each instruction. Then, codes are assigned to micro-operations such that the Hamming distance of codes between micro-operations with higher transition rates is smaller. Experimental results on a x86 real mode symbolic micro-code set show that the proposed algorithm reduces the switching activity by 32% with only 6% area increase compared to the results of NOVA input encoding.

아파트 平面類型別 空間利用의 行態的 特性에 관한 硏究

손광제,정준현 대구대학교 과학기술연구소 1998 科學技術硏究 Vol.5 No.3

This study has a subject for the mass housing (alias dictus, Apartment) by unit plans on the Taegu urban area, and has a process of surveying and analyzing the actual using states of dweller in the residential space. It also investigates the spatial using corresponded to the living activities. As results, a cultural searching for urban housing is disciplined with the positive study for surveying the living contents emerged from the residential spaces. The finding of this study indicates the fuction of sleeping, eating, hosting, familiarity and family ritual differ among the housing and floor types. The similaries and differences among housing as well as floor types are discused and implications are provided.